Knee OsteoarthritisNCT07917559
EFFECT OF ADDING BLOOD FLOW RESTRICTION TRAINING TO CLOSED CHAIN EXERCISE IN KNEE OSTEOARTHRITIS
A study testing Traditional and Closed Kinetic Chain Exercise Program in people with Knee Osteoarthritis, run by Rasha Abdel Kader Abdel Azeem Khtab at 1 site in Egypt.
Trial summary
Knee osteoarthritis is a common joint condition that causes knee pain, stiffness, muscle weakness, and difficulty performing daily activities such as walking, climbing stairs, and standing up from a chair. Exercise therapy is commonly used to improve muscle strength, reduce pain, and restore physical function. Read more about this study
- Who is it for?
- Ages 40 to 60 years
- Conditions the study is for
- Knee Osteoarthritis
- What is being tested?
- Traditional and Closed Kinetic Chain Exercise Program
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 1 Dec 2026to 28 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 40 to 60 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Participants diagnosed with mild to moderate knee osteoarthritis (Kellgren-Lawrence grades II-III).
- Participants aged between 40 and 60 years.
- Body mass index (BMI) ranging from 25 to 29.9 kg/m².
- Presence of chronic knee pain for at least three months.
- Pain intensity of ≥3/10 on the Visual Analog Scale (VAS) or equivalent WOMAC pain score.
- Ability to ambulate independently and perform closed kinetic chain exercises.
- Participants who are medically fit to participate in low-load resistance exercise with or without blood flow restriction training.
- Willingness to participate and provide written informed consent.
Who cannot join
- History of knee surgery within the previous 12 months.
- Presence of severe knee osteoarthritis (Kellgren-Lawrence grade IV).
- Diagnosis of inflammatory joint diseases, such as rheumatoid arthritis.
- Presence of cardiovascular, vascular, or neurological disorders that contraindicate blood flow restriction training.
- Participation in any other structured lower limb strengthening or blood flow restriction training program during the study period.
- Cognitive impairment or inability to understand and follow exercise instructions.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site
Outpatient Physical Therapy Clinics in Cairo, Egypt
Cairo, Cairo Governorate, 11511
Rasha A Khattab, Master Degree, +201129635873, mf1952004@gmail.com
Rasha A Khattab, MSc
About this study
Knee osteoarthritis is a common joint condition that causes knee pain, stiffness, muscle weakness, and difficulty performing daily activities such as walking, climbing stairs, and standing up from a chair. Exercise therapy is commonly used to improve muscle strength, reduce pain, and restore physical function. However, some patients may find traditional strengthening exercises difficult because of pain and increased stress on the knee joint.
Blood flow restriction (BFR) training is a rehabilitation technique that uses a specialized cuff placed around the upper thigh to partially restrict blood flow during exercise. This technique may help improve muscle strength while using lighter exercise loads.
Read more
The purpose of this study is to investigate whether adding blood flow restriction training to traditional physical therapy and closed kinetic chain exercises provides additional benefits for patients with knee osteoarthritis.
This randomized controlled trial will include 60 male and female participants aged 40 to 60 years with mild to moderate knee osteoarthritis. Participants will be randomly assigned to one of two groups, with 30 participants in each group.
The first group will receive traditional physical therapy exercises combined with closed kinetic chain exercises, such as mini-squats, step-ups, step-downs, partial lunges, and wall slides.
The second group will receive the same exercise program with the addition of blood flow restriction training.
Both groups will participate in supervised treatment sessions twice weekly for eight weeks, for a total of 16 sessions.
The researchers will assess knee pain, knee range of motion, quadriceps muscle strength, knee function, mobility and fall risk, quality of life, and patient satisfaction. Assessments will be conducted before treatment, immediately after the eight-week intervention, and one month after completing treatment.
The study aims to determine whether adding blood flow restriction training to closed kinetic chain exercises can improve rehabilitation outcomes in individuals with knee osteoarthritis.
Read the detailed description
Knee osteoarthritis (KOA) is a chronic degenerative joint disorder characterized by progressive cartilage deterioration, pain, stiffness, reduced muscle strength, and functional limitations. Quadriceps muscle weakness is a major contributing factor to impaired knee stability and reduced physical performance in individuals with knee osteoarthritis.
Closed kinetic chain (CKC) exercises are commonly used in knee osteoarthritis rehabilitation because they involve functional weight-bearing movements that promote coordinated muscle activation, joint stability, and neuromuscular control. However, conventional resistance training may be difficult for patients who experience pain or cannot tolerate high mechanical loads.
Blood flow restriction (BFR) training is a rehabilitation approach that involves applying a pneumatic cuff to the proximal thigh during low-load exercise. By partially restricting blood flow, BFR training may stimulate muscular adaptations while reducing the need for high external resistance.
This study will investigate the effectiveness of adding blood flow restriction training to closed kinetic chain exercises in patients with mild to moderate knee osteoarthritis.
Study Design:
This study will be conducted as a randomized controlled trial involving 60 male and female participants diagnosed with mild to moderate knee osteoarthritis (Kellgren-Lawrence grades II-III).
Participants will be aged between 40 and 60 years and have a body mass index ranging from 25 to 29.9 kg/m².
Eligible participants will be recruited from outpatient physical therapy clinics in Cairo, Egypt.
Participants will be randomly allocated into two equal groups using a computer-generated randomization method.
Intervention:
Group A (Control Group):
Thirty participants will receive a traditional therapeutic exercise program combined with closed kinetic chain exercises.
Traditional exercises will include seated knee extensions, hip adduction and abduction exercises, straight leg raises, short-arc knee extensions, ankle pumps, and hamstring curls.
Closed kinetic chain exercises will include mini-squats, step-ups, step-downs, partial lunges, and wall slides.
Group B (Experimental Group):
Thirty participants will receive the same traditional and closed kinetic chain exercise program with the addition of blood flow restriction training.
Blood flow restriction will be applied using a specialized pneumatic cuff positioned around the proximal thigh during low-load resistance and closed kinetic chain exercises.
Both groups will receive 16 supervised treatment sessions over eight weeks, with two sessions per week.
Outcome Assessment:
The effectiveness of the interventions will be evaluated using the following measures:
- Pain intensity using the Numeric Pain Rating Scale (NPRS).
- Knee range of motion using a smartphone-based digital inclinometer.
- Quadriceps muscle strength using a hand-held dynamometer.
- Knee function using the Knee Injury and Osteoarthritis Outcome Score (KOOS).
- Functional mobility and fall risk using the Timed Up and Go (TUG) test.
- Health-related quality of life using the Short Form-36 (SF-36) questionnaire.
- Patient satisfaction using the Patient Satisfaction Questionnaire Short Form (PSQ-18).
Outcome assessments will be performed at baseline, immediately after the eight-week intervention, and at a one-month follow-up.
The study will compare changes in clinical and functional outcomes between the two groups to determine whether adding blood flow restriction training provides additional therapeutic benefits compared with traditional and closed kinetic chain exercises alone.
- Conditions
- Knee Osteoarthritis
- Being tested
- Traditional and Closed Kinetic Chain Exercise Program
- Keywords
- Knee Osteoarthritis, Blood Flow Restriction Training, Closed Kinetic Chain Exercises, Physical Therapy, Quadriceps Muscle Strength, Knee Pain, Functional Performance, Rehabilitation
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Traditional and Closed Kinetic Chain Exercise ProgramOther
A supervised therapeutic exercise program consisting of traditional strengthening exercises and closed kinetic chain exercises, including mini-squats, step-ups, step-downs, partial lunges, and wall slides. The program will be performed twice weekly for eight weeks.
| Study group | Role | What they receive |
|---|---|---|
| Traditional Exercise and Closed Kinetic Chain Exercises | Active comparator | Participants in the control group will receive a traditional therapeutic exercise program combined with closed kinetic chain exercises, including seated knee extensions, hip adduction and abduction, straight leg raises, short-arc knee extensions, ankle pumps, hamstring curls, mini-squats, step-ups, step-downs, partial lunges, and wall slides. Treatment will be delivered twice weekly for eight weeks, for a total of 16 supervised sessions. Receives: Other: Traditional and Closed Kinetic Chain Exercise Program |
| Blood Flow Restriction Training Combined with Closed Kinetic Chain Exercises | Experimental | Participants in the experimental group will receive the same traditional therapeutic exercise and closed kinetic chain exercise program as the control group, with the addition of blood flow restriction training. Blood flow restriction will be applied using a pneumatic cuff positioned around the proximal thigh during low-load resistance or closed kinetic chain exercises. Treatment will be delivered twice weekly for eight weeks, for a total of 16 supervised sessions. Receives: Other: Traditional and Closed Kinetic Chain Exercise Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Knee Pain Intensity Measured by the Numeric Pain Rating Scale (NPRS)
Knee pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), an 11-point self-reported scale ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain intensity. Changes from baseline will be assessed after treatment and at follow-up.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Knee Range of Motion Measured by a Smartphone Digital Inclinometer
Knee joint range of motion will be measured in degrees using a smartphone-based digital inclinometer application. Knee flexion and extension angles will be assessed to evaluate changes in joint mobility following the intervention. Changes from baseline will be evaluated at week 8 and week 12.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Quadriceps Muscle Strength Measured by a Hand-Held Dynamometer
Quadriceps muscle strength will be assessed using a hand-held dynamometer to measure isometric muscle force during voluntary contraction. The assessment will be performed using standardized testing procedures. Changes in quadriceps muscle strength from baseline will be evaluated after treatment and at follow-up.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Secondary outcomes (4)
Change in Knee Function Measured by the Knee Injury and Osteoarthritis Outcome Score (KOOS)
Knee-related function will be assessed using the Knee Injury and Osteoarthritis Outcome Score (KOOS), a 42-item questionnaire covering five subscales: pain, symptoms, activities of daily living, sport and recreation, and knee-related quality of life. Each subscale is transformed to a score ranging from 0 to 100, with higher scores indicating better knee-related outcomes.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Functional Mobility Measured by the Timed Up and Go (TUG) Test
Functional mobility will be assessed using the Timed Up and Go (TUG) test. Participants will be instructed to stand up from a chair, walk three meters, turn around, return to the chair, and sit down. The time required to complete the task will be recorded in seconds. Lower completion times indicate better functional mobility.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Health-Related Quality of Life Measured by the Short Form-36 (SF-36)
Health-related quality of life will be assessed using the Short Form-36 (SF-36) questionnaire, which consists of 36 items evaluating physical and mental health domains. Scores range from 0 to 100, with higher scores indicating better health-related quality of life. Changes from baseline will be evaluated following treatment and at follow-up.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Patient Satisfaction Measured by the Patient Satisfaction Questionnaire (PSQ-18)
Patient satisfaction with healthcare services will be assessed using the Patient Satisfaction Questionnaire Short Form (PSQ-18). The questionnaire contains 18 items covering seven dimensions: general satisfaction, technical quality, interpersonal manner, communication, financial aspects, time spent with the healthcare provider, and accessibility and convenience. Items are rated using a five-point Likert scale.
Measured: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2026
- Study start1 Dec 2026 (estimated)
- Primary completion31 Dec 2027 (estimated)
- Study completion28 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Knee OsteoarthritisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This study is a two-arm, parallel-group randomized controlled trial. Sixty participants with knee osteoarthritis will be randomly assigned to either a control group receiving traditional physical therapy and closed kinetic chain exercises or an experimental group receiving the same program combined with blood flow restriction training. Both groups will receive treatment twice weekly for eight weeks.
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Rasha Abdel Kader Abdel Azeem Khtab
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Rasha Abdel Kader Abdel Azeem Khtab, Cairo University
- Investigators
- Rasha A Khattab, MSc, Principal investigator, Cairo University, Faculty of Physical Therapy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07917559
- Sponsor's protocol ID
- BFR training on Osteoarthritis
- Other IDs
- P.T.REC/012/006531
- Status last verified
- Oct 2026
- First submitted
- 30 Oct 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Li Y, Fu S, Zhang D, Liu M, Liu H. Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a randomized controlled trial. BMC Musculoskelet Disord. 2025 Aug 8;26(1):769. doi: 10.1186/s12891-025-09051-7.
PubMed 40781308Michael HJ, Pham HD, Li LSK, Semciw AI, Scholes MJ, Hannington M, King MG. The Efficacy of Closed Versus Open Kinetic Chain Exercise in Knee Osteoarthritis-A Systematic Review and Meta-Analysis. Physiother Res Int. 2025 Oct;30(4):e70105. doi: 10.1002/pri.70105.
PubMed 40890564Lin Q, Yu D, Zhang Y, Chen X, Qin J, Wu F. Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials. Front Physiol. 2025 Mar 17;16:1524480. doi: 10.3389/fphys.2025.1524480. eCollection 2025.
PubMed 40166718
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EFFECT OF ADDING BLOOD FLOW RESTRICTION TRAINING TO CLOSED CHAIN EXERCISE IN KNEE OSTEOARTHRITIS
- ClinicalTrials.gov ID
- NCT07917559
- Acronym / sponsor ID
- BFR training on Osteoarthritis
- Conditions
- Knee Osteoarthritis
- Keywords
- Knee Osteoarthritis, Blood Flow Restriction Training, Closed Kinetic Chain Exercises, Physical Therapy, Quadriceps Muscle Strength, Knee Pain, Functional Performance, Rehabilitation
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Rasha Abdel Kader Abdel Azeem KhtabUniversity, hospital or other
- Study start
- 1 Dec 2026 (estimated)
- Primary completion
- 31 Dec 2027 (estimated)
- Study completion
- 28 Feb 2028 (estimated)
- First posted
- 4 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Knee osteoarthritis is a common joint condition that causes knee pain, stiffness, muscle weakness, and difficulty performing daily activities such as walking, climbing stairs, and standing up from a chair. Exercise therapy is commonly used to improve muscle strength, reduce pain, and restore physical function. However, some patients may find traditional strengthening exercises difficult because of pain and increased stress on the knee joint.
Blood flow restriction (BFR) training is a rehabilitation technique that uses a specialized cuff placed around the upper thigh to partially restrict blood flow during exercise. This technique may help improve muscle strength while using lighter exercise loads.
The purpose of this study is to investigate whether adding blood flow restriction training to traditional physical therapy and closed kinetic chain exercises provides additional benefits for patients with knee osteoarthritis.
This randomized controlled trial will include 60 male and female participants aged 40 to 60 years with mild to moderate knee osteoarthritis. Participants will be randomly assigned to one of two groups, with 30 participants in each group.
The first group will receive traditional physical therapy exercises combined with closed kinetic chain exercises, such as mini-squats, step-ups, step-downs, partial lunges, and wall slides.
The second group will receive the same exercise program with the addition of blood flow restriction training.
Both groups will participate in supervised treatment sessions twice weekly for eight weeks, for a total of 16 sessions.
The researchers will assess knee pain, knee range of motion, quadriceps muscle strength, knee function, mobility and fall risk, quality of life, and patient satisfaction. Assessments will be conducted before treatment, immediately after the eight-week intervention, and one month after completing treatment.
The study aims to determine whether adding blood flow restriction training to closed kinetic chain exercises can improve rehabilitation outcomes in individuals with knee osteoarthritis.
Detailed description
Knee osteoarthritis (KOA) is a chronic degenerative joint disorder characterized by progressive cartilage deterioration, pain, stiffness, reduced muscle strength, and functional limitations. Quadriceps muscle weakness is a major contributing factor to impaired knee stability and reduced physical performance in individuals with knee osteoarthritis.
Closed kinetic chain (CKC) exercises are commonly used in knee osteoarthritis rehabilitation because they involve functional weight-bearing movements that promote coordinated muscle activation, joint stability, and neuromuscular control. However, conventional resistance training may be difficult for patients who experience pain or cannot tolerate high mechanical loads.
Blood flow restriction (BFR) training is a rehabilitation approach that involves applying a pneumatic cuff to the proximal thigh during low-load exercise. By partially restricting blood flow, BFR training may stimulate muscular adaptations while reducing the need for high external resistance.
This study will investigate the effectiveness of adding blood flow restriction training to closed kinetic chain exercises in patients with mild to moderate knee osteoarthritis.
Study Design:
This study will be conducted as a randomized controlled trial involving 60 male and female participants diagnosed with mild to moderate knee osteoarthritis (Kellgren-Lawrence grades II-III).
Participants will be aged between 40 and 60 years and have a body mass index ranging from 25 to 29.9 kg/m².
Eligible participants will be recruited from outpatient physical therapy clinics in Cairo, Egypt.
Participants will be randomly allocated into two equal groups using a computer-generated randomization method.
Intervention:
Group A (Control Group):
Thirty participants will receive a traditional therapeutic exercise program combined with closed kinetic chain exercises.
Traditional exercises will include seated knee extensions, hip adduction and abduction exercises, straight leg raises, short-arc knee extensions, ankle pumps, and hamstring curls.
Closed kinetic chain exercises will include mini-squats, step-ups, step-downs, partial lunges, and wall slides.
Group B (Experimental Group):
Thirty participants will receive the same traditional and closed kinetic chain exercise program with the addition of blood flow restriction training.
Blood flow restriction will be applied using a specialized pneumatic cuff positioned around the proximal thigh during low-load resistance and closed kinetic chain exercises.
Both groups will receive 16 supervised treatment sessions over eight weeks, with two sessions per week.
Outcome Assessment:
The effectiveness of the interventions will be evaluated using the following measures:
- Pain intensity using the Numeric Pain Rating Scale (NPRS).
- Knee range of motion using a smartphone-based digital inclinometer.
- Quadriceps muscle strength using a hand-held dynamometer.
- Knee function using the Knee Injury and Osteoarthritis Outcome Score (KOOS).
- Functional mobility and fall risk using the Timed Up and Go (TUG) test.
- Health-related quality of life using the Short Form-36 (SF-36) questionnaire.
- Patient satisfaction using the Patient Satisfaction Questionnaire Short Form (PSQ-18).
Outcome assessments will be performed at baseline, immediately after the eight-week intervention, and at a one-month follow-up.
The study will compare changes in clinical and functional outcomes between the two groups to determine whether adding blood flow restriction training provides additional therapeutic benefits compared with traditional and closed kinetic chain exercises alone.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This study is a two-arm, parallel-group randomized controlled trial. Sixty participants with knee osteoarthritis will be randomly assigned to either a control group receiving traditional physical therapy and closed kinetic chain exercises or an experimental group receiving the same program combined with blood flow restriction training. Both groups will receive treatment twice weekly for eight weeks.
| Arm | Type | Receives |
|---|---|---|
| Traditional Exercise and Closed Kinetic Chain Exercises | Active comparator | Other: Traditional and Closed Kinetic Chain Exercise ProgramParticipants in the control group will receive a traditional therapeutic exercise program combined with closed kinetic chain exercises, including seated knee extensions, hip adduction and abduction, straight leg raises, short-arc knee extensions, ankle pumps, hamstring curls, mini-squats, step-ups, step-downs, partial lunges, and wall slides. Treatment will be delivered twice weekly for eight weeks, for a total of 16 supervised sessions. |
| Blood Flow Restriction Training Combined with Closed Kinetic Chain Exercises | Experimental | Other: Traditional and Closed Kinetic Chain Exercise ProgramParticipants in the experimental group will receive the same traditional therapeutic exercise and closed kinetic chain exercise program as the control group, with the addition of blood flow restriction training. Blood flow restriction will be applied using a pneumatic cuff positioned around the proximal thigh during low-load resistance or closed kinetic chain exercises. Treatment will be delivered twice weekly for eight weeks, for a total of 16 supervised sessions. |
Who may qualify
- Ages
- 40 to 60 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (8 listed)
- Participants diagnosed with mild to moderate knee osteoarthritis (Kellgren-Lawrence grades II-III).
- Participants aged between 40 and 60 years.
- Body mass index (BMI) ranging from 25 to 29.9 kg/m².
- Presence of chronic knee pain for at least three months.
- Pain intensity of ≥3/10 on the Visual Analog Scale (VAS) or equivalent WOMAC pain score.
Key exclusion criteria (6 listed)
- History of knee surgery within the previous 12 months.
- Presence of severe knee osteoarthritis (Kellgren-Lawrence grade IV).
- Diagnosis of inflammatory joint diseases, such as rheumatoid arthritis.
- Presence of cardiovascular, vascular, or neurological disorders that contraindicate blood flow restriction training.
- Participation in any other structured lower limb strengthening or blood flow restriction training program during the study period.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Traditional and Closed Kinetic Chain Exercise ProgramA supervised therapeutic exercise program consisting of traditional strengthening exercises and closed kinetic chain exercises, including mini-squats, step-ups, step-downs, partial lunges, and wall slides. The program will be performed twice weekly for eight weeks. | Other | Blood Flow Restriction Training Combined with Closed Kinetic Chain Exercises, Traditional Exercise and Closed Kinetic Chain Exercises |
Primary outcome
Change in Knee Pain Intensity Measured by the Numeric Pain Rating Scale (NPRS)
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Knee pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), an 11-point self-reported scale ranging from 0 (no pain) to 10 (worst imaginable pain). Higher scores indicate greater pain intensity. Changes from baseline will be assessed after treatment and at follow-up.
Change in Knee Range of Motion Measured by a Smartphone Digital Inclinometer
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Knee joint range of motion will be measured in degrees using a smartphone-based digital inclinometer application. Knee flexion and extension angles will be assessed to evaluate changes in joint mobility following the intervention. Changes from baseline will be evaluated at week 8 and week 12.
Change in Quadriceps Muscle Strength Measured by a Hand-Held Dynamometer
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Quadriceps muscle strength will be assessed using a hand-held dynamometer to measure isometric muscle force during voluntary contraction. The assessment will be performed using standardized testing procedures. Changes in quadriceps muscle strength from baseline will be evaluated after treatment and at follow-up.
4 secondary outcomes
Change in Knee Function Measured by the Knee Injury and Osteoarthritis Outcome Score (KOOS)
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Functional Mobility Measured by the Timed Up and Go (TUG) Test
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Health-Related Quality of Life Measured by the Short Form-36 (SF-36)
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Change in Patient Satisfaction Measured by the Patient Satisfaction Questionnaire (PSQ-18)
Time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Background: PubMed 40781308Li Y, Fu S, Zhang D, Liu M, Liu H. Effect of low-intensity resistance training at different levels of blood flow restriction on pain, proprioception and muscle strength in patients with knee osteoarthritis: a randomized controlled trial. BMC Musculoskelet Disord. 2025 Aug 8;26(1):769. doi: 10.1186/s12891-025-09051-7.
- Background: PubMed 40890564Michael HJ, Pham HD, Li LSK, Semciw AI, Scholes MJ, Hannington M, King MG. The Efficacy of Closed Versus Open Kinetic Chain Exercise in Knee Osteoarthritis-A Systematic Review and Meta-Analysis. Physiother Res Int. 2025 Oct;30(4):e70105. doi: 10.1002/pri.70105.
- Background: PubMed 40166718Lin Q, Yu D, Zhang Y, Chen X, Qin J, Wu F. Impact of low-load blood flow restriction training on knee osteoarthritis pain and muscle strength: a systematic review and meta-analysis of randomized controlled trials. Front Physiol. 2025 Mar 17;16:1524480. doi: 10.3389/fphys.2025.1524480. eCollection 2025.
- Individual participant dataSharing planned: Undecided
Related trials for Knee Osteoarthritis
Active, not recruiting
Study to Evaluate the Safety and Effectiveness of the REAL INTELLIGENCE™ CORI™ in Total Knee Arthroplasty (TKA) Procedure
Arthroplasty, Replacement
Recruiting
Aquatic Exercise in Patients With Knee Osteoarthritis
Central Sensitization, Knee Osteoarthristis
Not yet recruitingObservational study
Comparative Effectiveness and Safety of Two Hyaluronic Acid Products in Knee Osteoarthritis
Osteoarthritis, Knee
Not yet recruiting
Wearable Device Guided Exercise for Patients on Total Knee Arthroplasty Wait-list
Knee Osteoarthristis
Active, not recruiting
Comparative Effect of Dual Task Training and Rhythmic Stabilization in Knee Osteoarthritis Patients
Knee Osteoarthritis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Rasha A Khattab, MSc principal investigator
Cairo University, Faculty of Physical Therapy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Traditional and Closed Kinetic Chain Exercise Program in people with Knee Osteoarthritis, run by Rasha Abdel Kader Abdel Azeem Khtab at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Rasha A Khattab, MSc (+201129635873, mf1952004@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Knee Pain Intensity Measured by the Numeric Pain Rating Scale (NPRS) (time frame: Baseline, week 8 (post-treatment), and week 12 (one-month follow-up).). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07917559, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026; AzTrials last refreshed its copy on 4 Nov 2026.