AzTrials
AzTrials

Acute Respiratory FailureISMVNCT01093482

Third International Study on Mechanical Ventilation

An observational study of Acute Respiratory Failure, run by Hospital Universitario Getafe at 477 sites in 38 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients 2. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Acute Respiratory Failure
How many people
8,151 participants
Where
477 sitesin 38 countries
Study dates
Apr 2010to Sep 2010
Phase
Observational
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Mechanically ventilated patients

Who may be able to join

  • Patients who are admitted to the intensive care unit and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours.
  • Patients who are admitted to the intensive care unit and require non-invasive mechanical ventilation (BIPAP or CPAP with nasal or facial mask) for more than 1 hour.

Who cannot join

  • Patients less than 18 years old

Trial locations and contacts

477 sites in 38 countries.

477 sites in 38 countries

Spain98 sites

  • Hospital Juan Canalejo

    A Coruña

  • Hospital General de Albacete

    Albacete

  • Hospital Príncipe de Asturias

    Alcalá de Henares

  • Fundación Hospital Universitario de Alcorcón

    Alcorcón

  • Hospital General de Alicante

    Alicante

  • Hospital San Juan

    Alicante

  • Hospital Torrecárdenas

    Almería

  • Hospital del Tajo

    Aranjuez

  • Hospital del Sureste

    Arganda

  • Hospital San Agustín

    Avilés

  • Hospital Germans Trias i Pujol

    Badalona

  • Hospital de Cruces

    Barakaldo

  • Hospital Clinic-IDIBAPS (ICU medical & ICU respiratory)

    Barcelona

  • Hospital de la Santa Creu y Sant Pau

    Barcelona

  • Hospital del Mar

    Barcelona

  • Hospital Sagrado Corazón

    Barcelona

  • Hospital SCIAS

    Barcelona

  • Hospital San Pedro de Alcántara

    Cáceres

  • Hospital Santa María del Rosell

    Cartagena

  • Hospital de la Plana

    Castellon

  • Hospital General de Castellón

    Castellon

  • Hospital Provincial de Castellón

    Castellon

  • Complejo Hospitalario de Ciudad Real

    Ciudad Real

  • Hospital Universitario Reina Sofia

    Córdoba

  • Hospital del Henares

    Coslada

  • Hospital de Don Benito

    Don Benito

  • Complejo Hospitalario de Donostia

    Donostia / San Sebastian

  • Hospital del Poniente

    El Ejido

  • Hospital General Universitario de Elche

    Elche

  • Hospital Arquitecto Marcide

    Ferrol

  • Hospital de Fuenlabrada

    Fuenlabrada

  • Hospital de Galdakao

    Galdakao

  • Hospital Universitario de Getafe

    Getafe

  • Hospital de Cabueñes

    Gijón

  • Hospital Universitario Doctor Josep Trueta

    Girona

  • Hospital Virgen de las Nieves

    Granada

  • Hospital General de Guadalajara

    Guadalajara

  • Hospital Juan Ramón Jimenez

    Huelva

  • Complejo Hospitalario de Jaen

    Jaén

  • Hospital General de Jerez de la Frontera

    Jérez de La Frontera

  • Hospital General de La Palma

    la palma

  • Hospital Doctor Negrín

    Las Palmas

  • Hospital Insular de Gran Canaria

    Las Palmas

  • Complejo Hospitalario de León

    León

  • Hospital Arnau de Vilanova

    Lleida

  • Hospital de San Pedro

    Logroño

  • Complejo Hospitalario Xeral-Calde

    Lugo

  • Fundación Jiménez Díaz

    Madrid

  • Hospital 12 de Octubre (Trauma ICU)

    Madrid

  • Hospital 12 de Octubre

    Madrid

  • Hospital Clínico San Carlos

    Madrid

  • Hospital de la Princesa

    Madrid

  • Hospital Gregorio Marañón

    Madrid

  • Hospital Infanta Leonor

    Madrid

  • Hospital Quirón

    Madrid

  • Hospital Universitario de la Paz

    Madrid

  • Hospital Universitario Puerta de Hierro

    Majadahonda

  • Hospital Carlos Haya

    Málaga

  • Hospital Universitario Virgen de la Victoria

    Málaga

  • Hospital de Mataró

    Mataró

  • Hospital de Móstoles

    Móstoles

  • Hospital J .M. Morales Meseguer

    Murcia

  • Hospital Universitario Reina Sofia

    Murcia

  • Hospital Virgen de la Arrixaca

    Murcia

  • Hospital Vega Baja de Orihuela

    Orihuela

  • Complejo Hospitalario de Ourense

    Ourense

  • Hospital Central de Asturias

    Oviedo

  • Hospital Rio Carrión

    Palencia

  • Hospital Son Llatzer

    Palma de Mallorca

  • Hospital Universitario Son Espasses

    Palma de Mallorca

  • Complejo Hospitalario de Navarra

    Pamplona

  • Hospital Infanta Cristina

    Parla

  • Complejo Hospitalario Montecelo

    Pontevedra

  • Hospital Universitario de San Juan

    Reus

  • Hospital Parc Taulí

    Sabadell

  • Hospital de Sagunto

    Sagunto

  • Complejo Hospitalario de Salamanca

    Salamanca

  • Hospital Clínico de Salamanca

    Salamanca

  • Complejo Hospitalario de Santiago de Compostela

    Santiago de Compostela

  • Hospital General de Segovia

    Segovia

  • Hospital Universitario de Valme

    Seville

  • Hospital Virgen del Rocío

    Seville

  • Hospital General de Soria

    Soria

  • Hospital Mutua de Terrassa

    Terrassa

  • Hospital Obispo Polanco

    Teruel

  • Complejo Hospitalario de Toledo

    Toledo

  • Hospital de Torrevieja

    Torrevieja

  • Hospital Infanta Elena

    Valdemoro

  • Hospital Universitario de la Fe

    Valencia

  • Hospital Universitario Dr. Peset

    Valencia

  • Hospital Clínico de Valladolid

    Valladolid

  • Hospital Rio Hortega

    Valladolid

  • Hospital Meixoeiro

    Vigo

  • Hospital Santiago Apóstol

    Vitoria-Gasteiz

  • Hospital Lluis Alcanyis

    Xàtiva

  • Hospital de Zamora

    Zamora

  • Hospital Clínico Lozano Blesa

    Zaragoza

  • Hospital Royo Vilanova

    Zaragoza

Other trials in Spain

China42 sites

  • Beijing Chaoyang Hospital

    Beijing

  • Beijing Hospital

    Beijing

  • Beijing Huaxin Hospital

    Beijing

  • Beijing TCM Hospital

    Beijing

  • Beijing Tongren Hospital

    Beijing

  • Peking Union Medical College Hospital

    Beijing

  • Peking University 3rd Hospital

    Beijing

  • PLA 304 Hospital

    Beijing

  • PLA General Hospital

    Beijing

  • PLA Navy General Hospital

    Beijing

  • Sino-Japanese Friendship Hospital

    Beijing

  • Jilin University 2nd Hospital

    Changchun

  • Sichuan Provincial Hospital

    Chengdu

  • West China Hospital

    Chengdu

  • Chongqing Medical University 1st Hospital

    Chongqing

  • Daping Hospital

    Chongqing

  • Yunnan Chuxiong People's Hospital

    Chuxiong

  • Dalian Medical University 1st Hospital

    Dalian

  • Guangdong General Hospital

    Guangdong

  • Sun Yet-Sen University 6th Hospital

    Guangzhou

  • Hainan Medical College Hospital

    Haikou

  • Hainan Provincial People's Hospital

    Haikou

  • Zhejiang Haining People's Hospital

    Haining

  • Zhejiang Tongde Hospital

    Hangzhou

  • North District Hospital

    Hong Kong

  • Pamela Youde Nethersole Eastern Hospital

    Hong Kong

  • Prince Margaret Hospital

    Hong Kong

  • Prince Of Wales Hospital

    Hong Kong

  • Queen Elizabeth Hospital

    Hong Kong

  • Kunming City 3rd People's Hospital

    Kunming

  • Kunming Medical College 1st Hospital

    Kunming

  • Nanchang University 2nd Hospital

    Nanchang

  • Southeast University Zhongda Hospital

    Nanjing

  • Nantong 1st People's Hospital

    Nantong

  • Hebei Medical University 4th Hospital

    Shijiazhuang

  • Suzhou University 1st Hospital

    Suzhou

  • Fengrun District People's Hospital

    Tangshan

  • Wuhan University Zhongnan Hospital

    Wuhan

  • Wuxi Municipal People's Hospital

    Wuxi

  • Xi'an Jiaotong University 1st Hospital

    Xi'an

  • Xuzhou Central Hospital

    Xuzhou

  • Yantai Yuhuangding Hospital

    Yantai

Other trials in China

Argentina40 sites

  • Hospital Naval Puerto Belgrano

    Bahía Blanca

  • Clinica Bazterrica

    Buenos Aires

  • Clínica Santa Isabel

    Buenos Aires

  • Hospital A. Posadas

    Buenos Aires

  • Hospital Churruca-Visca

    Buenos Aires

  • Hospital Español

    Buenos Aires

  • Hospital General de Agudos Bernardino Rivadavia

    Buenos Aires

  • Hospital General de Agudos Dalmacio Vélez Sársfield

    Buenos Aires

  • Hospital General de Agudos donación Francisco Santojanni

    Buenos Aires

  • Hospital General de Agudos Juan A. Fernandez

    Buenos Aires

  • Hospital General de Agudos P. Piñeiro

    Buenos Aires

  • Hospital Municipal Coronel Suárez

    Buenos Aires

  • Hospital Universitario, Universidad Abierta Interamericana

    Buenos Aires

  • Sanatorio Anchorena

    Buenos Aires

  • Sanatorio de la Trinidad

    Buenos Aires

  • Sanatorio de los Arcos

    Buenos Aires

  • Sanatorio Dr. Julio Méndez

    Buenos Aires

  • Sanatorio Mater Dei

    Buenos Aires

  • Sanatorio Otamendi y Miroli

    Buenos Aires

  • Hospital Regional de Comodoro Rivadavia

    Comodoro Rivadavia

  • Hospital Tránsito Cáceres de Allende

    Córdoba

  • Sanatorio Allende

    Córdoba

  • Hospital Zonal Francisco López Lima

    General Roca

  • Hospital Interzonal General de Agudo Profesor Dr .Luis Guemes

    Haedo

  • Hospital Interzonal de Agudos San Martin

    La Plata

  • Hospital Privado de Comunidad

    Mar del Plata

  • Hospital Central

    Mendoza

  • Hospital Lagomaggiore

    Mendoza

  • Hospital Universitario Austral

    Pilar

  • Policlínico Atlántico del Sur

    Río Gallegos

  • Hospital Regional Rio Grande

    Rio Grande

  • Hospital Provincial del Centenario

    Rosario

  • Sanatorio de la Trinidad

    San Isidro

  • Sanatorio Las Lomas

    San Isidro

  • Hospital de San Luis

    San Luis

  • Hospital Pablo Soria

    San Salvador de Jujuy

  • Sanatorio Nuestra Señora del Rosario

    San Salvador de Jujuy

  • Sanatorio Juncal

    Temperley

  • Clínica Olivos

    Vicente López

  • Clínica Privada de Especialidades de Villa María

    Villa María

Other trials in Argentina

Germany28 sites

  • Katholische Stiftung Marienhospital Aachen

    Aachen

  • Universitaetsklinikum Aachen

    Aachen

  • St. Nikolaus-Stiftshospital GmbH

    Andernach

  • Klinikum Bad Salzungen GmbH

    Bad Salzungen

  • Ermstalklinik Bad Urach

    Bad Urach

  • Charité Universitaetsklinikum (ICU medical-surgical & ICU other)

    Berlin

  • Lungenklinik Heckeshorn

    Berlin

  • Evangelisches Waldkrankenhaus Bad Godesberg gGmbH

    Bonn

  • Universitaetsklinikum Bonn (ICU medical-surgical & ICU surgical)

    Bonn

  • Carl-Thiem-Klinikum Cottbus gGmbH

    Cottbus

  • Evangelisches Krankenhaus Elisabethenstift gGmbH

    Darmstadt

  • Universitaetsklinikum Carl Gustav Carus

    Dresden

  • Evangelisches Diakoniekrankenhaus

    Freiburg im Breisgau

  • Universitaetsklinikum der Georg-August-Universitaet

    Göttingen

  • Staedtisches Krankenhaus Martha-Maria Halle-Doelau gGmbH

    Halle

  • Allgemeines Krankenhaus Harburg

    Hamburg

  • Medizinische Hochschule Hannover

    Hanover

  • Vivantes Krankenhaus am Urban

    Kreuzberg

  • Staedtisches Klinikum Lueneburg

    Lüneburg

  • Universitaetsklinikum

    Magdeburg

  • Hufeland Klinikum GmbH

    Mühlhausen

  • Dietrich-Bonhoeffer Klinikum Neubrandenburg

    Neubrandenburg

  • Klinikum der Universitaet Regensburg

    Regensburg

  • Ermstalklinik Staedtisches Krankenhaus Sindelfingen

    Sindelfingen

  • Bundeswehrkrankenhaus Ulm

    Ulm

  • Universitaetsklinikum der Martin-Luther-Universitaet Halle-Wittenberg

    Wittenberg

  • Staedtisches Klinikum Wolfenbuttel

    Wolfenbüttel

  • Georgius-Agricola-Klinikum Zeitz

    Zeitz

Other trials in Germany

Brazil23 sites

  • Hospital da Baleia

    Belo Horizonte

  • Hospital da Polícia Militar

    Belo Horizonte

  • Hospital de Pronto Socorro Risoleta Tolentino Neves

    Belo Horizonte

  • Hospital Dia e Maternidade Unimed-BH

    Belo Horizonte

  • Hospital Felício Rocho

    Belo Horizonte

  • Hospital Júlia Kubitschek

    Belo Horizonte

  • Hospital Luxemburgo

    Belo Horizonte

  • Hospital Madre Teresa

    Belo Horizonte

  • Hospital Nossa Senhora Aparecida

    Belo Horizonte

  • Hospital São Francisco-Setimig

    Belo Horizonte

  • Hospital Universitario Sao Jose

    Belo Horizonte

  • Hospital Vera Cruz

    Belo Horizonte

  • Hospital Vila da Serra

    Belo Horizonte

  • Hospital Santa Rita

    Contagem

  • Hospital São João de Deus

    Divinópolis

  • Hospital de Messejana

    Fortaleza

  • Hospital Universitário Walter Cantídio

    Fortaleza

  • Hospital Universitário da Universidade Federal de Juiz de Fora

    Juiz de Fora

  • Hospital Vaz Monteiro

    Lavras

  • Santa Casa de Misericórdia de Ouro Preto

    Ouro Preto

  • Hospital Arnaldo Gavazza Filho

    Ponte Nova

  • Hospital Nossa Senhora das Graças

    Sete Lagoas

  • Hospital São João Batista

    Viçosa

Other trials in Brazil

Uruguay22 sites

  • CAAMOC Carmelo

    Carmelo

  • Orameco

    Colonia del Sacramento

  • Hospital de Florida

    Florida

  • CRAMI

    Las Piedras

  • Hospital de Maldonado

    Maldonado

  • Sanatorio Mautone

    Maldonado

  • Sanatorio CAMS

    Mercedes

  • CASMU Nº2

    Montevideo

  • Circulo Católico

    Montevideo

  • CUDAM

    Montevideo

  • Hospital de Clínicas

    Montevideo

  • Hospital Español

    Montevideo

  • Hospital Evangélico

    Montevideo

  • Hospital Maciel

    Montevideo

  • Hospital Pasteur

    Montevideo

  • Hospital Policial

    Montevideo

  • Impassa

    Montevideo

  • Sanatorio Americano

    Montevideo

  • CAAMEPA

    Pando

  • COMEPA

    Paysandú

  • Hospital Escuela del Litoral

    Paysandú

  • Sanatorio Cantegril

    Punta del Este

Other trials in Uruguay

Australia20 sites

  • Calvary Wakefield Hospital

    Adelaide

  • Flinders Medical Center

    Adelaide

  • Ballarat Health Services

    Ballarat

  • Bendigo Hospital

    Bendigo

  • Mater Health Services

    Brisbane

  • Canberra Hospital

    Canberra

  • Royal Darwin Hospital

    Darwin

  • Barwon Health, Geelong Hospital

    Geelong

  • Royal Hobart Hospital

    Hobart

  • Liverpool Hospital

    Liverpool

  • Alfred Hospital

    Melbourne

  • Royal Melbourne Hospital

    Melbourne

  • St Vincent's Hospital

    Melbourne

  • The Northern Hospital

    Melbourne

  • The Western Hospital

    Melbourne

  • Central Gippsland Hospital

    Sale

  • Concord Hospital

    Sydney

  • Nepean Hospital

    Sydney

  • St George Hospital

    Sydney

  • St Vincent's Hospital

    Sydney

Other trials in Australia

Colombia19 sites

  • Clínica General del Norte

    Barranquilla

  • Clínica Fundadores

    Bogotá

  • Clínica Shaio

    Bogotá

  • Grupo Cimca Hospital de San José (medical ICU)

    Bogotá

  • Grupo Cimca Hospital de Suba

    Bogotá

  • Grupo Cimca Hospital San José

    Bogotá

  • Hospital Santa Clara

    Bogotá

  • Fundación cardiovascular colombiana

    Bucaramanga

  • Centro Medico Imbanaco

    Cali

  • Clínica Fundación Valle Lili

    Cali

  • Nuevo Hospital Bocagrande

    Cartagena

  • Hospital Federico Lleras Acosta

    Ibague

  • Hospital San Rafael

    Itagüí

  • Clinica Universitaria Bolivariana

    Medellín

  • Clínica Cardiovascular

    Medellín

  • Clínica Las Américas

    Medellín

  • Clínica Medellín & Universidad Pontificia Bolivariana

    Medellín

  • Corbic

    Medellín

  • Hospital General de Medellín

    Medellín

Other trials in Colombia

United States18 sites

  • Boston Medical Center

    Boston, Massachusetts, 02118

  • Henry Ford Hospital Detroit

    Detroit, Michigan, 48202

  • University Of Texas Medical Branch at Galveston

    Galveston, Texas, 77555

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242

  • University of Louisville School of Medicine

    Louisville, Kentucky, 40202

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226

  • Morristown Medical Center

    Morristown, New Jersey, 07960

  • Vanderbilt University School Of Medicine

    Nashville, Tennessee, 37232

  • The Mount Sinai Medical Center

    New York, New York, 10029

  • Bronx Lebanon Hospital Center

    New York, New York, 10457

  • New York Methodist Hospital

    New York, New York, 11215

  • UMDNJ-New Jersey Medical School

    Newark, New Jersey, 07101

  • Oklahoma City VA Medical Center

    Oklahoma City, Oklahoma, 73104

  • Oklahoma University Health Science Center & VA medical Center

    Oklahoma City, Oklahoma, 73104

  • Omaha VA Medical Center

    Omaha, Nebraska, 68105

  • University Hospital San Antonio and South Texas Veterans Health Care System

    San Antonio, Texas, 78229

  • Baystate Medical Center

    Springfield, Massachusetts, 01199

  • Temple Clinic, Scott & White Healthcare

    Temple, Texas, 76508

Other trials in United States

India16 sites

  • Kalinga Hospital

    Bhubaneswar

  • Apollo Hospitals

    Chennai

  • Artemis Health Institute

    Gūrgaon

  • CHL Apollo Hospital

    Indore

  • Tata Main Hospital

    Jamshedpur

  • AMRI Hospitals Kolkata

    Kolkata

  • Calcutta medical research institute (CMRI)

    Kolkata

  • Calcutta Medical Research Institute

    Kolkata

  • Kasturba Medical College

    Manipal

  • Bombay Hospital Institute of Medical Sciences

    Mumbai

  • Hinduja Hospital

    Mumbai

  • Saifee Hospital

    Mumbai

  • Tata Memorial Hospital

    Mumbai

  • Ruby Hall Clinic

    Pune

  • CARE Hospitals

    Surat

  • Spandan Multispeciality Hospital

    Vadodara

Other trials in India

Italy15 sites

  • Ospedale Policlinico, Università Di Bari

    Bari

  • Policlinico Universitario "S. Orsola-Malpighi"

    Bologna

  • Ospedale "San Giovanni Di Dio"

    Florence

  • Ospedale "Santa Maria Annunziata"

    Florence

  • Fondazione IRCCS "Cà Grande" Ospedale Maggiore Policlinico, Università Di Milano

    Milan

  • Ospedale "San Gerardo", Università Di Milano Bicocca

    Monza

  • Ospedale "V. Monaldi"

    Naples

  • Ospedale Policlinico "Federico II", Università Di Napoli

    Naples

  • Ospedale Maggiore Della Carità, Università Del Piemonte Orientale "Amedeo Avogadro"

    Novara

  • Ospedale "Arnas Civico, Di Cristina, Benfratelli"

    Palermo

  • Policlinico "P. Giaccone", Università Di Palermo

    Palermo

  • Fondazione IRCCS Policlinico "S. Matteo", Università Di Pavia (ICU 1 & ICU 2)

    Pavia

  • Policlinico "Agostino Gemelli", Università Cattolica Del Sacro Cuore

    Roma

  • Policlinico "Umberto I", Università La Sapienza

    Roma

  • Ospedale "San Giovanni Battista - Molinette", Università Di Torino

    Torino

Other trials in Italy

Mexico15 sites

  • Centenario Hospital Miguel Hidalgo

    Aguascalientes

  • Hospital Regional de Pemex

    Ciudad Madero

  • Hospital Mérida Yucatán

    Mérida

  • Hospital General de México

    Mexico City

  • Instituto Nacional De Ciencias Médicas y Nutrición Salvador Zubirán

    Mexico City

  • Hospital Juárez de México

    México DF

  • Hospital Regional 1° de Octubre, ISSSTE

    México DF

  • Hospital Regional de Zona No.1 del IMSS

    México DF

  • Hospital Ángeles de las Lomas

    México DF

  • Instituto Nacional de Cancerología

    México DF

  • Umae Hospital De Especialidades Dr. Antonio Fraga Mouret

    México DF

  • Centro Médico ABC

    México, DF

  • Hospital Español de México

    Miguel Hidalgo

  • Hospital Universitario de Nuevo León 'Dr. Eleuterio González'

    Nuevo León

  • Hospital Regional de Alta Especialidad de la Mujer

    Villahermosa

Other trials in Mexico

Ecuador12 sites

  • Hospital José Carrasco Arteaga

    Cuenca

  • Hospital Luis Vernaza

    Guayaquil

  • Hospital San Vicente de Paul

    Ibarra

  • Hospital Carlos Andrade Marín

    Quito

  • Hospital de la Policía

    Quito

  • Hospital de los Valles

    Quito

  • Hospital de SOLCA (ICU medical surgical & ICU medical)

    Quito

  • Hospital Enrique Garcés

    Quito

  • Hospital Eugenio Espejo

    Quito

  • Hospital General de las Fuerzas Armadas

    Quito

  • Hospital Metropolitano

    Quito

  • Hospital Pablo Arturo Suárez

    Quito

Other trials in Ecuador

South Korea12 sites

  • Hospital Korea University of Ansan

    Ansan

  • Hallym University Medical Center

    Anyang

  • Hospital Chungbuk National University

    Cheongju-si

  • Hospital Chuncheon Sacred Heart Hospital, Hallym University Medical Center

    Chuncheon

  • Hospital Catholic University of Daegu

    Daegu

  • Hospital Dongguk University of Gyeongju

    Gyeongju

  • Asan Medical Center, University of Ulsan

    Seoul

  • Hospital Ewha Womans University Mokdong

    Seoul

  • Hospital Severance, Yonsei University Health System

    Seoul

  • Samsung Medical Center, Sungkyunkwan University

    Seoul

  • Hospital Yonsei University Wonju Christian

    Wŏnju

  • Hospital Pusan National University of Yangsan

    Yangsan

Other trials in South Korea

France11 sites

  • Hôpital d'Armentières

    Armentières

  • Centre Hospitalier de Châlons en Champagne

    Châlons-en-Champagne

  • CHU Henri Mondor

    Créteil

  • CHU d'Angers

    d'Angers

  • CHU De Grenoble

    Grenoble

  • Centre Hospitalier Du Mans

    Le Mans

  • Hôpital Édouard Herriot

    Lyon

  • Centre Hospitalier De Montauban

    Montauban

  • Centre Hospitalier De Roanne

    Roanne

  • CHU Charles Nicolle

    Rouen

  • Centre Hospitalier De Saint-Malo

    St-Malo

Other trials in France

Canada10 sites

  • William Osler Health Science Centre

    Brampton, Ontario

  • Queen Elizabeth II Health Sciences Centre

    Halifax, Nova Scotia

  • Saint Joseph Hospital

    Hamilton, Ontario

  • Ottawa Hospital

    Ottawa, Ontario

  • Mount Sinai Hospital

    Toronto, Ontario

  • Saint Michael´s Hospital

    Toronto, Ontario

  • Sunnybrook Health Science Centre

    Toronto, Ontario

  • Toronto General Hospital

    Toronto, Ontario

  • Toronto Hospital Western Division

    Toronto, Ontario

  • Toronto Western Hospital

    Toronto, Ontario

Other trials in Canada

Portugal10 sites

  • Hospital Garcia de Orta

    Almada

  • Hospital da Luz

    Amadora

  • Hospital de Cascais

    Cascais

  • Centro Hospitalar de Lisboa Central

    Lisbon

  • Centro Hospitalar de Lisboa Norte

    Lisbon

  • Hospital de Santo Antonio dos Capuchos, Centro Hospitalar de Lisboa Central, E.P.E.

    Lisbon

  • Centro Hospitalar Do Porto - Hospital Geral De Santo António

    Porto

  • Instituto Português de Oncología Francisco Gentil

    Porto

  • Hospital De São Sebastião

    Seide

  • Centro Hospitalar Trás-Os-Montes E Alto Douro

    Vila Real

Other trials in Portugal

Netherlands8 sites

  • Onze Lieve Vrouwe Gasthuis (OLVG)

    Amsterdam

  • Vrije Universiteit Medisch Centrum (VUMC) (Three units)

    Amsterdam

  • Kennemer Gasthuis

    Haarlem

  • Tjongerschans Ziekenhuis

    Heerenveen

  • Spaarneziekenhuis

    Hoofddorp

  • Medical Center Leeuwarden (MCL)

    Leeuwarden

  • Universitair Medisch Centrum Maastricht

    Maastricht

  • Medisch Centrum Haaglanden

    The Hague

Other trials in Netherlands

Turkey (Türkiye)8 sites

  • Uludag University Faculty of Medicine

    Bursa

  • Erciye Üniversity

    Erciyes

  • Anadolu Medical Center Istanbul

    Istanbul

  • Atatürk Hospital

    Izmir

  • Sutcu İmam University

    Kahramanmaraş

  • Kirikkale University

    Kirikkale

  • Faculty of Medicine Mersin University

    Mersin

  • Medical Faculty of Yuzuncu Yil University

    Van

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New Zealand7 sites

  • CVICU Auckland City Hospital

    Auckland

  • DCCM Auckland City Hospital

    Auckland

  • Middlemore

    Auckland

  • Christchurch Hospital

    Christchurch

  • Waikato

    Hamilton

  • Tauranga Hospital

    Tauranga

  • Wellington Hospital

    Wellington

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Denmark6 sites

  • Holbak

    Holbæk

  • Koge

    Køge

  • Naestved

    Næstved

  • Nykobing Falster

    Nykøbing Falster

  • Roskilde

    Roskilde

  • Slagelse

    Slagelse

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Tunisia5 sites

  • Hospital Abderrahmane Mami

    Aryanah

  • Hospital Taher Sfar City

    Mahdia

  • Hospital Fattouma Bourguina (ICU medical & ICU surgical)

    Monastir

  • CHU Habib Bourguiba

    Sfax

  • Hospital Universitarie Farhat Hached

    Sousse

Other trials in Tunisia

Greece4 sites

  • Agios Pavlos General Hospital

    Thessaloniki

  • Ahepa Hospital

    Thessaloniki

  • Gennimata Hospital

    Thessaloniki

  • Papageorgiou Hospital

    Thessaloniki

Other trials in Greece

Russia4 sites

  • City Hospital Number 1 of Arkhangelsk

    Arkhangelsk

  • Hospital No.7

    Moscow

  • National Institute Of Surgery Named After A.V. Vishnevskij

    Moscow

  • Hospital No.14

    Yekaterinburg

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Venezuela4 sites

  • Hospital Centro de Especialidades

    Anzoátegui

  • Hospital Clínico Universitario

    Caracas

  • Hospital de Clínicas

    Caracas

  • Hospital Miguel Pérez Carreño

    Caracas

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Chile3 sites

  • Hospital de Copiapo

    Copiapó

  • Hospital de Coquimbo

    Coquimbo

  • Instituto Nacional del Tórax

    Santiago

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Morocco3 sites

  • Hôpital des Specialites

    Rabat

  • Hôpital Ibn Sina (Three units)

    Rabat

  • Hôpital Militaire D'Instruction Mohamed V

    Rabat

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Bolivia2 sites

  • Hospital Obrero No.1

    La Paz

  • Instituto Gastroenterológico

    La Paz

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Hungary2 sites

  • Kenezy Hospital

    Debrecen

  • University of Szeged (Four ICU)

    Szeged

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Peru2 sites

  • Hospital Edgardo Rebagliatti Martins

    Lima

  • Hospital Guillermo Almenara Irigoyen

    Lima

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Egypt1 site

  • Cairo University Hospitals

    Cairo

Other trials in Egypt

Japan1 site

  • Tokyo Women's Medical University

    Tokyo

Other trials in Japan

Panama1 site

  • Hospital Rafael Hernández

    Chiriquí

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Poland1 site

  • Karol Marcinkowski University Of Medical Sciences

    Poznan

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Puerto Rico1 site

  • VA Caribbean Health Care System

    San Juan, PR, 09221

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Saudi Arabia1 site

  • King Saud Bin Abdulaziz University for Health Sciences

    Riyadh

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Taiwan1 site

  • Chi Mei Medical Center

    Tainan

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Vietnam1 site

  • Viet Duc Hospital

    Hanoi

Other trials in Vietnam

About this study

Official title: Third Prospective, Observational, International, Multicenter Study on Mechanical Ventilation

The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units:

  1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients
  2. Secondary analyses:
  • To know the current status of mechanical ventilation in the intensive care unit and determine the number and percentage of patients who are admitted to an intensive care unit and require mechanical ventilation.
  • To compare the results with prior data collected in previous observational studies (1998 and 2004)
  • Non-invasive positive pressure ventilation
  • Weaning
  • Use of adjuvant therapies as steroids or selective digestive decontamination
  • Sedation including prevalence of delirium in mechanically ventilated patients
  • Prediction of the duration of mechanical ventilation
  • Other
Read the detailed description

Mechanical ventilation is commonly used in patients admitted to intensive care units. Clinical studies have investigated some of the aspects associated with its utilization, and have contributed to improve the knowledge and management of patients with acute respiratory failure. In 1998 the invesgtigators conducted the first international study on mechanical ventilation, including 5183 patients who were mechanically ventilated longer than 12 hours (Esteban A. JAMA 2002). Six years later, the investigators carried out the second international study on mechanical ventilation including 4968 patients. These studies allowed us to analyze the evolution of mechanical ventilation and to judge the concordance of practice with results of randomized trials (Esteban A. Am J Respir Crit Care 2008). The main finding of this study was the high degree of concordance between observed changes in mechanical ventilation practice and changes predicted from reports of randomized controlled trials. However, despite apparently beneficial changes in ventilatory practice, the investigators were not able to detect significant differences in clinical outcomes over this time period. Our results serve as an updated benchmark on the usual care and outcomes of mechanically ventilated patients in a 'real-world' setting.

The investigators now propose to conduct a third international study of mechanical ventilation, 6 years after the 2nd study and 12 years after the original. This will again be a prospective, multicenter single-cohort study, which will enroll consecutive patients who have received mechanical ventilation for at least 12 hours during a 1-month period, and will follow each patient for the duration of mechanical ventilation, up to 28 days. With this 3rd study the investigators aim: 1) to determine if the observed changes that the investigators reported previously are maintained over time; 2) to evaluate if the changes implemented have impacted outcomes; 3) to analyze some aspects related to withdrawal of mechanical ventilation; and implementation non-invasive positive pressure ventilation; and 4) to evaluate what differences may occur between geographical areas.

Keywords
mechanical ventilation, epidemiology, outcomes, mortality, weaning, sedation, non-invasive positive pressure ventilation

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT01093482
Study groupRoleWhat they receive
mechanically ventilated patients1. Patients who are admitted to the participating intensive care units and require invasive mechanical ventilation (endotracheal tube or tracheostomy) for more than 12 hours. 2. Patients who are admitted to the participating intensive care units and require non-invasive mechanical ventilation (Bilevel positive airway pressure (BIPAP) or continuous positive airway pressure (CPAP) with nasal or facial mask) for more than 1 hour.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. All-cause Mortality

    Mortality at discharge from intensive care unit

    Measured: At day 28 after the beginning of mechanical ventilation

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted25 Mar 2010 (estimated)
  2. Study startApr 2010
  3. Primary completionJul 2010
  4. Study completionSep 2010

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
8,151 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01093482
Sponsor's protocol ID
ISMV-2010
Acronym
ISMV
Status last verified
Feb 2018
First submitted
23 Mar 2010
Last updated
1 Mar 2018
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Esteban A, Anzueto A, Frutos F, Alia I, Brochard L, Stewart TE, Benito S, Epstein SK, Apezteguia C, Nightingale P, Arroliga AC, Tobin MJ; Mechanical Ventilation International Study Group. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA. 2002 Jan 16;287(3):345-55. doi: 10.1001/jama.287.3.345.

    PubMed 11790214

  • Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonzalez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Montanez AM, Anzueto A; VENTILA Group. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med. 2008 Jan 15;177(2):170-7. doi: 10.1164/rccm.200706-893OC. Epub 2007 Oct 25.

    PubMed 17962636

  • Nin N, Muriel A, Penuelas O, Brochard L, Lorente JA, Ferguson ND, Raymondos K, Rios F, Violi DA, Thille AW, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Soto L, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A, Sznajder JI, Esteban A; VENTILA Group. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med. 2017 Feb;43(2):200-208. doi: 10.1007/s00134-016-4611-1. Epub 2017 Jan 20.

    PubMed 28108768

  • Esteban A, Frutos-Vivar F, Muriel A, Ferguson ND, Penuelas O, Abraira V, Raymondos K, Rios F, Nin N, Apezteguia C, Violi DA, Thille AW, Brochard L, Gonzalez M, Villagomez AJ, Hurtado J, Davies AR, Du B, Maggiore SM, Pelosi P, Soto L, Tomicic V, D'Empaire G, Matamis D, Abroug F, Moreno RP, Soares MA, Arabi Y, Sandi F, Jibaja M, Amin P, Koh Y, Kuiper MA, Bulow HH, Zeggwagh AA, Anzueto A. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med. 2013 Jul 15;188(2):220-30. doi: 10.1164/rccm.201212-2169OC.

    PubMed 23631814

Questions about this trial

What is this clinical trial studying?

An observational study of Acute Respiratory Failure, run by Hospital Universitario Getafe at 477 sites in 38 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 1 Mar 2018. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 477 sites in Spain, China, Argentina, Germany, Brazil and 33 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 26 Jan 2018). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

All-cause Mortality (time frame: At day 28 after the beginning of mechanical ventilation). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01093482, which also lists 4 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Mar 2018.

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