Cardiac ArrestpediRES-QNCT02708134
Quality of Pediatric Resuscitation in a Multicenter Collaborative
An observational study of Cardiac Arrest and Cardiopulmonary Arrest, run by Children's Hospital of Philadelphia at 63 sites in 15 countries.
Trial summary
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. Read more about this study
- Who is it for?
- Ages 0 to 18 years
- Conditions the study is for
- Cardiac Arrest, Cardiopulmonary Arrest
- How many people
- 7,000 participants
- Where
- 63 sitesin 15 countries
- Study dates
- 2 May 2016to Jan 2030
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 0 to 18 years
- All sexes
- No healthy volunteers
- Child, Adult
Study population: Data will be collected from pediatric cardiac arrest events as part of standard clinical operations.
Who may be able to join
- Patient received chest compressions for at least 1 minute
- Patient between gestational age ≥37 weeks and 18 years of age
Who cannot join
- Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event
Trial locations and contacts
63 sites in 15 countries. Contact the study team or a site near you to ask about taking part.
63 sites in 15 countries
United States42 sites, 42 recruiting
- Recruiting
Akron Children's
Akron, Ohio, 44308
Claire Hanson, MD
- Recruiting
Albany Medical Center
Albany, New York, 12208
Ilana Harwayne-Gidansky, MD
- Recruiting
Children's Healthcare of Atlanta (CHOA)
Atlanta, Georgia, 30322
Prakadeshwari Rajapreyar
- Recruiting
Children's Colorado
Aurora, Colorado, 80045
Kimberly DiMaria
- Recruiting
Dell Children's Medical Center
Austin, Texas, 78723
Daniel Stromberg, MD
- Recruiting
The Johns Hopkins Hospital
Baltimore, Maryland, 21287
Elizabeth Hunt
- Recruiting
Massachusetts General Hospital
Boston, Massachusetts, 02114
Michael Flaherty
- Recruiting
Boston Children's
Boston, Massachusetts, 02115
Monica Kleinmann
- Recruiting
University of North Carolina
Chapel Hill, North Carolina, 27514
Afsaneh Pirzadeh
- Not yet recruiting
Medical University of South Carolina
Charleston, South Carolina
Allison Whalen, MD
- Recruiting
Lurie Children's (Children's Hospital of Chicago)
Chicago, Illinois, 60611
Candace Mannarino
- Recruiting
University of Chicago, Comer Children's Hospital
Chicago, Illinois, 60637
Priti Jani
- Recruiting
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
Maya Dewan
- Recruiting
Nationwide Children's Hospital
Columbus, Ohio, 43205
Tensing Maa
- Recruiting
Medical City Children's Hospital
Dallas, Texas, 75230
Tia Raymond
- Recruiting
University of Texas Southwestern
Dallas, Texas, 75390
Priscilla Yu, MD
- Recruiting
Riley Hospital for Children
Indianapolis, Indiana, 46202
Kamal Abulebda
- Recruiting
University of Iowa Stead Family Children's Hospital
Iowa City, Iowa, 52242
Sarah Haskell
- Recruiting
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756
Kelly Corbett
- Recruiting
Kentucky Children's Hospital
Lexington, Kentucky, 40536
Rhea Vidrine
- Recruiting
Kaiser Permanente
Los Angeles, California, 90027
Gim H Tan
- Recruiting
Cedars-Sinai Medical Center
Los Angeles, California, 90048
Dipti Padhya, MD
- Recruiting
University of California, Los Angeles
Los Angeles, California, 90095
Neeraj Srivastava
- Recruiting
Valley Children's Hospital
Madera, California, 93636
Tara Lemoine
- Recruiting
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
Andrea Maxwell
- Recruiting
University of Minnesota Masonic Children's Hospital
Minneapolis, Minnesota, 55454
Alexandra Marquez
- Recruiting
Mount Sinai Kravis Children's Hospital
New York, New York, 10029
Sandeep Gangadharam
- Recruiting
Morgan Stanley Children's Hospital
New York, New York, 10032
Anita Sen
- Recruiting
Nebraska Medical Center
Omaha, Nebraska
Laura Ortmann
- Recruiting
Chldren's Hospital of Orange County
Orange, California, 92868
Jennifer Hayes
- Recruiting
Stanford University
Palo Alto, California, 94304
Marc Berg
- Recruiting
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
Vinay Nadkarni, MD, MS, 215-590-7430, nadkarni@chop.edu
- Recruiting
Cohen Children's Medical Center
Queens, New York, 11040
Todd Sweberg
- Recruiting
Children's Hospital of Richmond at VCU
Richmond, Virginia, 23219
Michelle Olson, MD
- Recruiting
The Children's Hospital of San Antonio
San Antonio, Texas, 78207
Utpal Bhalala
- Recruiting
Rady Children's Hospital
San Diego, California, 92123
Helen Harvey
- Recruiting
Seattle Children's Hospital
Seattle, Washington, 98105
Joan Roberts
- Recruiting
St. Louis Children's Hospital
St Louis, Missouri, 63110
Ashley Turner
- Not yet recruiting
All Children's Hospital
St. Petersburg, Florida, 33701
Ladonna Bingham, MD
- Recruiting
Stony Brook University Hospital
Stony Brook, New York, 11794
Ilana Harwayne-Gidansky
- Recruiting
Upstate Golisano Children's Hospital
Syracuse, New York, 13210
Angela Wratney
- Recruiting
Nemours Children's Hospital
Wilmington, Delaware, 19803
Yosef Levenbrown
Australia3 sites, 3 recruiting
- Recruiting
Perth Children's Hospital
Nedlands, 6009
Simon Erickson
- Recruiting
Queensland Children's Hospital
South Brisbane, 4101
Jason Acworth
- Recruiting
The Children's Hospital at Westmead
Westmead, New South Wales, 2145
Andrea Christoff
Canada3 sites, 3 recruiting
- Recruiting
Alberta Children's
Calgary, AB T3B
Jonathan Gilleland
- Recruiting
Stollery Children's Hospital
Edmonton, Alberta, T6G 2B7
Allan DeCaen
- Recruiting
BC Children's
Vancouver, British Columbia, V6H 3N1
Srinivas Murthy
Japan3 sites, 3 recruiting
- Recruiting
Aichi Children's Health and Medical Center
Aichi, 474-8710
Takanari lkeyama
- Recruiting
Kobe Children's Hospital (Hyogo Prefectural)
Kobe, 650-0047
Hiro Kurosawa
- Recruiting
Tokyo Metropolitan Children's Medical Center
Tokyo, 183-8561
Kazuhiro Shoya
Singapore2 sites, 2 recruiting
- Recruiting
National University Hospital
Singapore, 119074
Jacqueline Ong
- Recruiting
KK Women's & Children's Hospital
Singapore, 229899
Gene Ong
Brazil1 site, 1 recruiting
- Recruiting
Sabara Hospital Infantil
São Paulo, 01227-200
Nelson Horigeshi
Italy1 site, 1 recruiting
- Recruiting
IRCCS Ospedale Pediatrico Bambino Gesù
Roma, 486686
Orsola Gawronski
Netherlands1 site, 1 recruiting
- Recruiting
Erasmus MC - Sophia Children's
Rotterdam, 3015
Corinne Buysse
New Zealand1 site, 1 recruiting
- Recruiting
Starship Children's Hospital
Auckland, 1023
Gabrielle Nuthall
South Korea1 site, 1 recruiting
- Recruiting
Seoul National University Bundang Hospital
Seongnam, 13620
Dongbum Suh
Spain1 site, 1 recruiting
- Recruiting
Gregorio Marañón General University Hospital
Madrid, 46 28007
Jesus Lopez-Herce
Taiwan1 site, 1 recruiting
- Recruiting
National Taiwan University Hospital
Taipei, 100229
Shu-Chen Huang
Thailand1 site, 1 recruiting
- Recruiting
King Chulalongkorn University
Bangkok, 10330
Rujipat Samransamruajkit
United Kingdom1 site, 1 recruiting
- Recruiting
Great Ormond Street Hospital
London, WC1N 3JH
Sophie Skelett
About this study
Official title: Quality of Pediatric Resuscitation in a Multicenter Collaborative: An Observational Study
This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests.
The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.
Read the detailed description
Cardiac arrests in children are a major public health problem. Thousands of children each year in the USA are treated with cardiopulmonary resuscitation (CPR) and managed after their cardiac arrest. Neurological outcomes following these in-hospital CPR events are often abnormal. As children with neurological deficits following CPR are a major burden for families and society, improving neurological outcomes through superior chest compression delivery during CPR and optimal care and management after cardiac arrest is an important clinical goal.
Therefore, the objective of this investigation is to obtain evidentiary support to associate the relationship of quantitative CPR quality data (depth, rate, chest compressions (CC) fraction, compression release) during CPR, post-cardiac arrest care (PCAC) and patient survival in those children who suffer an arrest within the study (RES-Q) Network.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest
- Keywords
- Chest compressions, Cardiopulmonary Resuscitation, Pediatric
- Medical subject headings
- Heart Arrest
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Pediatric Cardiac Arrests | Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR
Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.
Measured: 10 Years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Mar 2016 (estimated)
- Study start2 May 2016
- Primary completionJan 2030 (estimated)
- Study completionJan 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (12)Papers the sponsor has linked to this study.
- Other trials for Cardiac ArrestStudies of the same condition, open and under way.
- More trials run by Children's Hospital of PhiladelphiaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 7,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Children's Hospital of Philadelphia
- Sponsor type
- University, hospital or other
- Collaborators
- Zoll Medical Corporation
- Responsible party
- Sponsor
- Investigators
- Vinay Nadkarni, MD, MS, Principal investigator, Children's Hospital of Philadelphia
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02708134
- Sponsor's protocol ID
- 15-012099
- Acronym
- pediRES-Q
- Status last verified
- Oct 2026
- First submitted
- 28 Jan 2016
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- Individual data sharing
- No
Publications
Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, Sen AI, Atkins DL, Friess SH, de Caen AR, Kurosawa H, Sutton RM, Wolfe H, Berg RA, Silver A, Hunt EA, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Pediatr Crit Care Med. 2018 May;19(5):421-432. doi: 10.1097/PCC.0000000000001520.
PubMed 29533355Sweberg T, Sen AI, Mullan PC, Cheng A, Knight L, Del Castillo J, Ikeyama T, Seshadri R, Hazinski MF, Raymond T, Niles DE, Nadkarni V, Wolfe H; pediatric resuscitation quality (pediRES-Q) collaborative investigators. Description of hot debriefings after in-hospital cardiac arrests in an international pediatric quality improvement collaborative. Resuscitation. 2018 Jul;128:181-187. doi: 10.1016/j.resuscitation.2018.05.015. Epub 2018 May 26.
PubMed 29768181Pfeiffer S, Lauridsen KG, Wenger J, Hunt EA, Haskell S, Atkins DL, Duval-Arnould JM, Knight LJ, Cheng A, Gilfoyle E, Su F, Balikai S, Skellett S, Hui MY, Niles DE, Roberts JS, Nadkarni VM, Tegtmeyer K, Dewan M; Pediatric Resuscitation Quality Collaborative Investigators. Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative. Pediatr Emerg Care. 2021 Aug 1;37(8):e431-e435. doi: 10.1097/PEC.0000000000001748.
PubMed 31045955Esangbedo I, Yu P, Raymond T, Niles DE, Hanna R, Zhang X, Wolfe H, Griffis H, Nadkarni V; Pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Pediatric in-hospital CPR quality at night and on weekends. Resuscitation. 2020 Jan 1;146:56-63. doi: 10.1016/j.resuscitation.2019.10.039. Epub 2019 Nov 14.
PubMed 31734222Wolfe HA, Wenger J, Sutton R, Seshadri R, Niles DE, Nadkarni V, Duval-Arnould J, Sen AI, Cheng A. Cold Debriefings after In-hospital Cardiac Arrest in an International Pediatric Resuscitation Quality Improvement Collaborative. Pediatr Qual Saf. 2020 Jul 8;5(4):e319. doi: 10.1097/pq9.0000000000000319. eCollection 2020 Jul-Aug.
PubMed 32766493Stromberg D, Raymond TT, Centers G, Vaez Z, Je S, Thomas A, Nadkarni V, Howsmon DP; PediRes-Q Investigators. Interposed abdominal compression CPR in pediatric cardiac arrest: early results from a multicenter comparison to standard CPR. Resuscitation. 2025 Oct;215:110676. doi: 10.1016/j.resuscitation.2025.110676. Epub 2025 Jun 16.
PubMed 40516688Jensen S, Loeb D, Zackoff M, Lautz AJ, Zhang B, Gray J, Tegtmeyer K, Dewan M. CPR coach presence is associated with increased cardiopulmonary resuscitation guideline adherence in pediatric in-hospital cardiac arrest: a retrospective cohort study. Resuscitation. 2025 Oct;215:110664. doi: 10.1016/j.resuscitation.2025.110664. Epub 2025 Jun 4.
PubMed 40480368Raymond TT, Yu P, Esangbedo I, Sweberg T, Lasa JJ, Zhang X, Griffis H, Nadkarni V; pediRES-Q investigators. Outcomes after extracorporeal cardiopulmonary resuscitation in pediatric in-hospital cardiac arrest: does quality of CPR matter? Resuscitation. 2025 Jun;211:110599. doi: 10.1016/j.resuscitation.2025.110599. Epub 2025 Apr 7.
PubMed 40204231Raymond TT, Esangbedo ID, Rajapreyar P, Je S, Zhang X, Griffis HM, Wakeham MK, Petersen TL, Kirschen MP, Topjian AA, Lasa JJ, Francoeur CI, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Cerebral Oximetry During Pediatric In-Hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Crit Care Med. 2024 May 1;52(5):775-785. doi: 10.1097/CCM.0000000000006186. Epub 2024 Jan 5.
PubMed 38180092Ong GY, Chen ZJ, Niles DE, Srinivasan V, Sen AI, Skellett S, Ikeyama T, Del Castillo J, Berg RA, Nadkarni VM. Poor Concordance of One-Third Anterior-Posterior Chest Diameter Measurements With Absolute Age-Specific Chest Compression Depth Targets in Pediatric Cardiac Arrest Patients. J Am Heart Assoc. 2023 Jul 18;12(14):e028418. doi: 10.1161/JAHA.122.028418. Epub 2023 Jul 8.
PubMed 37421276Gray JM, Raymond TT, Atkins DL, Tegtmeyer K, Niles DE, Nadkarni VM, Pandit SV, Dewan M; pediRES-Q Investigators. Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest. Pediatr Crit Care Med. 2023 Aug 1;24(8):e390-e396. doi: 10.1097/PCC.0000000000003241. Epub 2023 Apr 28.
PubMed 37115167Raymond TT, Pandit SV, Griffis H, Zhang X, Hanna R, Niles DE, Silver A, Lasa JJ, Haskell SE, Atkins DL, Nadkarni VM; Pediatric Resuscitation Quality Collaborative (pediRES-Q) Investigators. Effect of Amplitude Spectral Area on Termination of Fibrillation and Outcomes in Pediatric Cardiac Arrest. J Am Heart Assoc. 2021 Jun 15;10(12):e020353. doi: 10.1161/JAHA.120.020353. Epub 2021 Jun 5.
PubMed 34096341