Coronary Heart DiseaseCCHSNCT02993172
The Copenhagen City Heart Study
An observational study of Coronary Heart Disease and Stroke, run by Bispebjerg Hospital.
Trial summary
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. The initial sample has been re-invited up to four times and supplemented by younger individuals. Read more about this study
- Who is it for?
- Ages 20 years and older
- Conditions the study is for
- Coronary Heart Disease, Stroke, Heart Failure
- How many people
- 23,891 participants
- Where
- No sites listed yet
- Study dates
- Jan 1976to Jan 2014
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Age.stratified random sample of the census population
Who may be able to join
- Background population living in a defined area of Copenhagen
Who cannot join
- None
About this study
Official title: The Copenhagen City Heart Study 'Østerbroundersøgelsen'
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. The initial sample has been re-invited up to four times and supplemented by younger individuals. The study includes questionnaires, clinical assessment and biomarkers. The population have been followed in a number of outcome registries and more than 900 scientific papers have been published.
Read the detailed description
The Copenhagen City Heart Study, also known as "Østerbroundersøgelsen", is a large prospective cardio-vascular population study of 20,000 women and men that was launched in 1975 by Dr Peter Schnohr and Dr Gorm Jensen together with statistician Jørgen Nyboe and Prof. A. Tybjærg Hansen.
The original purpose of the study was to focus on prevention of coronary heart disease and stroke. During the years many other aspects have been added to the study: pulmonary diseases, heart failure, arrhythmia, alcohol, arthrosis, eye diseases, allergy, epilepsia, dementia, stress, vital exhaustion, social network, sleep-apnoe, ageing and genetics. In the fourth and fifth wave of the examination echocardiography was included.
The Copenhagen City Heart Study has invited a random sample of the census population in an area of central Copenhagen in five waves. The primary population was a random sample of 19,329 men and women 20-93 years old, drawn from a population of approximately 90,000 inhabitants aged 20 years or older living in a central part of Copenhagen (Østerbro). Using the unique personal identification number (Central-Personal-Register-code), consisting of date of birth and a registration number, the sample was age-stratified within 5-year age groups, with the main emphasis on the age groups from 35 to 70 years. The total number of participants invited to the first four examinations was: 19,329+500+3,000+1,062 = 23,891 men and women. Of the original 14,223 examined at the first examination 3,092 (21.7%) have been examined in all four examinations.
Follow-up of mortality and morbidity using the unique personal identification number is performed by linkage to a number of nation-wide disease registries. Follow-up completion rate is almost 100 percent (less than 0.1% have been lost to follow-up mainly through emigration), which is very uncommon for large population studies.
Overview of the patients examined in the Copenhagen City Heart Study:
- st exam: 1976-78, 19,329 invited, 14,223 (73.6%) attended
- nd exam: 1981-83, 18,059 invited, 12,698 (71.2%) attended
- rd exam: 1991-94, 16,563 invited, 10.135 (61.2%) attended
- th exam: 2001-03,12,600 invited, 6,238 (49.5%) attended
- th exam: 2011-2014, approx 10,000 invited, approx 5000 (50%) attended
The Copenhagen City Heart Study is governed by a Steering Committee. The data from the Copenhagen City Heart Study is made available to researchers upon application to and approval by the Steering Committee. The following constitute the Steering Committee:
Gorm Jensen and Peter Schnohr (initiators), Peter Lange, Eva Prescott, Børge Nordestgaard, Morten Grønbæk, Anne Tybjærg Hansen, Stig Bojesen, Finn Gyntelberg, Jan Skov Jensen and Merete Appleyard
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer, Myocardial Infarction, Chronic Obstructive Pulmonary Disease
- Medical subject headings
- Coronary Disease, Stroke, Heart Failure, Neoplasms, Myocardial Infarction, Pulmonary Disease, Chronic Obstructive
What is being measured
The primary outcome is the main question the study is designed to answer.
Registry based disease outcomes, mainly cardiovascular, pulmonary and cancer outcomes
Measured: Latest registry update december 31 2014
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted15 Dec 2016 (estimated)
- Study startJan 1976
- Primary completionJan 2014
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Coronary Heart DiseaseStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 23,891 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bispebjerg Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Eva Prescott, Bispebjerg Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT02993172
- Sponsor's protocol ID
- CCHS
- Acronym
- CCHS
- Status last verified
- Dec 2016
- First submitted
- 9 Dec 2016
- Last updated
- 15 Dec 2016
- Results posted
- No
- Data monitoring committee
- No
Publications
Isozaki S, Skjelbred T, Warming PE, Casarini E, Prescott EIB, Jabbari R, Mujkanovic J, Tfelt-Hansen J. Leisure-time physical activity and risk of sudden cardiac death: a 28-year follow-up from the Copenhagen City Heart Study. EClinicalMedicine. 2026 Mar 10;93:103825. doi: 10.1016/j.eclinm.2026.103825. eCollection 2026 Mar.
PubMed 41852925Larsen BS, Olsen FJ, Andersen DM, Madsen CV, Mogelvang R, Jensen GB, Schnohr P, Aplin M, Host NB, Christensen H, Sajadieh A, Biering-Sorensen T. Left Atrial Volumes and Function, and Long-Term Incidence of Ischemic Stroke in the General Population. J Am Heart Assoc. 2022 Sep 20;11(18):e027031. doi: 10.1161/JAHA.122.027031. Epub 2022 Sep 8.
PubMed 36073645Olsen FJ, Skaarup KG, Lassen MCH, Johansen ND, Sengelov M, Jensen GB, Schnohr P, Marott JL, Sogaard P, Gislason G, Svendsen JH, Mogelvang R, Aalen JM, Remme EW, Smiseth OA, Biering-Sorensen T. Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS. Circ Cardiovasc Imaging. 2022 May;15(5):e013712. doi: 10.1161/CIRCIMAGING.121.013712. Epub 2022 May 10.
PubMed 35535593Svendstrup M, Allin KH, Angquist L, Schnohr P, Jensen GB, Linneberg A, Thuesen B, Astrup A, Saris WHM, Vestergaard H, Sorensen TIA. Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions? Am J Clin Nutr. 2018 Nov 1;108(5):913-921. doi: 10.1093/ajcn/nqy187.
PubMed 30475965
Study at a glance
From the registry record, last updated by the sponsor on 15 Dec 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Copenhagen City Heart Study 'Østerbroundersøgelsen'
- ClinicalTrials.gov ID
- NCT02993172
- Acronym / sponsor ID
- CCHS / CCHS
- Conditions
- Coronary Heart Disease, Stroke, Heart Failure, Cancer, Myocardial Infarction, Chronic Obstructive Pulmonary Disease
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 23,891 participants (actual)
- Lead sponsor
- Bispebjerg HospitalUniversity, hospital or other
- Study start
- Jan 1976
- Primary completion
- Jan 2014 (actual)
- First posted
- 15 Dec 2016 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The Copenhagen City Heart Study is an ongoing cardiovascular population study initiated in 1976 which has examined approximately 25,000 individuals from the general population. The initial sample has been re-invited up to four times and supplemented by younger individuals. The study includes questionnaires, clinical assessment and biomarkers. The population have been followed in a number of outcome registries and more than 900 scientific papers have been published.
Detailed description
The Copenhagen City Heart Study, also known as "Østerbroundersøgelsen", is a large prospective cardio-vascular population study of 20,000 women and men that was launched in 1975 by Dr Peter Schnohr and Dr Gorm Jensen together with statistician Jørgen Nyboe and Prof. A. Tybjærg Hansen.
The original purpose of the study was to focus on prevention of coronary heart disease and stroke. During the years many other aspects have been added to the study: pulmonary diseases, heart failure, arrhythmia, alcohol, arthrosis, eye diseases, allergy, epilepsia, dementia, stress, vital exhaustion, social network, sleep-apnoe, ageing and genetics. In the fourth and fifth wave of the examination echocardiography was included.
The Copenhagen City Heart Study has invited a random sample of the census population in an area of central Copenhagen in five waves. The primary population was a random sample of 19,329 men and women 20-93 years old, drawn from a population of approximately 90,000 inhabitants aged 20 years or older living in a central part of Copenhagen (Østerbro). Using the unique personal identification number (Central-Personal-Register-code), consisting of date of birth and a registration number, the sample was age-stratified within 5-year age groups, with the main emphasis on the age groups from 35 to 70 years. The total number of participants invited to the first four examinations was: 19,329+500+3,000+1,062 = 23,891 men and women. Of the original 14,223 examined at the first examination 3,092 (21.7%) have been examined in all four examinations.
Follow-up of mortality and morbidity using the unique personal identification number is performed by linkage to a number of nation-wide disease registries. Follow-up completion rate is almost 100 percent (less than 0.1% have been lost to follow-up mainly through emigration), which is very uncommon for large population studies.
Overview of the patients examined in the Copenhagen City Heart Study:
- st exam: 1976-78, 19,329 invited, 14,223 (73.6%) attended
- nd exam: 1981-83, 18,059 invited, 12,698 (71.2%) attended
- rd exam: 1991-94, 16,563 invited, 10.135 (61.2%) attended
- th exam: 2001-03,12,600 invited, 6,238 (49.5%) attended
- th exam: 2011-2014, approx 10,000 invited, approx 5000 (50%) attended
The Copenhagen City Heart Study is governed by a Steering Committee. The data from the Copenhagen City Heart Study is made available to researchers upon application to and approval by the Steering Committee. The following constitute the Steering Committee:
Gorm Jensen and Peter Schnohr (initiators), Peter Lange, Eva Prescott, Børge Nordestgaard, Morten Grønbæk, Anne Tybjærg Hansen, Stig Bojesen, Finn Gyntelberg, Jan Skov Jensen and Merete Appleyard
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Age.stratified random sample of the census population
Key inclusion criteria (1 listed)
- Background population living in a defined area of Copenhagen
Key exclusion criteria (1 listed)
- None
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Registry based disease outcomes, mainly cardiovascular, pulmonary and cancer outcomes
Time frame: Latest registry update december 31 2014
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Dec 2016.
- Derived from this study: PubMed 41852925Isozaki S, Skjelbred T, Warming PE, Casarini E, Prescott EIB, Jabbari R, Mujkanovic J, Tfelt-Hansen J. Leisure-time physical activity and risk of sudden cardiac death: a 28-year follow-up from the Copenhagen City Heart Study. EClinicalMedicine. 2026 Mar 10;93:103825. doi: 10.1016/j.eclinm.2026.103825. eCollection 2026 Mar.
- Derived from this study: PubMed 36073645Larsen BS, Olsen FJ, Andersen DM, Madsen CV, Mogelvang R, Jensen GB, Schnohr P, Aplin M, Host NB, Christensen H, Sajadieh A, Biering-Sorensen T. Left Atrial Volumes and Function, and Long-Term Incidence of Ischemic Stroke in the General Population. J Am Heart Assoc. 2022 Sep 20;11(18):e027031. doi: 10.1161/JAHA.122.027031. Epub 2022 Sep 8.
- Derived from this study: PubMed 35535593Olsen FJ, Skaarup KG, Lassen MCH, Johansen ND, Sengelov M, Jensen GB, Schnohr P, Marott JL, Sogaard P, Gislason G, Svendsen JH, Mogelvang R, Aalen JM, Remme EW, Smiseth OA, Biering-Sorensen T. Normal Values for Myocardial Work Indices Derived From Pressure-Strain Loop Analyses: From the CCHS. Circ Cardiovasc Imaging. 2022 May;15(5):e013712. doi: 10.1161/CIRCIMAGING.121.013712. Epub 2022 May 10.
- Derived from this study: PubMed 30475965Svendstrup M, Allin KH, Angquist L, Schnohr P, Jensen GB, Linneberg A, Thuesen B, Astrup A, Saris WHM, Vestergaard H, Sorensen TIA. Is abdominal obesity at baseline influencing weight changes in observational studies and during weight loss interventions? Am J Clin Nutr. 2018 Nov 1;108(5):913-921. doi: 10.1093/ajcn/nqy187.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Coronary Heart Disease and Stroke, run by Bispebjerg Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Dec 2016. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Registry based disease outcomes, mainly cardiovascular, pulmonary and cancer outcomes (time frame: Latest registry update december 31 2014). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT02993172, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Dec 2016; AzTrials last refreshed its copy on 31 Oct 2026.