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Chronic Kidney Disease(CKD)KNOW-PedCKDNCT02165878

KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease

An observational study of Chronic Kidney Disease(CKD), run by Seoul National University Hospital at 1 site in South Korea.

Unknown status

Status not confirmed. The sponsor has not verified this record for over two years, so it may be out of date.

Official record
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Trial summary

KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) is a nation-wide, ten-year longitudinal cohort study, launched in 2011. The aim of the study is to assess the characteristics and risk factors of progression and complications of CKD of Korea. Read more about this study

Who is it for?
Ages Up to 20 years
Conditions the study is for
Chronic Kidney Disease(CKD)
How many people
458 participants
Where
1 siteSouth Korea
Study dates
Mar 2011to Dec 2021
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Up to 20 years
  • All sexes
  • No healthy volunteers
  • Child, Adult

Study population: CKD stage 1 through 5 Ages below 20

Who may be able to join

  • Age: < 20 yr
  • CKD stage 1 through 5 of KDIGO guideline
  • predialysis

Who cannot join

  • Dialysis

Trial locations and contacts

1 site in 1 country.

South Korea1 site

  • Seoul National University Hospital

    Seoul, 110-744

Other trials in South Korea

About this study

Official title: KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease

KNOW-CKD (KoreaN cohort study for Outcome in patients With Chronic Kidney Disease) is a nation-wide, ten-year longitudinal cohort study, launched in 2011. The aim of the study is to assess the characteristics and risk factors of progression and complications of CKD of Korea. Pediatric sub-cohort of KNOW-CKD is planned to enroll 450 children with CKD, stage I to V (pre-dialysis).

Read the detailed description

Seven major pediatric nephrology centers of Korea enrolled children younger than 20 years who had CKD. Medical history taking, questionaire assessment of socio-economic status, anthropometric measurement, and clinical assessment using laboratory and imaging tests were done. Outcome is development of LV hypertrophy or hypertension, growth, neuropsychological status, behavioral status, kidney growth, and quality of life.

Keywords
Chronic kidney disease(CKD)
Medical subject headings
Renal Insufficiency, Chronic

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT02165878
Study groupRoleWhat they receive
Children and adolescentchildren and adolescent CKD patients of any etiology

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. eGFR

    eGFR in mL/min/1.73 m2

    Measured: 10 years

Secondary outcomes (6)

  1. Development of cardiovascular disease

    Hypertrophy in g/m2

    Measured: 10 years

  2. Metabolic bone disease

    Bone Dexametry in z score

    Measured: 10 years

  3. Anemia

    Anemia in g/dL

    Measured: 10 years

  4. Growth

    Height in z score

    Measured: 10 years

  5. Health-related quality of life (HRQOL)

    PedsQL 4.0 Generic Core Scale Module (Mapi Research Trust, on behalf of Dr James W. Varni, copyright owner of PedsQL™)

    Measured: 10 years

  6. Cognitive skills and emotional development

    K-WAIS score

    Measured: 10 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted18 Jun 2014 (estimated)
  2. Study startMar 2011
  3. Primary completionDec 2016
  4. Study completionDec 2021 (estimated)

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
458 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT02165878
Sponsor's protocol ID
2013E3301601
Other IDs
KNOW-PedCKD
Acronym
KNOW-PedCKD
Status last verified
Sep 2018
First submitted
11 Jun 2014
Last updated
7 Sep 2018
Results posted
No
Data monitoring committee
Yes
Individual data sharing
No

Publications

  • Lim SH, Park E, Han KH, Song JY, Kim SH, Choi N, Cho H, Kim JY, Shin JI, Lee KH, Cho MH, Park MJ, Baek HS, Lee JH, Jung J, Yang EM, Kim JH, Ha IS, Kang HG, Ahn YH. Comparison of estimated and measured GFR in pediatric CKD patients transitioning from adolescence to adulthood: results from KNOW-PedCKD. BMC Nephrol. 2026 Apr 2;27(1):306. doi: 10.1186/s12882-026-04942-w.

    PubMed 41928132

  • Kang NR, Ahn YH, Park E, Lee KH, Baek HS, Kim SH, Cho H, Cho MH, Shin JI, Lee JH, Cheong HI, Kang HG, Park YS, Ha IS, Moon DS, Han KH. Intellectual Functioning of Pediatric Patients with Chronic Kidney Disease: Results from the KNOW-Ped CKD. J Korean Med Sci. 2021 May 24;36(20):e138. doi: 10.3346/jkms.2021.36.e138.

    PubMed 34032031

  • Baek HS, Kim SH, Kang HG, Choi HJ, Cheong HI, Ha IS, Han KH, Cho HY, Shin JI, Park YS, Lee JH, Ahn YH, Park E, Cho MH. Dyslipidemia in pediatric CKD patients: results from KNOW-PedCKD (KoreaN cohort study for Outcomes in patients With Pediatric CKD). Pediatr Nephrol. 2020 Aug;35(8):1455-1461. doi: 10.1007/s00467-020-04545-z. Epub 2020 Mar 30.

    PubMed 32232640

  • Kang NR, Ahn YH, Park E, Choi HJ, Kim SH, Cho H, Cho MH, Shin JI, Lee JH, Park YS, Cheong HI, Kang HG, Ha IS, Kwack YS, Han KH. Mental health and psychosocial adjustment in pediatric chronic kidney disease derived from the KNOW-Ped CKD study. Pediatr Nephrol. 2019 Oct;34(10):1753-1764. doi: 10.1007/s00467-019-04292-w. Epub 2019 Jun 20.

    PubMed 31222663

  • Kang HG, Choi HJ, Han KH, Kim SH, Cho HY, Cho MH, Shin JI, Lee JH, Lee J, Oh KH, Park YS, Cheong HI, Ahn C, Ha IS. KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods. BMC Nephrol. 2016 Mar 25;17:35. doi: 10.1186/s12882-016-0248-0.

    PubMed 27012243

Questions about this trial

What is this clinical trial studying?

An observational study of Chronic Kidney Disease(CKD), run by Seoul National University Hospital at 1 site in South Korea.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: status not confirmed, as of the sponsor's last update on 7 Sep 2018. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in South Korea. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Results are not available in the source record.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

eGFR (time frame: 10 years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT02165878, which also lists 5 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 7 Sep 2018.

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