HealthyNCT03130322
SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)
A study testing Imagery and Sleep questionnaires, MEG recordings (pre-test) and Practice session in people with Healthy, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been… Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Imagery and Sleep questionnaires, MEG recordings (pre-test) and Practice session
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 51 participants
- Where
- 1 siteFrance
- Study dates
- 9 Dec 2015to 4 Jul 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy right-handed persons without neurologic disease
- Persons having signed informed consent for a neuroimagery study
Who cannot join
- Persons under curatorship or any administrative/judicial measure
- Participants refusing to be informed of the results of the experiment
- Pregnant women
- Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
- Persons using a pacemaker, insulin pump, or working regularly with iron filings
- Claustrophobic persons
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice
This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.
- Conditions
- Healthy
- Being tested
- Imagery and Sleep questionnaires, MEG recordings (pre-test), Practice session, MEG recordings (Post-test), MRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Imagery and Sleep questionnairesOther
Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep
MEG recordings (pre-test)Other
Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h).
Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.
Practice sessionOther
Participants of the Day group perform a block of motor imagery practice of the two motor tasks.
MEG recordings (Post-test)Other
Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test)
MRIOther
The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.
| Study group | Role | What they receive |
|---|---|---|
| NightPP | Experimental | Participants of the NightPP will be subjected to one MRI session and two MEG recording sessions: the first one before a physical practice session of the two motor tasks investigated in the study, and second MEG session right after practice. Receives: Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI |
| NightMI | Experimental | Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice. Receives: Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI |
| NightCtrl | Experimental | Participants of the NightCtrl will be subjected to one MRI session and two MEG recording sessions: the first one before a mental rotation practice session, a second MEG session right after practice,and second MEG session right after practice. Receives: Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI |
| Day | Experimental | Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice. Receives: Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
Evidence of MEG correlates of sleep motor consolidation (day 1)
The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Measured: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Evidence of MEG correlates of sleep motor consolidation (day 2)
The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Measured: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Secondary outcomes (5)
Time needed to complete the motor tasks (day 1)
The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task).
Measured: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Evidence of MEG correlates of sleep motor consolidation
The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Measured: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks
The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).
Measured: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Time needed to complete the motor tasks
The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task).
Measured: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks 2
The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).
Measured: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Apr 2017
- Study start9 Dec 2015
- Primary completion9 Dec 2017
- Study completion4 Jul 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 51 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Alain Nicolas, MD, Principal investigator, CH le Vinatier
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03130322
- Sponsor's protocol ID
- 69HCL16_0676
- Status last verified
- Sep 2025
- First submitted
- 10 Mar 2017
- Last updated
- 15 Sep 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Di Rienzo F, Debarnot U, Daligault S, Delpuech C, Doyon J, Guillot A. Brain plasticity underlying sleep-dependent motor consolidation after motor imagery. Cereb Cortex. 2023 Nov 27;33(23):11431-11445. doi: 10.1093/cercor/bhad379.
PubMed 37814365
Study at a glance
From the registry record, last updated by the sponsor on 15 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice
- ClinicalTrials.gov ID
- NCT03130322
- Acronym / sponsor ID
- 69HCL16_0676
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 51 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 9 Dec 2015 (actual)
- Primary completion
- 9 Dec 2017 (actual)
- Study completion
- 4 Jul 2018 (actual)
- First posted
- 26 Apr 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| NightPP | Experimental | Other: Imagery and Sleep questionnaires, Other: MEG recordings (pre-test), Other: Practice session, Other: MEG recordings (Post-test), Other: MRIParticipants of the NightPP will be subjected to one MRI session and two MEG recording sessions: the first one before a physical practice session of the two motor tasks investigated in the study, and second MEG session right after practice. |
| NightMI | Experimental | Other: Imagery and Sleep questionnaires, Other: MEG recordings (pre-test), Other: Practice session, Other: MEG recordings (Post-test), Other: MRIParticipants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice. |
| NightCtrl | Experimental | Other: Imagery and Sleep questionnaires, Other: MEG recordings (pre-test), Other: Practice session, Other: MEG recordings (Post-test), Other: MRIParticipants of the NightCtrl will be subjected to one MRI session and two MEG recording sessions: the first one before a mental rotation practice session, a second MEG session right after practice,and second MEG session right after practice. |
| Day | Experimental | Other: Imagery and Sleep questionnaires, Other: MEG recordings (pre-test), Other: Practice session, Other: MEG recordings (Post-test), Other: MRIParticipants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice. |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Healthy right-handed persons without neurologic disease
- Persons having signed informed consent for a neuroimagery study
Key exclusion criteria (6 listed)
- Persons under curatorship or any administrative/judicial measure
- Participants refusing to be informed of the results of the experiment
- Pregnant women
- Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
- Persons using a pacemaker, insulin pump, or working regularly with iron filings
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Imagery and Sleep questionnairesParticipants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep | Other | Day, NightCtrl, NightMI, NightPP |
| MEG recordings (pre-test)Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible. | Other | Day, NightCtrl, NightMI, NightPP |
| Practice sessionParticipants of the Day group perform a block of motor imagery practice of the two motor tasks. | Other | Day, NightCtrl, NightMI, NightPP |
| MEG recordings (Post-test)Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test) | Other | Day, NightCtrl, NightMI, NightPP |
| MRIThe registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session. | Other | Day, NightCtrl, NightMI, NightPP |
Primary outcome
Evidence of MEG correlates of sleep motor consolidation (day 1)
Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
Evidence of MEG correlates of sleep motor consolidation (day 2)
Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.
5 secondary outcomes
Time needed to complete the motor tasks (day 1)
Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Evidence of MEG correlates of sleep motor consolidation
Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks
Time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Time needed to complete the motor tasks
Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks 2
Time frame: Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 15 Sep 2025.
- Results publication: PubMed 37814365Di Rienzo F, Debarnot U, Daligault S, Delpuech C, Doyon J, Guillot A. Brain plasticity underlying sleep-dependent motor consolidation after motor imagery. Cereb Cortex. 2023 Nov 27;33(23):11431-11445. doi: 10.1093/cercor/bhad379.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alain Nicolas, MD principal investigator
CH le Vinatier
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Imagery and Sleep questionnaires, MEG recordings (pre-test) and Practice session in people with Healthy, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 15 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Evidence of MEG correlates of sleep motor consolidation (day 1) (time frame: Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03130322, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 15 Sep 2025; AzTrials last refreshed its copy on 5 Nov 2026.