StrokeNCT00355836
Recovery of Hand Function Through Mental Practice.
A study testing Mental Imagery in people with Stroke, run by University of Aberdeen at 2 sites in United Kingdom.
Trial summary
The purpose of this study is to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness. Read more about this study
- Who is it for?
- Any age
- Conditions the study is for
- Stroke
- What is being tested?
- Mental Imagery
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 135 participants
- Where
- 2 sitesUnited Kingdom
- Study dates
- Nov 2004to Feb 2007
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Confirmed diagnosis of stroke in the last 1-6 months Persisting upper limb weakness -
Who cannot join
- Alcohol/ Drug abuse Psychiatric history Previous illness that has impacted on individuals Activity of Daily living
- Dementia (assessed by MSQ) Severe Aphasia
Trial locations and contacts
2 sites in 1 country.
United Kingdom2 sites
University of Aberdeen
Aberdeen, AB24 3FX
Ninewells Hospital
Dundee
About this study
Official title: Can Motor Imagery Enhance Recovery of Hand Function After Stroke? Evaluation of Motor Imagery Training.
The purpose of this study is to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness.
Read the detailed description
Stroke is a common and highly debilitating illness. Many patients (41-45%) experience chronic motor impairments (Dijkerman et al., 1996) and limitations in activities of daily living (Wade \& Langton Hewer, 1987) even after extensive neurological rehabilitation. They often result in long-term dependence at a considerable cost to the carers and the health service. It is therefore crucial to optimise motor recovery after stroke. This study investigates the therapeutic benefits of motor imagery training in stroke patients with a motor weakness.
Evidence for the idea that motor imagery training could enhance the recovery of hand function comes from several separate bases of evidence: the sports literature; neurophysiological evidence; evidence from health psychology research; as well as preliminary findings using motor imagery techniques in stroke patients.
There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate the redistribution of brain activity, which accompanies recovery of hand function, thus resulting in a reduced motor deficit. Patients are assessed before and after a four-week evaluation period. In this randomised controlled trial 45 patients daily mentally rehearse movements with their affected hand under close supervision. Their recovery is compared to 45 patients who perform closely supervised non-motor mental rehearsal, and 45 patients who are not engaged in a training program.
- Conditions
- Stroke
- Being tested
- Mental Imagery
- Keywords
- Motor Imagery, Stroke, Neuro-rehabilitation, health psychology, neuroscience, randomised controlled trial
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mental ImageryBehavioural
What is being measured
The primary outcome is the main question the study is designed to answer.
Action Research Arm Test (ARAT) (Lyle, 1981)
Secondary outcomes (5)
Grip strength (dynamometer; Heller et al., 1987),
Nine hole pegboard task (Mathiowetz et al., 1985, Wade [ref]),
Function Limitation Profile
Barthel Index
Recovery Locus of Control
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Jul 2006 (estimated)
- Study startNov 2004
- Primary completionFeb 2007
- Study completionFeb 2007
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Double blind
- Enrolment
- 135 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Aberdeen
- Sponsor type
- University, hospital or other
- Collaborators
- Chief Scientist Office of the Scottish Government
- Investigators
- Marie Johnston, Prof, Principal investigator, University of Aberdeen
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00355836
- Sponsor's protocol ID
- CZH/4/153
- Status last verified
- Nov 2015
- First submitted
- 24 Jul 2006
- Last updated
- 5 Nov 2015
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Can Motor Imagery Enhance Recovery of Hand Function After Stroke? Evaluation of Motor Imagery Training.
- ClinicalTrials.gov ID
- NCT00355836
- Acronym / sponsor ID
- CZH/4/153
- Conditions
- Stroke
- Keywords
- Motor Imagery, Stroke, Neuro-rehabilitation, health psychology, neuroscience, randomised controlled trial
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 135 participants (estimated)
- Lead sponsor
- University of AberdeenUniversity, hospital or other
- Collaborators
- Chief Scientist Office of the Scottish Government
- Study start
- Nov 2004
- Primary completion
- Feb 2007 (actual)
- Study completion
- Feb 2007 (actual)
- First posted
- 25 Jul 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to assess the therapeutic benefits of motor imagery training in stroke patients with persistent motor weakness.
Detailed description
Stroke is a common and highly debilitating illness. Many patients (41-45%) experience chronic motor impairments (Dijkerman et al., 1996) and limitations in activities of daily living (Wade \& Langton Hewer, 1987) even after extensive neurological rehabilitation. They often result in long-term dependence at a considerable cost to the carers and the health service. It is therefore crucial to optimise motor recovery after stroke. This study investigates the therapeutic benefits of motor imagery training in stroke patients with a motor weakness.
Evidence for the idea that motor imagery training could enhance the recovery of hand function comes from several separate bases of evidence: the sports literature; neurophysiological evidence; evidence from health psychology research; as well as preliminary findings using motor imagery techniques in stroke patients.
There is evidence to suggest that mental rehearsal of movement can produce effects normally attributed to practising the actual movements. Imagining hand movements could stimulate the redistribution of brain activity, which accompanies recovery of hand function, thus resulting in a reduced motor deficit. Patients are assessed before and after a four-week evaluation period. In this randomised controlled trial 45 patients daily mentally rehearse movements with their affected hand under close supervision. Their recovery is compared to 45 patients who perform closely supervised non-motor mental rehearsal, and 45 patients who are not engaged in a training program.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Double blind
Who may qualify
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (1 listed)
- Confirmed diagnosis of stroke in the last 1-6 months Persisting upper limb weakness -
Key exclusion criteria (2 listed)
- Alcohol/ Drug abuse Psychiatric history Previous illness that has impacted on individuals Activity of Daily living
- Dementia (assessed by MSQ) Severe Aphasia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mental Imagery | Behavioural | – |
Primary outcome
Action Research Arm Test (ARAT) (Lyle, 1981)
5 secondary outcomes
Grip strength (dynamometer; Heller et al., 1987),
Nine hole pegboard task (Mathiowetz et al., 1985, Wade [ref]),
Function Limitation Profile
Barthel Index
Recovery Locus of Control
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2015.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Marie Johnston, Prof principal investigator
University of Aberdeen
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mental Imagery in people with Stroke, run by University of Aberdeen at 2 sites in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Nov 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Action Research Arm Test (ARAT) (Lyle, 1981). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2015.