ObesityNCT00434265
Obesity, Physical Inactivity or Dietary Fat ?
A study testing Physical training in people with Obesity, run by University Hospital, Strasbourg, France at 2 sites in France.
Trial summary
Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in… Read more about this study
- Who is it for?
- Ages 18 to 55 years, men only
- Conditions the study is for
- Obesity
- What is being tested?
- Physical training
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 12 participants
- Where
- 2 sitesFrance
- Study dates
- Mar 2007to Aug 2011
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 55 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Men between 18 and 55
- IMC >25 and <30 kg/m2 and waist circumference >102 cm
- Familial antecedents of obesity
- Physical inactivity (PAL<1.5, according to MOSPA-questionnaire and accelerometry)
- Acceptation of physical training and body weight control during the study
Who cannot join
- Any drug interfering with energetic or lipid metabolism
- Any contradiction to moderate physical training
- Diabetes or arterial hypertension treatment
- Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH)
- Consumption of more than 40 g alcohol per day
- Recent voluntary or involuntary weight modification (3kg the next three months)
- A recent trip outside France before and during stable isotope measures.
Trial locations and contacts
2 sites in 1 country.
France2 sites
Service des Explorations Fonctionelles Respiratoires et de l'Exercice - Hôpital Civil
Strasbourg, 67091
Service de Médecine Interne et de Nutrition - Hôpital de Hautepierre
Strasbourg, 67098
About this study
Official title: OBESITY, PHYSICAL INACTIVITY OR DIETARY FAT ? Role of Physical Activity in the Trafficking of Dietary Fatty Acids Varying in Length and Saturation Degree.
Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies. Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle. Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain. Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects. One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids. We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat. Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.
- Conditions
- Obesity
- Being tested
- Physical training
- Keywords
- Obesity, Exercise, Fat oxidation, Overweigh (IMC>25 and IMC<30)
- Medical subject headings
- Obesity, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Physical trainingBehavioural
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of fat oxidation induced by physical training, according to fat type (oleate vs palmitate)
Secondary outcomes (2)
Variations of oleate and palmitate postprandial kinetic in different lipoprotein fractions
Expression of different muscle and adipose tissue genes
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Feb 2007 (estimated)
- Study startMar 2007
- Study completionAug 2011
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by University Hospital, Strasbourg, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 12 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Collaborators
- PRNA (INSERM/INRA), Fondation Coeur et Artères, Centre National de la Recherche Scientifique, France, Louis Pasteur University, Strasbourg
- Responsible party
- Sponsor
- Investigators
- Chantal Simon, MD, Study director, Hôpitaux Universitaires de Strasbourg
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00434265
- Sponsor's protocol ID
- 3493
- Status last verified
- Dec 2025
- First submitted
- 12 Feb 2007
- Last updated
- 16 Dec 2025
- Results posted
- No
Publications
Jacobi D, Perrin AE, Grosman N, Dore MF, Normand S, Oppert JM, Simon C. Physical activity-related energy expenditure with the RT3 and TriTrac accelerometers in overweight adults. Obesity (Silver Spring). 2007 Apr;15(4):950-6. doi: 10.1038/oby.2007.605.
PubMed 17426330
Study at a glance
From the registry record, last updated by the sponsor on 16 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- OBESITY, PHYSICAL INACTIVITY OR DIETARY FAT ? Role of Physical Activity in the Trafficking of Dietary Fatty Acids Varying in Length and Saturation Degree.
- ClinicalTrials.gov ID
- NCT00434265
- Acronym / sponsor ID
- 3493
- Conditions
- Obesity
- Keywords
- Obesity, Exercise, Fat oxidation, Overweigh (IMC>25 and IMC<30)
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 12 participants (actual)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Collaborators
- PRNA (INSERM/INRA), Fondation Coeur et Artères, Centre National de la Recherche Scientifique, France, Louis Pasteur University, Strasbourg
- Study start
- Mar 2007
- Study completion
- Aug 2011 (actual)
- First posted
- 13 Feb 2007 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Obesity is the consequence of a chronic disequilibrium of fat balance. Genetic factors determine predisposition to obesity, but the most often mentioned idea is that environmental factors, such as a high-fat diet and a sedentary lifestyle, join to favour weight gain and explain the increased prevalence of obesity in our westernized societies. Since lipogenesis is negligible in humans, obesity represents the consequence of altered fat partitioning between oxidation and storage, likely due to a preferential directing of dietary fat towards adipose tissue and away from muscle. Interventions that favour partitioning of dietary fat towards muscle for oxidation might thus protect against weight gain. Exercise may be one kind of such intervention but the scant data on dietary fat metabolism does not allow clear conclusions, in particular in obese subjects. One question concerns the impact of the type of fat eaten: the effects of physical inactivity may vary according to the length and saturation degree of the fatty acids. We hypothesize that 1) physical activity of moderate intensity, independently of its effect on energy balance, will favor a preferential trafficking towards adipose tissue, will modify the expression of genes implicated in fat oxidation and storage and partly correct the abnormalities observed in obese subjects, 2) effects of physical activity vary according to the saturation degree of fat. Twelve obese subjects, aged 18 to 55, will undergo tests before and after 2 months of training at current recommendations to ascertain dietary fat partitioning using stable isotopes and to determine changes in gene expression with muscle and adipose tissue microbiopsies.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Single group
- Masking
- None (open label)
Who may qualify
- Ages
- 18 to 55 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Men between 18 and 55
- IMC >25 and <30 kg/m2 and waist circumference >102 cm
- Familial antecedents of obesity
- Physical inactivity (PAL<1.5, according to MOSPA-questionnaire and accelerometry)
- Acceptation of physical training and body weight control during the study
Key exclusion criteria (7 listed)
- Any drug interfering with energetic or lipid metabolism
- Any contradiction to moderate physical training
- Diabetes or arterial hypertension treatment
- Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH)
- Consumption of more than 40 g alcohol per day
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Physical training | Behavioural | – |
Primary outcome
Proportion of fat oxidation induced by physical training, according to fat type (oleate vs palmitate)
2 secondary outcomes
Variations of oleate and palmitate postprandial kinetic in different lipoprotein fractions
Expression of different muscle and adipose tissue genes
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Dec 2025.
- Results publication: PubMed 17426330Jacobi D, Perrin AE, Grosman N, Dore MF, Normand S, Oppert JM, Simon C. Physical activity-related energy expenditure with the RT3 and TriTrac accelerometers in overweight adults. Obesity (Silver Spring). 2007 Apr;15(4):950-6. doi: 10.1038/oby.2007.605.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Chantal Simon, MD study director
Hôpitaux Universitaires de Strasbourg
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Physical training in people with Obesity, run by University Hospital, Strasbourg, France at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of fat oxidation induced by physical training, according to fat type (oleate vs palmitate). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00434265, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Dec 2025.