Clinical trials: Chronic Kidney Disease(CKD)
Hyperphosphatemia
A Phase1 Study to Explore the Safety of EOS789 in Patients With Chronic Kidney Disease and Hyperphosphatemia on Hemodialysis
This study is a randomized study designed as a 2x2 cross-over in two periods (Period 1 and Period 2) to assess the safety, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of EOS789 in patients with chronic kidney…
- Trial name
- NCT02965053
- Testing
- EOS789, Renvela
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Chugai Pharmaceutical
Chronic Kidney Disease Requiring Hemodialysis, Chronic Kidney Disease
Serum circ_DLGAP4, lncRNA KCNQ1OT1, and Their Targets by Erythropoietin Resistance in Chronic Kidney Disease
Non-coding RNAs have evolved as biomarkers and as phased and specific therapeutic targets for chronic kidney disease (CKD). However, their clinical significance in CKD patients is largely unexplored.
- Trial name
- NCT07037953
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Chronic Renal Failure
Effects of Cyclosporine A on Pancreatic Insulin Secretion
Our primary aim is to investigate if cyclosporine A reduces insulin secretion.
- Trial name
- NCT00139035
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- University of Oslo School of Pharmacy
Chronic Kidney Diseases, Metabolic Syndrome
Theory-based Health Behaviour Change Intervention in Patients of Metabolic Syndrome With Chronic Kidney Disease
The pilot study will adopt a 2-arm, pretest-posttest, and assessor-blind randomized controlled trial design to examine the feasibility and acceptability of a theory-based health behaviour change intervention and examine its…
- Trial name
- NCT06527768
- Testing
- Theory-based health behaviour change interventio
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stage 5 Chronic Kidney Disease
Impact of a Multidisciplinary Intensive Management Clinic on Outcomes in Multi-Ethnic Asian Incident Hemodialysis Patients
Patients with end-stage renal disease are most vulnerable in the early months following hemodialysis (HD) initiation. Data from the United States Renal Data System and Singapore Renal Registry showed high mortality rates in the…
- Trial name
- NCT01509690
- Testing
- Multidisciplinary, intensive and collaborative care
- Where
- Singapore
- Volunteers
- 150 people
- Sponsor
- National University of Singapore
Chronic Kidney Disease, Periodontitis
Effectiveness of Subgingival Instrumentation on Delaying End-stage Renal Disease Among Chronic Kidney Disease Patients
Chronic kidney disease (CKD) and periodontitis share a bidirectional inflammatory relationship, with cytokines such as IL-6, TNF-α, and hsCRP driving progression in both conditions.
- Conditions
- Chronic Kidney Disease, Periodontitis, End Stage Renal Disease (ESRD)
- Trial name
- NCT07635797
- Testing
- Subgingival Instrumentation, Oral Hygiene Instructions
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Chronic Renal Failure, Chronic Kidney Disease
Safety & Efficacy of Peginesatide for Maintenance Treatment of Anemia in Participants With Chronic Kidney Disease on Hemodialysis
The purpose of this study was to evaluate the safety and efficacy of peginesatide in the maintenance treatment of anemia in participants on dialysis.
- Conditions
- Chronic Renal Failure, Chronic Kidney Disease, Anemia
- Trial name
- EMERALD 2 (NCT00597584)
- Testing
- peginesatide, Epoetin alfa or Epoetin beta
- Where
- 84 sites in United States, Bulgaria and 7 more
- Volunteers
- 823 people
- Sponsor
- Affymax
Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant
Biomarkers and Outcome Predictors of Pediatric Nephrotic Syndrome: A Genetic, Transcriptomic, and Secretome Multiomics Study
Idiopathic Nephrotic Syndrome is a rare disease of the kidneys, which typically affects children. For most affected children there is the need of a prolonged treatment with drugs reducing the activity of the immune system, also…
- Conditions
- Nephrotic Syndrome Steroid-Dependent, Nephrotic Syndrome Steroid-Resistant, Nephrotic Syndrome in Children, Glomerulonephritis
- Trial name
- PRECISE (NCT06792448)
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hepatitis C Viral, Chronic Kidney Disease stage3
A Study for G1b CHC Patients With CKD-3 Treated With Grazoprevir Plus Elbasvir
The regimen using grazoprevir plus elbasvir treatment is promising in Japan, because it may safely be used for the elderly patients with renal dysfunction.
- Trial name
- NCT03144635
- Testing
- Grazoprevir plus Elbasvir
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Kyushu University
Chronic Kidney Disease
Keto-/Amino Acid Supplemented Low Protein Diet in Patients With Chronic Kidney Disease
Keto-/amino acid supplemented low protein diet can reduce uremic symptoms, improve nutritional status, delay dialysis therapy and enhance health-related quality of life in our patients with stage V CKD in comparison to…
- Trial name
- NCT00364884
- Testing
- ketoaminoacid
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Evaluation of Early Inflammatory Process in CKD
Studying the Relationship Between Mean Platelet Volume and Neutrophil/ Lymphocyte Ratio With Inflammation and Proteinuria in Chronic Kidney Disease
Inflammation begins during early stages of CKD in which neutrophil counts are increased, whereas lymphocyte counts are decreased during inflammation.
- Trial name
- NCT03149068
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Anemia, Chronic Kidney Disease
Study to Assess Darbepoetin Alfa Dosing for the Correction of Anemia in Pediatric Patients With Chronic Kidney Disease
The primary objectives of this study are the following: 1. To test if the proportion of participants achieving a hemoglobin value greater than or equal to 10.0 g/dL at any time point after the first dose during the study is…
- Conditions
- Anemia, Chronic Kidney Disease, Kidney Disease
- Trial name
- NCT00436748
- Testing
- Darbepoetin Alfa
- Where
- 67 sites in United States, Belgium and 8 more
- Volunteers
- 116 people
- Sponsor
- Amgen
Chronic Renal Failure, Hypertension
Low Sodium Dialysate and Ambulatory Blood Pressure Measurement Parameters
End stage renal disease (ESRD) is related with increased cardiovascular mortality and morbidity. Hypertension (HT) is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients.
- Trial name
- NCT02621450
- Testing
- standart dialysis, low sodium dialysis
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Chronic Kidney Disease
Skin Autofluorescence as a Risk Marker in People Receiving Dialysis.
The purpose of the present study is to investigate the association between the accumulation of advanced glycation end-products (AGE) and adverse outcomes (e.g.
- Trial name
- AGED (NCT02878317)
- Where
- United Kingdom
- Volunteers
- 81 people
- Sponsor
- University of Nottingham
Renal Insufficiency, Chronic
Impact of Physical Activity on Patients With Chronic Kidney Disease Not Receiving Dialysis Followed in the TIRCEL Network. An Exposed / Unexposed Study (PHYSALYS)
PHYSALYS is an observational multicenter study. It's an analytical study comparing 2 groups: patients exposed to physical activity and unexposed.
- Trial name
- PHYSALYS (NCT02818010)
- Testing
- Global Physical Activity Questionnaire
- Volunteers
- 259 people
- Sponsor
- Hospices Civils de Lyon
Cognitive Function, Preclinical, Chronic Kidney Diseases
Exercise Training and Cognitive Function in Kidney Disease
Chronic kidney disease (CKD), affects over 45% of all individuals over 70 years of age. Patients with moderate CKD have more than a two-fold increased risk of cognitive impairment than those without CKD; furthermore, as many as…
- Conditions
- Cognitive Function, Preclinical, Chronic Kidney Diseases, Older Adults
- Trial name
- NCT03197038
- Testing
- Partially supervised home-based walking exercise, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Cardiovascular Diseases, Diabetes Mellitus
Determinants of Cardiovascular Disease, Kidney Disease and Diabetes
Cardiovascular disease (CVD), chronic kidney disease (CKD), diabetes mellitus (DM) and HIV infection are long-term conditions (LTC) with major health implications for people of African ancestry.
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- NCT04646408
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Kidney Failure, Chronic
Resistance Training and Diet in Patients With Chronic Renal Failure
This study will examine the effects of long-term adherence to a low protein diet (LPD) of 0.6 g/kg-1/d-1 with and without progressive resistance exercise training in patients with impaired renal function on body composition…
- Trial name
- NCT00018317
- Testing
- low protein diet, resistance training, combination of diet control and exercise
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Chronic Renal Failure, Polycystic Kidney Disease
Mesenchymal Stem Cells Transplantation in Patients With Chronic Renal Failure Due to Polycystic Kidney Disease
This study was designed to provide confirmation of safety of mesenchymal stem cells (MSCs) therapy in chronic renal failure due to autosomal dominant polycystic kidney disease (ADPKD).
- Trial name
- NCT02166489
- Testing
- Intravenous injection autologous mesenchymal stem cells
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
CKD (Chronic Kidney Disease) Stage 5D, Pneumonia
Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients
The investigators compare two strata of vaccinated patients: those recently vaccinated and those vaccinated more than two years ago. The primary objective is to compare pneumonia rates between the groups.
- Trial name
- DOPPIO (NCT03350425)
- Where
- 12 sites in Germany
- Volunteers
- 792 people
- Sponsor
- University of Cologne
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