PhysiologyNCT01154582
Nutritional Quality of Egg Proteins and Effect on Satiety
A study testing Egg snack and Cottage cheese in people with Physiology and Nutrition, run by Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement at 2 sites in France.
Trial summary
The project aims to precisely quantify the postprandial amino acid utilization of egg proteins in vivo in humans, and also to assess their satiating power, in relation with nutrient postprandial waves and incretin secretions. For that purpose, 2 independent studies are conducted. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Physiology, Nutrition
- What is being tested?
- Egg snack and Cottage cheese
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 43 participants
- Where
- 2 sitesFrance
- Study dates
- Feb 2009to not given
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy volunteers
- BMI between 18 and 25
Who cannot join
- Allergy to egg or milk protein
- Digestive or metabolic pathology
- Positiveness to HIV, Hepatitis B and C
- Smokers
Trial locations and contacts
2 sites in 1 country.
France2 sites
Centre de recherche sur volontaires
Bobigny, 93
Centre de recherche sur Volontaires
Nantes, 44
About this study
The project aims to precisely quantify the postprandial amino acid utilization of egg proteins in vivo in humans, and also to assess their satiating power, in relation with nutrient postprandial waves and incretin secretions. For that purpose, 2 independent studies are conducted. The first one is realized using stable isotopes on 8 volunteers ingesting an egg test meal. The second one is a cross over design performed on 30 volunteers to compare the satiating effect of 2 equivalent snacks: whole eggs or cottage cheese.
- Conditions
- Physiology, Nutrition
- Being tested
- Egg snack, Cottage cheese
- Keywords
- ingestive behavior
- Medical subject headings
- Feeding Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Egg snackDietary supplement
subject consume 4 cooked whole eggs, providing 380 kcal
Cottage cheeseDietary supplement
Subjects consume 200 g of cottage cheese, providing 380 kcal
| Study group | Role | What they receive |
|---|---|---|
| Egg | Experimental | Not described Receives: Dietary Supplement: Egg snack |
| Cottage cheese | Experimental | Not described Receives: Dietary Supplement: Cottage cheese |
What is being measured
The primary outcome is the main question the study is designed to answer.
energy intake at lunch following the snack
Dietary amino acid utilization
transfer of stables isotopes used as intrinsic markers of egg proteins to metabolic pools
Secondary outcomes (3)
plasma incretin concentrations
insulin, glucagon, GLP-1, PYY, ghrelin, GIP
postprandial nutrient waves
plasma glucose, cholesterol, triglyceride, urea
neoglucogenesis
Endogenous production of glucose and contribution of dietary amino acids
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Jul 2010 (estimated)
- Study startFeb 2009
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for PhysiologyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Enrolment
- 43 participants (actual)
Sponsor and investigators
- Lead sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
- Sponsor type
- University, hospital or other
- Collaborators
- National Research Agency, France
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01154582
- Sponsor's protocol ID
- OVONUTRIAL
- Status last verified
- Jun 2010
- First submitted
- 30 Jun 2010
- Last updated
- 6 Oct 2025
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Fromentin C, Tome D, Nau F, Flet L, Luengo C, Azzout-Marniche D, Sanders P, Fromentin G, Gaudichon C. Dietary proteins contribute little to glucose production, even under optimal gluconeogenic conditions in healthy humans. Diabetes. 2013 May;62(5):1435-42. doi: 10.2337/db12-1208. Epub 2012 Dec 28.
PubMed 23274906
Study at a glance
From the registry record, last updated by the sponsor on 6 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Nutritional Quality of Egg Proteins and Effect on Satiety
- ClinicalTrials.gov ID
- NCT01154582
- Acronym / sponsor ID
- OVONUTRIAL
- Conditions
- Physiology, Nutrition
- Keywords
- ingestive behavior
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 43 participants (actual)
- Lead sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'EnvironnementUniversity, hospital or other
- Collaborators
- National Research Agency, France
- Study start
- Feb 2009
- First posted
- 1 Jul 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The project aims to precisely quantify the postprandial amino acid utilization of egg proteins in vivo in humans, and also to assess their satiating power, in relation with nutrient postprandial waves and incretin secretions. For that purpose, 2 independent studies are conducted. The first one is realized using stable isotopes on 8 volunteers ingesting an egg test meal. The second one is a cross over design performed on 30 volunteers to compare the satiating effect of 2 equivalent snacks: whole eggs or cottage cheese.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Egg | Experimental | Dietary Supplement: Egg snack |
| Cottage cheese | Experimental | Dietary Supplement: Cottage cheese |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Healthy volunteers
- BMI between 18 and 25
Key exclusion criteria (4 listed)
- Allergy to egg or milk protein
- Digestive or metabolic pathology
- Positiveness to HIV, Hepatitis B and C
- Smokers
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Egg snacksubject consume 4 cooked whole eggs, providing 380 kcal | Dietary supplement | Egg |
| Cottage cheeseSubjects consume 200 g of cottage cheese, providing 380 kcal | Dietary supplement | Cottage cheese |
Primary outcome
energy intake at lunch following the snack
Dietary amino acid utilization
transfer of stables isotopes used as intrinsic markers of egg proteins to metabolic pools
3 secondary outcomes
plasma incretin concentrations
postprandial nutrient waves
neoglucogenesis
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Oct 2025.
- Derived from this study: PubMed 23274906Fromentin C, Tome D, Nau F, Flet L, Luengo C, Azzout-Marniche D, Sanders P, Fromentin G, Gaudichon C. Dietary proteins contribute little to glucose production, even under optimal gluconeogenic conditions in healthy humans. Diabetes. 2013 May;62(5):1435-42. doi: 10.2337/db12-1208. Epub 2012 Dec 28.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Egg snack and Cottage cheese in people with Physiology and Nutrition, run by Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement at 2 sites in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
energy intake at lunch following the snack. The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01154582, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Oct 2025.