Eating DisorderNCT03347565
Brain Function in Adolescent Eating Disorders and Healthy Peers
An observational study of Eating Disorder, run by University of California, San Diego at 1 site in United States.
Trial summary
This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. Read more about this study
- Who is it for?
- Ages 14 to 17 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Eating Disorder
- How many people
- 155 participants
- Where
- 1 siteUnited States
- Study dates
- 21 Jul 2017to 8 May 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 17 years
- Women only
- Healthy volunteers accepted
- Child
Study population: This study is currently enrolling adolescent females between the ages of 14-17 who are right handed and who are either currently ill with an eating disorder or who have never had an eating disorder or any other mental illness
Who may be able to join
- Female
- Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
- Medically stable
- Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).
Who cannot join
- Psychotic illness/other mental illness requiring hospitalization
- Current dependence on drugs or alcohol
- Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
- On psychoactive medication
- Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
- Neurological or medical disorders such as seizure disorder
Show all 9Show fewer
- Any contraindication to undergoing an MRI
- Major depressive disorder
- Left handed
Trial locations and contacts
1 site in 1 country.
United States1 site
University of California San Diego
San Diego, California, 92121
About this study
Official title: Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders
This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).
- Conditions
- Eating Disorder
- Keywords
- adolescents, healthy controls
- Medical subject headings
- Feeding and Eating Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Adolescents with an Eating Disorder | Females between the ages of 14-17 currently diagnosed with an eating disorder (including ARFID, Anorexia Nervosa, Bulimia Nervosa, OSFED) | |
| Healthy Controls | Females between the ages of 14-17 with no psychiatric conditions |
What is being measured
The primary outcome is the main question the study is designed to answer.
Brain function
Functional Magnetic Resonance imaging will be used to assess brain activation associated with inhibition, impulsivity, and control
Measured: 1 year (fMRI Scan)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Nov 2017
- Study start21 Jul 2017
- Primary completion1 Nov 2024
- Study completion8 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Eating DisorderStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 155 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of California, San Diego
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Christina Wierenga, University of California, San Diego
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03347565
- Sponsor's protocol ID
- 170664
- Status last verified
- May 2026
- First submitted
- 15 Nov 2017
- Last updated
- 13 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: De-identified data including data dictionaries will be uploaded to NIMH per their data sharing requirements
Study at a glance
From the registry record, last updated by the sponsor on 13 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Neurocircuitry of Temperament and Motivated Behavior in Adolescent Eating Disorders
- ClinicalTrials.gov ID
- NCT03347565
- Acronym / sponsor ID
- 170664
- Conditions
- Eating Disorder
- Keywords
- adolescents, healthy controls
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 155 participants (actual)
- Lead sponsor
- University of California, San DiegoUniversity, hospital or other
- Study start
- 21 Jul 2017 (actual)
- Primary completion
- 1 Nov 2024 (actual)
- Study completion
- 8 May 2026 (actual)
- First posted
- 20 Nov 2017 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study of adolescent eating disorders (ED) will examine the association of temperament-based classifications, brain activation during incentive processing, and ED symptoms at time of scan and 1 year later to better understand the neurobiology and symptoms of ED. We will recruit 150 females currently ill with an ED and 50 controls ages 14-17 to investigate how temperaments reflecting greater inhibition, impulsivity, or effortful control correspond to 1) clinical symptoms and 2) the brain's response to anticipation and outcome of salient stimuli, and 3) by collecting follow-up clinical data one year later, identify how temperament-based subtypes predict ED symptom change (e.g., clinical prediction). Data collection will rely on a technology called functional magnetic resonance imaging (fMRI).
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Adolescents with an Eating Disorder | – | –Females between the ages of 14-17 currently diagnosed with an eating disorder (including ARFID, Anorexia Nervosa, Bulimia Nervosa, OSFED) |
| Healthy Controls | – | –Females between the ages of 14-17 with no psychiatric conditions |
Who may qualify
- Ages
- 14 to 17 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Child
- Study population
- This study is currently enrolling adolescent females between the ages of 14-17 who are right handed and who are either currently ill with an eating disorder or who have never had an eating disorder or any other mental illness
Key inclusion criteria (4 listed)
- Female
- Meet DSM-V criteria for an Eating Disorder or Never met criteria for an Eating disorder
- Medically stable
- Post-Pubertal (must have started menses, but subsequent loss of menses secondary to ED is fine).
Key exclusion criteria (9 listed)
- Psychotic illness/other mental illness requiring hospitalization
- Current dependence on drugs or alcohol
- Physical conditions known to influence eating or weight (e.g, diabetes mellitus, pregnancy).
- On psychoactive medication
- Organic brain syndromes, delirium, psychotic disorders, or intellectual disability
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Brain function
Time frame: 1 year (fMRI Scan)
Functional Magnetic Resonance imaging will be used to assess brain activation associated with inhibition, impulsivity, and control
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 13 May 2026.
- Individual participant dataSharing planned: Yes. De-identified data including data dictionaries will be uploaded to NIMH per their data sharing requirements
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Eating Disorder, run by University of California, San Diego at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 13 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Brain function (time frame: 1 year (fMRI Scan)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 May 2026.