Cerebellum DiseaseNCT03112408
Eye Movements and Visuo-spatial Perception
A study testing Forward adaptation of reactive saccades, Backward adaptation of reactive saccades and Execution of reactive saccades in people with Cerebellum Disease, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
This research aims to highlight the key roles of the cerebellar and cortical fronto-parietal networks in the coupling of eye movements with visual perception and visuo-spatial attention. Read more about this study
- Who is it for?
- Ages 18 to 80 yearsHealthy volunteers can take part
- Conditions the study is for
- Cerebellum Disease
- What is being tested?
- Forward adaptation of reactive saccades, Backward adaptation of reactive saccades and Execution of reactive saccades
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 24 participants
- Where
- 1 siteFrance
- Study dates
- 26 Sep 2018to 2 Oct 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Age : from 18 to 80 ans included
- Visual acuity monocularly at distance and near corrected : > 5/10
- Possible understanding of experimental guidelines
- Possible respect for sustained seated position
- Subject covered by social security
- Agreement of the subject
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- Cerebellar patients - Cerebellar degenerative disease (group A) or stroke (group B, délai depuis l'AVC : delay from the stroke : at least 1 month)
- Scanner or MRI showing diffuse atrophy (group A) or focal cerebellar lesion (group B)
- Healthy subjects
- Absence of known ophtalmological or neurological pathology
- Stroke patients - ischemic or hemorrhagic stroke
- Encephalic MRI or CT scan showing an unique lesion
- Minimal delay of one year after the stroke
Who cannot join
- Visual acuity monocularly < 5/10
- Language disorder restricting oral and reading comprehension of the study
- Severe disability limiting the maintenance of sitting position and concentration capacities for a period of 30 minutes consecutive
- Poor French language skills
- Non-stabilized medical condition
- Psychotropic medication intake
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- Pregnant and / or nursing women
- Subject under guardianship or curatorship
- Subject frequently in healthcare or social care for purposes other than research
- Subject deprived of liberty by a judicial or administrative decision
- Cerebellar patients
- Disorders prohibiting the correct performance of the task (tremor, ocular instability)
- Stroke patients
- Hemianopsia homonima lateral
- Neurological degenerative disease
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Coupling Between Adaptation of Saccadic Eye Movements and Visuo-spatial Perception and Attention Processes: a Behavioural Study in Humans.
This research aims to highlight the key roles of the cerebellar and cortical fronto-parietal networks in the coupling of eye movements with visual perception and visuo-spatial attention.
Read the detailed description
The first axe of this research focuses on the role of the cerebellum which has a major contribution to sensorimotor adaptation and more precisely in saccadic adaptation but the nature of this contribution is still debated. A classical assumption stipulates cerebellum has an exclusive action on saccadic burst generator in the brainstem whereas recent data increasingly support the view that cerebellum could also modulates cerebral cortex through a cerebello-thalamo-cortical pathway. On the other hand, several studies have shown that modification of saccade amplitude by saccadic adaptation leads to a distortion of the visual localization of briefly flashed spatial probes but no study to date has tested, the contribution of the cerebellum in these adaptation-induced mislocalizations. The main objective of this axe is to define the role of the cerebellum not only in saccadic adaptation, but also in mislocalizations which occur after adaptation. Moreover, in testing this assumption, arguments in favour -or in disfavor- of the action of the cerebellum on cortical stages dedicated to visuo-spatial perceptual processing will be provided. Besides, variability of cerebellar lesion (or cerebellar dysfunction) location in patients can lead to different pattern in saccadic adaptation and localization task performances. Identification of dissociations between these two abilities in some patients will define more precisely the role of the cerebellum in the coupling between saccadic adaptation and visuo spatial perception as an oculomotor plasticity territory and / or as a territory underlying the error signal coding generating this type of plasticity.
This second axe of this research aims to apply basic findings in healthy subject on the coupling between oculomotor plasticity and spatial attention to patients with parietal lesion, in order to evaluate a rehabilitation procedure for neglect patients. Habchi and colleagues showed that the adaptation of reactive saccades in the left hemifield has a boosting effect on attentional performance in the same hemifield. The coupling between these two mechanisms highlighted in healthy subjects can be used as fundamentals in the elaboration of a rehabilitation procedure for attentional disorders in the neglect syndrome. This syndrome is mainly observed after cerebral lesions in the right hemisphere, and is characterized by very disabling cognitive disorders such as an alteration of the spatial representation of left hemi-space and/or left hemi-body. stimulation of sensorimotor plasticity thanks to prismatic adaptation could be used as a rehabilitation procedure for this syndrome. Being another efficient way to stimulate sensorimotor plasticity, the equip believe that saccadic adaptation can also be used as a rehabilitation procedure for neglect patients. Moreover, due to its tight coupling with visual attention, the benefits of saccadic adaptation could be even stronger and longer lasting than the visuo-manual plasticity induced by prismatic adaptation.
- Conditions
- Cerebellum Disease
- Being tested
- Forward adaptation of reactive saccades, Backward adaptation of reactive saccades, Execution of reactive saccades, Generation of reactive saccades
- Keywords
- cerebellar lesion, saccadic adaptation, spatial localization, visuo spatial perception, eye movements
- Medical subject headings
- Cerebellar Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Forward adaptation of reactive saccadesBehavioural
Protocol of reactive saccade where the target is displaced in the same direction as the saccade in order to induce an adaptive increase of saccade amplitude ('forward adaptation')
Backward adaptation of reactive saccadesBehavioural
Protocol of reactive saccade where the target is displaced in a direction opposite to the saccade in order to induce an adaptive decrease of saccade amplitude ('backward adaptation')
Execution of reactive saccadesBehavioural
Control protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in forward and backward adaptation conditions)
Generation of reactive saccadesBehavioural
Control protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in adaptation condition)
| Study group | Role | What they receive |
|---|---|---|
| FORWARD (Axe 1) | Experimental | Not described Receives: Behavioral: Forward adaptation of reactive saccades |
| BACKWARD (Axe 1) | Experimental | Not described Receives: Behavioral: Backward adaptation of reactive saccades |
| CONTROL (Axe 1) | Experimental | Not described Receives: Behavioral: Execution of reactive saccades |
| ADAPTATION (Axe 2) | Experimental | Not described Receives: Behavioral: Backward adaptation of reactive saccades |
| CONTROL (Axe 2) | Experimental | Not described Receives: Behavioral: Generation of reactive saccades |
What is being measured
The primary outcome is the main question the study is designed to answer.
Saccadic adaptation efficiency
〖Adaptation〗_rate= (〖Amplitude 〗_post-〖Amplitude 〗_pre)/〖Amplitude 〗_pre
Measured: At time of each experimental session, up to 2 months, since first experimental visit until last visit
Secondary outcomes (2)
Evolution of localization-task performances
〖Improvement〗_performances= (〖Mislocalization 〗_post-〖Mislocalization 〗_pre)/〖Mislocalization 〗_pre
Measured: At time of each experimental session, up to 2 months, since first experimental visit until last visit
Evolution of attentional performances assessed by neuropsychological tests of neglect
〖Improvement〗_performances= (〖Score 〗_post-〖Score〗_pre)/〖Score〗_pre
Measured: At time of each experimental session, up to 2 months, since first experimental visit until last visit
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted13 Apr 2017
- Study start26 Sep 2018
- Primary completion2 Oct 2020
- Study completion2 Oct 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cerebellum DiseaseStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 24 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Caroline Tilikete, MD, Principal investigator, Hospices Civils de Lyon
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03112408
- Sponsor's protocol ID
- 69HCL17_0109
- Other IDs
- 2017-A00942-51
- Status last verified
- Aug 2025
- First submitted
- 29 Mar 2017
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Cheviet A, Masselink J, Koun E, Salemme R, Lappe M, Froment-Tilikete C, Pelisson D. Cerebellar signals drive motor adjustments and visual perceptual changes during forward and backward adaptation of reactive saccades. Cereb Cortex. 2022 Sep 4;32(18):3896-3916. doi: 10.1093/cercor/bhab455.
PubMed 34979550
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Coupling Between Adaptation of Saccadic Eye Movements and Visuo-spatial Perception and Attention Processes: a Behavioural Study in Humans.
- ClinicalTrials.gov ID
- NCT03112408
- Acronym / sponsor ID
- 69HCL17_0109
- Conditions
- Cerebellum Disease
- Keywords
- cerebellar lesion, saccadic adaptation, spatial localization, visuo spatial perception, eye movements
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 24 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 26 Sep 2018 (actual)
- Primary completion
- 2 Oct 2020 (actual)
- Study completion
- 2 Oct 2020 (actual)
- First posted
- 13 Apr 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This research aims to highlight the key roles of the cerebellar and cortical fronto-parietal networks in the coupling of eye movements with visual perception and visuo-spatial attention.
Detailed description
The first axe of this research focuses on the role of the cerebellum which has a major contribution to sensorimotor adaptation and more precisely in saccadic adaptation but the nature of this contribution is still debated. A classical assumption stipulates cerebellum has an exclusive action on saccadic burst generator in the brainstem whereas recent data increasingly support the view that cerebellum could also modulates cerebral cortex through a cerebello-thalamo-cortical pathway. On the other hand, several studies have shown that modification of saccade amplitude by saccadic adaptation leads to a distortion of the visual localization of briefly flashed spatial probes but no study to date has tested, the contribution of the cerebellum in these adaptation-induced mislocalizations. The main objective of this axe is to define the role of the cerebellum not only in saccadic adaptation, but also in mislocalizations which occur after adaptation. Moreover, in testing this assumption, arguments in favour -or in disfavor- of the action of the cerebellum on cortical stages dedicated to visuo-spatial perceptual processing will be provided. Besides, variability of cerebellar lesion (or cerebellar dysfunction) location in patients can lead to different pattern in saccadic adaptation and localization task performances. Identification of dissociations between these two abilities in some patients will define more precisely the role of the cerebellum in the coupling between saccadic adaptation and visuo spatial perception as an oculomotor plasticity territory and / or as a territory underlying the error signal coding generating this type of plasticity.
This second axe of this research aims to apply basic findings in healthy subject on the coupling between oculomotor plasticity and spatial attention to patients with parietal lesion, in order to evaluate a rehabilitation procedure for neglect patients. Habchi and colleagues showed that the adaptation of reactive saccades in the left hemifield has a boosting effect on attentional performance in the same hemifield. The coupling between these two mechanisms highlighted in healthy subjects can be used as fundamentals in the elaboration of a rehabilitation procedure for attentional disorders in the neglect syndrome. This syndrome is mainly observed after cerebral lesions in the right hemisphere, and is characterized by very disabling cognitive disorders such as an alteration of the spatial representation of left hemi-space and/or left hemi-body. stimulation of sensorimotor plasticity thanks to prismatic adaptation could be used as a rehabilitation procedure for this syndrome. Being another efficient way to stimulate sensorimotor plasticity, the equip believe that saccadic adaptation can also be used as a rehabilitation procedure for neglect patients. Moreover, due to its tight coupling with visual attention, the benefits of saccadic adaptation could be even stronger and longer lasting than the visuo-manual plasticity induced by prismatic adaptation.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Factorial
- Masking
- Single blind (participant)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| FORWARD (Axe 1) | Experimental | Behavioral: Forward adaptation of reactive saccades |
| BACKWARD (Axe 1) | Experimental | Behavioral: Backward adaptation of reactive saccades |
| CONTROL (Axe 1) | Experimental | Behavioral: Execution of reactive saccades |
| ADAPTATION (Axe 2) | Experimental | Behavioral: Backward adaptation of reactive saccades |
| CONTROL (Axe 2) | Experimental | Behavioral: Generation of reactive saccades |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- Age : from 18 to 80 ans included
- Visual acuity monocularly at distance and near corrected : > 5/10
- Possible understanding of experimental guidelines
- Possible respect for sustained seated position
- Subject covered by social security
Key exclusion criteria (15 listed)
- Visual acuity monocularly < 5/10
- Language disorder restricting oral and reading comprehension of the study
- Severe disability limiting the maintenance of sitting position and concentration capacities for a period of 30 minutes consecutive
- Poor French language skills
- Non-stabilized medical condition
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Forward adaptation of reactive saccadesProtocol of reactive saccade where the target is displaced in the same direction as the saccade in order to induce an adaptive increase of saccade amplitude ('forward adaptation') | Behavioural | FORWARD (Axe 1) |
| Backward adaptation of reactive saccadesProtocol of reactive saccade where the target is displaced in a direction opposite to the saccade in order to induce an adaptive decrease of saccade amplitude ('backward adaptation') | Behavioural | ADAPTATION (Axe 2), BACKWARD (Axe 1) |
| Execution of reactive saccadesControl protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in forward and backward adaptation conditions) | Behavioural | CONTROL (Axe 1) |
| Generation of reactive saccadesControl protocol of reactive saccade with no displacement of the saccadic target (controlling for non specific factors possibly involved in adaptation condition) | Behavioural | CONTROL (Axe 2) |
Primary outcome
Saccadic adaptation efficiency
Time frame: At time of each experimental session, up to 2 months, since first experimental visit until last visit
〖Adaptation〗_rate= (〖Amplitude 〗_post-〖Amplitude 〗_pre)/〖Amplitude 〗_pre
2 secondary outcomes
Evolution of localization-task performances
Time frame: At time of each experimental session, up to 2 months, since first experimental visit until last visit
Evolution of attentional performances assessed by neuropsychological tests of neglect
Time frame: At time of each experimental session, up to 2 months, since first experimental visit until last visit
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Results publication: PubMed 34979550Cheviet A, Masselink J, Koun E, Salemme R, Lappe M, Froment-Tilikete C, Pelisson D. Cerebellar signals drive motor adjustments and visual perceptual changes during forward and backward adaptation of reactive saccades. Cereb Cortex. 2022 Sep 4;32(18):3896-3916. doi: 10.1093/cercor/bhab455.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Caroline Tilikete, MD principal investigator
Hospices Civils de Lyon
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Forward adaptation of reactive saccades, Backward adaptation of reactive saccades and Execution of reactive saccades in people with Cerebellum Disease, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Saccadic adaptation efficiency (time frame: At time of each experimental session, up to 2 months, since first experimental visit until last visit). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03112408, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.