Resveratrol in Healthy Adult Participants

Criteria:

• Healthy adult participants meeting the following criteria:
• Limit cruciferous vegetables to no more than one serving each week for about 6 weeks
• Limit resveratrol-containing foods (i.e., wine, peanuts, mulberries, grapes, cranberries, blueberries, and huckleberries) to no more than one serving each per day for about 6 weeks
• No caffeine-containing food or beverages (e.g., coffee, colas, chocolate, or over-the-counter medications) or food items that have been reported to affect drug/carcinogen metabolizing enzymes (e.g., grapefruit, grapefruit juice, cruciferous vegetables, and food cooked over charcoal) beginning 72 hours before and until 8 hours after each set of CYP probe drug administration
• Leukocytes >= 3,000/uL
• Absolute neutrophil count >= 1,500/uL
• Platelet count >= 100,000/uL
• Total bilirubin =< 2.0 mg/dL
• AST/ALT =< 1.5 times upper limit of normal (ULN)
• Creatinine =< ULN
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• Must have a resting systolic blood pressure >= 100 mm Hg at screening and prior to probe drug administration
• Must not consume more than three drinks of alcohol per week on average
• No prior invasive cancers (i.e., non-skin cancer) within the past 5 years
• No history of allergic reactions to resveratrol-containing products or CYP probe drugs (e.g, caffeine, dextromethorphan, losartan, or buspirone)
• No uncontrolled intercurrent illness including, but not limited to, any of the following:
• Ongoing or active infection
• Symptomatic congestive heart failure
• Unstable angina pectoris
• Cardiac arrhythmia
• Psychiatric illness or social situation that would limit compliance with study requirements
• No over-the-counter medications beginning 72 hours before and until 8 hours after each CYP probe drug administration
• No participation in another clinical intervention trial within the past 3 months
• No concurrent medications or supplements that are known CYP enzyme inducers or inhibitors
• No concurrent herbal medicines, dietary supplements, or above-standard vitamins or minerals (a standard daily multivitamin or mineral supplement is acceptable)
• Non-smoking, defined as not currently smoking or stopped smoking more than 1 year ago
• Normal liver and renal function
• Able and willing to adhere to the following dietary restrictions:
• ECOG performance status (PS) 0-1 OR Karnofsky PS 70-100%