Tooth DiseaseCollegeBowlNCT00726063
A Prospective Study Evaluating the Performance of Nanotite Osseotite Implants When Placed by Graduate Student Programs
A study testing Nanotite dental implant and Osseotite dental implant in people with Tooth Disease and Partial Edentulism, run by ZimVie at 1 site in United States.
Trial summary
This study will evaluate the contributions of the Nanotite implant design when used by graduate students in their first year of placing implants. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Tooth Disease, Partial Edentulism
- What is being tested?
- Nanotite dental implant and Osseotite dental implant
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 241 participants
- Where
- 1 siteUnited States
- Study dates
- Apr 2008to Oct 2012
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- patients of either sex and of any race, 18 years of age or older
- patients for whom a decision has already been made to use dental implants for treating edentulism in the mandible or maxilla
Who cannot join
- patients who are known to be pregnant
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Alabama Birmingham
Birmingham, Alabama, 35294
About this study
Official title: A Prospective Randomized-controlled Evaluation of Nanotite and Osseotite Surfaced Implant Performance in Graduate Student Programs
This study will evaluate the contributions of the Nanotite implant design when used by graduate students in their first year of placing implants.
Read the detailed description
This multicenter, prospective, randomized-controlled study will compare the performance of the Nanotite vs. the standard Ossotite implants when placed by graduate students with little or no prior experience. Enrolled patients will have the study site(s) randomized to either a Nanotite (test) or an Osseotite (control) implant. The manner of treatment observed at the participating center will be followed for this study.
Study Hypothesis: The performance of the Nanotite implant in this study will be no different than or superior to that of the Osseotite implant placed during the early period of graduate student training.
- Conditions
- Tooth Disease, Partial Edentulism
- Being tested
- Nanotite dental implant, Osseotite dental implant
- Keywords
- dental implants, Nanotite implant, Osseotite implants, multicenter, randomized, clinical study, partial edentulism, prosthesis
- Medical subject headings
- Tooth Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Nanotite dental implantDevice
Also called Nanotite endosseous dental implant
Nanotite root form titanium dental implant
Osseotite dental implantDevice
Also called Osseotite endosseous dental implant
Osseotite Root form titanium dental implant
| Study group | Role | What they receive |
|---|---|---|
| Nanotite implant | Experimental | Nanotite dental implant Receives: Device: Nanotite dental implant |
| Osseotite implant | Active comparator | Osseotite dental implant Receives: Device: Osseotite dental implant |
What is being measured
The primary outcome is the main question the study is designed to answer.
Integration Success of the Implant
Measured: 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Jul 2008 (estimated)
- Study startApr 2008
- Primary completionOct 2012
- Study completionOct 2012
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Other trials for Tooth DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- implant types were randomized- 2 different surface treatments
- Masking
- None (open label)
- Enrolment
- 241 participants (actual)
Sponsor and investigators
- Lead sponsor
- ZimVie
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Michael S Reddy, DMD, Principal investigator, University of Alabama at Birmingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00726063
- Sponsor's protocol ID
- 2613
- Acronym
- CollegeBowl
- Status last verified
- Mar 2022
- First submitted
- 29 Jul 2008
- Last updated
- 28 Jul 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Prospective Randomized-controlled Evaluation of Nanotite and Osseotite Surfaced Implant Performance in Graduate Student Programs
- ClinicalTrials.gov ID
- NCT00726063
- Acronym / sponsor ID
- CollegeBowl / 2613
- Conditions
- Tooth Disease, Partial Edentulism
- Keywords
- dental implants, Nanotite implant, Osseotite implants, multicenter, randomized, clinical study, partial edentulism, prosthesis
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 241 participants (actual)
- Lead sponsor
- ZimVieIndustry (pharma, biotech, devices)
- Study start
- Apr 2008 (actual)
- Primary completion
- Oct 2012 (actual)
- Study completion
- Oct 2012 (actual)
- First posted
- 31 Jul 2008 (estimated)
- Results
- Posted 12 Feb 2014
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will evaluate the contributions of the Nanotite implant design when used by graduate students in their first year of placing implants.
Detailed description
This multicenter, prospective, randomized-controlled study will compare the performance of the Nanotite vs. the standard Ossotite implants when placed by graduate students with little or no prior experience. Enrolled patients will have the study site(s) randomized to either a Nanotite (test) or an Osseotite (control) implant. The manner of treatment observed at the participating center will be followed for this study.
Study Hypothesis: The performance of the Nanotite implant in this study will be no different than or superior to that of the Osseotite implant placed during the early period of graduate student training.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- implant types were randomized- 2 different surface treatments
| Arm | Type | Receives |
|---|---|---|
| Nanotite implant | Experimental | Device: Nanotite dental implantNanotite dental implant |
| Osseotite implant | Active comparator | Device: Osseotite dental implantOsseotite dental implant |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- patients of either sex and of any race, 18 years of age or older
- patients for whom a decision has already been made to use dental implants for treating edentulism in the mandible or maxilla
Key exclusion criteria (1 listed)
- patients who are known to be pregnant
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Nanotite dental implantAlso: Nanotite endosseous dental implantNanotite root form titanium dental implant | Device | Nanotite implant |
| Osseotite dental implantAlso: Osseotite endosseous dental implantOsseotite Root form titanium dental implant | Device | Osseotite implant |
Primary outcome
Integration Success of the Implant
Time frame: 1 year
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Jul 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Michael S Reddy, DMD principal investigator
University of Alabama at Birmingham
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Nanotite dental implant and Osseotite dental implant in people with Tooth Disease and Partial Edentulism, run by ZimVie at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 12 Feb 2014). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Integration Success of the Implant (time frame: 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Jul 2026; AzTrials last refreshed its copy on 3 Nov 2026.