Clinical trials: Physiology
Metabolic Disorders, Cancer
A Natural History Study of Metabolic Sizing in Health and Disease
Background: Scientists have long used simple measures (such as height and weight) to estimate how much a person s body uses food (calories) as energy, as commonly called the metabolic rate.
- Conditions
- Metabolic Disorders, Cancer, Chronic Kidney Disease, Diabetes
- Trial name
- NCT05398783
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Normal Physiology
Developing Transcranial Neuromodulation Protocols for Learning and Decision-Making
Background: People with substance use disorder (SUD) often have changes in brain function that can make it difficult to control drug-seeking behavior.
- Trial name
- NCT06561828
- Testing
- continuous Theta Burst Stimulation (cTBS), intermittent Theta Burst Stimulation (iTBS)
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Behaviour, Psychology
Breastfeeding Relaxation Intervention Among Mothers of Preterm Infants in Hospital Sultan Abdul Aziz Shah (HSAAS)
This study is designed to compare the effects of four relaxation interventions on both physiological and psychological outcomes in lactating mothers of preterm infants.
- Conditions
- Behaviour, Psychology, Physiology, Therapy
- Trial name
- NCT06864455
- Testing
- Guided Imagery Meditation, Religious Recitation, Infant Video with Music
- Where
- Malaysia
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Normal Physiology
Causal Mechanisms of Odor-Guided Behavior in Humans
Background: Little is known about how different regions of the brain responsible for the human sense of smell guide behaviors. In this study, researchers use a technique called transcranial ultrasound stimulation (TUS) to learn…
- Trial name
- NCT07099092
- Testing
- TUS PirC, TUS Amy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Exercise Physiology, Metabolic Hormones
Effects of Different Exercise Types on Irisin, Leptin, and Ghrelin Levels in Sedentary Women
This interventional study aims to investigate the acute effects of three different exercise modalities-aerobic exercise, anaerobic exercise, and high-intensity interval training (HIIT)-on irisin, leptin, and ghrelin levels in…
- Trial name
- ILEX (NCT07805772)
- Testing
- Aerobic Exercise, Anaerobic Exercise, High-Intensity Interval Training (HIIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Inonu University
Exercise Physiology, Blood Parameters
Blood Parameter Changes Following Aerobic Exercise in Professional Soccer Players
This study aims to investigate acute changes in serum ferritin, folate, vitamin B12, and parathyroid hormone (PTH) levels following aerobic exercise in professional soccer players.
- Trial name
- ABP-Soccer (NCT07826598)
- Testing
- 20-Meter Shuttle Run Test
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Inonu University
Motor Function of Healthy Physiology
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System
Objectives When a stroke damages the part of the brain that controls movement, people have weakness and difficulty using their hand.
- Trial name
- NCT00453505
- Testing
- TMS, tDCS, tACS
- Where
- United States
- Volunteers
- 976 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Normal Physiology
Development Of Neuroimaging Methods To Assess The Neurobiology Of Addiction
Background: Abusing alcohol, drugs, and other substances can cause serious health problems. These substances also can affect brain function.
- Trial name
- NCT02535702
- Testing
- In vivo MRS, fMRI, EEG/EOG
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Layer-specific Contribution to Consolidation of Skill Learning in the Primary Motor Cortex
Background: Training in a new motor skill often involves periods of active practice and periods of rest. During early motor skill learning, improvements in performance usually happen during the short rest periods between practice…
- Trial name
- NCT04431011
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Major Depressive Disorder, Substance Use Disorder
Defining Neurobiological Links Between Substance Use and Mental Illness
Background: Nicotine dependence leads to about 480,000 deaths every year in the United States. People with major depressive disorder (MDD) are twice as likely to use nicotine compared to the general population.
- Conditions
- Major Depressive Disorder, Substance Use Disorder, Normal Physiology
- Trial name
- NCT05538910
- Testing
- Nicotine Patch
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Skin Physiology After Fractional CO₂ Laser Treatment, Skin Physiology After Thermage Treatment
Pre- and Post-procedure Skin Knowledge Study
The goal of this exploratory clinical trial is to characterize and compare skin clinical signs, skin physiology and subjective well-being before and after CO₂ fractional laser or Thermage treatment.
- Trial name
- NCT07895303
- Testing
- CO₂ fractional laser skin treatment, Thermage skin tightening treatment, Neutral broad-spectrum sunscreen
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water.
- Trial name
- DrinkAge (NCT07892742)
- Testing
- Water
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Polytechnic University of Santarém
Obesity, Puberty
Investigating the Impact of Obesity on Pubertal Development in Girls
Background: Studies suggest that overweight girls may be developing breast tissue, and therefore starting puberty, earlier than normal weight girls. However, it is hard to distinguish breast tissue from fatty tissue.
- Conditions
- Obesity, Puberty, Normal Physiology
- Trial name
- NCT02583646
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Normal Physiology
Characterization of an Optically Pumped Magnetometer (OPM) Magnetoencephalography (MEG) Array
Background: Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Researchers are testing a new type of magnetic field sensor called OPM.
- Trial name
- NCT04950309
- Testing
- SQUID MEG, OPM MEG
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cardiovascular Physiology
Effects of Tart Cherry and Aronia Extract Supplementation on Selected Physiological Parameters in Endurance-Trained Men
This study will evaluate the effects of four weeks of oral supplementation with a double-standardized tart cherry (Prunus cerasus) and aronia (Aronia melanocarpa) extract on cardiovascular regulation and exercise performance in…
- Trial name
- NCT07885098
- Testing
- Standardized Tart Cherry and Aronia Extract
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Cell Physiology Education
RGE-Based Cell Physiology Education for International Medical Students
This study evaluated an integrated active-learning approach for teaching cell physiology to international medical students at Tehran University of Medical Sciences.
- Trial name
- NCT07885553
- Testing
- RGE-Based Cell Physiology Education
- Where
- Iran
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Pain, Normal Physiology
Neural and Psychological Mechanisms of Pain Perception
Background: Painful stimuli cause changes in a network of brain regions called the "Pain Matrix." But most of these regions respond to many other stimuli, not just pain.
- Conditions
- Pain, Normal Physiology, Healthy Volunteers
- Trial name
- NCT02446262
- Testing
- Instructions, Attention, Thermal Pain
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Physiology, Healthy Volunteers
Sociocultural & Biobehavioral Influences on Pain Expression and Assessment
Objective The current proposal investigates behavioral, psychophysiological, and social processes that may help explain biases and disparate outcomes in pain.
- Conditions
- Normal Physiology, Healthy Volunteers, Pain
- Trial name
- NCT03258580
- Testing
- Medoc thermal stimulator, Electric shock stimulator, Cold water bath
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Normal Physiology
Perception, Sensation, Cognition and Action in Humans
Background: When people see and hear, the brain changes signals from the eyes and ears into perceptions and thoughts. No one fully understands how this happens.
- Trial name
- NCT03407066
- Where
- 2 sites in United States
- Volunteers
- 10,200 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)