Osteoarthritis,KneeNCT02967744
NSAID Treatment of Patients With Osteoarthritis
A study testing NSAID in people with Osteoarthritis,Knee, run by Aalborg University at 1 site in Denmark.
Trial summary
The study investigates associations between pre treatment pain intensity and central pain mechanisms on the effect of 8-week treatment of NSAIDs in patients with knee osteoarthritis. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Osteoarthritis,Knee
- What is being tested?
- NSAID
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 162 participants
- Where
- 1 siteDenmark
- Study dates
- Jan 2016to 1 Feb 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Diagnosed Knee Ostoarthritis
Who cannot join
- Current ulcer diagnosed by endoscope
- Asthma or other allergic reaction to NSIADs
- Kidney disease
- Myocardial infarction within the last six months
- Severe hyper tension (systolic ≥180mmHg, diastolic ≥110mmHg)
- Severe thrombocytopenia (thrombocyst count <50x10^9/l)
- Insufficience lever or kidney function
Trial locations and contacts
1 site in 1 country.
Denmark1 site
Center for Sensory Motor Interaction, Aalborg University
Aalborg East, 9220
About this study
Official title: BEVAR: Patientspecifik Behandling Ved Artrose - Et "Proof-of-concept"- Kvalitetssikringsstudie
The study investigates associations between pre treatment pain intensity and central pain mechanisms on the effect of 8-week treatment of NSAIDs in patients with knee osteoarthritis.
- Conditions
- Osteoarthritis,Knee
- Being tested
- NSAID
- Medical subject headings
- Osteoarthritis, Knee
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
NSAIDDrug
NSAIDs are among the most common pain treatments for patients with osteoarthritis.
| Study group | Role | What they receive |
|---|---|---|
| NSAID treatment | Experimental | 8 weeks of NSAID treatment Receives: Drug: NSAID |
What is being measured
The primary outcome is the main question the study is designed to answer.
Pain intensity measured on a 10cm visual analog scale
Patients will be asked to rate the pain intensity 8 weeks after treatment on a 10cm visual analog scale (0 indicating no pain, 10 indicating worst imaginable pain
Measured: 8 weeks after treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Nov 2016 (estimated)
- Study startJan 2016
- Primary completionJan 2018
- Study completion1 Feb 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Osteoarthritis,KneeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 162 participants (actual)
Sponsor and investigators
- Lead sponsor
- Aalborg University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Kristian Kjær Petersen, Aalborg University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02967744
- Sponsor's protocol ID
- N-20140077
- Status last verified
- Feb 2024
- First submitted
- 14 Nov 2016
- Last updated
- 22 Feb 2024
- Results posted
- No
- Data monitoring committee
- No
Publications
Giordano R, Arendt-Nielsen L, Hertel E, Olesen AE, Petersen KK. Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis. Eur J Pain. 2025 Nov;29(10):e70140. doi: 10.1002/ejp.70140.
PubMed 41020650Hertel E, Arendt-Nielsen L, Olesen AE, Andersen MS, Petersen KK. Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain. 2024 Aug 1;165(8):1719-1726. doi: 10.1097/j.pain.0000000000003194. Epub 2024 Feb 20.
PubMed 38381930
Study at a glance
From the registry record, last updated by the sponsor on 22 Feb 2024. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- BEVAR: Patientspecifik Behandling Ved Artrose - Et "Proof-of-concept"- Kvalitetssikringsstudie
- ClinicalTrials.gov ID
- NCT02967744
- Acronym / sponsor ID
- N-20140077
- Conditions
- Osteoarthritis,Knee
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 162 participants (actual)
- Lead sponsor
- Aalborg UniversityUniversity, hospital or other
- Study start
- Jan 2016
- Primary completion
- Jan 2018 (actual)
- Study completion
- 1 Feb 2018 (actual)
- First posted
- 18 Nov 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The study investigates associations between pre treatment pain intensity and central pain mechanisms on the effect of 8-week treatment of NSAIDs in patients with knee osteoarthritis.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| NSAID treatment | Experimental | Drug: NSAID8 weeks of NSAID treatment |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Diagnosed Knee Ostoarthritis
Key exclusion criteria (7 listed)
- Current ulcer diagnosed by endoscope
- Asthma or other allergic reaction to NSIADs
- Kidney disease
- Myocardial infarction within the last six months
- Severe hyper tension (systolic ≥180mmHg, diastolic ≥110mmHg)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| NSAIDNSAIDs are among the most common pain treatments for patients with osteoarthritis. | Drug | NSAID treatment |
Primary outcome
Pain intensity measured on a 10cm visual analog scale
Time frame: 8 weeks after treatment
Patients will be asked to rate the pain intensity 8 weeks after treatment on a 10cm visual analog scale (0 indicating no pain, 10 indicating worst imaginable pain
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Feb 2024.
- Derived from this study: PubMed 41020650Giordano R, Arendt-Nielsen L, Hertel E, Olesen AE, Petersen KK. Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis. Eur J Pain. 2025 Nov;29(10):e70140. doi: 10.1002/ejp.70140.
- Derived from this study: PubMed 38381930Hertel E, Arendt-Nielsen L, Olesen AE, Andersen MS, Petersen KK. Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain. 2024 Aug 1;165(8):1719-1726. doi: 10.1097/j.pain.0000000000003194. Epub 2024 Feb 20.
Related trials for Osteoarthritis,Knee
Recruiting
Effect of Anti-inflammatory Diet in Osteoarthritis
Osteoarthritis, Knee
Active, not recruitingPhase 2/3
Single vs Triple Hyaluronic Acid in Knee Osteoarthritis
Osteoarthritis, Knee
Not yet recruiting
Holistic Healing for Knee Osteoarthritis
Knee Osteoarthritis (Knee OA)
RecruitingObservational study
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
Knee Osteoarthritis
Not yet recruiting
The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity
Osteoarthritis of the Knee
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing NSAID in people with Osteoarthritis,Knee, run by Aalborg University at 1 site in Denmark.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Feb 2024. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Denmark. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Pain intensity measured on a 10cm visual analog scale (time frame: 8 weeks after treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02967744, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Feb 2024; AzTrials last refreshed its copy on 7 Nov 2026.