Clinical trials: Acute Respiratory Failure
Respiratory Failure
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF)
Acute respiratory failure (ARF) is a life-threatening emergency which occurs due to impaired gas exchange. In the US, the number of hospitalisations owing to acute respiratory failure was 1,917,910 in the year 2009.(1) The…
- Trial name
- NCT03271671
- Testing
- NAVA during Non invasive ventilation, PSV during Non invasive ventilation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Respiratory Distress Syndrome, Noninvasive Ventilation
Helmet vs Face Mask in Patients With Acute Respiratory Distress Syndrome
The objective of this study is to evaluate the efficacy of noninvasive ventilation with helmet in reducing endotracheal intubation rates in comparison with Noninvasive Ventilation (NIV) facemask among patients with Acute…
- Conditions
- Acute Respiratory Distress Syndrome, Noninvasive Ventilation, Corona Virus Disease, Acute Respiratory Failure
- Trial name
- NCT04507802
- Testing
- Non invasive ventilation via helmet
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Distress Syndrome, ARDS
Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
- Trial name
- IMPROVENT (NCT03225807)
- Where
- United States
- Volunteers
- 8,692 people
- Sponsor
- Intermountain Health Care, Inc.
ARDS (Acute Respiratory Distress Syndrome)
Pressure Release Ventilation Compared to Lung Protective Ventilation in Moderate and Severe ARDS
This study compares two different ways of providing mechanical ventilation to patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition in which the lungs become inflamed and make it…
- Trial name
- NCT07803614
- Testing
- Arm 1 Intervention Name: Low-Tidal-Volume Ventilation (LTV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Koot Ahmad
Acute Coronary Syndrome, Chronic Heart Failure
Influenza Vaccination During Coronavirus Disease 2019 Outbreak After Acute Coronary Syndrome and Chronic Heart Failure
Study Description: Background: Well-known fact that the number of cardiovascular diseases is on the rise during influenza epidemic.
- Trial name
- IV-ACS&CHF (NCT05232292)
- Testing
- Ultrix Quadri
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Samara Regional Cardiology Dispensary
ARDS, Respiratory Effort
Comparison of Guiding Sedation Level by Respiratory Effort Versus Usual Care in Mechanically Ventilated Patients: A Randomized Controlled Trial (EFFORT-GUIDE Trial 2)
The objective of this research is to utilize respiratory effort parameters as a tool to assist in adjusting sedative drug levels for patients undergoing mechanical ventilation in the intensive care unit, in comparison to the…
- Conditions
- ARDS, Respiratory Effort, Mechanical Ventilation Complication, Sedation
- Trial name
- NCT06242236
- Testing
- The respiratory effort parameters guide sedative dosage.
- Where
- Thailand
- Volunteers
- 156 people
- Sponsor
- Ramathibodi Hospital
Chronic Respiratory Failure, Acute Respiratory Failure
Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure
Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection…
- Trial name
- NCT06952816
- Testing
- Emily.AI
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Aether Tech S.L.
Acute Hypercapnic Respiratory Failure
Volume-targeted Versus Pressure-limited Noninvasive Ventilation in Patients With Acute Hypercapnic Respiratory Failure
Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that targets a preseted tidal volume (VT) by automated adjustment of pressure support, could guarantee the delivered VT over pressure-limited noninvasive ventilation…
- Trial name
- NCT02538263
- Testing
- Volume-targeted noninvasive ventilation
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Respiratory Failure, Diaphragmatic Function
Efficacy of High Velocity Nasal Insufflation
The purpose of this study is to assess the effect of HFNC on esophageal pressure and diaphragmatic function in patients with acute respiratory failure
- Conditions
- Acute Respiratory Failure, Diaphragmatic Function, Esophageal Pressure
- Trial name
- NCT03929055
- Testing
- Physiological assesment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan
Severe Bronchiolitis
Prone Position Effects on Work of Breathing and Intrinsic PEEP in Children With Severe Acute Viral Bronchiolitis
Acute viral bronchiolitis is the first cause of respiratory distress in infant. Airway inflammation increases the respiratory system resistances and dynamic hyperinflation. This leads to an increase in the work of breathing.
- Trial name
- BRONCHIO-DV (NCT02602678)
- Testing
- Supine then Prone position, Prone then supine position
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Hospices Civils de Lyon
Covid19
Epidemiologic, Clinical and Molecular Characteristics of Patients With Acute Respiratory Failure Affected by 2019-NCOV.
The main purpose of this study is to identify possible predictor factor of mortality in patients affected by COVID-19 with respiratory failure needing oxygen therapy or ventilatory support.
- Trial name
- NCT04552340
- Testing
- Patient with SAR-CoV-2 infection
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Istituto Clinico Humanitas
Dyspnea
Artificial Intelligence to Improve Physicians' Interpretation of Chest X-Rays in Breathless Patients
Identifying the cause of breathlessness in acute patients in the emergency department is critical and challenging. The chest X-ray is central but challenging to read for non-radiologist physicians.
- Trial name
- XRAI (NCT05117320)
- Testing
- AI support
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Acute Hypoxemic Respiratory Failure
Prediction of Duration of Mechanical Ventilation in Acute Hypoxemic Respiratoty Failure
Acute hypoxemic respiratory failure (AHRF) is a common cause of admission in intensive care units (ICUs) worldwide. We will assess machine learning (ML) techniques for prediction of prolonged duration (> or = to 7 days) of…
- Trial name
- PREMIER (NCT06815523)
- Testing
- Machine learning and logistic regression for the training/testing cohort and validation cohort
- Where
- 2 sites in Spain
- Volunteers
- 1,241 people
- Sponsor
- Jesus Villar
Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High
Assessing Lung Inhomogeneity During Ventilation for Acute Hypoxemic Respiratory Failure
Mechanical ventilation can cause damage by overstretching the lungs, especially when the lungs are collapsed or edematous. Raising ventilator pressures can reduce lung collapse and this can prevent overstretching from mechanical…
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Pressure High, Hypoxemic Respiratory Failure
- Trial name
- ALIVE (NCT03589482)
- Testing
- Electrical Impedance Tomography, ExPRESS-derived PEEP level
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Explore Potential Plasma and BALF Immunometabolic and Lipidomic Biomarkers for Identifying ARDS Endotypes
Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes high mortality (41% to 58%). Previous studies have reported that biomarkers can facilitate phenotypic diagnosis of ARDS, enabling precision…
- Trial name
- NCT05451342
- Testing
- Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
COVID-19
ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
A phase 2/3, randomized, double blind, placebo-controlled study to evaluate the efficacy and the safety of ABX464 in treating inflammation and preventing acute respiratory failure in patients aged ≥65 and patients aged ≥18 with…
- Trial name
- Mir-Age (NCT04393038)
- Testing
- ABX464
- Where
- 30 sites in Belgium, Brazil and 6 more
- Volunteers
- 509 people
- Sponsor
- Abivax S.A.
Acute Respiratory Failure, Post Intensive Care Syndrome
Observational Study of Expected ARF Recovery
This is an observational cohort study of the association between patient expectations for functional recovery and quality of life among acute respiratory failure survivors 6 months after hospital discharge.
- Trial name
- OSEAR (NCT03797313)
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- Johns Hopkins University
Acute Kidney Failure, Acute Kidney Insufficiency
Kidney Precision Medicine Project (KPMP) - COVID-19 Protocol
Since its inception, KPMP has developed sophisticated protocols for collection and analysis of human kidney tissue, and for collection of biofluids.
- Conditions
- Acute Kidney Failure, Acute Kidney Insufficiency, Acute Renal Failure, Acute Renal Injury
- Trial name
- NCT05384899
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Washington
Respiratory Failure With Hypoxia
Helmet Noninvasive Ventilation vs. High-flow Nasal Cannula in Moderate-to-severe Acute Hypoxemic Respiratory Failure
Helmet noninvasive ventilation and high-flow nasal cannula are novel tools for the first-line treatment of acute hypoxemic respiratory failure.
- Trial name
- HENIVOTpilot (NCT04502576)
- Testing
- Noninvasive respiratory support
- Where
- 5 sites in Italy
- Volunteers
- 110 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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