HealthyMEEGAPERFNCT03233282
EEG Monitoring for PERFormance Anticipation
A study testing Electroencephalography (EEG) multi-sensor, Magnetoencephalography (MEG) and Behavioral Measures in people with Healthy, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. Read more about this study
- Who is it for?
- Ages 18 to 70 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- Electroencephalography (EEG) multi-sensor, Magnetoencephalography (MEG) and Behavioral Measures
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 169 participants
- Where
- 1 siteFrance
- Study dates
- 30 May 2013to 31 May 2018
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years;
- Having duly completed the entire confidential medical questionnaire;
- Written consent of free, informed and express participation;
- No hearing problems;
- Having normal or corrected vision;
- Affiliation to a Social Security scheme.
Show all 14Show fewer
- Adult subjects, male or female, right-handed or left-handed, from 18 years up to 35 years;
- Practicing at least five hours of sports per week;
- Presenting a certificate of no contraindication to an exercise test, intense sports practice or an energy sport in competition of the current year;
- Having duly completed the entire confidential medical questionnaire;
- Without cardiovascular or motor disability;
- Without tumoral, inflammatory, cardiac, pulmonary, renal, digestive (malabsorption syndrome) or liver disease;
- Written consent of free, informed and express participation;
- Affiliation to a Social Security scheme.
Who cannot join
- Pregnant women, nursing mothers or those of childbearing age without contraception
- Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty
- Persons protected by the law
- Persons who have performed a maximum stress test within 15 days of the date of inclusion,
- In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...).
- Metal implants incompatible with MRI (for the subjects concerned, see appendices)
- Metallic implants incompatible with the MEG (for the subjects concerned, see appendices)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation
Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.
- Conditions
- Healthy
- Being tested
- Electroencephalography (EEG) multi-sensor, Magnetoencephalography (MEG), Behavioral Measures, Reaction time measurement, Assessment of physical performance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Electroencephalography (EEG) multi-sensorOther
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method.
Magnetoencephalography (MEG)Other
Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method.
Behavioral MeasuresOther
The evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick.
Reaction time measurementOther
The assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement.
Assessment of physical performanceOther
The assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed).
Electrooculogram (EOG)Other
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Electromyogram (EMG)Other
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Electrocardiogram with 3 leadsOther
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Electrodermogram (EDG)Other
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Consumption of O2 (VO2)Other
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
Production of CO2 (VCO2)Other
In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study.
| Study group | Role | What they receive |
|---|---|---|
| Cognitive Fatigability | Other | Not described Receives: Other: Electroencephalography (EEG) multi-sensor; Other: Magnetoencephalography (MEG); Other: Behavioral Measures; Other: Reaction time measurement; Other: Assessment of physical performance; Other: Electrooculogram (EOG); Other: Electromyogram (EMG); Other: Electrocardiogram with 3 leads |
| Physical Fatigability | Other | Not described Receives: Other: Electroencephalography (EEG) multi-sensor; Other: Magnetoencephalography (MEG); Other: Behavioral Measures; Other: Reaction time measurement; Other: Assessment of physical performance; Other: Electrooculogram (EOG); Other: Electromyogram (EMG); Other: Electrocardiogram with 3 leads; Other: Electrodermogram (EDG); Other: Consumption of O2 (VO2); Other: Production of CO2 (VCO2) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.
The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time.
Measured: 7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG).
Measured: 7 hours
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.
Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG)
Measured: 7 hours
Secondary outcomes (2)
Refine (locate at the level of the cortex), the origin of these physiological markers
Several types of recordings, passive and non-invasive, will be realized:
- Electrooculogram (EOG);
- electromyography (EMG);
- electrocardiogram (ECG); Systematically in "physical" experiments and for some "cognitive" experiments.
Measured: 7 hours
Distinguish between different time scales of performance
Several types of recordings, passive and non-invasive, will be realized:
- electrodermogram (EDG);
- the consumption of O2 (VO2);
- production of CO2 (VCO2). Only and systematically, in "physical" experiments.
Measured: 7 hours
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Jul 2017
- Study start30 May 2013
- Primary completion31 May 2018
- Study completion31 May 2018
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 169 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Julien JUNG, MD, Principal investigator, Hospices Civils de Lyon
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03233282
- Sponsor's protocol ID
- 69HCL16_0661
- Acronym
- MEEGAPERF
- Status last verified
- Sep 2025
- First submitted
- 25 Apr 2017
- Last updated
- 3 Oct 2025
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Poinsard L, Berthomier C, Clemencon M, Brandewinder M, Essid S, Damon C, Rigaud F, Benichoux A, Maby E, Fornoni L, Bouchet P, Beers PV, Massot B, Revol P, Creveaux T, Collet C, Mattout J, Pialoux V, Billat V. EEG-Metabolic Coupling and Time Limit at V O2max During Constant-Load Exercise. J Funct Morphol Kinesiol. 2025 Sep 26;10(4):369. doi: 10.3390/jfmk10040369.
PubMed 41133559Véronique Billat, Christian Berthomier, Michel Clémençon, Marie Brandewinder, Slim Essid, Cécilia Damon, François Rigaud, Alexis Bénichoux, Emmanuel Maby, Lesly Fornoni, Patrick Bouchet , Pascal Van Beers, Bertrand Massot, Patrice Revol, Luc Poinsard, Thomas Creveaux, Christian Collet, Jérémie Mattout and Vincent Pialoux. Electroencephalography Response during an Incremental Test According to the VO2max Plateau Incidence. Applied Sciences. 2024, 14, 5411.
Seguin P, Maby E, Fouillen M, Otman A, Luaute J, Giraux P, Morlet D, Mattout J. The challenge of controlling an auditory BCI in the case of severe motor disability. J Neuroeng Rehabil. 2024 Jan 18;21(1):9. doi: 10.1186/s12984-023-01289-3.
PubMed 38238759
Study at a glance
From the registry record, last updated by the sponsor on 3 Oct 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Electrophysiological and Bioenergetic Study of Variations in Cognitive and Physical Performance in Healthy Humans: EEG Monitoring for PERFormance Anticipation
- ClinicalTrials.gov ID
- NCT03233282
- Acronym / sponsor ID
- MEEGAPERF / 69HCL16_0661
- Conditions
- Healthy
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 169 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 30 May 2013 (actual)
- Primary completion
- 31 May 2018 (actual)
- Study completion
- 31 May 2018 (actual)
- First posted
- 28 Jul 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Identify, characterize and then validate electrophysiological markers linking electrophysiological cerebral activity and performance in cognitive and physical fatigability in humans. To do this, noninvasive explorations of electroencephalography (EEG) and magnetoencephalography (MEG) will be carried out under two conditions of different experiments, the first one that induces a cognitive fatigability and the second one that induces physical fatigability.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Cognitive Fatigability | Other | Other: Electroencephalography (EEG) multi-sensor, Other: Magnetoencephalography (MEG), Other: Behavioral Measures, Other: Reaction time measurement, Other: Assessment of physical performance, Other: Electrooculogram (EOG), Other: Electromyogram (EMG), Other: Electrocardiogram with 3 leads |
| Physical Fatigability | Other | Other: Electroencephalography (EEG) multi-sensor, Other: Magnetoencephalography (MEG), Other: Behavioral Measures, Other: Reaction time measurement, Other: Assessment of physical performance, Other: Electrooculogram (EOG), Other: Electromyogram (EMG), Other: Electrocardiogram with 3 leads, Other: Electrodermogram (EDG), Other: Consumption of O2 (VO2), Other: Production of CO2 (VCO2) |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (14 listed)
- Adult subjects, male or female, right-handed or left-handed, from 18 years up to 70 years;
- Having duly completed the entire confidential medical questionnaire;
- Written consent of free, informed and express participation;
- No hearing problems;
- Having normal or corrected vision;
Key exclusion criteria (7 listed)
- Pregnant women, nursing mothers or those of childbearing age without contraception
- Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of liberty or of liberty
- Persons protected by the law
- Persons who have performed a maximum stress test within 15 days of the date of inclusion,
- In the course of drug treatments against indicated for the protocol (treatment for neurological diseases, psychiatric ...).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Electroencephalography (EEG) multi-sensorElectrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG), which is a non-invasive method. | Other | Cognitive Fatigability, Physical Fatigability |
| Magnetoencephalography (MEG)Electrophysiological measurements of brain activity will be performed by magnetoencephalography (MEG) which is a non-invasive method. | Other | Cognitive Fatigability, Physical Fatigability |
| Behavioral MeasuresThe evaluation of cognitive performance will be carried out by means of behavioral measures, push-button type, handling of a mouse or a joystick. | Other | Cognitive Fatigability, Physical Fatigability |
| Reaction time measurementThe assessment of cognitive performance will be carried out using standard behavioral measures, such as reaction time measurement. | Other | Cognitive Fatigability, Physical Fatigability |
| Assessment of physical performanceThe assessment of physical performance will be based both on bioenergetic measurements and on quantitative data collected in continuous and relative to the effort (eg instantaneous pedaling speed). | Other | Cognitive Fatigability, Physical Fatigability |
| Electrooculogram (EOG)In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Cognitive Fatigability, Physical Fatigability |
| Electromyogram (EMG)In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Cognitive Fatigability, Physical Fatigability |
| Electrocardiogram with 3 leadsIn order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Cognitive Fatigability, Physical Fatigability |
| Electrodermogram (EDG)In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Physical Fatigability |
| Consumption of O2 (VO2)In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Physical Fatigability |
| Production of CO2 (VCO2)In order to extract artifacts and verify the physical performances of the subjects, under the conditions of physical fatigability, peripheral electrophysiological recordings will be necessary and complementary to meet the objectives set in this study. | Other | Physical Fatigability |
Primary outcome
Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability.
Time frame: 7 hours
The evaluation of cognitive performance will be carried out by means of conventional behavioral measures, of the press-button type, handling of a mouse or of a joystick and measurement of reaction time.
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with EEG.
Time frame: 7 hours
Electrophysiological measurements of cerebral activity will be performed by multi-sensor electroencephalography (EEG).
Identify electrophysiological markers in humans depending on whether the experimental conditions induce physical fatigability with MEG.
Time frame: 7 hours
Electrophysiological measurements of cerebral activity will be carried out by magnetoencephalography (MEG)
2 secondary outcomes
Refine (locate at the level of the cortex), the origin of these physiological markers
Time frame: 7 hours
Distinguish between different time scales of performance
Time frame: 7 hours
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Oct 2025.
- Results publication: PubMed 41133559Poinsard L, Berthomier C, Clemencon M, Brandewinder M, Essid S, Damon C, Rigaud F, Benichoux A, Maby E, Fornoni L, Bouchet P, Beers PV, Massot B, Revol P, Creveaux T, Collet C, Mattout J, Pialoux V, Billat V. EEG-Metabolic Coupling and Time Limit at V O2max During Constant-Load Exercise. J Funct Morphol Kinesiol. 2025 Sep 26;10(4):369. doi: 10.3390/jfmk10040369.
- Results publicationVéronique Billat, Christian Berthomier, Michel Clémençon, Marie Brandewinder, Slim Essid, Cécilia Damon, François Rigaud, Alexis Bénichoux, Emmanuel Maby, Lesly Fornoni, Patrick Bouchet , Pascal Van Beers, Bertrand Massot, Patrice Revol, Luc Poinsard, Thomas Creveaux, Christian Collet, Jérémie Mattout and Vincent Pialoux. Electroencephalography Response during an Incremental Test According to the VO2max Plateau Incidence. Applied Sciences. 2024, 14, 5411.
- Derived from this study: PubMed 38238759Seguin P, Maby E, Fouillen M, Otman A, Luaute J, Giraux P, Morlet D, Mattout J. The challenge of controlling an auditory BCI in the case of severe motor disability. J Neuroeng Rehabil. 2024 Jan 18;21(1):9. doi: 10.1186/s12984-023-01289-3.
Related trials for Healthy
Recruiting
THE EFFECTS OF GAME-BASED EXERCISE PROGRAMS
Physical Activity, Body Image
Not yet recruitingPhase 1
A Phase I Study of GLR2053 Tablets in Chinese Healthy Adult Participants
Atopic Dermatitis
Recruiting
Colon-delivered Riboflavin and Gut Microbiota Composition
Microbiome Dysbiosis, Gut Health
Not yet recruiting
Neuroergonomic Analysis of a Brain-Computer Interface Device (BCI)
Healthy Volunteers - Male and Female
RecruitingPhase 1
First-in-Human Trial to Assess REGN20423 in Healthy Adult Participants and Adult Participants With Atopic Dermatitis
Healthy Volunteer, Atopic Dermatitis
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Julien JUNG, MD principal investigator
Hospices Civils de Lyon
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Electroencephalography (EEG) multi-sensor, Magnetoencephalography (MEG) and Behavioral Measures in people with Healthy, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 14 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Oct 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Identify electrophysiological markers in humans depending on whether the experimental conditions induce cognitive fatigability. (time frame: 7 hours). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03233282, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Oct 2025.