Neural Bases of Arithmetic ProcessingNCT02899676
Cerebral Bases of Arithmetics Processing
A study testing neuropsychological testing, functional magnetic resonance imaging and simple arithmetic operations in people with Neural Bases of Arithmetic Processing, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
The aim of this study was to identify neural correlates involved in arthmetics processing in adults and children aged 8 to 14 with normal cognitive function. Brain area will be identified by functional magnetic resonance imaging (IRMf). Read more about this study
- Who is it for?
- Ages 8 to 24 yearsHealthy volunteers can take part
- Conditions the study is for
- Neural Bases of Arithmetic Processing
- What is being tested?
- neuropsychological testing, functional magnetic resonance imaging and simple arithmetic operations
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 79 participants
- Where
- 1 siteFrance
- Study dates
- 18 Mar 2014to 9 May 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 24 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- children aged 8 to 14 with parents' consent
- adults aged 18 to 24
- right-handed
- affiliated to the French social security
Who cannot join
- known neurological disorders including epilepsia
- known psychiatric disorders including Attention Deficit Disorder
- birth complications needing intensive care
- central nervous system treatment
- important hearing disabilities
- not corrected impaired vision
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Neural Bases of Arithmetic Processing: MRIf Study in Adults and Children
The aim of this study was to identify neural correlates involved in arthmetics processing in adults and children aged 8 to 14 with normal cognitive function. Brain area will be identified by functional magnetic resonance imaging (IRMf).
- Conditions
- Neural Bases of Arithmetic Processing
- Being tested
- neuropsychological testing, functional magnetic resonance imaging, simple arithmetic operations
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
neuropsychological testingOther
functional magnetic resonance imagingOther
Also called IRMf
simple arithmetic operationsOther
| Study group | Role | What they receive |
|---|---|---|
| Healthy subjects aged 18 to 24 | Experimental | Subjects without neurological or psychiatric history Receives: Other: neuropsychological testing; Other: functional magnetic resonance imaging; Other: simple arithmetic operations |
| Healthy subjects aged 8 to 11 | Experimental | Subjects without neurological or psychiatric history Receives: Other: neuropsychological testing; Other: functional magnetic resonance imaging; Other: simple arithmetic operations |
| Healthy subjects aged 12 to 14 | Experimental | Subjects without neurological or psychiatric history Receives: Other: neuropsychological testing; Other: functional magnetic resonance imaging; Other: simple arithmetic operations |
What is being measured
The primary outcome is the main question the study is designed to answer.
Brain area activity in arithmetic processing will be identified by IRMf
Brain activity is identified by IRMf
Measured: up to 60 days after inclusion
Secondary outcomes (1)
Parietal region activity in arithmetic processing will be identified by IRMf
comparison between group aged to 12to 14 and group aged to 8 to 11
Measured: up to 60 days after inclusion
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2016 (estimated)
- Study start18 Mar 2014
- Primary completion9 May 2018
- Study completion9 May 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Neural Bases of Arithmetic ProcessingStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 79 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02899676
- Sponsor's protocol ID
- 2013.801
- Status last verified
- Dec 2025
- First submitted
- 2 Sep 2016
- Last updated
- 19 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
Publications
Mathieu R, Epinat-Duclos J, Leone J, Fayol M, Thevenot C, Prado J. Hippocampal spatial mechanisms relate to the development of arithmetic symbol processing in children. Dev Cogn Neurosci. 2018 Apr;30:324-332. doi: 10.1016/j.dcn.2017.06.001. Epub 2017 Jun 13.
PubMed 28648549
Study at a glance
From the registry record, last updated by the sponsor on 19 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neural Bases of Arithmetic Processing: MRIf Study in Adults and Children
- ClinicalTrials.gov ID
- NCT02899676
- Acronym / sponsor ID
- 2013.801
- Conditions
- Neural Bases of Arithmetic Processing
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 79 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 18 Mar 2014 (actual)
- Primary completion
- 9 May 2018 (actual)
- Study completion
- 9 May 2018 (actual)
- First posted
- 14 Sep 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study was to identify neural correlates involved in arthmetics processing in adults and children aged 8 to 14 with normal cognitive function. Brain area will be identified by functional magnetic resonance imaging (IRMf).
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Healthy subjects aged 18 to 24 | Experimental | Other: neuropsychological testing, Other: functional magnetic resonance imaging, Other: simple arithmetic operationsSubjects without neurological or psychiatric history |
| Healthy subjects aged 8 to 11 | Experimental | Other: neuropsychological testing, Other: functional magnetic resonance imaging, Other: simple arithmetic operationsSubjects without neurological or psychiatric history |
| Healthy subjects aged 12 to 14 | Experimental | Other: neuropsychological testing, Other: functional magnetic resonance imaging, Other: simple arithmetic operationsSubjects without neurological or psychiatric history |
Who may qualify
- Ages
- 8 to 24 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (4 listed)
- children aged 8 to 14 with parents' consent
- adults aged 18 to 24
- right-handed
- affiliated to the French social security
Key exclusion criteria (6 listed)
- known neurological disorders including epilepsia
- known psychiatric disorders including Attention Deficit Disorder
- birth complications needing intensive care
- central nervous system treatment
- important hearing disabilities
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| neuropsychological testing | Other | Healthy subjects aged 12 to 14, Healthy subjects aged 18 to 24, Healthy subjects aged 8 to 11 |
| functional magnetic resonance imagingAlso: IRMf | Other | Healthy subjects aged 12 to 14, Healthy subjects aged 18 to 24, Healthy subjects aged 8 to 11 |
| simple arithmetic operations | Other | Healthy subjects aged 12 to 14, Healthy subjects aged 18 to 24, Healthy subjects aged 8 to 11 |
Primary outcome
Brain area activity in arithmetic processing will be identified by IRMf
Time frame: up to 60 days after inclusion
Brain activity is identified by IRMf
1 secondary outcome
Parietal region activity in arithmetic processing will be identified by IRMf
Time frame: up to 60 days after inclusion
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Dec 2025.
- Results publication: PubMed 28648549Mathieu R, Epinat-Duclos J, Leone J, Fayol M, Thevenot C, Prado J. Hippocampal spatial mechanisms relate to the development of arithmetic symbol processing in children. Dev Cogn Neurosci. 2018 Apr;30:324-332. doi: 10.1016/j.dcn.2017.06.001. Epub 2017 Jun 13.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing neuropsychological testing, functional magnetic resonance imaging and simple arithmetic operations in people with Neural Bases of Arithmetic Processing, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 19 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brain area activity in arithmetic processing will be identified by IRMf (time frame: up to 60 days after inclusion). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02899676, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Dec 2025; AzTrials last refreshed its copy on 1 Nov 2026.