ObesityNCT01387438
The Incidence,Factors,and Importance of Brown Adipose Tissue in Chinese Adults
An observational study of Obesity, run by Huashan Hospital at 1 site in China.
Trial summary
Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in material and energy metabolism. However, most of these studies were tumor-based populations and retrospective study. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Obesity
- How many people
- 200 participants
- Where
- 1 siteChina
- Study dates
- Dec 2009to Dec 2013
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Subjects who underwent scanning PET-CT at Huashan Hospital Medical Centre from 2009 to 2013
Who may be able to join
- Subjects with detectable brown adipose tissue
- Negative controls,consisting of one subject who underwent PET/CT scans at the same day but without detectable BAT
Who cannot join
- Younger than 18 years
- Pregnant women
- With implantable medical electronic instrument
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Cross-sectional Study on the Incidence,Factors,and Importance of Brown Adipose Tissue in Adult Chinese
Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in material and energy metabolism. However, most of these studies were tumor-based populations and retrospective study. Due to the large amount in our cohort, the investigators are able to promote a cross-sectional study of the incidence and factors of BAT in adult chinese. In addition, the investigators can analyse the metabolic profiles in healthy adults with active BAT.
Read the detailed description
The investigators will perform a cross sectional analysis on the chinese adults who use 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to scan the whole body at Huashan Hospital from 2009 to 2013. BAT activity will be measured by PET/CT. Not only demographic data on sex, age, medication and medical history,but also data on body composition and physical examination will be collected for all subjects. Imaging date,outdoor temperature and fasting blood samples will be collected as well. In addition, the investigators will analyse the metabolic profiles in healthy adults with active BAT and their negative controls,such as lipid profiles,fasting glucose and insulin sensitivity, adipokines and other biochemical markers.
- Conditions
- Obesity
- Keywords
- Brown Adipose Tissue, Cross sectional study, Chinese Adults, Factor
- Medical subject headings
- Obesity
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Jul 2011 (estimated)
- Study startDec 2009
- Primary completionDec 2013 (estimated)
- Study completionDec 2013 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- More trials run by Huashan HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 200 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Huashan Hospital
- Sponsor type
- University, hospital or other
- Investigators
- Yiming Li, Doctor, Study chair, Huashan Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01387438
- Sponsor's protocol ID
- KY2009-279
- Status last verified
- Nov 2009
- First submitted
- 30 Jun 2011
- Last updated
- 4 Jul 2011
- Results posted
- No
- Data monitoring committee
- Yes
Publications
Miao Q, Wang Y, Zhang Q, Wu W, Yu Y, Zeng F, Yang Y, Zuo C, Guan Y, Liew CW, Bluher M, Li Y, Wang X. Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans. Int J Obes (Lond). 2025 Jul;49(7):1264-1271. doi: 10.1038/s41366-025-01744-2. Epub 2025 Mar 18.
PubMed 40102590
Study at a glance
From the registry record, last updated by the sponsor on 4 Jul 2011. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cross-sectional Study on the Incidence,Factors,and Importance of Brown Adipose Tissue in Adult Chinese
- ClinicalTrials.gov ID
- NCT01387438
- Acronym / sponsor ID
- KY2009-279
- Conditions
- Obesity
- Keywords
- Brown Adipose Tissue, Cross sectional study, Chinese Adults, Factor
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 200 participants (estimated)
- Lead sponsor
- Huashan HospitalUniversity, hospital or other
- Study start
- Dec 2009
- Primary completion
- Dec 2013 (estimated)
- Study completion
- Dec 2013 (estimated)
- First posted
- 4 Jul 2011 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Previous studies have shown that active brown adipose tissue (BAT) is present in adults and may play important roles in material and energy metabolism. However, most of these studies were tumor-based populations and retrospective study. Due to the large amount in our cohort, the investigators are able to promote a cross-sectional study of the incidence and factors of BAT in adult chinese. In addition, the investigators can analyse the metabolic profiles in healthy adults with active BAT.
Detailed description
The investigators will perform a cross sectional analysis on the chinese adults who use 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) to scan the whole body at Huashan Hospital from 2009 to 2013. BAT activity will be measured by PET/CT. Not only demographic data on sex, age, medication and medical history,but also data on body composition and physical examination will be collected for all subjects. Imaging date,outdoor temperature and fasting blood samples will be collected as well. In addition, the investigators will analyse the metabolic profiles in healthy adults with active BAT and their negative controls,such as lipid profiles,fasting glucose and insulin sensitivity, adipokines and other biochemical markers.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Subjects who underwent scanning PET-CT at Huashan Hospital Medical Centre from 2009 to 2013
Key inclusion criteria (2 listed)
- Subjects with detectable brown adipose tissue
- Negative controls,consisting of one subject who underwent PET/CT scans at the same day but without detectable BAT
Key exclusion criteria (3 listed)
- Younger than 18 years
- Pregnant women
- With implantable medical electronic instrument
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Jul 2011.
- Derived from this study: PubMed 40102590Miao Q, Wang Y, Zhang Q, Wu W, Yu Y, Zeng F, Yang Y, Zuo C, Guan Y, Liew CW, Bluher M, Li Y, Wang X. Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans. Int J Obes (Lond). 2025 Jul;49(7):1264-1271. doi: 10.1038/s41366-025-01744-2. Epub 2025 Mar 18.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Yiming Li, Doctor study chair
Huashan Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Obesity, run by Huashan Hospital at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 4 Jul 2011. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01387438, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Jul 2011.