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Mood DisordersPhase 2/3NCT00423462

First Experimental Study of Transference-Interpretations (FEST)

A Phase 2/3 study testing Brief dynamic psychotherapy in people with Mood Disorders and Anxiety Disorders, run by University of Oslo at 1 site in Norway.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Analysis of the ongoing patient-therapist interaction, the transference, is considered a key active ingredient in psychoanalytically oriented psychotherapy and psychoanalysis.However, one century after Sigmund Freuds's famous "Dora" case, the first clinical description of transference, no study of transference… Read more about this study

Who is it for?
Ages 20 to 60 years
What is being tested?
Brief dynamic psychotherapy
How many people
100 participants
Where
1 siteNorway
Study dates
Jan 1993to Dec 2005
Phase
Phase 2/3
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 20 to 60 years
  • All sexes
  • No healthy volunteers
  • Adult

Who may be able to join

  • Age 20 - 60 years
  • Diagnoses Mood-disorder, non-psychotic
  • Anxiety disorders
  • Personality disorders
  • Interpersonal problems not due to a mental disorder

Who cannot join

  • Psychotic disorders
  • Bipolar disorder
  • Organic brain disorder
  • Substance abuse
  • Long-term (years) disability
  • Mental retardation

Trial locations and contacts

1 site in 1 country.

Norway1 site

  • Department of Psychiatry, Faculty of Medicine, University of Oslo

    Oslo, 0881 Oslo

Other trials in Norway

About this study

Official title: First Experimental Study of Transference Interpretations (FEST)

Analysis of the ongoing patient-therapist interaction, the transference, is considered a key active ingredient in psychoanalytically oriented psychotherapy and psychoanalysis.However, one century after Sigmund Freuds's famous "Dora" case, the first clinical description of transference, no study of transference interpretations have been published.In the present study 100 out-patients were randomized to receive one year weekly dynamic psychotherapy, with and without transference interpretations. That is, one treatment component,transference interpretations, were added to a comparison condition, therapy of the same format, by the same therapists, but without use of transference interpretation.

All treatment session were audiotaped, and treatment integrity have been carefully checked. Patients were evaluated at treatment termination, one year after treatment termination and three years after treatment termination. Enrollment of patients started january 1993, and all follow-up evaluations completed by December 2005.

Read the detailed description

This study is designed to measure specific long-term effects of transference interpretations in dynamic psychotherapy, using an experimental dismantling design. One hundred psychiatric out-patients, referred to seven study therapists, to receive exploratory dynamic psychotherapy, were randomized to one year weekly dynamic psychotherapy, with and without transference interpretations.They suffered from mood,anxiety,and personality disorders or interpersonal problems not due to a mental disorder. All treatment sessions were audiotaped and treatment integrity carefully checked.All patients have been evaluated before treatment, after treatment, one year after termination of treatment, and three years after termination of treatment. The main outcome measures were the Psychodynamic Functioning Scales (PFS) and Inventory of Interpersonal Problems-Circumplex version (IIP-C).Chang over time is assessed using linear mixed model analyses.

The main hypothesis is that patients treated with transference interpretations will have a more favourable course over the whole study period of four years.

The second hypothesis is that suitable patients, that is patients with a life long pattern of more mature object relations (QOR) and/or patients without comorbid personality disorders will do better with transference interpretations.

Insight and identification with the therapist will be analyzed as putative mediators of long-term change in interpersonal functioning

Being tested
Brief dynamic psychotherapy
Keywords
Psychotherapy, Long-term effects
Medical subject headings
Mood Disorders, Anxiety Disorders, Personality Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Brief dynamic psychotherapyBehavioural

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. The Psychodynamic Functioning Scales (PFS), clinician rated

  2. Inventory if Interpersonal Problems-Circumplex version (IIP-C), self-report

Secondary outcomes (2)

  1. The Global Assessment of Functioning Scale (GAF)

  2. Global Severity Index (GSI) from SCL-90-R

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted18 Jan 2007 (estimated)
  2. Study startJan 1993
  3. Study completionDec 2005

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2/3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Single blind
Enrolment
100 participants
IDs, dates and publications
ClinicalTrials.gov ID
NCT00423462
Sponsor's protocol ID
FEST307/95
Status last verified
Aug 2007
First submitted
16 Jan 2007
Last updated
27 Aug 2007
Results posted
No

Publications

  • Hoglend P, Amlo S, Marble A, Bogwald KP, Sorbye O, Sjaastad MC, Heyerdahl O. Analysis of the patient-therapist relationship in dynamic psychotherapy: an experimental study of transference interpretations. Am J Psychiatry. 2006 Oct;163(10):1739-46. doi: 10.1176/ajp.2006.163.10.1739.

    PubMed 17012684

  • Nissen-Lie HA, Dahl HJ, Hoglend PA. Patient factors predict therapists' emotional countertransference differently depending on whether therapists use transference work in psychodynamic therapy. Psychother Res. 2022 Jan;32(1):3-15. doi: 10.1080/10503307.2020.1762947. Epub 2020 May 13.

    PubMed 32404003

  • Tallberg P, Ulberg R, Johnsen Dahl HS, Hoglend PA. Core conflictual relationship theme: the reliability of a simplified scoring procedure. BMC Psychiatry. 2020 Apr 6;20(1):150. doi: 10.1186/s12888-020-02558-4.

    PubMed 32252696

  • Sorbye O, Dahl HJ, Eells TD, Amlo S, Hersoug AG, Haukvik UK, Hartberg CB, Hoglend PA, Ulberg R. Psychodynamic case formulations without technical language: a reliability study. BMC Psychol. 2019 Oct 24;7(1):67. doi: 10.1186/s40359-019-0337-5.

    PubMed 31651367

  • Ulberg R, Ness E, Dahl HS, Hoglend PA, Critchfield K, Blayvas P, Amlo S. Relational interventions in psychotherapy: development of a therapy process rating scale. BMC Psychiatry. 2016 Sep 6;16(1):310. doi: 10.1186/s12888-016-1021-4.

    PubMed 27600314

  • Ulberg R, Amlo S, Hoglend P. Manual for Transference Work Scale; a micro-analytical tool for therapy process analyses. BMC Psychiatry. 2014 Nov 18;14:291. doi: 10.1186/s12888-014-0291-y.

    PubMed 25404145

  • Ulberg R, Amlo S, Hersoug AG, Dahl HS, Hoglend P. The effects of the therapist's disengaged feelings on the in-session process in psychodynamic psychotherapy. J Clin Psychol. 2014 May;70(5):440-51. doi: 10.1002/jclp.22088. Epub 2014 Mar 27.

    PubMed 24677205

  • Ulberg R, Hoglend P, Marble A, Johansson P. Women respond more favorably to transference intervention than men: a randomized study of long-term effects. J Nerv Ment Dis. 2012 Mar;200(3):223-9. doi: 10.1097/NMD.0b013e318247cb6d.

    PubMed 22373759

  • Hoglend P, Hersoug AG, Bogwald KP, Amlo S, Marble A, Sorbye O, Rossberg JI, Ulberg R, Gabbard GO, Crits-Christoph P. Effects of transference work in the context of therapeutic alliance and quality of object relations. J Consult Clin Psychol. 2011 Oct;79(5):697-706. doi: 10.1037/a0024863.

    PubMed 21859184

  • Ulberg R, Hoglend P, Marble A, Sorbye O. From submission to autonomy: approaching independent decision making. A single-case study in a randomized, controlled study of long-term effects of dynamic psychotherapy. Am J Psychother. 2009;63(3):227-43. doi: 10.1176/appi.psychotherapy.2009.63.3.227.

    PubMed 19845088

  • Ulberg R, Johansson P, Marble A, Hoglend P. Patient sex as moderator of effects of transference interpretation in a randomized controlled study of dynamic psychotherapy. Can J Psychiatry. 2009 Feb;54(2):78-86. doi: 10.1177/070674370905400205.

    PubMed 19254438

Questions about this trial

What is this clinical trial studying?

A Phase 2/3 study testing Brief dynamic psychotherapy in people with Mood Disorders and Anxiety Disorders, run by University of Oslo at 1 site in Norway.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 27 Aug 2007. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Norway. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this combined phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

The Psychodynamic Functioning Scales (PFS), clinician rated. The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00423462, which also lists 11 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2007.

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