Cardiac Arrest SurvivorsDESACNCT02494414
Outcome of Cardiac Arrest Survivors
An observational study of Cardiac Arrest Survivors, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
Trial summary
Early prognosis of cardiac arrest - nearly 40000 new cases per year in France - has been extensively studied, highlighting a poor outcome (less than 8% at hospital discharge). However, little is known on mid and long-term prognostic factors and how these patients do survive from the event. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cardiac Arrest Survivors
- What is being tested?
- Long-term follow-up
- How many people
- 601 participants
- Where
- 1 siteFrance
- Study dates
- 24 Jul 2015to 22 Jan 2021
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Patients will be prospectively included if they are discharged alive from intensive care after being resuscitated from a cardiac arrest
Who may be able to join
- Patients alive after resuscitation from a out-of-hospital cardiac arrest
- All causes for cardiac arrest
- Age above 18
- Informed consent from the patient or next of kin
Who cannot join
- Impossibility for communication after hospital discharge, whatever the cause (language, residence…)
- Follow-up refusal from the patient or next of kin
Trial locations and contacts
1 site in 1 country.
France1 site
INSERM U970 Centre de Recherche Cardiovasculaire de Paris Equipe 4, Epidémiologie Cardiovasculaire et Mort Subite
Paris, 75000
About this study
Official title: Outcome of Cardiac Arrest Survivors: Prospective Cohort of Ile-de-France
Early prognosis of cardiac arrest - nearly 40000 new cases per year in France - has been extensively studied, highlighting a poor outcome (less than 8% at hospital discharge). However, little is known on mid and long-term prognostic factors and how these patients do survive from the event.
Using a regional cohort, the aim of the study is to describe long-term survival rate of cardiac arrest survivors, and to assess the influence of treatment strategies on survival and functional outcome.
Read the detailed description
The collection of clinical and biological data of patients who experienced cardiac arrest and survive from hospital, including a regular follow-up with qualitative data (functional, neurological and quality of life) may provide important benchmark on the evolution of these patients and on the impact of acute interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective treatments).
Using a large identified cohort of survivors of cardiac arrest, we aim to describe the qualitative long-term prognosis of these cardiac arrest patients (functional, neurological and quality of life status). Secondarily, we intend to identify the long-term prognostic factors, and particularly the role of early interventions, using a long-term and qualitative combined endpoint (vital status, functional scales, SF36).
This project is observational and will include all patients over 18 admitted alive after non-traumatic cardiac arrest in the area of Ile-de-France (France), whatever the cause of the cardiac arrest. Patients or their proxies, refusing their participation, will not be included.
We will collect all pre- and in-hospital information related to the event and performs prospectively interviews at 3 months and every year anniversary. The questionnaire will include vital status, cardiovascular events, medication and a complete qualitative report (SF36, ADL scale, OPC, CPC, social-professional activities).
This project will provide important data over time on the evolution of these patients. Findings will help in measuring the role of different strategies on long-term prognosis and consequently improve the overall management of cardiac arrest.
- Conditions
- Cardiac Arrest Survivors
- Being tested
- Long-term follow-up
- Keywords
- Cardiac arrest, outcome, neurological status
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Long-term follow-upOther
Vital and neurological follow-up
| Study group | Role | What they receive |
|---|---|---|
| French prospective cohort of cardiac arrest survivors | Outcome of cardiac arrest survivors: prospective cohort of Ile-de-France Receives: Other: Long-term follow-up |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cerebral Performance Categories Scale
Combined vital and neurological status
Measured: at last follow-up (48 months max)
Secondary outcomes (5)
SF-36 (Short-Form General Health Survey)
Quality of life
Measured: at last follow-up (48 months max)
Overall Performance Categories (OPC)
Measured: at last follow-up (48 months max)
Activities of Daily Living (ADL) scale
Measured: at last follow-up (48 months max)
New cardiovascular events
Measured: at last follow-up (48 months max)
New York Heart Association (NYHA) status
Measured: at last follow-up (48 months max)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Jul 2015 (estimated)
- Study start24 Jul 2015
- Primary completion22 Jan 2021
- Study completion22 Jan 2021
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiac Arrest SurvivorsStudies of the same condition, open and under way.
- More trials run by Assistance Publique - Hôpitaux de ParisThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 601 participants (actual)
Sponsor and investigators
- Lead sponsor
- Assistance Publique - Hôpitaux de Paris
- Sponsor type
- University, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Responsible party
- Sponsor
- Investigators
- Jean-Philippe Empana, MD, Study chair, INSERM U970 Centre de Recherche Cardiovasculaire de Paris Equipe 4, Epidémiologie Cardiovasculaire et Mort Subite
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02494414
- Sponsor's protocol ID
- NI11054
- Other IDs
- AOR12068
- Acronym
- DESAC
- Status last verified
- Jun 2026
- First submitted
- 20 Apr 2015
- Last updated
- 1 Jul 2026
- Results posted
- No
- Data monitoring committee
- No
Publications
Dumas F, Bougouin W, Perier MC, Marin N, Goulenok C, Vieillard-Baron A, Diehl JL, Legriel S, Deye N, Cronier P, Ricome S, Chemouni F, Mekontso-Dessap A, Champigneulle B, Combes A, Demoule A, Thuong M, Sonneville R, Contou D, Outin H, Lamhaut L, Chelly J, Beganton F, Marijon E, Geri G, Jouven X, Empana JP, Cariou A. Long-Term Neurological Outcome of Out-of-Hospital Cardiac Arrest Survivors and Associated Factors: Results of the DESAC Study, a French Multicentric Prospective Cohort. Circ Popul Health Outcomes. 2026 May;19(5):e012269. doi: 10.1161/CIRCOUTCOMES.125.012269. Epub 2026 Apr 9.
PubMed 41953986
Study at a glance
From the registry record, last updated by the sponsor on 1 Jul 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Outcome of Cardiac Arrest Survivors: Prospective Cohort of Ile-de-France
- ClinicalTrials.gov ID
- NCT02494414
- Acronym / sponsor ID
- DESAC / NI11054
- Conditions
- Cardiac Arrest Survivors
- Keywords
- Cardiac arrest, outcome, neurological status
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 601 participants (actual)
- Lead sponsor
- Assistance Publique - Hôpitaux de ParisUniversity, hospital or other
- Collaborators
- URC-CIC Paris Descartes Necker Cochin
- Study start
- 24 Jul 2015 (actual)
- Primary completion
- 22 Jan 2021 (actual)
- Study completion
- 22 Jan 2021 (actual)
- First posted
- 10 Jul 2015 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Early prognosis of cardiac arrest - nearly 40000 new cases per year in France - has been extensively studied, highlighting a poor outcome (less than 8% at hospital discharge). However, little is known on mid and long-term prognostic factors and how these patients do survive from the event.
Using a regional cohort, the aim of the study is to describe long-term survival rate of cardiac arrest survivors, and to assess the influence of treatment strategies on survival and functional outcome.
Detailed description
The collection of clinical and biological data of patients who experienced cardiac arrest and survive from hospital, including a regular follow-up with qualitative data (functional, neurological and quality of life) may provide important benchmark on the evolution of these patients and on the impact of acute interventions (such as cardio-pulmonary resuscitation, defibrillation, emergent coronary revascularization, neuroprotective treatments).
Using a large identified cohort of survivors of cardiac arrest, we aim to describe the qualitative long-term prognosis of these cardiac arrest patients (functional, neurological and quality of life status). Secondarily, we intend to identify the long-term prognostic factors, and particularly the role of early interventions, using a long-term and qualitative combined endpoint (vital status, functional scales, SF36).
This project is observational and will include all patients over 18 admitted alive after non-traumatic cardiac arrest in the area of Ile-de-France (France), whatever the cause of the cardiac arrest. Patients or their proxies, refusing their participation, will not be included.
We will collect all pre- and in-hospital information related to the event and performs prospectively interviews at 3 months and every year anniversary. The questionnaire will include vital status, cardiovascular events, medication and a complete qualitative report (SF36, ADL scale, OPC, CPC, social-professional activities).
This project will provide important data over time on the evolution of these patients. Findings will help in measuring the role of different strategies on long-term prognosis and consequently improve the overall management of cardiac arrest.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| French prospective cohort of cardiac arrest survivors | – | Other: Long-term follow-upOutcome of cardiac arrest survivors: prospective cohort of Ile-de-France |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Patients will be prospectively included if they are discharged alive from intensive care after being resuscitated from a cardiac arrest
Key inclusion criteria (4 listed)
- Patients alive after resuscitation from a out-of-hospital cardiac arrest
- All causes for cardiac arrest
- Age above 18
- Informed consent from the patient or next of kin
Key exclusion criteria (2 listed)
- Impossibility for communication after hospital discharge, whatever the cause (language, residence…)
- Follow-up refusal from the patient or next of kin
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Long-term follow-upVital and neurological follow-up | Other | French prospective cohort of cardiac arrest survivors |
Primary outcome
Cerebral Performance Categories Scale
Time frame: at last follow-up (48 months max)
Combined vital and neurological status
5 secondary outcomes
SF-36 (Short-Form General Health Survey)
Time frame: at last follow-up (48 months max)
Overall Performance Categories (OPC)
Time frame: at last follow-up (48 months max)
Activities of Daily Living (ADL) scale
Time frame: at last follow-up (48 months max)
New cardiovascular events
Time frame: at last follow-up (48 months max)
New York Heart Association (NYHA) status
Time frame: at last follow-up (48 months max)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jul 2026.
- Results publication: PubMed 41953986Dumas F, Bougouin W, Perier MC, Marin N, Goulenok C, Vieillard-Baron A, Diehl JL, Legriel S, Deye N, Cronier P, Ricome S, Chemouni F, Mekontso-Dessap A, Champigneulle B, Combes A, Demoule A, Thuong M, Sonneville R, Contou D, Outin H, Lamhaut L, Chelly J, Beganton F, Marijon E, Geri G, Jouven X, Empana JP, Cariou A. Long-Term Neurological Outcome of Out-of-Hospital Cardiac Arrest Survivors and Associated Factors: Results of the DESAC Study, a French Multicentric Prospective Cohort. Circ Popul Health Outcomes. 2026 May;19(5):e012269. doi: 10.1161/CIRCOUTCOMES.125.012269. Epub 2026 Apr 9.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jean-Philippe Empana, MD study chair
INSERM U970 Centre de Recherche Cardiovasculaire de Paris Equipe 4, Epidémiologie Cardiovasculaire et Mort Subite
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiac Arrest Survivors, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Jul 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cerebral Performance Categories Scale (time frame: at last follow-up (48 months max)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02494414, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jul 2026.