Research institution
University of Sao Paulo Clinical Trials
Studies where University of Sao Paulo is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 161Telangiectasias, Reticular Veins
Foam Sclerotherapy With or Without Transdermal Laser for Reticular Veins and Telangiectasias
This prospective, randomized, controlled, intraindividual split-leg clinical trial will compare isolated polidocanol foam sclerotherapy with the Cryo-Laser After Foam (CLaF) technique for the treatment of reticular veins and…
- Conditions
- Telangiectasias, Reticular Veins, Chronic Venous Disease
- Trial name
- NCT07793630
- Testing
- Polidocanol foam sclerotherapy, Transdermal 1064 nm Nd:YAG Laser
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Sao Paulo
Knee Osteoarthritis
Platelet-Rich Plasma, Hyaluronic Acid, or Their Combination for Knee Osteoarthritis in Athletes
The goal of this clinical trial is to learn whether a single knee injection of platelet-rich plasma (PRP) combined with hyaluronic acid (HA) works better than PRP alone or HA alone to relieve pain and improve function in…
- Trial name
- NCT07901153
- Testing
- Leukocyte-Poor Platelet-Rich Plasma, High Molecular Weight Hyaluronic Acid
- Where
- Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity (Disorder), Inflammation
Effects of Taurine Supplementation and Morning or Evening High-intensity Exercise on Circadian Clock Genes and Inflammatory Parameters in Adult Women With Obesity
The goal of this clinical trial is to evaluate whether taurine supplementation, alone or combined with high-intensity interval training (HIIT) performed in morning or evening, affects circadian clock gene expression and…
- Trial name
- NCT07910747
- Testing
- Taurine supplementation, High-intensity interval training (HIIT)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Lupus Erythematosus, Systemic
CD19-Directed CAR-T Cell Therapy in Refractory Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system mistakenly attacks the body's own tissues and organs.
- Trial name
- CLEVER-SLE (NCT07659704)
- Testing
- Autologous CD19-Directed CAR-T Cells Manufactured at Ribeirão Preto Blood Center
- Where
- 2 sites in Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo
Spinal Cord Injuries (SCI)
AI-Guided Multi-Electrode Transcutaneous Spinal Cord Stimulation for Gait Rehabilitation in People With Spinal Cord Injury or Stroke
The goal of this clinical trial is to investigate whether personalized multi-electrode transcutaneous spinal cord stimulation (tSCS), guided by machine learning (ML) and combined with gait training, can improve walking function…
- Trial name
- NCT07895888
- Testing
- Single-Electrode Tonic tSCS, Multi-Electrode Spatiotemporal tSCS
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Healthy Adult Participants
Acute Effects of a Single Dose of Ayahuasca on Cerebral Metabolism in Healthy Volunteers: a PET Study
Open-label trial with healthy adults
- Trial name
- NCT07893912
- Testing
- Ayahuasca
- Where
- Brazil
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Suicidal Ideation, Suicidal Behavior
Intravenous Ketamine for Acute Suicidal Crisis and Psychiatric Hospital Length of Stay
This randomized, double-blind, active placebo-controlled superiority trial will evaluate whether intravenous esketamine reduces time to psychiatric hospital discharge in adults hospitalized because of acute suicide risk.
- Trial name
- NCT07888933
- Testing
- Esketamine, Midazolam (Intravenous)
- Where
- Brazil
- Volunteers
- 106 people
- Sponsor
- University of Sao Paulo
Sudden Cardiac Death, Cardiac Arrhythmias
Cardiovascular Pre-participation Screening in Children and Adolescents
Sports participation is strongly encouraged in children and adolescents, but intense training at early ages may reveal hidden heart conditions that increase the risk of sudden cardiac death.
- Trial name
- NCT07862504
- Testing
- Pre-participation clinical evaluation, Diagnostic Test: Resting 12-lead electrocardiogram, Diagnostic Test: Step test (Harvard step test)
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Autoimmune Rheumatic Diseases, Tooth Extraction
Antibiotic Prophylaxis After Simple Tooth Extraction in Immunosuppressed Patients With Autoimmune Rheumatic Diseases
This randomized, double-blind, placebo-controlled clinical trial aims to evaluate whether single-dose amoxicillin prophylaxis administered prior to simple tooth extraction reduces postoperative infection rates inpatients with…
- Conditions
- Autoimmune Rheumatic Diseases, Tooth Extraction, Infection Prevention, Antibiotic Prophylaxis
- Trial name
- PRO-EXOD (NCT07275580)
- Testing
- Amoxicillin
- Where
- Brazil
- Volunteers
- 352 people
- Sponsor
- University of Sao Paulo General Hospital
Long QT Syndrome, Channelopathies
Physical Activity and Functional Capacity in Patients With Congenital Long QT Syndrome
Patients with congenital long QT syndrome (LQTS) have traditionally been discouraged from physical activity and competitive sports, although the rate of exercise-related arrhythmic events is considered low.
- Trial name
- CANMOVE (NCT07862491)
- Testing
- Questionnaires, Cardiopulmonary exercise testing, 24-hour Holter monitoring
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo
Completed, with results posted
All 57Sarcopenic Obesity, Aging
Protein Supplementation in Elderly With Sarcopenic Obesity Undergoing Caloric Restriction and Exercise
This study aims to investigate if protein supplementation increases the benefits of exercise training in the elderly with sarcopenic obesity undergoing caloric restriction.
- Trial name
- NCT04981366
- Testing
- Protein supplement, isocaloric supplement
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- University of Sao Paulo General Hospital
Uveomeningoencephalitic Syndrome, Inflammation
Multimodal Analysis and Electroretinogram in VKH From Acute Onset - Part I
Patients with acute onset Vogt-Koyanagi-Harada disease (VKHD) were prospectively included in this study. They were systematically followed with clinical, posterior segment imaging exams and full-field electroretinogram during a…
- Conditions
- Uveomeningoencephalitic Syndrome, Inflammation, Choroid Disease, Visual Impairment
- Trial name
- NCT03811366
- Testing
- Corticosteroid monotherapy
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- University of Sao Paulo
Knee Osteoarthritis, Pain, Chronic
Association of Acupuncture and Cupping in Advanced Knee Osteoarthritis
Given the lack of studies in the literature associating the use of acupuncture and sliding suction cup in patients with advanced knee osteoarthritis, the objective of this study is to evaluate the benefits of this association in…
- Trial name
- NCT04168593
- Testing
- Acupuncture
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetic Neuropathies
Effects of Foot Muscle Strengthening in Daily Activity in Diabetic Neuropathic Patients
The main objective of this trial is to investigate the effects of foot muscle strengthening in daily activity of patients with diabetic neuropathy.
- Trial name
- NCT02790931
- Testing
- Intervention Group
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetic Neuropathies
Effect of Educational Booklet for Foot-related Exercises for Prevention and Treatment in People With Diabetic Neuropathy
The main objective of this trial is to investigate the effect of an educational booklet foot-related exercise in diabetic neuropathy status, functional outcomes and gait biomechanics in people with diabetic neuropathy.
- Trial name
- FOCA-II (NCT04008745)
- Testing
- Educational and home-based physical therapy by foot-related exercises
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital