SuicideEMODESNCT02901769
Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide
A study testing fMRI in people with Suicide, run by Rennes University Hospital at 1 site in France.
Trial summary
Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability. Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Suicide
- What is being tested?
- fMRI
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 26 participants
- Where
- 1 siteFrance
- Study dates
- Feb 2013to Jul 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Right-handed,
- Depressed suicide attempters for the first group,
- Depressed patients with past history of suicidal acts for the second group,
- Depressed patients with no history of suicidal acts for the third group,
- Healthy controls for the fourth group.
Who cannot join
- Another psychiatric trouble than depression,
- Another psychotrope treatment than SSRI/SNRI and/or benzodiazepine at inclusion and/or one month before,
- For the first and secand groups : more than fous suicidals acts within the past 3 years,
- Deficits that do not allow test realisation (visual audition troubles, cognitif deficits,
- Prosopagnosia,
- Pregnancy,
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- Severe central nervous system disease or somatic disease,
- MRI contra-indication,
- Major benefiting from a legal protective measure,
- No coverage care.
Trial locations and contacts
1 site in 1 country.
About this study
Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability.
This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls.
The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.
- Conditions
- Suicide
- Being tested
- fMRI
- Medical subject headings
- Suicide
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
fMRIOther
two fMRI paradigms, emotional prosody recognition and decision making
| Study group | Role | What they receive |
|---|---|---|
| Depressed suicide attempters | Experimental | 20 subjects Receives: Other: fMRI |
| Depressed patients with past history of | Experimental | 20 subjects Receives: Other: fMRI |
| Depressed patients with no history of | Experimental | 20 subjects Receives: Other: fMRI |
| Healthy controls | Placebo comparator | 20 subjects Receives: Other: fMRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
fMRI activation area
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Sep 2016 (estimated)
- Study startFeb 2013
- Primary completion2 Jul 2018
- Study completionJul 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SuicideStudies of the same condition, open and under way.
- More trials run by Rennes University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Single group
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rennes University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02901769
- Sponsor's protocol ID
- 2011-A00944-37
- Acronym
- EMODES
- Status last verified
- Jun 2026
- First submitted
- 5 Sep 2016
- Last updated
- 15 Jun 2026
- Results posted
- No
Study at a glance
From the registry record, last updated by the sponsor on 15 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide
- ClinicalTrials.gov ID
- NCT02901769
- Acronym / sponsor ID
- EMODES / 2011-A00944-37
- Conditions
- Suicide
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Rennes University HospitalUniversity, hospital or other
- Study start
- Feb 2013 (actual)
- Primary completion
- 2 Jul 2018 (actual)
- Study completion
- Jul 2019 (actual)
- First posted
- 15 Sep 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability.
This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls.
The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.
Study design
- Primary purpose
- Other
- Allocation
- Non-randomised
- Intervention model
- Single group
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| Depressed suicide attempters | Experimental | Other: fMRI20 subjects |
| Depressed patients with past history of | Experimental | Other: fMRI20 subjects |
| Depressed patients with no history of | Experimental | Other: fMRI20 subjects |
| Healthy controls | Placebo comparator | Other: fMRI20 subjects |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Right-handed,
- Depressed suicide attempters for the first group,
- Depressed patients with past history of suicidal acts for the second group,
- Depressed patients with no history of suicidal acts for the third group,
- Healthy controls for the fourth group.
Key exclusion criteria (10 listed)
- Another psychiatric trouble than depression,
- Another psychotrope treatment than SSRI/SNRI and/or benzodiazepine at inclusion and/or one month before,
- For the first and secand groups : more than fous suicidals acts within the past 3 years,
- Deficits that do not allow test realisation (visual audition troubles, cognitif deficits,
- Prosopagnosia,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| fMRItwo fMRI paradigms, emotional prosody recognition and decision making | Other | Depressed patients with no history of, Depressed patients with past history of, Depressed suicide attempters, Healthy controls |
Primary outcome
fMRI activation area
Time frame: 1 day
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing fMRI in people with Suicide, run by Rennes University Hospital at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 10 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
fMRI activation area (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Jun 2026.