Parkinson's DiseaseNCT00591344
The Effect of Exercise on Individuals With Parkinson's Disease
A study testing Progressive resistance training and Modified Fitness Counts in people with Parkinson's Disease, run by University of Illinois Chicago at 1 site in United States.
Trial summary
The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most beneficial. Read more about this study
- Who is it for?
- Ages 50 to 67 years
- Conditions the study is for
- Parkinson's Disease
- What is being tested?
- Progressive resistance training and Modified Fitness Counts
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 51 participants
- Where
- 1 siteUnited States
- Study dates
- Oct 2007to Oct 2011
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 67 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- a diagnosis of PD
- Up to the age of 67
- on at least 1 DA drug, may be on several PD medications
- able to walk for six minutes (may take rest breaks)
- able to come off their PD medication for testing (12 hour overnight withdrawal of antiparkinsonian medications)
- able to stay on stable PD medications for at least 6 months
- live within a 30 mile radius of Chicago
- Hoehn and Yahr Score: II - III while in the "Off" PD medication state
Who cannot join
- history of any other neurological disorder as determined by medical history and neurological exam
- history of a known injury, disease, or other disorder that might interfere with motor function in the proposed experiments
- a score less than 23 on the Mini-Mental State Examination
- currently involved in an active, ongoing formal exercise program deep brain stimulation surgery
- known cardiac problem or significant hypertension
- depression that may interfere with regular exercise
- hallucinations or being treated for hallucinations
Trial locations and contacts
1 site in 1 country.
United States1 site
Physical Therapy Department at the University of Illinois at Chicago
Chicago, Illinois, 60612
About this study
The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most beneficial.
Read the detailed description
Parkinson's disease (PD) negatively affects the quality of life for a million individuals in the United States. While medication and surgery are the most effective treatments for PD, physicians and people with PD often delay using these treatments because of their considerable adverse side effects. Until a cure for PD is discovered, there is a compelling need to develop interventions that provide relief of symptoms without causing negative side effects.
Recent research suggests that exercise may provide symptom relief in some characteristics of PD. While various exercise interventions appear to effectively improve motor, functional, and quality-of-life issues, the research is mixed regarding the nature, extent and duration of these improvements. Understanding how multiple characteristics of PD change and whether they can be modified by different exercise programs is essential to determining if an exercise program is clinically effective for PD.
This study is designed to compare the initial (six months), and then long-term (2 years) effect that 2 different exercise programs (progressive resistance program or flexibility program) have on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease. The goal is to determine which program is most beneficial. Results from this study will be used to determine which exercise program produces the most beneficial effects on neuro-physiological, motor, functional and quality-of-life measures.
NOTE: Recruitment for Parkinson's disease participants is now closed.
- Conditions
- Parkinson's Disease
- Being tested
- Progressive resistance training, Modified Fitness Counts
- Keywords
- Parkinson's disease, exercise
- Medical subject headings
- Parkinson Disease, Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Progressive resistance trainingBehavioural
Exercise twice a week for 2 years doing either progressive resistance training. The The PRE program consisted of 11 strengthening exercises: chest press, latissimus pull downs, reverse flys, double leg press, hip extension, shoulder press, biceps curl, rotary calf (ankle plantar flexion), triceps extension, seated quadriceps extension and back extension.
Modified Fitness CountsBehavioural
The modified Fitness Counts program was taken from Chapters 2 and 3 of the Parkinson's disease: Fitness Counts booklet and focused on non-progressive stretching, strengthening and balance exercises.
| Study group | Role | What they receive |
|---|---|---|
| Progressive resistance training | Active comparator | Subjects will perform between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Receives: Behavioral: Progressive resistance training |
| Modified Fitness Counts | Active comparator | Subjects will perform between 60 and 90 minutes of modified Fitness Counts two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. Receives: Behavioral: Modified Fitness Counts |
What is being measured
The primary outcome is the main question the study is designed to answer.
Off Medication UPDRS Part III, Motor Subscale Score
UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Secondary outcomes (34)
On Medication UPDRS-III
UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for the UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
L-dopa equivalent-mg/Day
This was the equivalent amount of dopamine (mg/day) each subject was prescribed based upon all of their PD medications.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Elbow Flexion Strength
This is the MVC for elbow flexion
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Ankle Plantar Flexion Strength
This is a measure of the MVC for ankle plantar flexion strength
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Elbow Extension Strength
This is a measure of the MVC for elbow extension
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Ankle Dorsiflexion Strength
This is a measure of the MVC for ankle dorsiflexion
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Percentage of Agonist EMG Signal Contained in the 0-5, 5-15, 15-30, and 35-50 Hz Frequency Bins During Isometric Contractions
This is a measure of the percentage of the EMG signal that is contained in different frequency bins during a MVC (elbow flexion/extension; ankle DF/PF), a 50% of MVC elbow fleixon contraction, and a 5 NM elbow flexion contraction.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
The Integral of the First Agonist Burst
The Integral of the first agonist EMG signal from onset of the agonist EMG signal until peak velocity
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the First 30 ms of the Agonist Burst
The integral of the first 30 msec of the agonist EMG.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the Antagonist Burst
the area under the rectified antagonist signal form agonist EMG onset until the end of movement. This reflects the amount of antagonist activation during movement.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the Agonist Burst
Magnitude of the agonist burst reflects the amount of agonist activation during movement.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Duration of First Agonist Burst
Time in (ms) for the duration of the first agonist burst during a 72 degree elbow flexion movement and also the percentage of agonist EMG bursts until peak velocity
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Number of Agonist Bursts
This is the number of agonist bursts prior to peak velocity.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Co-contraction During Limb Acceleration
the amount of agonist and antagonist activity present during limb acceleration.
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Qant
The integral of the antagonist EMG signal from the onset of the agonist EMG to the end of the movement
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Time to Peak Velocity
Time of the onset of the movement to peak velocity.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Peak Movement Velocity
This is how fast an individual can perform a 72 degree elbow flexion movement
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Relaxation Time
Time for a subject to passively relax their muscle after performing and isometric contraction to 50% of their MVC
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Rise Time
This is the time is takes for an individual to go for rest to a 50% of a MVC contraction as fast as possible.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Spatiotemporal Gait Analysis
Spatiotemporal gait analysis using a pressure sensitive walk way allow for measurement of gait velocity, step length, single and double limb support time, cadence, ect.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Distance Walked in 6 Minutes
This is how far an individual can walk in 6 minutes
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Modified Physical Performance Test
This is an overall measure of physical fuction
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Time on the Timed up and go Test
This is the time it takes an individual to get up from a chair, walk 3 meters, turn around and walk back.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Berg Balance Scale Score
This is a overall measure of balance
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Functional Reach
The distance one can reach forward without taking a step.
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Stroop Test
This is a test of cognitive function. This test requires individuals to first say as many colors as they can under three different test conditions.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Brief Test of Attention
This is a cognitive test of an individuals ability to remember number. It is a test of working memory.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Digit Span Forward/Backward
This tests a persons ability to remember that were read to them both forward and then backwards.
Measured: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Parkinson 's Disease Quality of Life
PDQ-39 is a composite measure of quality of life in individuals with Parkinson's Disease.
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Epworth Sleepiness Scale
The Epworth Sleepiness Scale is used to determine the level of daytime sleepiness.
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Beck's Depression Inventory
This is a self-report rating inventory that measures characteristic attitudes and symptoms of depression.
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
50 ft Walk Time
Time it takes to walk 50 feet
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
50 Foot Walk Speed
The speed that aerson walks over 50 feet
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
5 Time Sit to Stand
The time it takes to stand up and sit down five times
Measured: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted11 Jan 2008 (estimated)
- Study startOct 2007
- Primary completionJul 2011
- Study completionOct 2011
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Parkinson's DiseaseStudies of the same condition, open and under way.
- More trials run by University of Illinois ChicagoThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 51 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Illinois Chicago
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Daniel Corcos, Northwestern University
- Investigators
- Daniel Corcos, Ph.D., Principal investigator, Northwestern University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00591344
- Sponsor's protocol ID
- R01NS028127
- Other IDs
- 5R01NS028127-16
- Status last verified
- Feb 2015
- First submitted
- 26 Dec 2007
- Last updated
- 5 Mar 2015
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
Publications
Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.
PubMed 38588457Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.
PubMed 36602886David FJ, Robichaud JA, Leurgans SE, Poon C, Kohrt WM, Goldman JG, Comella CL, Vaillancourt DE, Corcos DM. Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial. Mov Disord. 2015 Oct;30(12):1657-63. doi: 10.1002/mds.26291. Epub 2015 Jul 6.
PubMed 26148003
Study at a glance
From the registry record, last updated by the sponsor on 5 Mar 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effect of Exercise on Individuals With Parkinson's Disease
- ClinicalTrials.gov ID
- NCT00591344
- Acronym / sponsor ID
- R01NS028127
- Conditions
- Parkinson's Disease
- Keywords
- Parkinson's disease, exercise
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 51 participants (actual)
- Lead sponsor
- University of Illinois ChicagoUniversity, hospital or other
- Collaborators
- National Institute of Neurological Disorders and Stroke (NINDS)
- Study start
- Oct 2007
- Primary completion
- Jul 2011 (actual)
- Study completion
- Oct 2011 (actual)
- First posted
- 11 Jan 2008 (estimated)
- Results
- Posted 9 Feb 2015
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this trial is to compare the effect of two different exercise programs on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease to determine which program is most beneficial.
Detailed description
Parkinson's disease (PD) negatively affects the quality of life for a million individuals in the United States. While medication and surgery are the most effective treatments for PD, physicians and people with PD often delay using these treatments because of their considerable adverse side effects. Until a cure for PD is discovered, there is a compelling need to develop interventions that provide relief of symptoms without causing negative side effects.
Recent research suggests that exercise may provide symptom relief in some characteristics of PD. While various exercise interventions appear to effectively improve motor, functional, and quality-of-life issues, the research is mixed regarding the nature, extent and duration of these improvements. Understanding how multiple characteristics of PD change and whether they can be modified by different exercise programs is essential to determining if an exercise program is clinically effective for PD.
This study is designed to compare the initial (six months), and then long-term (2 years) effect that 2 different exercise programs (progressive resistance program or flexibility program) have on neuro-physiological, motor, functional, and quality-of-life issues in individuals with Parkinson's disease. The goal is to determine which program is most beneficial. Results from this study will be used to determine which exercise program produces the most beneficial effects on neuro-physiological, motor, functional and quality-of-life measures.
NOTE: Recruitment for Parkinson's disease participants is now closed.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Progressive resistance training | Active comparator | Behavioral: Progressive resistance trainingSubjects will perform between 60 and 90 minutes of progressive resistance training two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. |
| Modified Fitness Counts | Active comparator | Behavioral: Modified Fitness CountsSubjects will perform between 60 and 90 minutes of modified Fitness Counts two times a week for two years at a local gym. These sessions will be supervised by a personal trainer two times a week for the first six months of training and then once a week for the remaining 18 months of training. |
Who may qualify
- Ages
- 50 to 67 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- a diagnosis of PD
- Up to the age of 67
- on at least 1 DA drug, may be on several PD medications
- able to walk for six minutes (may take rest breaks)
- able to come off their PD medication for testing (12 hour overnight withdrawal of antiparkinsonian medications)
Key exclusion criteria (7 listed)
- history of any other neurological disorder as determined by medical history and neurological exam
- history of a known injury, disease, or other disorder that might interfere with motor function in the proposed experiments
- a score less than 23 on the Mini-Mental State Examination
- currently involved in an active, ongoing formal exercise program deep brain stimulation surgery
- known cardiac problem or significant hypertension
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Progressive resistance trainingExercise twice a week for 2 years doing either progressive resistance training. The The PRE program consisted of 11 strengthening exercises: chest press, latissimus pull downs, reverse flys, double leg press, hip extension, shoulder press, biceps curl, rotary calf (ankle plantar flexion), triceps extension, seated quadriceps extension and back extension. | Behavioural | Progressive resistance training |
| Modified Fitness CountsThe modified Fitness Counts program was taken from Chapters 2 and 3 of the Parkinson's disease: Fitness Counts booklet and focused on non-progressive stretching, strengthening and balance exercises. | Behavioural | Modified Fitness Counts |
Primary outcome
Off Medication UPDRS Part III, Motor Subscale Score
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
UPDRS part III, is an observer rated clinical measure of motor signs of PD. It is used as a measure of severity of motor signs. We measured this at baseline, 6 , 18 and 24 months. This is a ordinal scale of 0-4 which has 27 items which measures slowness of movement (Bradykinesia), Tremor, Rigidity (muscle stiffness) and postural instabilty. The total value for UPDRS part III scale which ranges from 0 to 108, with a larger number indicating a higher level of impairment.
34 secondary outcomes
On Medication UPDRS-III
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
L-dopa equivalent-mg/Day
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Elbow Flexion Strength
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Ankle Plantar Flexion Strength
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Elbow Extension Strength
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Ankle Dorsiflexion Strength
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Percentage of Agonist EMG Signal Contained in the 0-5, 5-15, 15-30, and 35-50 Hz Frequency Bins During Isometric Contractions
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
The Integral of the First Agonist Burst
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the First 30 ms of the Agonist Burst
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the Antagonist Burst
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Magnitude of the Agonist Burst
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Duration of First Agonist Burst
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Number of Agonist Bursts
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Co-contraction During Limb Acceleration
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Qant
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Time to Peak Velocity
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Peak Movement Velocity
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Relaxation Time
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Rise Time
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Spatiotemporal Gait Analysis
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Distance Walked in 6 Minutes
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Modified Physical Performance Test
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Time on the Timed up and go Test
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Berg Balance Scale Score
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Functional Reach
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Stroop Test
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Brief Test of Attention
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Cognitive Function - Digit Span Forward/Backward
Time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Parkinson 's Disease Quality of Life
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Epworth Sleepiness Scale
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Beck's Depression Inventory
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
50 ft Walk Time
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
50 Foot Walk Speed
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
5 Time Sit to Stand
Time frame: Obtained during initial evaluation & then every 6 six months to end of 2-yr training period
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Mar 2015.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 38588457Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2024 Apr 8;4(4):CD013856. doi: 10.1002/14651858.CD013856.pub3.
- Derived from this study: PubMed 36602886Ernst M, Folkerts AK, Gollan R, Lieker E, Caro-Valenzuela J, Adams A, Cryns N, Monsef I, Dresen A, Roheger M, Eggers C, Skoetz N, Kalbe E. Physical exercise for people with Parkinson's disease: a systematic review and network meta-analysis. Cochrane Database Syst Rev. 2023 Jan 5;1(1):CD013856. doi: 10.1002/14651858.CD013856.pub2.
- Derived from this study: PubMed 26148003David FJ, Robichaud JA, Leurgans SE, Poon C, Kohrt WM, Goldman JG, Comella CL, Vaillancourt DE, Corcos DM. Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial. Mov Disord. 2015 Oct;30(12):1657-63. doi: 10.1002/mds.26291. Epub 2015 Jul 6.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Daniel Corcos, Ph.D. principal investigator
Northwestern University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Progressive resistance training and Modified Fitness Counts in people with Parkinson's Disease, run by University of Illinois Chicago at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Mar 2015. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 9 Feb 2015). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Off Medication UPDRS Part III, Motor Subscale Score (time frame: obtained during initial evaluation & then every 6 six months to end of 2-yr training period). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00591344, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Mar 2015.