Muscle Quadriceps FemorisNCT00690547
Force Enhancement of Musculus Quadriceps Femoris During and After Excentric Muscle Activity in Vivo
An observational study of Muscle Quadriceps Femoris and Healthy, run by German Research Foundation at 1 site in Germany.
Trial summary
Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. Read more about this study
- Who is it for?
- Ages 20 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Muscle Quadriceps Femoris, Healthy
- What is being tested?
- muscle activation
- How many people
- 60 participants
- Where
- 1 siteGermany
- Study dates
- Oct 2008to Oct 2010
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Study population: males without previous muscular or neurophysiological diseases at an age between 20 and 40 years
Who may be able to join
- Males without previous muscular or neurophysiological diseases
- Age between 20 and 40 years
Who cannot join
- Previous muscular or neurophysiological diseases
Trial locations and contacts
1 site in 1 country.
Germany1 site
Technical University of Munich, Department of Biomechanics in Sports
Munich, 80809
About this study
Official title: Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.
Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.
Read the detailed description
The research proposal is resubmitted with no amendments made regarding content.
- Conditions
- Muscle Quadriceps Femoris, Healthy
- Being tested
- muscle activation
- Keywords
- Functionality, Deliberately, Activated, Quadriceps, Femoris, During, After, Active, Extension
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
muscle activationOther
activation of the muscle quadriceps femoris
| Study group | Role | What they receive |
|---|---|---|
| Test Group | Not described Receives: Other: muscle activation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).
Measured: 12 months
Secondary outcomes (3)
Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation
Measured: 12 months
Correlation between typ of muscle fiber and force enhancement in vivo
Measured: 12 months
Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength
Measured: 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jun 2008 (estimated)
- Study startOct 2008
- Primary completionOct 2010 (estimated)
- Study completionOct 2010 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Muscle Quadriceps FemorisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Time perspective
- Prospective
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- German Research Foundation
- Sponsor type
- University, hospital or other
- Investigators
- Ansgar Schmirtz, Prof. Dr., Principal investigator, Technical University of Munich, Department of Biomechanics in Sports
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00690547
- Sponsor's protocol ID
- DFG27112007
- Status last verified
- Nov 2009
- First submitted
- 30 May 2008
- Last updated
- 30 Nov 2009
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 30 Nov 2009. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Force Enhancement of m. Quadriceps Femoris During and After Excentric Muscle Activity in Vivo by Maximal and Sub-maximal Deliberately Activation.
- ClinicalTrials.gov ID
- NCT00690547
- Acronym / sponsor ID
- DFG27112007
- Conditions
- Muscle Quadriceps Femoris, Healthy
- Keywords
- Functionality, Deliberately, Activated, Quadriceps, Femoris, During, After, Active
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- German Research FoundationUniversity, hospital or other
- Study start
- Oct 2008
- Primary completion
- Oct 2010 (estimated)
- Study completion
- Oct 2010 (estimated)
- First posted
- 4 Jun 2008 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Force enhancement (FE) describes the phenomenon of strength potentialization of a muscle cell or the complete muscle during and after active extension compared to the strength of an isometric contraction with same muscle length. The underlying physiological mechanism of this phenomenon is not completely known today. In vitro trials indicate that the interaction of an active and a passive component on the cellular level are responsible for the higher strength measurements. So far FE could be shown in vitro and in vivo on muscle fibers and small human muscles. Further research is needed for verification of the existence of FE in voluntary motor activity in everyday life. In order to approach this objective the investigators will scrutinize the functionality of the deliberately activated musculus (m) quadriceps femoris during and after active extension on the basis of in vivo studies.
Detailed description
The research proposal is resubmitted with no amendments made regarding content.
Study design
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Test Group | – | Other: muscle activation |
Who may qualify
- Ages
- 20 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
- Study population
- males without previous muscular or neurophysiological diseases at an age between 20 and 40 years
Key inclusion criteria (2 listed)
- Males without previous muscular or neurophysiological diseases
- Age between 20 and 40 years
Key exclusion criteria (1 listed)
- Previous muscular or neurophysiological diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| muscle activationactivation of the muscle quadriceps femoris | Other | Test Group |
Primary outcome
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend).
Time frame: 12 months
3 secondary outcomes
Evidence of existence of the force enhancement by deliberately activated, great human muscle by sub-maximal activation
Time frame: 12 months
Correlation between typ of muscle fiber and force enhancement in vivo
Time frame: 12 months
Analysis of the alternation of length of the muscle fiber during and after excentric extension for the differentiated explanation of in vivo mechanism excentric and post-excentric strength
Time frame: 12 months
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Nov 2009.
Related trials for Muscle Quadriceps Femoris
Not yet recruitingObservational study
Isokinetic Knee Strength, Bilateral Muscle Balance, and Anaerobic Performance in Adolescent Athletes
Isokinetic Knee Strength, Hamstring-to-Quadriceps Strength Ratio
Not yet recruiting
EFFECT OF ADDING BLOOD FLOW RESTRICTION TRAINING TO CLOSED CHAIN EXERCISE IN KNEE OSTEOARTHRITIS
Knee Osteoarthritis
Recruiting
Blood Flow Restriction Training in Knee Arthropathy
Knee Arthroscopic Surgery, Arthrogenic Muscle Inhibition
Not yet recruitingObservational study
Q-Angle, Segment Length, Quadriceps, and Knee Alignment in Soccer Players
Soccer Players
Not yet recruiting
Beyond Voluntary Effort: Reliability and Validity of Magnetic Femoral Nerve Stimulation for Assessing Quadriceps Strength in Critically Ill Patient
Critical Illness, ICU-acquired Weakness
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ansgar Schmirtz, Prof. Dr. principal investigator
Technical University of Munich, Department of Biomechanics in Sports
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Muscle Quadriceps Femoris and Healthy, run by German Research Foundation at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 30 Nov 2009. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Identification of a potential Force enhancement by complex muscle activity with a high relevance for everyday life, for example more agile leg stretching (knee bend). (time frame: 12 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Nov 2009.