SuicideSPIRITNCT02759172
Suicide Prevention Intervention for At-Risk Individuals in Transition
A study testing Safety Planning Intervention in people with Suicide, run by Michigan State University at 2 sites in United States.
Trial summary
The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide. Each participant will be randomly assigned to today's standard care or to Safety Planning Intervention (SPI) method and then followed for one year after… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Suicide
- What is being tested?
- Safety Planning Intervention
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 800 participants
- Where
- 2 sitesUnited States
- Study dates
- 1 Apr 2016to 31 Dec 2019
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Unsentenced male and female pretrial jail detainees
- 18+ years of age
- at risk for suicide, operationalized as a response of "yes" on item 4 or greater on the initial 5 C-SSRS screening questions, indicating the presence of at least some active suicide ideation with some intent to act in the past month (i.e., individuals at higher risk, such as those who report intent with specific plan and/or suicide attempt/s in the last month, will also be included);
- speak and understand English well enough to understand questionnaires when they are read aloud.
Who cannot join
- expects to be sentenced and serve their sentence before being released to the community
- cannot provide the name and contact information of at least two locator persons
- does not have access to any telephone.
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Rhode Island Department of Corrections
Cranston, Rhode Island, 02879
Genesee County Jail
Flint, Michigan, 48502
About this study
Official title: Suicide Risk Reduction in the Year Following Jail Release: the SPIRIT Trial (Suicide Prevention Intervention for At-Risk Individuals in Transition)
The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide. Each participant will be randomly assigned to today's standard care or to Safety Planning Intervention (SPI) method and then followed for one year after release. Outcomes include suicide events, suicide attempts and ideation, psychiatric symptoms, functioning, treatment utilization, problem-solving, belongingness, and cost-effectiveness.
Read the detailed description
There were nearly 12 million admissions to US jails in 2012. Jailed individuals face a disproportionate risk for suicide. The time of arrest and jail detention represents an acute stressor that further exacerbates this risk. The epidemic of suicide during jail detention has been recognized. However, less attention has been paid to the high suicide risk and mortality in the months following jail release, as individuals re-enter their communities, are faced with financial, legal, and social stressors, and have increased access to lethal means (e.g., drugs, cars, firearms). Given that roughly 10% of all suicides in the U.S. with known circumstances occur following a recent criminal legal stressor (often arrest and jail detention), reducing suicide risk in the year after jail detention could have a noticeable impact on national suicide rates. Unlike prison, where individuals have already been sentenced and typically stay from months to years, most pretrial jail detainees are released within days. Therefore, brief interventions are required. Stanley and Brown's Safety Planning Intervention (SPI) is a brief, adjunctive suicide risk reduction intervention developed for suicidal patients presenting to urgent care settings. SPI incorporates evidence-based suicide risk reduction strategies in a low intensity, low cost intervention that can be delivered by a broad range of clinicians, making it scalable in the mental health resource-poor justice system. SPI reduces subsequent suicidal ideation and attempts among at-risk individuals in emergency rooms. However, there is no previous test of this intervention (or any other) for reducing suicidality following jail release. This RCT evaluates the effectiveness and cost-effectiveness of SPI for reducing suicide events (attempts, suicide behaviors, and suicide-related hospitalizations and emergency department visits) and attempts among 800 suicidal pretrial jail detainees from two jails in the year following jail release. It assesses critical mechanisms of suicide reduction in our target population: treatment utilization, suicide-related problem-solving, and belongingness. SPI will consist of safety planning during jail detention and follow-up phone sessions after jail release. Research with previously incarcerated individuals and with suicidal individuals in the community has shown that telephone follow-up intervention is feasible and powerful in building trust and reducing risk among these disenfranchised, isolated populations. This study will be the first randomized evaluation of a suicide prevention intervention in the vulnerable year after jail release. Beyond the human suffering and costs at an individual level, suicidal behavior incurs high economic costs in terms of health care costs and lost productivity. Jails are a catchment area for at-risk individuals at a time of high life stress and high suicide risk, providing an important opportunity for suicide prevention intervention, one that is currently being missed. This study will provide the data on costs and cost-adjusted outcomes that systems need to make informed decisions about adoption, speeding implementation. Thus, this study will contribute to knowledge about both mechanisms of action and system-level intervention effects.
- Conditions
- Suicide
- Being tested
- Safety Planning Intervention
- Keywords
- Suicide prevention, Jail
- Medical subject headings
- Suicide, Suicide Prevention
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Safety Planning InterventionBehavioural
Also called SPI
Brown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services.
| Study group | Role | What they receive |
|---|---|---|
| Safety Planning Intervention | Experimental | Brown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services. Receives: Behavioral: Safety Planning Intervention |
| Standard Care | No intervention | Standard Care for pretrial jail detainees is assessment of risk and stabilization to the extent possible during their jail detention. No post-release community follow-up is typically provided. This study will augment standard care with regular assessment and emergency referral post-release, as well as provision of a list of community resources. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Suicide Events
Number of suicide events (a composite of attempts, behaviors, suicide-related hospitalizations, and suicide deaths) in the year following jail release. Events are identified through self-report, hospital records, and death records.
Measured: One year after jail release
Secondary outcomes (9)
Suicide Attempts
Number of suicide attempts using the Columbia (C-SSRS) criteria.
Measured: One year after release from jail
Weeks of Active Suicide Ideation
Operationalized using the Longitudinal Interval Follow-Up Evaluation (LIFE)
Measured: One year after release from jail
Severity of Suicide Ideation
Columbia Suicide Severity Rating Scale (C-SSRS) Suicide Intensity Subscale score. Subscale scores range from 2 to 25, higher scores indicating more intense suicidal ideation.
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Time to First Suicide Event
Measured: One year after release from jail
Psychiatric Symptoms
NIH's Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) Cross-Cutting Measure total score. Scores range from 0 to 92, higher scores reflecting greater severity of psychiatric symptoms.
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Functioning
Veterans RAND 12-Item Health Survey (VR-12) total score. Scores range from 0 to 100, higher scores indicating greater functioning.
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Treatment Utilization
Number of outpatient mental health and substance use visits attended
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Suicide-related Problem-solving
Suicide-Related Coping Scale total score. Scores range from 0-68, higher scores indicating better suicide related coping.
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Belongingness
Interpersonal Needs Questionnaire-12 (INQ-12) belongingness subscale score. Scores range from 0-54, higher scores indicating higher levels of thwarted belongingness.
Measured: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 May 2016 (estimated)
- Study start1 Apr 2016
- Primary completion31 Dec 2019
- Study completion31 Dec 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for SuicideStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 800 participants (actual)
Sponsor and investigators
- Lead sponsor
- Michigan State University
- Sponsor type
- University, hospital or other
- Collaborators
- Brown University
- Responsible party
- Principal investigator, Jennifer E. Johnson, Michigan State University
- Investigators
- Jennifer Johnson, PhD, Principal investigator, Michigan State UniversityLauren Weinstock, PhD, Principal investigator, Brown University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02759172
- Sponsor's protocol ID
- U01MH106660
- Acronym
- SPIRIT
- Status last verified
- Nov 2025
- First submitted
- 26 Apr 2016
- Last updated
- 10 Dec 2025
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- Yes
- Individual data sharing
- Yes: De-identified data will be made available through relevant NIH and NIJ repositories after the trial has ended.
Publications
Arias SA, Weinstock LM, Cinader MK, Schall G, Pawlaczyk A, Chukwuorji JC, Johnson JE. Highest Columbia-Suicide Severity Rating Scale (C-SSRS) Screener Item Endorsed by Individuals Who Attempted Suicide Within 30 Days of Pretrial Detention. J Clin Psychol. 2026 Aug;82(8):1248-1253. doi: 10.1002/jclp.70147. Epub 2026 Apr 28.
PubMed 42048567Weinstock LM, Jones RN, Miller TR, Brown GK, Arias SA, Graves HR, Miller IW, Cerbo L, Rexroth J, Fitting H, Russell D, Kubiak S, Stein MD, Matkovic C, Yen S, Gaudiano BA, Johnson JE. Safety Planning vs Standard Care for Suicide Prevention After Pretrial Jail Detention: A Randomized Clinical Trial. JAMA Netw Open. 2025 Nov 3;8(11):e2543156. doi: 10.1001/jamanetworkopen.2025.43156.
PubMed 41212557
Study at a glance
From the registry record, last updated by the sponsor on 10 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Suicide Risk Reduction in the Year Following Jail Release: the SPIRIT Trial (Suicide Prevention Intervention for At-Risk Individuals in Transition)
- ClinicalTrials.gov ID
- NCT02759172
- Acronym / sponsor ID
- SPIRIT / U01MH106660
- Conditions
- Suicide
- Keywords
- Suicide prevention, Jail
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 800 participants (actual)
- Lead sponsor
- Michigan State UniversityUniversity, hospital or other
- Collaborators
- Brown University
- Study start
- 1 Apr 2016 (actual)
- Primary completion
- 31 Dec 2019 (actual)
- Study completion
- 31 Dec 2019 (actual)
- First posted
- 3 May 2016 (estimated)
- Results
- Posted 10 Dec 2025
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The four year SPIRIT Trial, or Suicide Prevention Intervention for at-Risk Individuals in Transition, will recruit 800 pretrial jail detainees at risk for suicide. Each participant will be randomly assigned to today's standard care or to Safety Planning Intervention (SPI) method and then followed for one year after release. Outcomes include suicide events, suicide attempts and ideation, psychiatric symptoms, functioning, treatment utilization, problem-solving, belongingness, and cost-effectiveness.
Detailed description
There were nearly 12 million admissions to US jails in 2012. Jailed individuals face a disproportionate risk for suicide. The time of arrest and jail detention represents an acute stressor that further exacerbates this risk. The epidemic of suicide during jail detention has been recognized. However, less attention has been paid to the high suicide risk and mortality in the months following jail release, as individuals re-enter their communities, are faced with financial, legal, and social stressors, and have increased access to lethal means (e.g., drugs, cars, firearms). Given that roughly 10% of all suicides in the U.S. with known circumstances occur following a recent criminal legal stressor (often arrest and jail detention), reducing suicide risk in the year after jail detention could have a noticeable impact on national suicide rates. Unlike prison, where individuals have already been sentenced and typically stay from months to years, most pretrial jail detainees are released within days. Therefore, brief interventions are required. Stanley and Brown's Safety Planning Intervention (SPI) is a brief, adjunctive suicide risk reduction intervention developed for suicidal patients presenting to urgent care settings. SPI incorporates evidence-based suicide risk reduction strategies in a low intensity, low cost intervention that can be delivered by a broad range of clinicians, making it scalable in the mental health resource-poor justice system. SPI reduces subsequent suicidal ideation and attempts among at-risk individuals in emergency rooms. However, there is no previous test of this intervention (or any other) for reducing suicidality following jail release. This RCT evaluates the effectiveness and cost-effectiveness of SPI for reducing suicide events (attempts, suicide behaviors, and suicide-related hospitalizations and emergency department visits) and attempts among 800 suicidal pretrial jail detainees from two jails in the year following jail release. It assesses critical mechanisms of suicide reduction in our target population: treatment utilization, suicide-related problem-solving, and belongingness. SPI will consist of safety planning during jail detention and follow-up phone sessions after jail release. Research with previously incarcerated individuals and with suicidal individuals in the community has shown that telephone follow-up intervention is feasible and powerful in building trust and reducing risk among these disenfranchised, isolated populations. This study will be the first randomized evaluation of a suicide prevention intervention in the vulnerable year after jail release. Beyond the human suffering and costs at an individual level, suicidal behavior incurs high economic costs in terms of health care costs and lost productivity. Jails are a catchment area for at-risk individuals at a time of high life stress and high suicide risk, providing an important opportunity for suicide prevention intervention, one that is currently being missed. This study will provide the data on costs and cost-adjusted outcomes that systems need to make informed decisions about adoption, speeding implementation. Thus, this study will contribute to knowledge about both mechanisms of action and system-level intervention effects.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Safety Planning Intervention | Experimental | Behavioral: Safety Planning InterventionBrown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services. |
| Standard Care | No intervention | –Standard Care for pretrial jail detainees is assessment of risk and stabilization to the extent possible during their jail detention. No post-release community follow-up is typically provided. This study will augment standard care with regular assessment and emergency referral post-release, as well as provision of a list of community resources. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Unsentenced male and female pretrial jail detainees
- 18+ years of age
- at risk for suicide, operationalized as a response of "yes" on item 4 or greater on the initial 5 C-SSRS screening questions, indicating the presence of at least some active suicide ideation with some intent to act in the past month (i.e., individuals at higher risk, such as those who report intent with specific plan and/or suicide attempt/s in the last month, will also be included);
- speak and understand English well enough to understand questionnaires when they are read aloud.
Key exclusion criteria (3 listed)
- expects to be sentenced and serve their sentence before being released to the community
- cannot provide the name and contact information of at least two locator persons
- does not have access to any telephone.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Safety Planning InterventionAlso: SPIBrown and Stanley's Safety Planning Intervention (SPI) is a brief, adjunctive intervention designed to reduce subsequent suicidal behavior in high-risk populations. The core element of SPI is the collaborative development of the Safety Plan, which is a prioritized written list of coping strategies and supports that individuals can use during or preceding suicidal crises. In this study, safety planning will occur during pretrial jail detention, with telephone follow-up in the community to conduct risk assessment, review the Safety Plan, problem-solve obstacles to treatment, and assist with linkage to services. | Behavioural | Safety Planning Intervention |
Primary outcome
Suicide Events
Time frame: One year after jail release
Number of suicide events (a composite of attempts, behaviors, suicide-related hospitalizations, and suicide deaths) in the year following jail release. Events are identified through self-report, hospital records, and death records.
9 secondary outcomes
Suicide Attempts
Time frame: One year after release from jail
Weeks of Active Suicide Ideation
Time frame: One year after release from jail
Severity of Suicide Ideation
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Time to First Suicide Event
Time frame: One year after release from jail
Psychiatric Symptoms
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Functioning
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Treatment Utilization
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Suicide-related Problem-solving
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Belongingness
Time frame: Assessed 1, 4, 8, and 12 months after release from jail, 12 months reported.
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 10 Dec 2025.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 42048567Arias SA, Weinstock LM, Cinader MK, Schall G, Pawlaczyk A, Chukwuorji JC, Johnson JE. Highest Columbia-Suicide Severity Rating Scale (C-SSRS) Screener Item Endorsed by Individuals Who Attempted Suicide Within 30 Days of Pretrial Detention. J Clin Psychol. 2026 Aug;82(8):1248-1253. doi: 10.1002/jclp.70147. Epub 2026 Apr 28.
- Derived from this study: PubMed 41212557Weinstock LM, Jones RN, Miller TR, Brown GK, Arias SA, Graves HR, Miller IW, Cerbo L, Rexroth J, Fitting H, Russell D, Kubiak S, Stein MD, Matkovic C, Yen S, Gaudiano BA, Johnson JE. Safety Planning vs Standard Care for Suicide Prevention After Pretrial Jail Detention: A Randomized Clinical Trial. JAMA Netw Open. 2025 Nov 3;8(11):e2543156. doi: 10.1001/jamanetworkopen.2025.43156.
- Individual participant dataSharing planned: Yes. De-identified data will be made available through relevant NIH and NIJ repositories after the trial has ended.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jennifer Johnson, PhD principal investigator
Michigan State University
Lauren Weinstock, PhD principal investigator
Brown University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Safety Planning Intervention in people with Suicide, run by Michigan State University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 10 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 10 Dec 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Suicide Events (time frame: One year after jail release). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02759172, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 10 Dec 2025.