Research institution
Hospices Civils de Lyon Clinical Trials
Studies where Hospices Civils de Lyon is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 359Craniostenosis
Multimodal Mechanical, Tissue, Architectural, and Histological Evaluation of the Bone and Sutures of the Parietal Bone in an Infant With Craniosynostosis.
The human skull is a complex structure that protects the underlying tissues, including the brain. Certain rare conditions and diseases, such as craniosynostosis-which affects 1 in 2,000 to 2,500 children-impair these functions…
- Trial name
- CRANIOMECA (NCT07650981)
- Testing
- Biological sample, bones sample and questionaires.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Frailty, Sarcopenia
PROfiles of FGF-19 Post-prandial Secretion in Older Adults With Frailty and Without Frailty
Fibroblast Growth Factor 19 (FGF-19) is an intestinal hormone secreted in the post-prandial state, whose primary role is to inhibit bile acid synthesis in the liver.
- Trial name
- PRO-FGF (NCT07893665)
- Testing
- FLEXMEAL : post-prandial blood sampling
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
End-stage Renal Disease (ESRD), Kidney Transplantation
Microbiota Changes Related to Outcomes in Kidney Transplantation
Chronic kidney disease affects approximately 10% of the world population. End-stage renal disease (ESRD) is associated with immune dysregulation, chronic inflammation, and alteration of the gut and urinary microbiota.
- Trial name
- MICRO-KT (NCT07893691)
- Testing
- Fecal samples, Urinary sample, Blood samples
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Smith-Magenis Syndrome, Autism Spectrum Disorder
Smith Magenis Syndrome and Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are a neurodevelopmental disorder. Their prevalence is estimated at around 0.4% of the general population worldwide.
- Trial name
- SMS/TSA (NCT05116904)
- Testing
- Assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Anaesthetic Induction, Respiratory Complications of Care
Two Modalities of Ventilation on the Occurrence of Respiratory Complications During Inhalational Anaesthetic Induction in Children
Induction of anesthesia by inhalation is the most common method of induction (70% in France) for young children admitted for non-emergency surgery. It has the advantage of not requiring an intravenous line.
- Conditions
- Anaesthetic Induction, Respiratory Complications of Care, Pediatrics, Ventilation
- Trial name
- PEDIAMOVE (NCT07767851)
- Testing
- Induction with PEEP (5 cmH2O) and PSV (2-12 cmH2O), Induction in spontaneous breathing
- Where
- 9 sites in France
- Volunteers
- 2,032 people
- Sponsor
- Hospices Civils de Lyon
Bladder Calculi, Continent Catheterizable Urinary Reservoir
Comparison of Trans-Stomial Bladder Lithotripsy Using Mini-Percutaneous Equipment Versus Trans-stomial Bladder Lithotripsy Using Flexible Fibroscope, Percutaneous Approach and Open Cystolithotomy in Patients With Continent Catheterizable Urinary Reservoir
The urological management of neurological patients is crucial to ensure patient survival and improve their quality of life. The natural progression of disease in central neurological bladders typically involves a major decrease…
- Conditions
- Bladder Calculi, Continent Catheterizable Urinary Reservoir, Trans-Stomal Bladder Lithotripsy, Open Cystolithotomy
- Trial name
- Mini-DUCC (NCT07643454)
- Testing
- QoL-DUCC questionnaire, Qualiveen Questionnaire
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Healthy Volunteers, Attentional Capture
Attentional Capture by Real-life Episodic Information
Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral…
- Trial name
- EPICAPTURE (NCT06934902)
- Testing
- Old vs new objects" encoding phase and fMRI, " incongruent vs. congruent contexts " encoding phase and fMRI
- Where
- France
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Cochlear Implants
Pitch Perception and Memory: Deficits and Training
Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing.
- Trial name
- Pitch_Train (NCT03707691)
- Testing
- Listening tests. Pitch training protocol, visuo-spatial training protocol, EEG/MEG/MRI recordings.
- Where
- France
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Carotid Atheroma
Carotid Plaque Characterization Using Innovative Ultrasound Techniques
Strokes are the second leading cause of disability and death worldwide (according to World Health Organization in 2019). They are ischemic in origin in 80% of cases.
- Trial name
- CARPUS (NCT06804707)
- Testing
- blood sampling, ultrasound imaging exam, High resolution MRI plaque exam
- Where
- France
- Volunteers
- 17 people
- Sponsor
- Hospices Civils de Lyon
Kidney Transplant Failure and Rejection
Efficiency of Everolimus for the Treatment of Kidney Transplanted Patients Presenting a Missing Self-induced NK-mediated Rejection
Background: Long-term success of organ transplantation is limited by the inexorable loss of graft function due to rejection. Prevalent dogma defends that allograft rejection is exclusively mediated by the adaptive immune system…
- Trial name
- STARR (NCT03955172)
- Testing
- Everolimus
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Completed, with results posted
All 3Acute Kidney Injury
A Net Ultrafiltration Challenge to Predict Preload-dependence (UF CHALLENGE)
Hemodynamic instability episodes are a frequent complication of renal replacement therapies in critically ill patients, and their incidence is associated with worse survival.
- Trial name
- UF CHALLENGE (NCT05214729)
- Testing
- Fast ultrafiltration challenge, Slow ultrafiltration challenge
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Williams Beuren Syndrome
Efficacy of Minoxidil in Children With Williams-Beuren Syndrome
The Williams-Beuren syndrome (WBS) is a sporadic congenital disorder characterized by a multisystem developmental impairment. This syndrome is caused by a microdeletion in chromosome 7q11.23 that encompasses loss of the elastin…
- Trial name
- Williams (NCT00876200)
- Testing
- Minoxidil
- Where
- 18 sites in France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Hemorrhagic Hereditary Telangiectasia (HHT)
Efficacy and Safety of a 0.1% Tacrolimus Nasal Ointment as a Treatment for Epistaxis in Hemorrhagic Hereditary Telangiectasia (HHT)
The recognized manifestations of HHT are all due to abnormalities in vascular structure. Epistaxis due to telangiectases formation is spontaneous, very variable, recurrent in 90% of patients, and associated with severe anemia in…
- Trial name
- TACRO (NCT03152019)
- Testing
- Protopic® (Tacrolimus) 0.1% ointment
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon