AzTrials
AzTrials

Type2 DiabetesPhase 3PROMINENTNCT03071692

Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabeTes (PROMINENT)

A Phase 3 study testing K-877 in people with Type2 Diabetes and Dyslipidemia, run by Kowa Research Institute, Inc. at 888 sites in 25 countries.

Terminated

Stopped early. The study ended before it was planned to and will not resume.

Official record
Search all trials

Trial summary

The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of: nonfatal Myocardial Infarction (MI) nonfatal ischemic stroke coronary revascularization; or Cardio Vascular (CV) death. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Type2 Diabetes, Dyslipidemia
What is being tested?
K-877
Type of treatment
Pill or oral medicine
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
10,544 participants
Where
888 sitesin 25 countries
Study dates
23 Mar 2017to 27 Jul 2022
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Fasting TG ≥ 200 mg/dL (2.26 mmol/L) and < 500 mg/dL (5.65 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)
  • HDL-C ≤ 40 mg/dL (1.03 mmol/L) at Visit 1 (Screening/Enrollment Visit) or Visit 1.1 (Retest)
  • Type 2 diabetes of longer than 12 weeks duration documented in medical records, for example: local laboratory evidence through medical record review of elevated HbA1c (≥ 6.5% [48 mmol/mol]), elevated plasma glucose (fasting ≥ 126 mg/dL [7.0 mmol/L], 2-hour ≥ 200 mg/dL [11.1 mmol/L] during oral glucose tolerance testing, or random value ≥ 200 mg/dL with classic symptoms, or currently taking medication for treatment of diabetes; AND either
  • Age ≥ 50 years if male or ≥ 55 years if female (primary prevention cohort); OR
  • Age ≥ 18 years and established systemic atherosclerosis (secondary prevention cohort), defined as any 1 of the following:
  • i. Prior MI or ischemic (non-hemorrhagic) stroke
Show all 11Show fewer
  • ii. Coronary angiographic lesion of ≥ 60% stenosis in a major epicardial vessel or ≥ 50% left main stenosis
  • iii. Asymptomatic carotid disease with ≥ 70% carotid artery stenosis
  • iv. Symptomatic carotid disease with ≥ 50% carotid artery stenosis
  • v. Symptomatic lower extremity PAD (ie, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing [eg, toe-brachial index, angiogram, or other imaging study])
  • vi. Prior arterial revascularization procedure (including coronary, carotid, or peripheral angioplasty/stenting, bypass, or atherectomy/endarterectomy)

Who cannot join

  • Current or planned use of fibrates or agents with PPAR-α agonist activity (eg, saroglitazar) within 6 weeks (42 days) of Visit 1 (Screening/Enrollment Visit). Note: PPAR-γ agonists (eg, glizatones such as pioglitazone and rosiglitazone) are allowed
  • Known sensitivity to PPAR-α agonists or tablet excipients
  • Initiation of, or change in, current TG-lowering therapy within 12 weeks of Visit 1 (if applicable). Note: TG-lowering therapy is defined as niacin > 100 mg/day or dietary supplements or prescription omega-3 fatty acids > 1 g/day
  • Type 1 diabetes mellitus

Trial locations and contacts

888 sites in 25 countries.

888 sites in 25 countries

United States242 sites

  • Synexus Clinical Research US, Inc.

    Akron, Ohio, 44311

  • Endocrine Group, L.L.P.

    Albany, New York, 12206

  • Stratton Veterans Affairs Medical Center - Albany

    Albany, New York, 12208

  • Raymond G. Murphy VA Medical Center

    Albuquerque, New Mexico, 87108

  • Cambridge Medical Trials

    Alexandria, Louisiana, 71301

  • Clinical Research Alliance, Inc

    Alhambra, California, 91801

  • Community Hospital of Anderson and Madison County, Inc.

    Anderson, Indiana, 46011

  • Synexus Clinical Research US, Inc.

    Anderson, South Carolina, 29621-2062

  • University of Michigan

    Ann Arbor, Michigan, 48105

  • Veterans Affairs Ann Arbor Healthcare System

    Ann Arbor, Michigan, 48105

  • Randolph Medical Associates

    Asheboro, North Carolina, 27203

  • OnSite Clinical Solutions, LLC

    Asheville, North Carolina, 28801

  • OhioHealth Heart & Vascular Physicians (Heartcare, Inc.) - Athens

    Athens, Ohio, 45701

  • Emory University

    Atlanta, Georgia, 30322

  • Lynn Institute of Denver

    Aurora, Colorado, 80012

  • Central Texas Clinical Research, LLC

    Austin, Texas, 78705

  • Baltimore VA medical centre

    Baltimore, Maryland, 21201

  • University of Maryland School of Medicine

    Baltimore, Maryland, 21201

  • Maryland Cardiovascular Specialists

    Baltimore, Maryland, 21229

  • Bay Pines VA Healthcare System

    Bay Pines, Florida, 33744

  • Southern Maine Health Care

    Biddeford, Maine, 04005

  • Synexus Clinical Research US, Inc.

    Birmingham, Alabama, 35211

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35233

  • VA Medical Center - Birmingham

    Birmingham, Alabama, 35233

  • Alabama Clinical Therapeutics, LLC

    Birmingham, Alabama, 35235

  • Joslin Diabetes Center

    Boston, Massachusetts, 02215

  • Meridien Research

    Bradenton, Florida, 34201

  • Clinical Research Of Brandon, LLC

    Brandon, Florida, 33511

  • PMG Research of Bristol, LLC

    Bristol, Tennessee, 37620

  • Northern Pines Health Center

    Buckley, Michigan, 49620

  • Buffalo VA Medical Center

    Buffalo, New York, 14215

  • Burke Internal Medicine & Research

    Burke, Virginia, 22015

  • Kernodle Clinic, Inc., Dept. of the Private Diagnostic Clinic, PLLC

    Burlington, North Carolina, 27215

  • Cadillac Clinical Research, LLC

    Cadillac, Michigan, 49601

  • Aultman Hospital

    Canton, Ohio, 44710

  • Cary Research Group, LLC

    Cary, North Carolina, 27518

  • PMG Research of Cary, LLC

    Cary, North Carolina, 27518

  • Chambersburg Hospital

    Chambersburg, Pennsylvania, 17201

  • Christie Clinic, LLC

    Champaign, Illinois, 61822

  • Synexus Clinical Research US, Inc.

    Chandler, Arizona, 85224-6279

  • Ralph H. Johnson VA Medical Center

    Charleston, South Carolina, 29401

  • Novant Health - Heart and Vascular Institute

    Charlotte, North Carolina, 28204

  • The Presbyterian Hospital

    Charlotte, North Carolina, 28204

  • Focus Clinical Research Solutions

    Charlotte, North Carolina, 28277

  • Chattanooga Medical Research, LLC

    Chattanooga, Tennessee, 37404

  • Chattanooga Research and Medicine (CHARM)

    Chattanooga, Tennessee, 37404

  • University Diabetes & Endocrine Consultants

    Chattanooga, Tennessee, 37411

  • WR-ClinSearch, LLC

    Chattanooga, Tennessee, 37421

  • Virginia Endocrinology Research

    Chesapeake, Virginia, 23321

  • Apex Medical Research, AMR, Inc.

    Chicago, Illinois, 60607

  • Hometown Urgent Care & Occupational Health

    Cincinnati, Ohio, 45215

  • Cincinnati Veterans Affairs Medical Center

    Cincinnati, Ohio, 45267

  • Clearwater Cardiovascular Consultants

    Clearwater, Florida, 33756

  • Louis Stokes Cleveland Dept of VA Medical Center

    Cleveland, Ohio, 44106

  • Aurora Care Clinic

    Costa Mesa, California, 92627

  • West Broadway Clinic

    Council Bluffs, Iowa, 51501

  • Cardiovascular Associates Research, LLC

    Covington, Louisiana, 70433

  • Partners in Clinical Research

    Cumberland, Rhode Island, 02864

  • Atlanta Heart Specialists, LLC

    Cumming, Georgia, 30041

  • Protenium Clinical Research

    Dallas, Texas, 75208

  • VA Medical Center - Dallas

    Dallas, Texas, 75216

  • North Texas Endocrine Center

    Dallas, Texas, 75231

  • Research Institute of Dallas, P.A.

    Dallas, Texas, 75231

  • Synexus Clinical Research US, Inc.

    Dallas, Texas, 75234

  • Daytona Heart Group

    Daytona Beach, Florida, 32114

  • VA Medical Center - Atlanta

    Decatur, Georgia, 30033

  • Cohen Medical Research Associates, LLC

    Delray Beach, Florida, 33446

  • Iowa Diabetes and Endocrinology Research Center, PLC

    Des Moines, Iowa, 50314

  • Alta Pharmaceutical Research Center, Inc.

    Dunwoody, Georgia, 30338

  • Monmouth Cardiology Associates

    Eatontown, New Jersey, 07724

  • Doctors Hospital at Renaissance

    Edinburg, Texas, 78539

  • AMCR Institute, Inc.

    Escondido, California, 92025

  • Synexus Clinical Research US, Inc.

    Evansville, Indiana, 47714

  • Deaconess Clinic

    Evansville, Indiana, 47725

  • Utah Cardiology, P.C. (Davis)

    Farmington, Utah, 84025

  • AMH Feasterville Family Health Care Center

    Feasterville, Pennsylvania, 19053

  • AA MRC LLC Ahmed Arif Medical Research Center

    Flint, Michigan, 48504

  • Texas Health Research & Education Institute

    Fort Worth, Texas, 76104

  • Texas Health Physicians Group

    Fort Worth, Texas, 76107

  • University of North Texas Health Science Center

    Fort Worth, Texas, 76107

  • Diabetes and Thyroid Center of Fort Worth

    Fort Worth, Texas, 76132

  • Rockwood Medical Clinic

    Fort Worth, Texas, 76164

  • Prestige Clinical Research Center

    Franklin, Ohio, 45005

  • Malcom Randall VA Medical Center

    Gainesville, Florida, 32608

  • New West Physicians, PC

    Golden, Colorado, 80401

  • Cardiology Associates of Bellin Health

    Green Bay, Wisconsin, 54301

  • Medication Management, LLC

    Greensboro, North Carolina, 27408

  • Triad Clinical Trials, LLC

    Greensboro, North Carolina, 27410

  • Mountain View Clinical Research, Inc.

    Greer, South Carolina, 29651

  • Fundamental Research, LLC

    Gulf Shores, Alabama, 36542

  • Clinical Investigation Specialists, Inc.

    Gurnee, Illinois, 60031

  • Pentucket Medical Associates

    Haverhill, Massachusetts, 01830

  • Synexus Clinical Research US, Inc.

    Henderson, Nevada, 89052

  • Clinical Trials of America-NC, LLC

    Hickory, North Carolina, 28601

  • PMG Research of Hickory, LLC

    Hickory, North Carolina, 28601

  • Edward Hines Jr. VA Hospital

    Hines, Illinois, 60141

  • Pines Clinical Research, Inc.

    Hollywood, Florida, 33024

  • Homestead Cardiac & Vein Center

    Homestead, Florida, 33030

  • East Texas Cardiology PA

    Houston, Texas, 77002

  • Endocrine Associates, LLC

    Houston, Texas, 77004

  • Heights Doctors Clinic

    Houston, Texas, 77008

  • Associates in Medicine

    Houston, Texas, 77027

  • Michael E. DeBakey VA Medical Center

    Houston, Texas, 77030

  • Southwest Clinical Trials

    Houston, Texas, 77081

  • National Institute of Clinical Research

    Huntington Beach, California, 92648-1717

  • Protenium Clinical Research

    Hurst, Texas, 76054

  • Medstar Health Research Institute

    Hyattsville, Maryland, 20782

  • VA Medical Center - Indianapolis

    Indianapolis, Indiana, 46202

  • GV Montgomery VA Medical Center

    Jackson, Mississippi, 39216

  • Westside Center for Clinical Research

    Jacksonville, Florida, 32205

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • Health Awareness, Inc.

    Jupiter, Florida, 33458

  • Kalispell Regional Medical Center dba Glacier View Research Institute

    Kalispell, Montana, 59901

  • University of Kansas Medical Center Research Institute, Inc.

    Kansas City, Kansas, 66160

  • Kansas City VA Medical Center

    Kansas City, Missouri, 64128

  • Clinical Investigation Specialists Inc

    Kenosha, Wisconsin, 53144

  • Holston Medical Group, P.C.

    Kingsport, Tennessee, 37660

  • Metro Knoxville HMA, LLC

    Knoxville, Tennessee, 37934

  • Mayo Clinic Health System

    La Crosse, Wisconsin, 54601

  • Centex Studies Inc.

    Lake Charles, Louisiana, 70601

  • Meridien Research

    Lakeland, Florida, 33805

  • Sparrow Clinical Research Institute

    Lansing, Michigan, 48912

  • Clearwater Cardiovascular & Interventional Consultants

    Largo, Florida, 33777

  • Red Rock Clinical Research LLC

    Las Vegas, Nevada, 89146

  • VA Eastern Kansas Health Care

    Leavenworth, Kansas, 66048

  • Family Medical Associates

    Levittown, Pennsylvania, 19056

  • The Research Group of Lexington, LLC

    Lexington, Kentucky, 40503

  • Ocean State Clinical Research Partners

    Lincoln, Rhode Island, 02865

  • NJ Heart

    Linden, New Jersey, 07036

  • Main Street Physician's Care - Waterway

    Little River, South Carolina, 29566

  • Central Arkansas Veterans Healthcare System

    Little Rock, Arkansas, 72205

  • Southwest Family Medicine

    Littleton, Colorado, 80127

  • VA Loma Linda Healthcare System

    Loma Linda, California, 92354

  • VA Long Beach Healthcare System

    Long Beach, California, 90822

  • Eastside Clinical Research Associates

    Los Angeles, California, 90022

  • VA Greater Los Angeles Healthcare System

    Los Angeles, California, 90073

  • Richard S. Cherlin, MD

    Los Gatos, California, 95032

  • Robley Rex VA Medical Center

    Louisville, Kentucky, 40206

  • Meriter Medical Group, Inc.

    Madison, Wisconsin, 53713

  • Carient Heart and Vascular

    Manassas, Virginia, 20109

  • Craig S Thompson MD LLC

    Marion, Ohio, 43302

  • Heart Clinic of Southern Oregon

    Medford, Oregon, 97504

  • VA Medical Center - Memphis

    Memphis, Tennessee, 38104

  • Synexus Clinical Research US, Inc.

    Mesa, Arizona, 85206

  • University of Miami

    Miami, Florida, 33136

  • Advanced Medical Research Institute

    Miami, Florida, 33174

  • South Shore Internal Medicine Associates

    Milton, Massachusetts, 02186

  • Zablocki VA Medical Center

    Milwaukee, Wisconsin, 53295

  • Winthrop Cardiology Associates

    Mineola, New York, 11501

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407

  • Mobile Heart Specialists, PC

    Mobile, Alabama, 36608

  • Research Institute of the Carolinas, PLC

    Mooresville, North Carolina, 28117

  • Diabetes and Endocrinology Consultants

    Morehead City, North Carolina, 28557

  • Cardiovascular Research of Northwest Indiana, LLC

    Munster, Indiana, 46321

  • Family Medicine of Sayebrook

    Myrtle Beach, South Carolina, 29588

  • Southern New Hampshire Diabetes and Endocrinology

    Nashua, New Hampshire, 03063

  • Tennessee Valley Healthcare System

    Nashville, Tennessee, 37232

  • Icahn School of Medicine at Mount Sinai

    New York, New York, 10029

  • Cardiology Physicians, PA

    Newark, Delaware, 19713

  • Advocate Health and Hospitals Corp

    Normal, Illinois, 61761

  • Intend Research

    Norman, Oklahoma, 73069

  • Lynn Institute of Norman

    Norman, Oklahoma, 73069

  • Captain James A. Lovell Federal Health Care Center

    North Chicago, Illinois, 60064

  • Northridge Clinical Research Inc.

    Northridge, California, 91324

  • Ocala Research Institute, Inc.

    Ocala, Florida, 34471

  • Morgan Medical Management & Consultants Inc.

    Ocala, Florida, 34474

  • Endocrine Associates of Florida

    Ocoee, Florida, 34761

  • Oklahoma City Clinic - Central

    Oklahoma City, Oklahoma, 73104

  • South Oklahoma Heart Research Group

    Oklahoma City, Oklahoma, 73135

  • Piedmont Research Partners

    Old Point Station, South Carolina, 29707

  • Specialty Physicians of Illinois

    Olympia Fields, Illinois, 60461

  • VA Nebraska-Western Iowa Health Care System

    Omaha, Nebraska, 68105

  • University of Nebraska Medical Center

    Omaha, Nebraska, 68198-4120

  • Research Physicians Network Alliance

    Orlando, Florida, 32803

  • Palo Alto Division

    Palo Alto, California, 94304

  • Synexus Clinical Research US, Inc.

    Papillion, Nebraska, 68046

  • Huntington Hospital - Research Department

    Pasadena, California, 91105

  • Houston Methodist Research Institute - CCAT Pearland

    Pearland, Texas, 77584

  • Andres Patron, D.O., P.A

    Pembroke Pines, Florida, 33026

  • DBC Research, Corp

    Pembroke Pines, Florida, 33029

  • Langhorne Cardiology Consultants, Inc.

    Pensacola, Florida, 32501

  • Arizona Arthritis & Rheumatology Research, PLLC

    Peoria, Arizona, 85381

  • Phoenix Veterans Adminstration Health Care System

    Phoenix, Arizona, 85012

  • Synexus Clinical Research US, Inc.

    Phoenix, Arizona, 85050

  • Pinehurst Medical Clinic Inc

    Pinehurst, North Carolina, 28374

  • VA Pittsburgh Healthcare System

    Pittsburgh, Pennsylvania, 15240

  • Preferred Primary Care Physicians

    Pittsburgh, Pennsylvania, 15317

  • Clinical Investigations of Texas

    Plano, Texas, 75075

  • Providence Veteran Administration Medical Center

    Providence, Rhode Island, 02908

  • PMG Research of Raleigh, LLC

    Raleigh, North Carolina, 27609

  • Rancho Cucamonga Clinical Research

    Rancho Cucamonga, California, 91730

  • VA Sierra Nevada Health Care System

    Reno, Nevada, 89502

  • Synexus Clinical Research US, Inc.

    Richfield, Minnesota, 55432

  • Clinical Research Partners, LLC

    Richmond, Virginia, 23220

  • McGuire DVA Medical Center

    Richmond, Virginia, 23249

  • The Valley Hospital

    Ridgewood, New Jersey, 07450

  • Roanoke Heart Institute

    Roanoke, Virginia, 24014

  • PMG Research of Rocky Mount, LLC

    Rocky Mount, North Carolina, 27804

  • Clearwater Cardiovascular Consultants

    Safety Harbor, Florida, 34695

  • Covenant Medical Center, Inc.

    Saginaw, Michigan, 48602

  • CentraCare Heart & Vascular

    Saint Cloud, Minnesota, 56303-1900

  • HealthEast Medical Research Institute

    Saint Paul, Minnesota, 55102

  • Delmarva Heart Research Foundation, Inc.

    Salisbury, Maryland, 21804

  • PMG Research of Salisbury, LLC

    Salisbury, North Carolina, 28144

  • Consano Clinical Research, LLC

    San Antonio, Texas, 78205

  • Sant Antonio Premiere Internal Medicine

    San Antonio, Texas, 78220

  • Briggs Clinical Research, LLC.

    San Antonio, Texas, 78224

  • Schnitzler Cardiovascular Consultants (SCC), PLLC

    San Antonio, Texas, 78229-3271

  • Bandera Family Healthcare Research LLC

    San Antonio, Texas, 78249

  • MD Strategies Research Centers

    San Diego, California, 92119

  • Alex Harrison, MD Inc.

    Santa Maria, California, 93454

  • Santa Rosa Cardiology Medical Group, Inc.

    Santa Rosa, California, 95404

  • Northeast Clinical Research of San Antonio

    Schertz, Texas, 78154

  • Fay West Family Practice

    Scottdale, Pennsylvania, 15683

  • Carolina Research Center, Inc.

    Shelby, North Carolina, 28150-3803

  • Overton Brooks VA Medical Center

    Shreveport, Louisiana, 71101

  • Montgomery Medical Inc.

    Smithfield, Pennsylvania, 15478

  • Palmetto Research Center, LLC

    Spartanburg, South Carolina, 29302

  • Spring Family Practice Associates

    Spring, Texas, 77379

  • Synexus Clinical Research US, Inc.

    St Louis, Missouri, 63141

  • Professional Health Care of Pinellas

    St. Petersburg, Florida, 33713

  • Suffolk Multispecialty Research

    Suffolk, Virginia, 23435

  • Palmetto Clinical Research

    Summerville, South Carolina, 29485

  • Clinical Research Institute of Arizona, LLC

    Surprise, Arizona, 85374

  • SUNY Upstate Medical University

    Syracuse, New York, 13210

  • VA Medical Center - Syracuse

    Syracuse, New York, 13210

  • James A. Haley VA Medical Center

    Tampa, Florida, 33612

  • Northwest Houston Heart Center

    Tomball, Texas, 77375

  • Atlanta Heart Specialists, LLC

    Tucker, Georgia, 30084

  • Synexus Clinical Research US, Inc.

    Tucson, Arizona, 85712

  • Eclipse Clinical Research

    Tucson, Arizona, 85745

  • Terence T. Hart, MD

    Tuscumbia, Alabama, 35674

  • Buynak Clinical Research

    Valparaiso, Indiana, 46383

  • Victoria Heart & Vascular Center

    Victoria, Texas, 77901

  • Corporation Lane Internal Medicine

    Virginia Beach, Virginia, 23462

  • Blue Coast Cardiology

    Vista, California, 92083

  • Hillcrest Family Health Clinics

    Waco, Texas, 76710

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708

  • The Iowa Clinic, PC

    West Des Moines, Iowa, 50266

  • VA Connecticut Healthcare Sys

    West Haven, Connecticut, 06516-2770

  • VA Medical Center

    White River Junction, Vermont, 05055

  • Clinical Research of Central Florida

    Winter Haven, Florida, 33880

Other trials in United States

Japan64 sites

  • Juntendo University Hospital

    Bunkyō City, Tokyo-To, 113-8431

  • Chiba University Hospital

    Chiba, Chiba, 260-8677

  • Fukuwa Clinic

    Chūōku, Tokyo-To, 103-0027

  • Tokyo-Eki Center-Building Clinic

    Chūōku, Tokyo-To, 103-0027

  • Nakahama Heart Clinic

    Fuchu-shi, Hiroshima, 726-0013

  • Fukuoka University Hospital

    Fukuoka, Fukuoka, 814-0180

  • Nippon Kokan Fukuyama Hospital

    Fukuyama-shi, Hiroshima, 721-0927

  • Public Central Hospital of Matto Ishikawa

    Hakusan-shi, Ishikawa-ken, 924-8588

  • NHO Hamada Medical Center

    Hamada-shi, Shimane, 697-8511

  • NHO Higashihiroshima Medical Center

    Higashihiroshima-shi, Hiroshima, 739-0041

  • Iwasaki Naika Clinic

    Higashiosaka-shi, Osaka, 577-0802

  • Takekawa Naika Clinic

    Higashiosaka-shi, Osaka, 577-0803

  • Tanaka Cardiology Clinic

    Hitachi-Naka, Ibaraki, 312-0032

  • IMS Miyoshi General Hospital

    Iruma-gun, Saitama, 354-0041

  • Rinku General Medical Center

    Izumisano, Osaka, 598-8577

  • Shiraiwa Medical Clinic

    Kashiwara-shi, Osaka, 582-0005

  • Fukuoka Tokushukai Hospital

    Kasuga-shi, Fukuoka, 816-0864

  • Hosoda Clinic

    Katsushika-ku, Tokyo-To, 124-0021

  • Sugiura Clinic

    Kawaguchi-shi, Saitama, 332-0012

  • Tokushukai Kishiwada Tokushukai Hospital

    Kishiwada-shi, Osaka, 596-8522

  • Steel Memorial Yawata Hospital

    Kitakyushu-shi, Fukuoka, 805-8508

  • NHO Fukuoka Higashi Medical Center

    Koga-shi, Fukuoka, 811-3195

  • NHI Komatsu Municipal Hospital

    Komatsu-shi, Ishikawa-ken, 923-8560

  • Southern Tohoku Medical Clinic

    Koriyama-shi, Fukushima, 963-8052

  • Hoshi General Hospital

    Koriyama-shi, Fukushima, 963-8501

  • Kumamoto University Hospital

    Kumamoto, Kumamoto, 860-8556

  • Ijinkai Takeda General Hospital

    Kyoto, Kyoto, 601-1495

  • Kyoto University Hospital

    Kyoto, Kyoto, 606-8507

  • Rakuwakai Otowa Hospital

    Kyoto, Kyoto, 607-8062

  • Kioroshikai Chibanishi General Hospital

    Matsudo-shi, Chiba, 270-2251

  • Seikeikai New Tokyo Heart Clinic

    Matsudo-shi, Chiba, 271-0077

  • Ehime Prefectural Central Hospital

    Matsuyama, Ehime, 790-0024

  • Toyukai Yutenji Medical Clinic (Yutenji Naika)

    Meguro-ku, Tokyo-To, 153-0053

  • Kuonkai Kamata Medical Clinic

    Morioka, Iwate, 020-0866

  • Iwate Medical University Uchimaru Medical Center Hospital

    Morioka, Iwate, 020-8505

  • Aichi Medical University Hospital

    Nagakute-shi, Aichi-ken, 480-1195

  • JOHAS Chubu Rosai Hospital

    Nagoya, Aichi-ken, 455-8530

  • Kojunkai Daido Clinic

    Nagoya, Aichi-ken, 457-8511

  • NHO Nagoya Medical Center

    Nagoya, Aichi-ken, 460-0001

  • Nakakinen Clinic Medical Corporation Kensei-kai

    Naka, Ibaraki, 311-0113

  • Okinawa Tokushukai Chubu Tokushukai Hospital

    Nakagami-gun, Okinawa, 901-2393

  • National Center For Geriatrics And Gerontology

    Obu-shi, Aichi-ken, 474-8511

  • Keiwakai Oita Oka Hospital

    Ōita, Oita Prefecture, 870-0192

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558

  • Chiyukai Fukuoka Shinmizumaki Hospital

    Onga-gun, Fukuoka, 807-0051

  • Kansai Electric Power Hospital

    Osaka, Osaka, 553-0003

  • Sato Hospital

    Osaki-shi, Miyagi, 989-6143

  • Shiga University of Medical Science Hospital

    Ōtsu, Shiga, 520-2192

  • Sohken Yamamoto Clinic

    Sagamihara-shi, Kanagawa, 252-0311

  • Miyanosawa Clinic of Internal Medicine and Cardiology

    Sapporo, Hokkaido, 063-0826

  • Tohoku Kosai Hospital

    Sendai, Miyagi, 980-0803

  • Sendai Kousei Hospital

    Sendai, Miyagi, 980-0873

  • Jichi Medical University Hospital

    Shimotsuke-shi, Tochigi, 329-0498

  • Shinjuku Research Park Clinic

    Shinjuku-ku, Tokyo-To, 169-0073

  • National Cerebral and Cardiovascular Center

    Suita-shi, Osaka, 564-8565

  • Nomura Clinic

    tabashi City, Tokyo-To, 173-0004

  • Josuikai Olive Takamatsu Medical Clinic

    Takamatsu, Kagawa-ken, 760-0076

  • Ryubokai Higashi Diabetes and Cardiovascular Clinic

    Tamana-shi, Kumamoto, 865-0016

  • Sanyukai Saino Clinic

    Tokorozawa-shi, Saitama, 359-1141

  • Fujita Health University Hospital

    Toyoake-shi, Aichi-ken, 470-1192

  • Senrichuo Ekimae Clinic

    Toyonaka-shi, Osaka, 560-0082

  • Yamaguchi University Hospital

    Ube-shi, Yamaguchi, 755-8505

  • NHO Saitama National Hospital

    Wako-shi, Saitama, 351-0102

  • NHO Yokohama Medical Center

    Yokohama, Kanagawa, 245-8575

Other trials in Japan

Canada51 sites

  • LMC Clinical Research Inc. (Barrie)

    Barrie, Ontario, L4N 7L3

  • LMC Clinical Research Inc. (Brampton)

    Brampton, Ontario, L6S 0C9

  • Aggarwal and Associates Ltd

    Brampton, Ontario, L6T 0G1

  • JBN Medical Diagnostic Services Inc.

    Burlington, Ontario, L7M 4Y1

  • LMC Clinical Research dba Manna Research Inc. Burlington North

    Burlington, Ontario, L7M 4Y1

  • LMC Clinical Research Inc. (Calgary)

    Calgary, Alberta, T2H 2G4

  • Cambridge Cardiac Care Centre

    Cambridge, Ontario, N1R 6V6

  • Joanne F. Liutkus Medicine Professional Corporation

    Cambridge, Ontario, N1R 7L6

  • Saul Vizel Professional Medicine Corporation

    Cambridge, Ontario, N1R 7R1

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9

  • LMC Clinical Research Inc. (Thornhill)

    Concord, Ontario, L4K 4M2

  • ALTA Clinical Research Inc.

    Edmonton, Alberta, T5A 4L8

  • Royal Alexandra Hospital, CK Hui Heart Centre

    Edmonton, Alberta, T5H 3V9

  • LMC Clinical Research Inc. (Etobicoke)

    Etobicoke, Ontario, M9R 4E1

  • Janik Research

    Greater Sudbury, Ontario, P3E 5M4

  • ViaCar Recherche Clinique Inc

    Greenfield Park, Quebec, J4V 2G8

  • Dawson Road Family Medical Clinic

    Guelph, Ontario, N1H 1B1

  • Clinique de Cardiologie de Levis

    Lévis, Quebec, G6V 4Z5

  • Centre de Dépistage et Recherche Cardiovasculaire Rive-Sud

    Longueuil, Quebec, J4M 2X1

  • LMC Clinical Research dba Manna Research Inc. Mirabel

    Mirabel, Quebec, J7J 2K8

  • Clinique Santé Cardio MC

    Montreal, Quebec, H1T 3Y7

  • CHUM Hôtel-Dieu

    Montreal, Quebec, H2W 1T8

  • Applied Medical Informatics Research Inc.

    Montreal, Quebec, H4A 3T2

  • LMC Clinical Research Inc. (Ottawa)

    Nepean, Ontario, K2J 0V2

  • Fraser Clinical Trials Inc.

    New Westminster, British Columbia, V3L 3W4

  • LMC Clinical Research Inc. (Oakville)

    Oakville, Ontario, L6M1M1

  • James Cha, MD

    Oshawa, Ontario, L1J 2K1

  • The Ottawa Hospital - Riverside Campus

    Ottawa, Ontario, K1H 7W9

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

  • Recherche Clinique Sigma Inc.

    Québec, Quebec, G1G 3Y8

  • Clinique Médicale St-Louis (Recherche) inc d/b/a/ Centre de Recherche Saint-Louis

    Québec, Quebec, G1W 4R4

  • ALPHA Recherche Clinique

    Québec, Quebec, G3K 2P8

  • DIEX Recherche Quebec Inc.

    Québec, G1N 4V3

  • Institut Universitaire de Cardiologie et de Pneumologie de Quebec

    Québec, G1V 4G5

  • Clinique des maladies Lipidiques de Quebec

    Québec, G1V 4M6

  • The Bailey Clinic

    Red Deer, Alberta, T4N 6V7

  • Recherche Médicale St-Jérôme Inc.

    Saint-Jérôme, Quebec, J7Z 5T3

  • LMC Clinical Research Inc. (Montreal)

    Saint-Laurent, Quebec, H4T 1Z9

  • Centre Medical des Carrieres

    Saint-Marc-des-Carrieres, Quebec, G0A 4B0

  • Scarborough Cardiology Research

    Scarborough Village, Ontario, M1E 5E9

  • Health Sciences Centre

    St. John's, Newfoundland and Labrador, NL A1B 3V6

  • Surrey Memorial Hospital

    Surrey, British Columbia, V3V 0C6

  • Humber River Hospital

    Toronto, Ontario, M3M 0B2

  • LMC Clinical Research Inc. (Bayview)

    Toronto, Ontario, M4G 3E8

  • St. Michael's Hospital

    Toronto, Ontario, M5B 1W8

  • LMC Clinical Research dba Manna Research Inc. Toronto

    Toronto, Ontario, M9W 4L6

  • BC Diabetes As Operated by Dr. TG Elliott, Inc.

    Vancouver, British Columbia, V5Y 3W2

  • Discovery Clinical Services Ltd.

    Victoria, British Columbia, V8T 5G4

  • Saint Boniface General Hospital

    Winnipeg, Manitoba, R2H 2A6

  • Rivergrove Medical Clinic

    Winnipeg, Manitoba, R2V 4W3

  • Winnipeg Clinic

    Winnipeg, Manitoba, R3A 1R9

Other trials in Canada

Ukraine48 sites

  • Cherkasy Regional Cardiological Center

    Cherkasy, 18009

  • CI Cherkasy RH of Cherkasy Regional Council

    Cherkasy, 18009

  • CMI CCH#3 Dep of Ther# w the beds of card profile HSEI of UBSMU

    Chernivtsi, 58000

  • RCI Chernivtsi Regional Endocrinology Center Policlinic Dept SHEI of UBSMU

    Chernivtsi, 58022

  • CI Dnipropetrovsk City Cl Hosp #9 of Dniprop Reg Council SI DMA of MOH of Ukr Ch of Endocrinology

    Dnipro, 49000

  • Medical Center of Limited Liability Company Medical Center Clinic of Family Medicine

    Dnipro, 49038

  • Regional CH Dept of Endocrinology SHEI Ivano-Frankivsk NMU

    Ivano-Frankivsk, 76008

  • CI Ivano-Frankivsk Reg Cl Card Center Dept of Chronic Ischemic Heart Dis SHEI Ivano-Frank NMU

    Ivano-Frankivsk, 76018

  • Ivano-Frankivsk CCH Dept of Therapy #1 SHEI Ivano-Frankivsk NMU

    Ivano-Frankivsk, 76018

  • CHI Kharkiv City Student Hosp Therap dept Nat Pharm Univer

    Kharkiv, 61002

  • CNE Prof. O.O. Shalimov Kharkiv City Clinical Hospital #2 KCC

    Kharkiv, 61037

  • GI L.T.Malaya Therapy National Institute of the NAMS of Ukraine

    Kharkiv, 61039

  • State Institution LT Malaya Inst. of Ther. of AMS of Ukraine

    Kharkiv, 61039

  • Railway Transport Kharkiv CH #1 of Healthcare Center Branch of PJSC Ukr Railway

    Kharkiv, 61103

  • Railway Transport Kharkiv CH#1 of Healthcare Center Branch of PJSC Ukrainian Railway

    Kharkiv, 61103

  • MC Doctor Alex Dept of General Practice-Family Medicine Kharkiv MA of PGE

    Kharkiv, 61106

  • CNE City Clin Hosp #8 of KCC Dept of Therapy Kharkiv MA of PGE of MOHU

    Kharkiv, 61176

  • CI Ye.Ye.Karabelesh Kherson City Clinical Hosp.

    Kherson, 73000

  • KCCC of Endocr Dept of General Endocrine Pathology O. O. Bogomolets NMU

    Kyiv, 01004

  • Kyiv CCH #12 Dept of Therapy O.O.Bogomolets NMU

    Kyiv, 01103

  • LLC Treatment and Diagnostic Center Adonis Plus

    Kyiv, 02002

  • MC of PHEI Institute of General Practice - Family Medicine

    Kyiv, 02002

  • Medical Center Blagomed Plus LLC

    Kyiv, 02081

  • Med Center 'Ok!Clinic+' of International Institute of Clinical Trials LLC

    Kyiv, 02091

  • MC of Subsidiary Production Unit Med Scient Pract Union Medbud of PJSc Holding Company Kyivmiskbud

    Kyiv, 03037

  • Kyiv CH on Railway Transport #2 of Branch Center of Healthcare Public Company Ukr Railway

    Kyiv, 03049

  • Med Center of Eurolab LLC Policlinic Outpatient Dept O.O.Bogomolets NMU

    Kyiv, 03110

  • SI National Scientific Centre of Radiation Medicine of NAMSU

    Kyiv, 03115

  • SI NSC M.D. Strazhesko Institute of Cardiology of NAMSU

    Kyiv, 03680

  • SI NSС M.D. Strazhesko Institute of Cardiology of NAMSU

    Kyiv, 03680

  • Department of Medical Services and Rehabilitation of State Joint Stock Holding Company Artem

    Kyiv, 04050

  • Medical Center of Limited Liability Company Medical Center Concilium Medical

    Kyiv, 04050

  • CI of Kyiv RC Regional Clinical Hospital #2

    Kyiv, 04053

  • SI V.P.Komisarenko Institute of E&M of NAMSU

    Kyiv, 04114

  • SI V.P.Komisarenko Institute of Endocrinology and Metabolism of NAMSU

    Kyiv, 04114

  • Lviv Reg St Clin Treatment - Diagnostic Endocrin Center, Dept of Polyclinic, D.Galytskyy Lviv NMU

    Lviv, 79010

  • Lviv Communal 4th City Clinical Hospital

    Lviv, 79011

  • Center of Reconstructive & Restorative Medicine (University Clinic) of Odessa National Medical Uni

    Odesa, 65000

  • CI Sumy City Clinical Hospital #1 Dept of Therapy Sumy SU Med Inst

    Sumy, 40021

  • Ternopil City Municipal Hospital #2 Dept of Gastroenterology Ternopil I.Ya. Gorbachevskyi SMU

    Ternopil, 46023

  • Transcarpathian Regional Clinical Cardiology Dispansery

    Uzhhorod, 88014

  • Private Small Enterprise Medical Center Pulse

    Vinnytsia, 21001

  • Vinnytsia RC Highly Special.Endocr.Center Dept of Therapy #2 M.I. Pyrogov NMU

    Vinnytsia, 21010

  • National Pirogov Memorial Medical University

    Vinnytsia, 21018

  • SRI of Invalid Rehabilitation (EST Complex) of Vinnytsia M.I.Pyrogov NMU MOHU

    Vinnytsia, 21029

  • CI Zapor CCH#10 SI ZMA PGE Ch of therapy clin pharmacol & endocrin

    Zaporizhzhya, 69001

  • CI Central City Hospital #1 of Zhytomyr

    Zhytomyr, 10002

  • Zhytomyr regional clinical hospital n.a. O.F. Gerbachevskyy

    Zhytomyr, 10002

Other trials in Ukraine

Russia41 sites

  • SBIH of Arkhangelsk region " First City Clinical hospital n.a. E. E. Volosevich"

    Arkhangelsk, 163001

  • TSHI "Altay Territorial Cardiologocal dispensary"

    Barnaul, 656055

  • FSHI "MSU of MoIA of RF of Kemerovo Region"

    Kemerovo, 650000

  • FSBI "Scientific-research Institute for Complex Problems of cardiovascular disease"

    Kemerovo, 650002

  • NSIH "Departmental Hospital on Station Kemerovo of OJSC "Russian Railways"

    Kemerovo, 650055

  • SAIH "Kemerovo Regional Clinical Hospital"

    Kemerovo, 650066

  • TSBIH "Krasnoyarsk Interdistrict Clinical Hospital of Emergency Medical Care n.a. N.S. Karpovich

    Krasnoyarsk, 660062

  • SBIH of Moscow "City Clinical Hospital n.a.Bakhrushinykh"

    Moscow, 107 014

  • SBHI "City Polyclinic #2 of Healthcare department of city of Moscow"

    Moscow, 117556

  • FSBIH "Central Clinical Hospital of Russian Academy of Sciences"

    Moscow, 117593

  • FSBI "Central Clinical Hospital with Polyclinic of the Department for Presidential Affairs of the RF

    Moscow, 121359

  • SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF

    Moscow, 127473

  • SBEI HPE "Moscow State Medical and Dentistry University n.a. A. I. Evdokimov" of the MoH of the RF

    Moscow, 129301

  • Murmansk Regional Clinical Hospital named after Bayandin

    Murmansk, 183047

  • SBIH of Novosibirsk Region "Clinical Emergency Hospital #2"

    Novosibirsk, 630008

  • SBIH of Novosibirsk region "City Clinical Hospital # 19"

    Novosibirsk, 630068

  • FSBSI "Scientific Research Institute of Therapy and Preventive Medicine"

    Novosibirsk, 630089

  • LLC "RC Medical"

    Novosibirsk, 630091

  • BIH of Omsk region "Clinical Medico-Sanitary Unit # 9

    Omsk, 644018

  • Llc Ultramed

    Omsk, 644024

  • SBIH of Perm territory " City Clinical Hospital # 2 n.a. Fedor Khristoforovich Gral"

    Perm, 614068

  • State Budgetary Healthcare Institution Clinical Medical Sani

    Perm, 614077

  • SHI "Perm Regional Hospital of War Veterans"

    Perm, 614097

  • City Emergency Hospital #2

    Rostov-on-Don, 344068

  • CJSC Clinic complex

    Saint Petersburg, 190013

  • FSBI North-West Federal Medical Research Center n.a. V.A. Almazov of MoH RF

    Saint Petersburg, 194156

  • SPb SBIH "City Multy-field Hospital # 2"

    Saint Petersburg, 194354

  • Saint-Petersburg SBHI "City outpatient clinic #28"

    Saint Petersburg, 195427

  • LLC "Institute of Medical Examinations"

    Saint Petersburg, 196084

  • Pavlov First Saint Petersburg State Medical University

    Saint Petersburg, 197022

  • Llc "Medinet"

    Saint Petersburg, 197136

  • SPb SBIH "Nikolaevskaya Hospital"

    Saint Petersburg, 198510

  • SPb SBIH "City Pokrovskaya Hospital"

    Saint Petersburg, 199106

  • LLC Medical Center Mart

    Saint Petersburg, 199178

  • SIH "Saratov City Clinical Hospital # 2 n.a. V.I. Razumovskiy"

    Saratov, 410028

  • SPb SBIH "City Hospital # 40 of Kurortnyi region"

    Sestroretsk, 197706

  • FSBI "Research Institute for Cardiology" of Siberian Branch RAMS

    Tomsk, 634012

  • SHI "Regional Clinical Hospital"

    Tver', 170036

  • SHI Ulyanovsk Reg Clinical Hospital

    Ulyanovsk, 432063

  • Yaroslavl Regional Clinical Hospital of War Veterans

    Yaroslavl, 150047

  • SEIHPE "Ural SMA of RosZdrav" b.o. LLC "City Hospital #41"

    Yekaterinburg, 620026

Other trials in Russia

Brazil40 sites

  • HUJBB-UFPA - Hospital Universitário João de Barros Barreto - Universidade Federal do Pará

    Belém, Pará, 66073-000

  • Hospital Felício Rocho

    Belo Horizonte, Minas Gerais, 30110-060

  • CARDRESEARCH - Cardiologia Assistencial

    Belo Horizonte, Minas Gerais, 30150-240

  • Maestri e Kormann Consultoria Medico Científica LTDA

    Blumenau, Santa Catarina, 89010-906

  • L2IP - Instituto de Pesquisas Clínicas Ltda.

    Brasília, Federal District, 70200-730

  • Hospital do Coração do Brasil

    Brasília, Federal District, 70390903

  • CECAP - Centro de Cardiologia Clínica

    Brasília, Federal District, 70710-100

  • Hospital Universitário de Brasília

    Brasília, Federal District, 70840-091

  • Clínica de Endocrinologia e Metabologia Ltda.

    Brasília, Federal District, 71655-175

  • Sociedade Hospitalar Angelina Caron

    Campina Grande do Sul, Paraná, 83430-000

  • Loema - Instituto de Pesquisa Clínica

    Campinas, São Paulo, 13010-001

  • IPCC - Instituto de Pesquisa Clínica de Campinas

    Campinas, São Paulo, 13060-080

  • Hospital Universitário

    Canoas, Rio Grande do Sul, 92425-900

  • Cline Research Center (Leite PS Consultoria Medica LTDA)

    Curitiba, Paraná, 80030-480

  • Núcleo de Pesquisa Clínica S/S

    Curitiba, Paraná, 80730-150

  • CARDIOINTERV Centro de Pesquisa S/S

    Goiânia, Goiás, 74210-050

  • Via Médica

    Goiânia, Goiás, 74223-130

  • HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

    Goiânia, Goiás, 74605-020

  • Paraná Medical Research Center

    Maringá, Paraná, 87015-000

  • Eurolatino Natal Pesquisas Médicas Ltda.

    Natal, Rio Grande do Norte, 59020-500

  • Hospital São Vicente de Paulo

    Passo Fundo, Rio Grande do Sul, 99010-080

  • Santa Casa de Misericórdia de Pelotas

    Pelotas, Rio Grande do Sul, 96015-290

  • Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-074

  • Hospital de Clínicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Centro de Pesquisas em Diabetes Ltda.

    Porto Alegre, Rio Grande do Sul, 90430-001

  • Centro de Pesquisa Clínica Maimônides - Maimônides Day Hospital

    Porto Alegre, Rio Grande do Sul, 90480-000

  • CCBR Brasil Centro de Pesquisas e Análises Clínicas Ltda.

    Rio de Janeiro, Rio Do Janeiro, 22271-100

  • Centro de Pesquisa Médica Santa Maria Ltda.

    Santa Maria, Rio Grande do Sul, 97015-530

  • CEMEC - Centro Multidisciplinar de Estudos Clínicos

    São Bernardo do Campo, São Paulo, 09780-000

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

  • ISPEM - Instituto São José dos Campos em Pesquisas Médicas

    São José dos Campos, São Paulo, 12243-280

  • CPQuali Pesquisa Clínica Ltda.

    São Paulo, São Paulo, 01228-000

  • CPCLIN - Centro de Pesquisas Clínicas Ltda.

    São Paulo, São Paulo, 01228-200

  • Clínica Paulista de Doenças Cardiovasculares Ltda.

    São Paulo, São Paulo, 01323-000

  • Dr. Consulta

    São Paulo, São Paulo, 04208-002

  • CEPIC - Centro Paulista de Investigação Clínica e Serviços Médicos

    São Paulo, São Paulo, 04266-010

  • Hospital das Clínicas da Faculdade de Medicina da USP

    São Paulo, São Paulo, 05403-000

  • Incor - Instituto do Coração - HCFMUSP

    São Paulo, São Paulo, 05403-000

  • IMC - Instituto de Moléstias Cardiovasculares Tatuí

    Tatuí, São Paulo, 18270-170

  • Santa Casa de Votuporanga

    Votuporanga, São Paulo, 15500-003

Other trials in Brazil

Poland38 sites

  • NZOZ Centrum Medyczne KERmed

    Bydgoszcz, 85-231

  • KARDIOMED Janczska Kociwska Ostki PodckaRekrzSp

    Elblag, 82-300

  • Poradnia Kardiologiczna Jarosław Jurowiecki

    Gdansk, 80-286

  • Synexus Polska SCM Sp. z o.o. Gdansku

    Gdansk, 80-382

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-952

  • Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii lek. med. Krzysztof Cymerman

    Gdynia, 81-157

  • Synexus Polska Sp. z o.o. Oddzial w Gdyni

    Gdynia, 81-537

  • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II

    Grodzisk Mazowiecki, 05-825

  • Synexus Polska Sp. z o.o. Oddzial w Katowicach

    Katowice, 40-040

  • Centrum Medyczne Pratia Katowice II

    Katowice, 40-084

  • SPSK Nr 7 SUM w Katowicach Gornoslaskie CM im. prof. Leszka Gieca

    Katowice, 40-635

  • Specjalistyczna Poradnia Kardiologiczna i Nadciśnienia Tętniczego

    Kielce, 25-525

  • Augustyn Monika

    Krakow, 30-363

  • Krakowskie Centrum Medyczne Sp. z o.o.

    Krakow, 31-501

  • Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Łodzi

    Lodz, 93-513

  • NZOZ ALL-MED Centrum Medyczne Specjalistyczne Gabinety Lekarskie

    Lodz, 94-048

  • Indywidualna Specjalistyczna Praktyka Lekarska

    Lodz, 94-255

  • KO-MED Centra Kliniczne Lublin II

    Lublin, 20-362

  • Clinical Best Solutions

    Lublin, 20-709

  • NZOZ Twoja Przychodnia

    Lublin, 20-857

  • NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia

    Nałęczów, 24-140

  • Medicome Sp. z o.o.

    Oświęcim, 32-600

  • Synexus Polska sp. z o.o. Oddzial w Poznaniu

    Poznan, 60-702

  • Praktyka Lekarska Ewa Krzyzagorska

    Poznan, 61-655

  • KO-MED Centra Kliniczne Pulawy

    Puławy, 24-100

  • NZOZ Przychodnia Specjalistyczna H. Rudzki, A. Wittek

    Ruda Śląska, 41-709

  • Centrum Medyczne Medyk

    Rzeszów, 35-055

  • Clinmed Research

    Skierniewice, 96-100

  • NZOZ Pro-Cordis Sopockie Centrum Bad. Kardiolog.

    Sopot, 81-717

  • NSZOZ Medicus

    Środa Wielkopolska, 63-000

  • KO-MED Centra Kliniczne Staszow

    Staszów, 28-200

  • Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Agnieszka Karczmarczyk Specjalista Chorob

    Szczecin, 71-531

  • NBR Polska

    Warsaw, 00-465

  • Centrum Medyczne Świat Pacjenta

    Warsaw, 00-631

  • Synexus Polska Sp. z o.o. Oddział w Warszawie

    Warsaw, 01-192

  • Centrum Zdrowia Tuchow Sp. z o.o.

    Wierzchosławice, 33-122

  • Synexus Polska Sp. z o.o. Oddział we Wroclawiu

    Wroclaw, 50-381

  • KO-MED Centra Kliniczne Zamosc

    Zamość, 22-400

Other trials in Poland

Bulgaria32 sites

  • MHAT 'Puls' AD

    Blagoevgrad, 2700

  • MHAT - Blagoevgrad, EOOD

    Blagoevgrad, 2700

  • MHAT "Yuliya Vrevska - Byala", EOOD

    Byala, 7100

  • MHAT-Haskovo, AD

    Haskovo, 6300

  • MHAT "Higia", AD - Pazardzhik

    Pazardzhik, 4400

  • MHAT - Pazardzhik AD

    Pazardzhik, 4400

  • MHAT "Sv. Pantaleymon - Pleven", OOD

    Pleven, 5800

  • SHATC Pleven EAD

    Pleven, 5800

  • UMHAT 'Dr. Georgi Stranski', EAD

    Pleven, 5800

  • UMHAT "Sv. Georgi", EAD

    Plovdiv, 4000

  • UMHAT "Kaspela", EOOD

    Plovdiv, 4002

  • MC Rusemed ltd.

    Rousse, 7013

  • Diagnostic Consultative Center II - Sofia OOD

    Sofia, 1040

  • Fifth MHAT - Sofia EAD

    Sofia, 1233

  • NMTH "Tsar Boris III"

    Sofia, 1233

  • MHAT - "National Heart Hospital" EAD

    Sofia, 1309

  • MHAT "Lyulin", EAD

    Sofia, 1336

  • Acibadem City Clinic Tokuda Hospital Ead

    Sofia, 1407

  • MC Start - d-r Todor Dimitrov EOOD

    Sofia, 1408

  • DCC "Alexandrovska", EOOD

    Sofia, 1431

  • UMHAT "Alexandrovska" EAD

    Sofia, 1431

  • UMHAT 'Tsaritsa Yoanna - ISUL', EAD

    Sofia, 1527

  • Fourth MHAT - Sofia EAD

    Sofia, 1606

  • Diagnostic Consultation Center CONVEX EOOD

    Sofia, 1680

  • Medical Center Kalimat

    Sofia, 1680

  • UMHAT 'Sveta Anna' AD

    Sofia, 1750

  • MC "Synexus - Sofia", EOOD

    Sofia, 1784

  • UMHAT "SofiaMed", OOD

    Sofia, 1797

  • MC "Orfey", EOOD

    Stara Zagora, 6000

  • SHATC "Cardiolife", OOD

    Varna, 9000

  • SHATC - Varna, EOOD

    Varna, 9002

  • MHAT "Sv. Panteleymon", AD

    Yambol, 8600

Other trials in Bulgaria

India31 sites

  • Ahmedabad Bariatrics and Cosmetics Pvt Ltd.

    Ahmedabad, Gujarat, 380015

  • S. A. L. Hospital & Medical Institute

    Ahmedabad, Gujarat, 380054

  • Fortis Hospitals Ltd.

    Bangalore, Karnataka, 560052

  • K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre

    Belagavi, Karnataka, 590010

  • Institute of Medical Sciences and SUM Hospital

    Bhubaneswar, Odisha, 751003

  • SRM Institutes for Medical Sciences

    Chennai, Tamil Nadu, 600026

  • Institute of Cardiovascular Diseases Madras Medical Mission

    Chennai, Tamil Nadu, 600037

  • Maharaja Agrasen Hospital

    Delhi, 110052

  • Medanta The Medicity

    Gurgaon, Haryana, 122001

  • GNRC Hospital

    Guwahati, Assam, 781006

  • Eternal Heart Care Centre

    Jaipur, Rajasthan, 302020

  • IPGMER and SSKM Hospital

    Kolkata, West Bengal, 700020

  • KRM Hospital & Research Centre

    Lucknow, Uttar Pradesh, 226010

  • JSS Hospital

    Mysuru, Karnataka, 570004

  • DDMM Heart Institute

    Nadiād, Gujarat, 387002

  • Meditrina Institute Of Medical Sciences

    Nagpur, Maharashtra, 440010

  • Supe Heart & Diabetes Hospital & Research Centre

    Nashik, Maharashtra, 422002

  • Vijaya Super Speciality Hospital

    Nellore, Andhra Pradesh, 524001

  • Loknayak Hospital

    New Delhi, National Capital Territory of Delhi, 110002

  • Sir Gangaram Hospital

    New Delhi, National Capital Territory of Delhi, 110060

  • Fortis Flight Lieutenant Rajan Dhall Hospital

    New Delhi, National Capital Territory of Delhi, 110070

  • 7-Orange Hospital

    Pimpri-Chinchwad, Maharashtra, 411033

  • Shree Multispecialty Hospital

    Pune, Maharashtra, 411006

  • King Edward Memorial Hospital Research Centre

    Pune, Maharashtra, 411011

  • Shri B. D. Mehta Mahavir Heart Institute

    Surat, Gujarat, 395002

  • BAPS Pramukhswami Hospital

    Surat, Gujarat, 395009

  • Medical College

    Thiruvananthapuram, Kerala, 695 011

  • Aashirwad Hospital

    Ulhasnagar, Maharashtra, 421001

  • Sterling Hospital

    Vadodara, Gujarat, 390007

  • Rhythm Heart Institute

    Vadodara, Gujarat, 391740

  • Galaxy Hospital

    Varanasi, Uttar Pradesh, 221010

Other trials in India

Argentina29 sites

  • Hospital Interzonal General de Agudos Dr Jose Penna

    Bahía Blanca, Buenos Aires, 8000

  • Hospital Italiano Regional del Sur

    Bahía Blanca, Buenos Aires, B8001HXM

  • Centro Medico Viamonte SRL

    Buenos Aires, Ciudad Autonoma Buenos Aires, C1120AAC

  • Hospital Sirio Libanes

    Caba, Ciudad Autonoma Buenos Aires, C1419GEP

  • Hospital Italiano

    Ciudad Autonoma Buenos Aires, Buenos Aires, C1181ACH

  • Consultorio Dr. Litvak Bruno

    Ciudad Autonoma Buenos Aires, 1406

  • Fundacion Favaloro

    Ciudad Autonoma Buenos Aires, C1093AAS

  • CIPREC

    Ciudad Autonoma Buenos Aires, C1119ACN

  • Investigaciones Medicas IMOBA S.R.L

    Ciudad Autonoma Buenos Aires, C1179AAB

  • Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada

    Ciudad Autonoma Buenos Aires, C1425AGC

  • CEDIC Centro de Investigaciones Clinicas

    Ciudad Autonoma Buenos Aires, C1425DES

  • Instituto Cardiovascular Buenos Aires

    Ciudad Autonoma Buenos Aires, C1428ART

  • CCBR - Buenos Aires - AR

    Ciudad Autonoma Buenos Aires, C1430CKE

  • Sanatorio Güemes

    Ciudad Autonoma de Bs. As., Ciudad Autonoma Buenos Aires, C1180AAX

  • Inst. Privado de Inv. Clinicas de Cordoba

    Córdoba, X5000AAW

  • Instituto Medico DAMIC

    Córdoba, X5003DCE

  • Hospital Privado Centro Medico de Cordoba S.A

    Córdoba, X5016KEH

  • Clinica del Prado

    Córdoba, X5020AAA

  • Instituto de Cardiologia de Corrientes

    Corrientes, 3400

  • CICLO

    La Plata, Buenos Aires, B1902AGY

  • Centro de Investigaciones Medicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600FYK

  • Instituto de Investigaciones Clinicas

    Mar del Plata, Buenos Aires, B7600FZ

  • Prevencion Cardiovascular Salta

    Salta, A4400CRC

  • Axismed S.R.L.- Clínica Mayo

    San Miguel de Tucumán, Tucumán Province, 4000

  • Instituto de Investigaciones Clinicas San Nicolas

    San Nicolás de los Arroyos, Buenos Aires, B2900DMH

  • Instituto Clinico Metabolico

    San Nicolás de los Arroyos, Buenos Aires, B2900DPA

  • Centro Medico Luquez

    San Vicente, Córdoba Province, X5006CBI

  • Clinica Olivos

    Vicente López, Buenos Aires, 1602

  • CEMEDIC - Centro de Especialidades Medicas

    Villa Luro, Ciudad Autonoma Buenos Aires, C1440CFD

Other trials in Argentina

Slovakia29 sites

  • Alian s.r.o.

    Bardejov, 085 01

  • Thyreomedical s.r.o.

    Bardejov, 08501

  • Metabol KLINIK s.r.o.

    Bratislava, 81108

  • Galenum, s.r.o.

    Bratislava, 821 07

  • DIAFA s.r.o.

    Bratislava, 82102

  • Diabet, spol. s.r.o.

    Bratislava, 82108

  • Kardiovaskularne centrum, s.r.o.

    Bratislava, 83101

  • Kardiologicka, interna a sonograficka amb. Kardio-Sanus, sro

    Bratislava, 84108

  • MEDISPEKTRUM PLUS s.r.o.

    Bratislava, 85101

  • MUDr. Vladimir Gergel, s.r.o.

    Bratislava, 85101

  • ENDIAMED, s.r.o.

    Dolný Kubín, 02601

  • MEDICUS plus s.r.o.

    Komárno, 94501

  • Human-Care s.r.o.

    Košice, 04001

  • Sukromna interna a kardiologicka ambulancia

    Košice, 04001

  • DIA- Kontrol s.r.o.

    Levice, 93401

  • CELL B, s.r.o.

    Levice, 93405

  • KARDIO 1 s.r.o.

    Lučenec, 984 39

  • IN-DIA s.r.o.

    Lučenec, 98401

  • MUDr. Zuzana Ochodnicka,

    Nitra, 94911

  • Fakultna nemocnica s poliklinikou Nove Zamky

    Nové Zámky, 94002

  • DIABETOL s.r.o.

    Prešov, 08001

  • Medispol s.r.o.

    Prešov, 08001

  • Nemocnica s poliklinikou sv. Barbory Roznava a.s.

    Rožňava, 04801

  • Peter Farkas MD, s.r.o.

    Šahy, 93601

  • Interna SK s.r.o.

    Svidník, 08901

  • Nemocnica arm. generala L. Svobodu Svidnik, a.s.,

    Svidník, 08901

  • Diabetes centrum, s.r.o.

    Trenčín, 91101

  • JAL s.r.o.

    Trnava, 91701

  • MEDIVASA s.r.o.

    Žilina, 01001

Other trials in Slovakia

Hungary28 sites

  • Lausmed Kft.

    Baja, 6500

  • Principal SMO Kft.

    Baja, 6500

  • DRC Gyogyszervizsgalo Kozpont Kft.

    Balatonfüred, 8230

  • Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz

    Békéscsaba, 5600

  • Belgyogyaszati es Kardiologiai Maganrendelo

    Békéscsaba, 5600

  • Clinexpert Kft.

    Budapest, 1033

  • Synexus Magyarorszag Kft.

    Budapest, 1036

  • CSALADGYOGYASZ Kft.

    Budapest, 1083

  • Semmelweis Egyetem

    Budapest, 1083

  • Borvo Clinic Kft.

    Debrecen, 4025

  • Debreceni Egyetem

    Debrecen, 4032

  • Meditoll Kft.

    Gödöllő, 2100

  • Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaza

    Gyula, 5700

  • Synexus Magyarorszag Egeszsegugyi Szolgaltato Kft.- Gyula DRS

    Gyula, 5700

  • BKS Research Kft.

    Hatvan, 3000

  • Z+P MED Egeszsegugyi, Kereskedelmi es Szolgaltato Bt.

    Kalocsa, 6300

  • Somogy Megyei Kaposi Mor Oktato Korhaz

    Kaposvár, 7400

  • Selye Janos Korhaz

    Komárom, 2900

  • IPR Hungary Kft.

    Miskolc, 3530

  • Kanizsai Dorottya Korhaz

    Nagykanizsa, 8800

  • Medifarma-98 Kft.

    Nyíregyháza, 4400

  • BORBANYA PRAXIS Kft.

    Nyíregyháza, H-4405

  • Dr. Nagy Laszlo Kardiologiai Maganrendeles

    Orosháza, 5900

  • Da Vinci Maganklinika

    Pécs, 7635

  • Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz

    Székesfehérvár, 8000

  • Tolna Megyei Balassa Janos Korhaz

    Szekszárd, 7100

  • Csolnoky Ferenc Korhaz

    Veszprém, 8200

  • Zala Megyei Szent Rafael Korhaz

    Zalaegerszeg, 8900

Other trials in Hungary

Germany27 sites

  • Neurologische Praxis Dr. Schoell & Kollegen

    Bad Homburg, Hesse, 61348

  • Diabetespraxis Prenzlauer Allee

    Berlin, 10409

  • Institut fuer klinische Forschung und Entwicklung Berlin GmbH

    Berlin, 10437

  • Studienzentrum Rankestrasse

    Berlin, 10789

  • Synexus Clinical Research GmbH

    Berlin, 12627

  • Synexus Clinical Research GmbH

    Bochum, North Rhine-Westphalia, 44787

  • Gemeinschaftspraxis Diabeteszentrum Dortmund Dr.med. Klaus Busch

    Dortmund, North Rhine-Westphalia, 44137

  • Kardiologische Praxis Gemeinschaftspraxis

    Dortmund, North Rhine-Westphalia, 44137

  • St. Johannes Hospital

    Dortmund, North Rhine-Westphalia, 44137

  • Klinikum Bielefeld gem. GmbH

    Dortmund, North Rhine-Westphalia, 44139

  • ZKS-Südbrandenburg -center for clinical studies Südbrandenburg GmbH

    Elsterwerda, Brandenburg, 04910

  • Katholisches Krankenhaus "St. Johann Nepomuk"

    Erfurt, Thuringia, 99097

  • Synexus Clinical Research GmbH

    Frankfurt am Main, Hesse, 60313

  • ClinPhenomics GmbH & Co KG

    Frankfurt am Main, Hesse, 60596

  • Universitaetsklinikum Freiburg

    Freiburg im Breisgau, Baden-Wurttemberg, 79106

  • Gemeinschaftspraxis fuer innere Medizin und Diabetologie

    Hamburg, 22607

  • Gemeinschaftspraxis Dr. Klein/ Minnich

    Künzing, Bavaria, 94550

  • Synexus Clinical Research GmbH

    Leipzig, Saxony, 04103

  • Gemeinschaftspraxis Dr. Taeschner / Dr. Bonigut

    Leipzig, Saxony, 04249

  • Klinikum der Universitaet Muenchen

    Munich, Bavaria, 80336

  • Deutsches Herzzentrum Muenchen

    Munich, Bavaria, 80636

  • GP Dr. Haggenmiller, PD Dr. Michael Jeserich

    Naumburg, Bavaria, 90402

  • Dr. Uwe Böckmann / Birgit Jacobs - Diabeteszentrum Neumünster

    Neumünster, Schleswig-Holstein, 24534

  • RED - Institut GmbH

    Oldenburg in Holstein, Schleswig-Holstein, 23758

  • Klinische Forschung Schwerin GmbH

    Schwerin, Mecklenburg-Vorpommern, 19055

  • Zentrum fuer Praevention und Rehabilitation

    Siegen, North Rhine-Westphalia, 57072

  • Praxis fuer Praevention und Therapie

    Villingen-Schwenningen, Baden-Wurttemberg, 78048

Other trials in Germany

Netherlands27 sites

  • Noordwest Ziekenhuisgroep

    Alkmaar, 1815 JD

  • Ziekenhuisgroep Twente, Almelo

    Almelo, 7609 PP

  • Meander Medisch Centrum

    Amersfoort, 3813 TZ

  • Ziekenhuis Amstelland

    Amstelveen, 1186 AM

  • BovenlJ Ziekenhuis

    Amsterdam, 1034 CS

  • Amsterdam UMC, Locatie AMC

    Amsterdam, 1105 AZ

  • Gelre ziekenhuizen, locatie Lukas

    Apeldoorn, 7334 DZ

  • Rijnstate

    Arnhem, 6815 AD

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Albert Schweitzer Ziekenhuis, Dordwijk

    Dordrecht, 3318 AT

  • Gelderse Vallei Ziekenhuis, Ede

    Ede, 6716 RP

  • Catharina Ziekenhuis Eindhoven

    Eindhoven, 5623 EJ

  • Spaarne Gasthuis, Hoofddorp

    Haarlem, 2035 RC

  • Zuyderland Medisch Centrum - Heerlen

    Heerlen, 6419 PC

  • Huisartsenpraktijk Gorecht

    Hoogezand, 9603 AE

  • Quality Care Research

    Kloosterhaar, 7694 AC

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA

  • Bravis Ziekenhuis, Roosendaal

    Roosendaal, 4708 AE

  • Maasstad Ziekenhuis, Zuider

    Rotterdam, 3079 DZ

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN

  • Albert Schweitzer Ziekenhuis, Zwijndrecht

    Sliedrecht, 3331 LZ

  • Haga Ziekenhuis

    The Hague, 2545 AA

  • Bernhoven Uden

    Uden, 5406 PT

  • UMC Utrecht

    Utrecht, 3508 GA

  • Diakonessenhuis, Utrecht

    Utrecht, 3582 KE

  • Maxima Medisch Centrum

    Veldhoven, 5504 DB

  • VieCuri Medisch Centrum

    Venlo, 5912 BL

Other trials in Netherlands

Czechia26 sites

  • Medicentrum Beroun spol. s.r.o.

    Beroun, 266 01

  • Nemocnice Milosrdnych bratri

    Brno, 639 00

  • Fakultni nemocnice u sv. Anny v Brne

    Brno, 65691

  • EDUMED s.r.o

    Broumov, 550 01

  • Poliklinika Chocen a.s.

    Choceň, 56501

  • Ordinace pro choroby srdce s.r.o.

    Chomutov, 430 02

  • MUDr. Jan Hubac s.r.o.

    Chrudim, 537 01

  • Nemocnice Havlickuv Brod p.o.

    Havlíčkův Brod, 580 22

  • Kardio-Pisova s.r.o.

    Hradec Králové, 500 02

  • MUDr. Tomas Edelsberger

    Krnov, 794 01

  • EDUMED s.r.o

    Náchod, 547 01

  • Agentura Science Pro Spol. s.r.o.

    Olomouc, 772 00

  • PreventaMed s.r.o.

    Olomouc, 77900

  • CCR Ostrava s.r.o.

    Ostrava, 702 00

  • MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna

    Prague, 101 00

  • Nemocnice na Frantisku

    Prague, 110 00

  • Synexus Czech s.r.o.

    Prague, 120 00

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 00

  • Corintez s.r.o.

    Prague, 158 00

  • ResTrial s.r.o.

    Prague, 18100

  • MUDr.Eva Mandakova MBA

    Rakovník, 269 01

  • Nemocnice Slany

    Slaný, 274 01

  • AeskuLab k.s.

    Teplice, 415 01

  • Kardiologicka ambulance MUDr. Ferkl s.r.o.

    Trutnov, 541 01

  • Clinical Trials Services s.r.o

    Uherské Hradiště, 68601

  • MUDr. Nina Zemkova s.r.o.

    Uherské Hradiště, 68601

Other trials in Czechia

South Africa22 sites

  • Cardiology Clinical Research

    Alberton, Gauteng, 1449

  • Synexus Helderberg Clinical Research Centre

    Cape Town, Western Cape, 7130

  • Corbod Research

    Cape Town, Western Cape, 7500

  • Tread Research

    Cape Town, Western Cape, 7500

  • Tiervlei Trial Centre

    Cape Town, Western Cape, 7530

  • Cape Town Medical Research Centre

    Cape Town, Western Cape, 7580

  • Paarl Research Centre

    Cape Town, Western Cape, 7646

  • Groote Schuur Hospital Lipid Laboratory

    Cape Town, Western Cape, 7925

  • Johese Clinical Research: Unitas

    Centurion, Gauteng, 0157

  • Medicross Roodepoort Clinical Research

    Johannesburg, Gauteng, 1724

  • Lenasia Clinical Trial Centre

    Johannesburg, Gauteng, 1827

  • Wits Clinical Research

    Johannesburg, Gauteng, 2013

  • Clinresco Centres (Pty) Ltd

    Kempton Park, Gauteng, 1619

  • Synexus SA - Stanza Clinical Research Centre

    Mamelodi East, Gauteng, 0122

  • Dr AA Mahomed Medical Centre

    Moloto South, Mpumalanga, 1022

  • Seeber, M

    Pretoria, Gauteng, 0002

  • Emmed Research

    Pretoria, Gauteng, 0084

  • Synexus SA Watermeyer Clinical Research Centre

    Pretoria, Gauteng, 0184

  • Johese Clinical Research: Midstream

    Pretoria, Gauteng, 1692

  • Dr JM Engelbrecht Practice

    Somerset West, Western Cape, 7130

  • Helderberg Research Institute

    Somerset West, Western Cape, 7130

  • Limpopo Clinical Research Initiative

    Thabazimbi, Limpopo, 0380

Other trials in South Africa

United Kingdom21 sites

  • Synexus Birmingham Clinical Research Centre

    Birmingham, West Midlands, B15 2SQ

  • Waterloo Medical Centre

    Blackpool, Lancashire, FY4 3AD

  • Synexus Wales Clinical Research Centre

    Cardiff, South Glamorgan, CF15 9SS

  • Broomfield Hospital

    Chelmsford, Essex, CM1 7ET

  • Synexus Lancashire Clinical Research Centre

    Chorley, Lancashire, PR7 7NA

  • Ninewells Hospital

    Dundee, Tayside Region, DD1 9SY

  • Synexus Scotland Clinical Research Centre

    Glasgow, Strathclyde, G20 OSP

  • Mounts Bay Medical Ltd

    Hayle, Cornwall, TR27 5DT

  • Synexus Hexham General Hospital

    Hexham, Northumberland, NE46 1QJ

  • Oak Tree Surgery

    Liskeard, Cornwall, PL14 3XA

  • Synexus Merseyside Clinical Research Centre

    Liverpool, Merseyside, L22 0LG

  • Barts Hospital

    London, Greater London, EC1A 7BE

  • Manchester Royal Infirmary

    Manchester, Greater Manchester, M13 9WL

  • Synexus Manchester Clinical Research Centre

    Manchester, Greater Manchester, M15 6SX

  • The Alverton Practice

    Penzance, Cornwall, TR18 4JH

  • Knowle House Surgery

    Plymouth, Devon, PL5 3JB

  • Synexus Thames

    Reading, Berkshire, RG2 0TG

  • Synexus Clinical Research North Tees

    Stockton-on-Tees, Durham, TS19 8PE

  • Morriston Hospital

    Swansea, SA6 6NL

  • Rame Medical Limited

    Torpoint, Cornwall, PL11 2TB

  • Torbay Hospital

    Torquay, Devon, TQ2 7AA

Other trials in United Kingdom

Romania19 sites

  • S.C. CMI Dr. Pletea Noemi S.R.L

    Bacau, 600154

  • Cabinet Medical Individual Diabet, Nutritie, Boli Metabolice Dr. Pop Lavinia

    Baia Mare, 430222

  • S.C Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L

    Brasov, 500283

  • S.C Clinica Medicala Data Plus S.R.L

    Bucharest, 010192

  • Spitalul Clinic Colentina

    Bucharest, 020125

  • Spitalul Clinic de Urgenta "Sfantul Pantelimon"

    Bucharest, 021659

  • Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu"

    Bucharest, 022328

  • S.C. Health Net S.R.L

    Bucharest, 030088

  • S.C Policlinica CCBR S.R.L

    Bucharest, 030463

  • CMI Dr. Stolea T. Violeta - Medic specialist diabet zaharat, nutritie si boli metabolice

    Bucharest, 061072

  • S.C. Medcon S.R.L.

    Buzău, 120203

  • S.C Grandmed S.R.L

    Oradea, 410159

  • S.C Pelican Impex S.R.L

    Oradea, 410469

  • S.C. Bella Praxis S.R.L

    Pașcani, 705200

  • S.C. Diabmed Dr. Popescu Alexandrina S.R.L

    Ploieşti, 100163

  • CMI Dr Busegeanu Mihaela Magdalena

    Ploieşti, 100342

  • S.C Mediab S.R.L

    Târgu Mureş, 540142

  • S.C Medicali's S.R.L

    Timișoara, 300359

  • Spitalul Clinic Judetean de Urgenta "Pius Brinzeu"

    Timișoara, 300723

Other trials in Romania

Mexico18 sites

  • Centro de Investigacion Clinica del Pacifico, S.A. de C.V.

    Acapulco de Juárez, Guerrero, 39670

  • Centro de Investigacion Cardiometabolica de Aguascalientes S.A de C.V

    Aguascalientes, 20230

  • Investigacion En Salud Y Metabolismo S.C.

    Chihuahua City, 31237

  • Instituto de Diabetes, Obesidad y Nutrición S.C.

    Cuautla, Morelos, 62746

  • Cardiologia Clinica e Intervencionista

    Guadalajara, Jalisco, 44670

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares S.C.

    Madero, Tamaulipas, 89440

  • Phytomedicamenta S.A. de C.V.

    Mexico City, Mexico City, 03100

  • Health Pharma Professional Research S.A. de C.V.

    Mexico City, Mexico City, 03810

  • Centro de Atención e Investigación en Factores de Riesgo Cardiovascular Omega S.C.

    Mexico City, Mexico City, 06700

  • Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran

    Mexico City, Mexico City, 14080

  • Mentrials S.A. de C.V.

    Mexico City, Mexico City, 67000

  • Universidad Autonoma de Nuevo Leon, Hospital Universitario Dr. Jose Eleuterio Gonzalez

    Monterrey, Nuevo León, 64460

  • Centro Medico San Francisco

    Monterrey, Nuevo León, 64710

  • Centro Integral Medico SJR S.C.

    San Juan del Río, Querétaro, 76800

  • Unidad Medica para la Salud Integral

    San Nicolás de los Garza, Nuevo León, 66465

  • Centro de Investigacion Cardiovascular y Metabolica

    Tijuana, Baja California Norte, 22500

  • Sociedad de Metabolismo y Corazon S.C

    Veracruz, 91900

  • Centro de Investigacion Medica de Occidente, S.C.

    Zapopan, Jalisco, 45116

Other trials in Mexico

Spain15 sites

  • Complejo Hospitalario Universitario A Coruña

    A Coruña, La Coruña, 15006

  • Hospital Virgen del Mar

    Almería, 04120

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Barcelona, 08916

  • Hospital del Mar

    Barcelona, 08003

  • Hospital Quironsalud Barcelona

    Barcelona, 08023

  • Hospital de la Santa Creu i Sant Pau

    Barcelona, 08025

  • Hospital Universitari Vall d'Hebron

    Barcelona, 08035

  • Hospital Universitario Reina Sofia

    Córdoba, Córdoba, 14004

  • Hospital Universitario Ramon y Cajal

    Madrid, 28034

  • Hospital Regional Universitario de Malaga

    Málaga, 29010

  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, Cádiz, 11540

  • Complejo Hospitalario Universitario de Santiago

    Santiago de Compostela, La Coruña, 15706

  • Nuevas tecnologías en Diabetes y Endocrinología

    Seville, 41003

  • Hospital Quironsalud Infanta Luisa

    Seville, 41010

  • Hospital Universitario Virgen Macarena

    Seville, 41071

Other trials in Spain

Denmark14 sites

  • Bioclinica

    Aalborg, 9000

  • Ålborg Universitets Hospital

    Aalborg, 9100

  • Aarhus University Hospital

    Aarhus, 8200

  • Bioclinica

    Ballerup Municipality, 2750

  • Amager-Hvidovre Hospital

    Copenhagen S, 2300

  • Sydvestjyds Sygehus Esbjerg

    Esbjerg, 6700

  • Amager-Hvidovre Hospital

    Glostrup Municipality, 2600

  • Herlev og Gentofte Hospital

    Hellerup, 2900

  • Herlev og Gentofte Hospital

    Herlev, 2730

  • Regionshospitalet Herning-Hospitalsenheden Vest

    Herning, 7400

  • Holbæk Sygehus

    Holbæk, 4300

  • Sjællands Universitetshospital

    Roskilde, 4000

  • OUH

    Svendborg, 5700

  • Bioclinica

    Vejle, 7100

Other trials in Denmark

Israel14 sites

  • HaEmek Medical Center

    Afula, 18101

  • Bnai Zion Medical Center

    Haifa, 31048

  • Rambam Health Care Center

    Haifa, 3109601

  • The Lady Davis Carmel Medical Center

    Haifa, 34362

  • Wolfson Medical Center

    Holon, 58100

  • Shaare Zedek Medical Center

    Jerusalem, 91031

  • Hadassah University Hospital - Ein Kerem

    Jerusalem, 91120

  • Galilee Medical Center

    Nahariya, 2210001

  • Rabin Medical Center-Beilinson Campus

    Petah Tikva, 49100

  • Chaim Sheba Medical Center

    Ramat Gan, 52621

  • Kaplan Medical Center

    Rehovot, 7610001

  • Ziv Medical Center

    Safed, 13100

  • Tel Aviv Sourasky Medical Center

    Tel Aviv, 6423906

  • Diabetes Medical Center

    Tel Aviv, 6937947

Other trials in Israel

Colombia8 sites

  • Centro de Investigacion Medico Asistencial S.A.S

    Barranquilla, 080020

  • IPS Centro Cientifico Asistencial S.A.S

    Barranquilla, 080020

  • Dexa Diab Servicios Médicos Limitada.

    Bogotá, 110221

  • Solano y Terront Servicios Médicos Ltda.

    Bogotá, 110221

  • Centro Cardiovascular Aristides Sotomayor Santa Lucia S.A.S. - IPS ASTALUC S.A.S. IPS

    Cartagena, 130010

  • Fundación Centro de Investigaciones Biomédicas Riescard

    Espinal, 00000

  • Fundación Oftalmológica de Santander - FOSCAL

    Floridablanca, 681004

  • Centro de Investigación Clínica CIC

    Medellín, 050021

Other trials in Colombia

France3 sites

  • CHU Tours - Hôpital Trousseau

    Chambray-lès-Tours, Indre Et Loire, 37170

  • CHU Nantes - Hopital Nord Laënnec

    Nantes, Loire Atlantique, 44093

  • Hôpital Bichat - Claude Bernard

    Paris, Paris, 75877

Other trials in France

Puerto Rico1 site

  • VA Medical Center - San Juan

    San Juan, 00927-5800

Other trials in Puerto Rico

About this study

The primary objective of the study is to determine whether pemafibrate administered twice daily will delay the time to first occurrence of any component of the clinical composite endpoint of:

  • nonfatal Myocardial Infarction (MI)
  • nonfatal ischemic stroke
  • coronary revascularization; or
  • Cardio Vascular (CV) death.
Read the detailed description

A multi-regional clinical trial with participating sites in the following countries. India is being conducted under a previous protocol version due to regulatory requirements.

  • Argentina
  • Brazil
  • Bulgaria
  • Canada
  • Colombia
  • Czech Republic
  • Denmark
  • France
  • Germany
  • Hungary
  • India
  • Israel
  • Japan
  • Mexico
  • Netherlands
  • Poland
  • Romania
  • Russian Federation
  • Slovakia
  • South Africa
  • Spain
  • Ukraine
  • United Kingdom
  • United States
Being tested
K-877, Placebo
Medical subject headings
Dyslipidemias

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • K-877Drug

    Also called pemafibrate

    0.2mg tablet

  • PlaceboDrug

    K-877 matching placebo tablet

Study groups in NCT03071692
Study groupRoleWhat they receive
Treatment GroupExperimentalK-877 (pemafibrate) tablet twice daily.
Receives: Drug: K-877
Control GroupPlacebo comparatorMatching K-877 placebo tablet twice daily.
Receives: Drug: Placebo

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of Participants With First Occurrence of 4-component Composite Primary Endpoint (Nonfatal MI, Nonfatal Ischemic Stroke, Coronary Revascularization, or CV Death)

    Number of participants experiencing their first occurrence of any component of the 4-component composite primary endpoint, which includes nonfatal myocardial infarction (MI), nonfatal ischemic stroke, coronary revascularization, or cardiovascular (CV) death. Each participant is counted only once, regardless of any subsequent events.

    Measured: From Baseline to a Median of 3.3 Years

Secondary outcomes (20)

  1. Number of Participants With First Occurrence of the 4-component Composite Secondary Endpoint (Nonfatal MI, Nonfatal Ischemic Stroke, Hospitalization for Unstable Angina Requiring Unplanned Coronary Revascularization, or CV Death)

    The 4-component composite secondary endpoints events are nonfatal myocardial infarction, nonfatal ischemic stroke, hospitalization for unstable angina requiring unplanned coronary revascularization, or cardiovascular death

    Measured: From Baseline to a Median of 3.3 Years

  2. Number of Participants With First Occurrence of the 3-component Composite Endpoint (Nonfatal Myocardial Infarction, Nonfatal Ischemic Stroke, or Cardiovascular Death)

    Number of Participants with First Occurrence of Composite Cardiovascular Events (nonfatal myocardial infarction, nonfatal ischemic stroke, or cardiovascular death)

    Measured: From Baseline to a Median of 3.3 Years

  3. Number of Participants With First Occurrence of Any Component of the Primary Endpoint or Hospitalization for Heart Failure

    Event is the first occurrence of any component of the composite endpoint of nonfatal myocardial infarction, nonfatal ischemic stroke, coronary revascularization, cardiovascular death, or hospitalization for heart failure

    Measured: From Baseline to a Median of 3.3 Years

  4. Number of Participants With Occurrence of Any Component of the Primary Endpoint or All-Cause Mortality

    Event is the first occurrence of any component of the composite endpoint of nonfatal myocardial infarction, nonfatal ischemic stroke, coronary revascularization, cardiovascular death, or all-cause mortality.

    Measured: From Baseline to a Median of 3.3 Years

  5. Total Number of Events of the 4-component Composite Primary Endpoint

    Total number of events for the 4-component composite primary endpoint, counting all occurrences, including multiple events in the same participant. The endpoint events include nonfatal myocardial infarction (MI), nonfatal ischemic stroke, coronary revascularization, and cardiovascular (CV) death.

    Measured: From Baseline to a Median of 3.3 Years

  6. Number of Participants With First Occurrence of Any New or Worsening Peripheral Artery Disease (PAD)

    Any new or worsening Peripheral artery disease (PAD), defined as incidence of lower extremity revascularization, intermittent claudication, rest pain, lower extremity ischemic ulceration, or major amputation with either ankle-brachial index ≤ 0.9 or other diagnostic testing (eg, toe-brachial index, angiogram, or other imaging study)

    Measured: From Baseline to a Median of 3.3 Years

  7. Number of Participants With First Occurrence of Nonfatal Myocardial Infarction

    Measured: From Baseline to a Median of 3.3 Years

  8. Number of Participants With First Occurrence of Nonfatal Ischemic Stroke

    Measured: From Baseline to a Median of 3.3 Years

  9. Number of Participants With First Occurrence of Coronary Revascularization

    Measured: From Baseline to a Median of 3.3 Years

  10. Number of Participants With First Occurrence of Cardiovascular Death

    Measured: From Baseline to a Median of 3.3 Years

  11. Number of Participants With First Occurrence of the 4-component Composite Endpoint by PPAR-α Gene Variant Subgroup (TT, CT, CC)

    Number of participants experiencing their first occurrence of any component of the 4-component composite primary endpoint (nonfatal myocardial infarction, nonfatal ischemic stroke, coronary revascularization, or cardiovascular death), reported as a subgroup analysis by PPAR-α gene variants (TT, CT, CC).

    Measured: From Baseline to a Median of 3.3 Years

  12. Percent Change From Baseline to Month 4 for Total Cholesterol (TC)

    Measured: Baseline to Month 4

  13. Percent Change From Baseline to Month 4 for Fasting Triglycerides

    Measured: Baseline to 4 Months

  14. Percent Change From Baseline to Month 4 for HDL - Cholesterol (HDL-C)

    Measured: Baseline to Month 4

  15. Percent Change From Baseline to Month 4 for Calculated Non-HDL Cholesterol (Non-HDL-C)

    Measured: Baseline to Month 4

  16. Percent Change From Baseline to Month 4 for Calculated VLDL Cholesterol

    Measured: Baseline to Month 4

  17. Percent Change From Baseline to Month 4 for Apolipoprotein A1 (ApoA1)

    Measured: Baseline to Month 4

  18. Percent Change From Baseline to Month 4 for Apolipoprotein CIII (ApoC3)

    Measured: Baseline to Month 4

  19. Percent Change From Baseline to Month 4 for Apolipoprotein E (ApoE)

    Measured: Baseline to Month 4

  20. Percent Change From Baseline to Month 6 for Non-fasting Remnant Cholesterol

    Measured: Baseline to Month 6

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted7 Mar 2017
  2. Study start23 Mar 2017
  3. Primary completion27 Jul 2022
  4. Study completion27 Jul 2022

Why it stopped: The study was stopped for futility based on efficacy results at the interim analysis; no unexpected safety findings were observed.

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
10,544 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03071692
Sponsor's protocol ID
K-877-302
Acronym
PROMINENT
Status last verified
Sep 2025
First submitted
23 Feb 2017
Last updated
25 Sep 2025
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No

Publications

  • Das Pradhan A, Glynn RJ, Fruchart JC, MacFadyen JG, Zaharris ES, Everett BM, Campbell SE, Oshima R, Amarenco P, Blom DJ, Brinton EA, Eckel RH, Elam MB, Felicio JS, Ginsberg HN, Goudev A, Ishibashi S, Joseph J, Kodama T, Koenig W, Leiter LA, Lorenzatti AJ, Mankovsky B, Marx N, Nordestgaard BG, Pall D, Ray KK, Santos RD, Soran H, Susekov A, Tendera M, Yokote K, Paynter NP, Buring JE, Libby P, Ridker PM; PROMINENT Investigators. Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk. N Engl J Med. 2022 Nov 24;387(21):1923-1934. doi: 10.1056/NEJMoa2210645. Epub 2022 Nov 5.

    PubMed 36342113

  • Pradhan AD, Paynter NP, Everett BM, Glynn RJ, Amarenco P, Elam M, Ginsberg H, Hiatt WR, Ishibashi S, Koenig W, Nordestgaard BG, Fruchart JC, Libby P, Ridker PM. Rationale and design of the Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes (PROMINENT) study. Am Heart J. 2018 Dec;206:80-93. doi: 10.1016/j.ahj.2018.09.011. Epub 2018 Sep 29.

    PubMed 30342298

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing K-877 in people with Type2 Diabetes and Dyslipidemia, run by Kowa Research Institute, Inc. at 888 sites in 25 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 11 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: stopped early, as of the sponsor's last update on 25 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 888 sites in United States, Japan, Canada, Ukraine, Russia and 20 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 25 Sep 2025). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of Participants With First Occurrence of 4-component Composite Primary Endpoint (Nonfatal MI, Nonfatal Ischemic Stroke, Coronary Revascularization, or CV Death) (time frame: From Baseline to a Median of 3.3 Years). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03071692, which also lists 2 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Sep 2025.

AzTrials uses cookies for analytics and advertising. You can accept or reject them; the site works either way. Privacy Policy.

Free account

Log in to keep searching

You’ve used your 3 free searches. AzTrials is free: log in or create a free account to keep searching clinical trials and save the ones you want to follow.

Create a free accountLog in