Chronic Low Back PainNCT03326362
Effects of Strength Training in Chronic Low Back Pain Patients
A study testing Resistance training in people with Chronic Low Back Pain, run by University of Sao Paulo at 1 site in Brazil.
Trial summary
Although it is known that chronic low back pain (CLBP) have a multifactorial etiology, the investigations about it are mostly specific to each investigation area, making difficult to understand this complex condition. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Chronic Low Back Pain
- What is being tested?
- Resistance training
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 26 participants
- Where
- 1 siteBrazil
- Study dates
- 6 Feb 2017to 29 Sep 2017
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Being ≥18 years old
- Present low back or lumbo-sacral pain and function restriction (i.e. >15% in the Oswestry Questionnaire) for 12 weeks or longer
- Do not present any functional anatomical-abnormalities, neuromuscular joint diseases and acute symptoms of pain
- Recent participation in an exercise program (at least 12 weeks)
- Pregnancy or diseases that can directly impact systemic inflammation (i.e: cancer, diabetes, hypertension)
Who cannot join
- Minimum adherence to the training protocol, defined as performing at least 75% of the training sessions.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Strength Training Upon Biomechanical, Morphological and Inflammatory Parameters of Chronic Low Back Pain Patients
Although it is known that chronic low back pain (CLBP) have a multifactorial etiology, the investigations about it are mostly specific to each investigation area, making difficult to understand this complex condition. The purpose of the study was to investigate CLBP from a multidisciplinary approach, analyzing biomechanical, morphological and inflammatory parameters aiming to compare the influence of two strength training protocols, one of low intensity and low volume (LIT) and one of high intensity and high volume (HIT). In both experiments, pain intensity and level of functional disability were analyzed (by analogue scale of pain and Oswestry Index), Ground Reaction Forces (GRF - AMTI BP600900 - 2000 force plate), kinematics of lower limbs (Inertial Sensors by Noraxon) and electromyography of the rectus abdominis, external oblique, lumbar multifidus, medial gluteus, vastus lateralis and biceps femoris muscles (TelemyoDTS) during gait and sit-to-stand, inflammatory cytokines by Multiplex in blood samples and cross-sectional area (CSA) of the lumbar multifidus by ultrasound imaging.
Read the detailed description
The subjects with CLBP were randomly assigned to two groups: the high intensity resistance training (HIRT) group and the low intensity resistance training (LIRT) groups.
All of the participants were informed of the purposes and procedures involved in the study and signed an informed consent form before participation. The experimental protocol was approved by the Institutional Review Board.
The intervention for both groups consisted of 12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions. The HIRT performed the squat, deadlift and lunge exercises, as these exercises induce high core muscles activity. HIRT started with two weeks of low intensity exercises emphasizing the activation of core muscles (pelvic elevation with feet on the floor, "superman", static supine bridge on bosu), and the technique of the selected resistance exercises (e.g. squat, deadlift, and lunges). Participants performed 3 sets of 10 repetitions per exercise. In the third and forth weeks, participants performed the exercises from the previous weeks and also static unipedal forward flexion on bosu and dynamic unipedal forward flexion and the main exercises with a load corresponding to (50% of the 1 RM load (Brzycki, 1993).This formula is applied in a test that the subject is encouraged to perform the maximal number of repetitions possible with a predetermined load. The chosen load must allow the subject to achieve a maximum of ten repetitions, which guarantee a good RM prediction. The weight lifted and repetitions performed are applied in the equation to calculate the 1 RM estimation.
From the 5th to the 12th week, participants performed only the selected resistance exercises (squat, deadlift and lundge) with progressive higher intensities (from 12RM to 8RM). A 3-min rest interval was allowed between sets and exercises.
The LIRT group performed very low intensity and volume exercises (i.e. 1 set per exercise). Exercises started with participants lying on a firm surface, with the back supported, knees bent and feet flat on the floor. Then, participants performed the following exercises: 1) inhaling and exhaling and then isometrically contract in gluteal and abdominal muscles for 20 seconds and relax; 2) raising the head, lifting the chin and shoulders toward the chest for 20 seconds and relax; 3) raising one knee towards the chest and raising the head and shoulders likewise in the second exercise for 20s, relaxing, and changing the leg.; 4) raising both knees towards the chest in the same time that raise the head and shoulder off the floor during 20 seconds and relax.
- Conditions
- Chronic Low Back Pain
- Being tested
- Resistance training
- Keywords
- chronic low back pain, strength training, biomechanics, inflammatory biomarkers
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance trainingOther
Comparison between high and low intensities trainings described in arms
| Study group | Role | What they receive |
|---|---|---|
| High intensity resistance training (HIRT) | Experimental | 12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions. The HIRT performed the squat, deadlift and lunge exercises, as these exercises induce high core muscles activity. HIRT started with two weeks of low intensity exercises emphasizing the activation of core muscles (pelvic elevation with feet on the floor, "superman", static supine bridge on bosu), and the technique of the selected resistance exercises (e.g. squat, deadlift, and lunges). Participants performed 3 sets of 10 repetitions per exercise. In the third and forth weeks, participants performed the exercises from the previous weeks and also static unipedal forward flexion on bosu and dynamic unipedal forward flexion and the main exercises with a load corresponding to (50% of the 1 RM load (Brzycki, 1993).
From the 5th to the 12th week, participants performed only the selected resistance exercises with progressive higher intensities (from 12RM to 8RM). Receives: Other: Resistance training |
| Low intensity resistance training (LIRT) | Active comparator | 12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions.The LIRT group performed very low intensity and volume exercises (i.e. 1 set per exercise). Exercises started with participants lying on a firm surface, with the back supported, knees bent and feet flat on the floor. Then, participants performed the following exercises: 1) inhaling and exhaling and then isometrically contract in gluteal and abdominal muscles for 20 seconds and relax; 2) raising the head, lifting the chin and shoulders toward the chest for 20 seconds and relax; 3) raising one knee towards the chest and raising the head and shoulders likewise in the second exercise for 20s, relaxing, and changing the leg.; 4) raising both knees towards the chest in the same time that raise the head and shoulder off the floor during 20 seconds and relax. Receives: Other: Resistance training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Electromyographic activity of lower limb muscles during walking and sit-to-stand.
Electromyographic signal (1500 Hz) will be obtained from rectus abdominis, left and right external oblique, left and right lumbar multifidus, gluteus medius of the dominant limb, biceps femoris of the dominant limb, and vastus lateralis of the dominant limb using a wireless device (TeleMyoDTS,,Noraxon,CITY, USA). The location of the electrodes followed the SENIAM project database. Before electrode placement, skin sites will be shaved and abraded to remove hair and dead skin. Bipolar active surface electrodes (Meditrace 200, Kendal, silver; recording diameter = 1 mm; inter-electrode distance = 1 cm) were used. Electromyographic signal will be filtered using a band pass fourth order Butterworth filter with cut off frequency of 20 Hz and 450Hz.EMG data will be normalized by 200ms RMS peak .
Measured: 12 weeks
Kinematic data for the lower limbs during walking and sit-to-stand
Seven inertial sensors (9DOF - Myomotion Inertial designed by Noraxon) will be placed on the pelvis and bilaterally in thigh, shank and foot. Sensors will be used to obtain three-dimensional orientation of the lower limbs in relation to pelvis and relative lower limb joints angles. Ankle dorsiflexion, knee extension and hip flexion were presented as a positive angles. Kinematic data will be sampled at 100 Hz and low-pass filtered at 6 Hz (fourth-order, zero-lag, Butterworth).
Measured: 12 weeks
Kinetic data for the lower limbs during walking and sit-to-stand
Vertical ground reaction force (GFR) data will be obtained using either one (i.e. sit-to-stand) or two (i.e walking) strain gauge force plates(AMTI BP600900 - 2000;Watertown, EUA).GFR data will be sampled at 200 Hz and low-pass filtered at 50 Hz (fourth-order, zero-lag, Butterworth), and normalized by bodyweight. Sit-to-stand GFR parameters will be: peak vertical force, time to peak vertical force, and load rate both for stand up phase and sit down phases. Selected walking kinematics parameters will be first and second vertical peak force, time to first and second vertical peaks, load rate, total impulse, maximal deflection (i.e. minimum force value between the peaks) and time to maximal deflection.
Measured: 12 weeks
Inflammatory Parameters
Blood samples (10 ml) will be obtained from the antecubital vein. After collection, the blood will be centrifuged at 3000 rpm for 15 min at 4° degrees. Plasma and serum will be storage in plastic microtubes at -80° degrees for posterior analysis of cytokines production of each participant by a qualified professional.
The Multiplex Analysis of Sample Protein Content will be performed: each 10 ml of collected blood sample will be incubated with the mixture of Megaplex microspheres and covered with the specific antibodies for 2 h. The detection of target antigens bounded to the microspheres will be performed with a mixture of biotinylated capture antibodies after incubation for 1 h followed by incubation with streptavidin labeled with phycoerithrin for 30 min. The microspheres will be then analyzed with the phycoerithrinMagpix® instrument (Life Technologies, Grand Island, NY, USA). Citokines concentration will be normalized to total protein concentration.
Measured: 12 weeks
Cross sectional area of lumbar multifidus
Lumbar multifidus ultrasound images will be obtained (transverse orientation at L4 in both sides of the spine with the subjects in prone lying position) using a B-mode ultrasound with a 7.5-MHz linear-array probe (SonoAce R3, Samsung-Medison, Gangwon-do, South Korea).The multifidus location will be determined by palpation of the spinous process of L5 and L4. L5 is deep, small and blunted bony point lying at the center of the lumbo-sacraldepression, on progression in a cranial direction is the comparatively large spinous process of L4. Ultrasound images will be obtained with SonoaceR3 equipment and their measurements in Image Jsoftware. For each subjects will be calculated the mean of CSA of the right and left sides of the lumbar multifidus.
Measured: 12 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted31 Oct 2017
- Study start6 Feb 2017
- Primary completion5 May 2017
- Study completion29 Sep 2017
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Chronic Low Back PainStudies of the same condition, open and under way.
- More trials run by University of Sao PauloThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Sao Paulo
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Juliana Pennone, University of Sao Paulo
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03326362
- Sponsor's protocol ID
- Juliana Pennone
- Status last verified
- Oct 2017
- First submitted
- 1 Oct 2017
- Last updated
- 31 Oct 2017
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Blackburn SE, Portney LG. Electromyographic activity of back musculature during Williams' flexion exercises. Phys Ther. 1981 Jun;61(6):878-85. Bressel E1, Willardson JM, Thompson B, Fontana FE. Effect of instruction, surface stability, and load intensity on trunk muscle activity. J Electromyogr Kinesiol. 2009 Dec;19(6):e500-4. doi: 10.1016/j.jelekin.2008.10.006. Epub 2008 Dec 2. Carpes, FP, Reinehr, FB, and Mota, CB. Effects of a program for trunk strength and stability on pain, low back and pelvis kinematics, and body balance: A pilot study. J Bodyw Mov Ther 12: 22-30, 2008. Clark, D, Lambert, M, and Hunter, A. Muscle activation in the loaded free barbell squat: a brief review. J Strength Cond Res 26: 1169-1178, 2012 Escamilla, RF, Francisco, AC, Kayes, A V, Speer, KP, and Moorman III, CT. An electromyographic analysis of sumo and conventional style deadlifts. Med Sci Sport Exerc 34: 682-688, 2002. Kristensen, J and Franklyn-Miller A. Resistance training in musculoskeletal rehabilitation: a systematic review. Br J Sports Med 46: 719-726, 2012.
Study at a glance
From the registry record, last updated by the sponsor on 31 Oct 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Strength Training Upon Biomechanical, Morphological and Inflammatory Parameters of Chronic Low Back Pain Patients
- ClinicalTrials.gov ID
- NCT03326362
- Acronym / sponsor ID
- Juliana Pennone
- Conditions
- Chronic Low Back Pain
- Keywords
- chronic low back pain, strength training, biomechanics, inflammatory biomarkers
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- University of Sao PauloUniversity, hospital or other
- Study start
- 6 Feb 2017 (actual)
- Primary completion
- 5 May 2017 (actual)
- Study completion
- 29 Sep 2017 (actual)
- First posted
- 31 Oct 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Although it is known that chronic low back pain (CLBP) have a multifactorial etiology, the investigations about it are mostly specific to each investigation area, making difficult to understand this complex condition. The purpose of the study was to investigate CLBP from a multidisciplinary approach, analyzing biomechanical, morphological and inflammatory parameters aiming to compare the influence of two strength training protocols, one of low intensity and low volume (LIT) and one of high intensity and high volume (HIT). In both experiments, pain intensity and level of functional disability were analyzed (by analogue scale of pain and Oswestry Index), Ground Reaction Forces (GRF - AMTI BP600900 - 2000 force plate), kinematics of lower limbs (Inertial Sensors by Noraxon) and electromyography of the rectus abdominis, external oblique, lumbar multifidus, medial gluteus, vastus lateralis and biceps femoris muscles (TelemyoDTS) during gait and sit-to-stand, inflammatory cytokines by Multiplex in blood samples and cross-sectional area (CSA) of the lumbar multifidus by ultrasound imaging.
Detailed description
The subjects with CLBP were randomly assigned to two groups: the high intensity resistance training (HIRT) group and the low intensity resistance training (LIRT) groups.
All of the participants were informed of the purposes and procedures involved in the study and signed an informed consent form before participation. The experimental protocol was approved by the Institutional Review Board.
The intervention for both groups consisted of 12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions. The HIRT performed the squat, deadlift and lunge exercises, as these exercises induce high core muscles activity. HIRT started with two weeks of low intensity exercises emphasizing the activation of core muscles (pelvic elevation with feet on the floor, "superman", static supine bridge on bosu), and the technique of the selected resistance exercises (e.g. squat, deadlift, and lunges). Participants performed 3 sets of 10 repetitions per exercise. In the third and forth weeks, participants performed the exercises from the previous weeks and also static unipedal forward flexion on bosu and dynamic unipedal forward flexion and the main exercises with a load corresponding to (50% of the 1 RM load (Brzycki, 1993).This formula is applied in a test that the subject is encouraged to perform the maximal number of repetitions possible with a predetermined load. The chosen load must allow the subject to achieve a maximum of ten repetitions, which guarantee a good RM prediction. The weight lifted and repetitions performed are applied in the equation to calculate the 1 RM estimation.
From the 5th to the 12th week, participants performed only the selected resistance exercises (squat, deadlift and lundge) with progressive higher intensities (from 12RM to 8RM). A 3-min rest interval was allowed between sets and exercises.
The LIRT group performed very low intensity and volume exercises (i.e. 1 set per exercise). Exercises started with participants lying on a firm surface, with the back supported, knees bent and feet flat on the floor. Then, participants performed the following exercises: 1) inhaling and exhaling and then isometrically contract in gluteal and abdominal muscles for 20 seconds and relax; 2) raising the head, lifting the chin and shoulders toward the chest for 20 seconds and relax; 3) raising one knee towards the chest and raising the head and shoulders likewise in the second exercise for 20s, relaxing, and changing the leg.; 4) raising both knees towards the chest in the same time that raise the head and shoulder off the floor during 20 seconds and relax.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| High intensity resistance training (HIRT) | Experimental | Other: Resistance training12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions. The HIRT performed the squat, deadlift and lunge exercises, as these exercises induce high core muscles activity. HIRT started with two weeks of low intensity exercises emphasizing the activation of core muscles (pelvic elevation with feet on the floor, "superman", static supine bridge on bosu), and the technique of the selected resistance exercises (e.g. squat, deadlift, and lunges). Participants performed 3 sets of 10 repetitions per exercise. In the third and forth weeks, participants performed the exercises from the previous weeks and also static unipedal forward flexion on bosu and dynamic unipedal forward flexion and the main exercises with a load corresponding to (50% of the 1 RM load (Brzycki, 1993). From the 5th to the 12th week, participants performed only the selected resistance exercises with progressive higher intensities (from 12RM to 8RM). |
| Low intensity resistance training (LIRT) | Active comparator | Other: Resistance training12 weeks of two weekly training sessions, with at least 48 hours of interval between sessions.The LIRT group performed very low intensity and volume exercises (i.e. 1 set per exercise). Exercises started with participants lying on a firm surface, with the back supported, knees bent and feet flat on the floor. Then, participants performed the following exercises: 1) inhaling and exhaling and then isometrically contract in gluteal and abdominal muscles for 20 seconds and relax; 2) raising the head, lifting the chin and shoulders toward the chest for 20 seconds and relax; 3) raising one knee towards the chest and raising the head and shoulders likewise in the second exercise for 20s, relaxing, and changing the leg.; 4) raising both knees towards the chest in the same time that raise the head and shoulder off the floor during 20 seconds and relax. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Being ≥18 years old
- Present low back or lumbo-sacral pain and function restriction (i.e. >15% in the Oswestry Questionnaire) for 12 weeks or longer
- Do not present any functional anatomical-abnormalities, neuromuscular joint diseases and acute symptoms of pain
- Recent participation in an exercise program (at least 12 weeks)
- Pregnancy or diseases that can directly impact systemic inflammation (i.e: cancer, diabetes, hypertension)
Key exclusion criteria (1 listed)
- Minimum adherence to the training protocol, defined as performing at least 75% of the training sessions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance trainingComparison between high and low intensities trainings described in arms | Other | High intensity resistance training (HIRT), Low intensity resistance training (LIRT) |
Primary outcome
Electromyographic activity of lower limb muscles during walking and sit-to-stand.
Time frame: 12 weeks
Electromyographic signal (1500 Hz) will be obtained from rectus abdominis, left and right external oblique, left and right lumbar multifidus, gluteus medius of the dominant limb, biceps femoris of the dominant limb, and vastus lateralis of the dominant limb using a wireless device (TeleMyoDTS,,Noraxon,CITY, USA). The location of the electrodes followed the SENIAM project database. Before electrode placement, skin sites will be shaved and abraded to remove hair and dead skin. Bipolar active surface electrodes (Meditrace 200, Kendal, silver; recording diameter = 1 mm; inter-electrode distance = 1 cm) were used. Electromyographic signal will be filtered using a band pass fourth order Butterworth filter with cut off frequency of 20 Hz and 450Hz.EMG data will be normalized by 200ms RMS peak .
Kinematic data for the lower limbs during walking and sit-to-stand
Time frame: 12 weeks
Seven inertial sensors (9DOF - Myomotion Inertial designed by Noraxon) will be placed on the pelvis and bilaterally in thigh, shank and foot. Sensors will be used to obtain three-dimensional orientation of the lower limbs in relation to pelvis and relative lower limb joints angles. Ankle dorsiflexion, knee extension and hip flexion were presented as a positive angles. Kinematic data will be sampled at 100 Hz and low-pass filtered at 6 Hz (fourth-order, zero-lag, Butterworth).
Kinetic data for the lower limbs during walking and sit-to-stand
Time frame: 12 weeks
Vertical ground reaction force (GFR) data will be obtained using either one (i.e. sit-to-stand) or two (i.e walking) strain gauge force plates(AMTI BP600900 - 2000;Watertown, EUA).GFR data will be sampled at 200 Hz and low-pass filtered at 50 Hz (fourth-order, zero-lag, Butterworth), and normalized by bodyweight. Sit-to-stand GFR parameters will be: peak vertical force, time to peak vertical force, and load rate both for stand up phase and sit down phases. Selected walking kinematics parameters will be first and second vertical peak force, time to first and second vertical peaks, load rate, total impulse, maximal deflection (i.e. minimum force value between the peaks) and time to maximal deflection.
Inflammatory Parameters
Time frame: 12 weeks
Blood samples (10 ml) will be obtained from the antecubital vein. After collection, the blood will be centrifuged at 3000 rpm for 15 min at 4° degrees. Plasma and serum will be storage in plastic microtubes at -80° degrees for posterior analysis of cytokines production of each participant by a qualified professional. The Multiplex Analysis of Sample Protein Content will be performed: each 10 ml of collected blood sample will be incubated with the mixture of Megaplex microspheres and covered with the specific antibodies for 2 h. The detection of target antigens bounded to the microspheres will be performed with a mixture of biotinylated capture antibodies after incubation for 1 h followed by incubation with streptavidin labeled with phycoerithrin for 30 min. The microspheres will be then analyzed with the phycoerithrinMagpix® instrument (Life Technologies, Grand Island, NY, USA). Citokines concentration will be normalized to total protein concentration.
Cross sectional area of lumbar multifidus
Time frame: 12 weeks
Lumbar multifidus ultrasound images will be obtained (transverse orientation at L4 in both sides of the spine with the subjects in prone lying position) using a B-mode ultrasound with a 7.5-MHz linear-array probe (SonoAce R3, Samsung-Medison, Gangwon-do, South Korea).The multifidus location will be determined by palpation of the spinous process of L5 and L4. L5 is deep, small and blunted bony point lying at the center of the lumbo-sacraldepression, on progression in a cranial direction is the comparatively large spinous process of L4. Ultrasound images will be obtained with SonoaceR3 equipment and their measurements in Image Jsoftware. For each subjects will be calculated the mean of CSA of the right and left sides of the lumbar multifidus.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 31 Oct 2017.
- BackgroundBlackburn SE, Portney LG. Electromyographic activity of back musculature during Williams' flexion exercises. Phys Ther. 1981 Jun;61(6):878-85. Bressel E1, Willardson JM, Thompson B, Fontana FE. Effect of instruction, surface stability, and load intensity on trunk muscle activity. J Electromyogr Kinesiol. 2009 Dec;19(6):e500-4. doi: 10.1016/j.jelekin.2008.10.006. Epub 2008 Dec 2. Carpes, FP, Reinehr, FB, and Mota, CB. Effects of a program for trunk strength and stability on pain, low back and pelvis kinematics, and body balance: A pilot study. J Bodyw Mov Ther 12: 22-30, 2008. Clark, D, Lambert, M, and Hunter, A. Muscle activation in the loaded free barbell squat: a brief review. J Strength Cond Res 26: 1169-1178, 2012 Escamilla, RF, Francisco, AC, Kayes, A V, Speer, KP, and Moorman III, CT. An electromyographic analysis of sumo and conventional style deadlifts. Med Sci Sport Exerc 34: 682-688, 2002. Kristensen, J and Franklyn-Miller A. Resistance training in musculoskeletal rehabilitation: a systematic review. Br J Sports Med 46: 719-726, 2012.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance training in people with Chronic Low Back Pain, run by University of Sao Paulo at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 31 Oct 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Electromyographic activity of lower limb muscles during walking and sit-to-stand. (time frame: 12 weeks). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03326362, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 31 Oct 2017.