Cervix; PregnancyMesConNCT03472066
Measurement of the Cervix During Pregnancy According to Age of Conization
An observational study of Cervix; Pregnancy, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical… Read more about this study
- Who is it for?
- Ages 18 years and older, women only
- Conditions the study is for
- Cervix; Pregnancy
- What is being tested?
- Previous conization and no previous conization
- How many people
- 2 participants
- Where
- 1 siteFrance
- Study dates
- 4 Oct 2018to 13 Apr 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- Women only
- No healthy volunteers
- Adult, Older adult
Study population: Including 84 evaluable patients for the primary endpoint would show a Pearson correlation of at least 0.3 between cervical size and age at conization. These calculations were carried out with a 5% risk of first bilateral species and 80% power. Taking into account the risk of incomplete data, we plan to include 90 patients. A control group of 90 patients will also be recruited.
Who may be able to join
- Patient referred since January 2008 with pregnancy between 2008 and 2017
- Pregnancy after conisation
- Cervix size between 21 and 24 SA before any obstetric event
- Control group: parity matching, asymptomatic patients
Who cannot join
- Threat of late miscarriage,
- Premature rupture of membranes before cervical echography,
- Other pregnancies after study of 1st pregnancy after conisation,
- No measurement of the conization specimen,
- Lost to follow-up,
- Age <18
- Twin Pregnancies
- Patient under guardianship
Trial locations and contacts
1 site in 1 country.
About this study
Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical conization during the growth phase reduced its growth potential, and induced shorter cervix during the upcoming pregnancy. No studies have been conducted investigating the age at which conization no longer had an impact on cervical size during pregnancy. This will help to identify the age at conisation below which patients will be identified as being at risk event, and thus offer increased monitoring and possibly prophylactic management by programmed strapping. We propose to measure the length of the cervix of pregnant patients who have benefited from conization, which is currently recommended by the Collège National des Gynécologues Obstetriciens Français .In addition, the investigators will use a control group consisting of non-con conical, parity-matched pregnant patients in whom a cervical measurement will also be performed.
- Conditions
- Cervix; Pregnancy
- Being tested
- Previous conization, no previous conization
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Previous conizationOther
a group of women who have been conized,
no previous conizationOther
group with asymptomatic patients on routine second trimester echography
| Study group | Role | What they receive |
|---|---|---|
| a group of women who have been conized | Previous conization Receives: Other: Previous conization | |
| control group with asymptomatic patients | on routine second trim no previous conization Receives: Other: no previous conization |
What is being measured
The primary outcome is the main question the study is designed to answer.
The main objective is to study the correlation between the size of the cervix and the age at conization. age at conization
Cervix length Measured during the second semester echography
Measured: 1 day
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Mar 2018
- Study start4 Oct 2018
- Primary completion13 Apr 2022
- Study completion13 Apr 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cervix; PregnancyStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Prospective
- Enrolment
- 2 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03472066
- Sponsor's protocol ID
- PI2017_843_0021
- Acronym
- MesCon
- Status last verified
- Jun 2026
- First submitted
- 14 Mar 2018
- Last updated
- 12 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 12 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Measurement of the Cervix During Pregnancy According to Age of Conization
- ClinicalTrials.gov ID
- NCT03472066
- Acronym / sponsor ID
- MesCon / PI2017_843_0021
- Conditions
- Cervix; Pregnancy
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 2 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- 4 Oct 2018 (actual)
- Primary completion
- 13 Apr 2022 (actual)
- Study completion
- 13 Apr 2022 (actual)
- First posted
- 21 Mar 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Treatment of precancerous lesions of the cervix by conization has been shown to increase the risk of premature delivery and premature rupture of the membranes. It has now been clearly established that the cervix is a growing organ during adolescence and early adulthood, It has been hypothetized that cervical conization during the growth phase reduced its growth potential, and induced shorter cervix during the upcoming pregnancy. No studies have been conducted investigating the age at which conization no longer had an impact on cervical size during pregnancy. This will help to identify the age at conisation below which patients will be identified as being at risk event, and thus offer increased monitoring and possibly prophylactic management by programmed strapping. We propose to measure the length of the cervix of pregnant patients who have benefited from conization, which is currently recommended by the Collège National des Gynécologues Obstetriciens Français .In addition, the investigators will use a control group consisting of non-con conical, parity-matched pregnant patients in whom a cervical measurement will also be performed.
Study design
- Observational model
- Case-control
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| a group of women who have been conized | – | Other: Previous conizationPrevious conization |
| control group with asymptomatic patients | – | Other: no previous conizationon routine second trim no previous conization |
Who may qualify
- Ages
- 18 years and older
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Including 84 evaluable patients for the primary endpoint would show a Pearson correlation of at least 0.3 between cervical size and age at conization. These calculations were carried out with a 5% risk of first bilateral species and 80% power. Taking into account the risk of incomplete data, we plan to include 90 patients. A control group of 90 patients will also be recruited.
Key inclusion criteria (4 listed)
- Patient referred since January 2008 with pregnancy between 2008 and 2017
- Pregnancy after conisation
- Cervix size between 21 and 24 SA before any obstetric event
- Control group: parity matching, asymptomatic patients
Key exclusion criteria (8 listed)
- Threat of late miscarriage,
- Premature rupture of membranes before cervical echography,
- Other pregnancies after study of 1st pregnancy after conisation,
- No measurement of the conization specimen,
- Lost to follow-up,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Previous conizationa group of women who have been conized, | Other | a group of women who have been conized |
| no previous conizationgroup with asymptomatic patients on routine second trimester echography | Other | control group with asymptomatic patients |
Primary outcome
The main objective is to study the correlation between the size of the cervix and the age at conization. age at conization
Time frame: 1 day
Cervix length Measured during the second semester echography
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jun 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cervix; Pregnancy, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 12 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The main objective is to study the correlation between the size of the cervix and the age at conization. age at conization (time frame: 1 day). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jun 2026.