Alzheimer's DiseaseNCT02018913
Blood-brain Barrier Leakage in Dementia. A Dynamic Contrast-enhanced MRI Study
An observational study of Alzheimer's Disease and Vascular Dementia, run by Maastricht University Medical Center.
Trial summary
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Yet, the cause of these diseases is still unknown. A potentially important initiating factor is a disrupted blood-brain barrier. This can initiate cerebral microangiopathy, which has frequently been associated with VaD. Read more about this study
- Who is it for?
- Ages 55 years and olderHealthy volunteers can take part
- Conditions the study is for
- Alzheimer's Disease, Vascular Dementia
- How many people
- 140 participants
- Where
- No sites listed yet
- Study dates
- Apr 2014to Apr 2018
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 55 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: To obtain variation in macrovascular pathology and cognitive outcome measures, patients with AD, VaD, mixed AD and VaD, mild cognitive impairment (due to AD), vascular cognitive impairment and subjective cognitive impairment will be included. The total number of patients is 120, approximately 20 patients per disorder category as mentioned above. The patients will be recruited from the memory clinic of the Maastricht University Medical Center. Also a group of 20 age-matched healthy controls will be included. The total number of participants is thus 140.
Who may be able to join
- Patients:
- Informed consent before participation in the study
- Age of 55 and older
- Diagnosed with AD, VaD, mixed AD and VaD, mild cognitive impairment, vascular cognitive impairment and subjective cognitive impairment
- MMSE ≥ 20 and patients are mentally competent (in general, individuals with an MMSE ≥18 are considered mentally competent)
- Healthy participants:
Show all 12Show fewer
- Informed consent before participation in the study
- Age of 55 and older
- No Diagnosis of dementia, prodromal dementia, or mild cognitive impairment.
- MMSE ≥ 26
- No substantial memory complaints (according to participant)
- Average age, gender and education is similar to the patient groups.
Who cannot join
- Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
- Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR < 30 mL/min; or known allergy to Gadovist. If participants have a low renal function as determined by <30 GFR <60, the PI will contact a radiologist (Paul Hofman). The radiologist will decide if this patient should be excluded.
- Major vascular disorders (e.g. stroke, heart disease)
- Psychiatric or neurological disorders: Major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 mnd); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
- Structural abnormalities of the brain
- Cognitive impairment due to alcohol/drug abuse or abuse of other substances.
- Absence of reliable informant (for patient groups)
About this study
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Yet, the cause of these diseases is still unknown. A potentially important initiating factor is a disrupted blood-brain barrier. This can initiate cerebral microangiopathy, which has frequently been associated with VaD. Nevertheless, also in most AD patients a substantial increase of vascular damage has been observed. The present study investigates the correlation between blood-brain-barrier breakdown and cognitive decline in AD and VaD. An innovative dynamic contrast-enhanced MRI scan that has recently been developed and tested at our institute, will be used to measure blood-brain barrier permeability.
Objective: We will investigate the relationship between this permeability measure and (i) cognitive performance and (ii) the status of MRI visible cerebrovascular pathology (i.e. white matter hyperintensities, lacunar infarctions, microbleeds) in the most common forms of dementia.
- Conditions
- Alzheimer's Disease, Vascular Dementia
- Medical subject headings
- Alzheimer Disease, Dementia, Vascular
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood brain barrier permeability as measured by T1-weighted dynamic contrast MRI
Measured: Up to 4 years: April 2014-April 2018
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Dec 2013 (estimated)
- Study startApr 2014
- Primary completionApr 2018 (estimated)
- Study completionApr 2018 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Alzheimer's DiseaseStudies of the same condition, open and under way.
- More trials run by Maastricht University Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 140 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Maastricht University Medical Center
- Sponsor type
- University, hospital or other
- Collaborators
- Netherlands Alzheimer Foundation
- Responsible party
- Principal investigator, F.R.J.Verhey, Maastricht University Medical Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02018913
- Sponsor's protocol ID
- NL46089.068.13
- Status last verified
- Dec 2013
- First submitted
- 11 Dec 2013
- Last updated
- 23 Dec 2013
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 23 Dec 2013. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Blood-brain Barrier Leakage in Dementia. A Dynamic Contrast-enhanced MRI Study
- ClinicalTrials.gov ID
- NCT02018913
- Acronym / sponsor ID
- NL46089.068.13
- Conditions
- Alzheimer's Disease, Vascular Dementia
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 140 participants (estimated)
- Lead sponsor
- Maastricht University Medical CenterUniversity, hospital or other
- Collaborators
- Netherlands Alzheimer Foundation
- Study start
- Apr 2014
- Primary completion
- Apr 2018 (estimated)
- Study completion
- Apr 2018 (estimated)
- First posted
- 23 Dec 2013 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Alzheimer's disease (AD) and vascular dementia (VaD) are the most common forms of dementia. Yet, the cause of these diseases is still unknown. A potentially important initiating factor is a disrupted blood-brain barrier. This can initiate cerebral microangiopathy, which has frequently been associated with VaD. Nevertheless, also in most AD patients a substantial increase of vascular damage has been observed. The present study investigates the correlation between blood-brain-barrier breakdown and cognitive decline in AD and VaD. An innovative dynamic contrast-enhanced MRI scan that has recently been developed and tested at our institute, will be used to measure blood-brain barrier permeability.
Objective: We will investigate the relationship between this permeability measure and (i) cognitive performance and (ii) the status of MRI visible cerebrovascular pathology (i.e. white matter hyperintensities, lacunar infarctions, microbleeds) in the most common forms of dementia.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 55 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- To obtain variation in macrovascular pathology and cognitive outcome measures, patients with AD, VaD, mixed AD and VaD, mild cognitive impairment (due to AD), vascular cognitive impairment and subjective cognitive impairment will be included. The total number of patients is 120, approximately 20 patients per disorder category as mentioned above. The patients will be recruited from the memory clinic of the Maastricht University Medical Center. Also a group of 20 age-matched healthy controls will be included. The total number of participants is thus 140.
Key inclusion criteria (12 listed)
- Informed consent before participation in the study
- Age of 55 and older
- Diagnosed with AD, VaD, mixed AD and VaD, mild cognitive impairment, vascular cognitive impairment and subjective cognitive impairment
- MMSE ≥ 20 and patients are mentally competent (in general, individuals with an MMSE ≥18 are considered mentally competent)
- Informed consent before participation in the study
Key exclusion criteria (7 listed)
- Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
- Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR < 30 mL/min; or known allergy to Gadovist. If participants have a low renal function as determined by <30 GFR <60, the PI will contact a radiologist (Paul Hofman). The radiologist will decide if this patient should be excluded.
- Major vascular disorders (e.g. stroke, heart disease)
- Psychiatric or neurological disorders: Major depression (< 12 months); history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder (< 12 mnd); cognitive impairment due to alcohol abuse; epilepsy; Parkinson's disease; MS; brain surgery; brain trauma; electroshock therapy; kidney dialysis; Meniere's disease; and brain infections.
- Structural abnormalities of the brain
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Blood brain barrier permeability as measured by T1-weighted dynamic contrast MRI
Time frame: Up to 4 years: April 2014-April 2018
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Dec 2013.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Alzheimer's Disease and Vascular Dementia, run by Maastricht University Medical Center.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 23 Dec 2013. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood brain barrier permeability as measured by T1-weighted dynamic contrast MRI (time frame: Up to 4 years: April 2014-April 2018). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Dec 2013.