Healthy VolunteersNCT03488082
MRI Study of Saccadic Adaptation
A study testing fMRI in people with Healthy Volunteers, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. Read more about this study
- Who is it for?
- Ages 18 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy Volunteers
- What is being tested?
- fMRI
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 36 participants
- Where
- 1 siteFrance
- Study dates
- 17 Oct 2018to 17 Jul 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Age: 18 to 40 years included,
Who cannot join
- Known ophthalmological or neurological pathology,
- Non-stabilized medical condition,
- Taking psychotropic treatment,
- No fluency in reading in French,
- Pregnant and / or breastfeeding woman
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Coupling Between Saccadic Adaptation and Visuospatial Perception Process: MRI Study in Humans
Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections).
The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.
- Conditions
- Healthy Volunteers
- Being tested
- fMRI
- Keywords
- saccadic adaptation, visual-spatial perception, fMRI
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
fMRIBehavioural
saccadic adaptation (target presentations, with or without target jump) during fMRI exam
| Study group | Role | What they receive |
|---|---|---|
| Measurement of the bold signal | Experimental | Not described Receives: Behavioral: fMRI |
What is being measured
The primary outcome is the main question the study is designed to answer.
BOLD signal
cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks).
Measured: throughout the behavioral experiment at Day 1
Secondary outcomes (1)
Eye movements
measurement of the eye movements (saccades) of the subject while fixating and shifting gaze toward visual targets (behavioral tasks).
Measured: during the development of saccadic adaptation (throughout the behavioral experiments at Day 1)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Apr 2018
- Study start17 Oct 2018
- Primary completion17 Jul 2020
- Study completion17 Jul 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 36 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Denis PELISSON, Principal investigator, INSERM U1208
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03488082
- Sponsor's protocol ID
- 69HCL18_0200
- Other IDs
- 2018-A00932-53
- Status last verified
- Aug 2025
- First submitted
- 28 Mar 2018
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Metais C, Nicolas J, Diarra M, Cheviet A, Koun E, Pelisson D. Neural substrates of saccadic adaptation: Plastic changes versus error processing and forward versus backward learning. Neuroimage. 2022 Nov 15;262:119556. doi: 10.1016/j.neuroimage.2022.119556. Epub 2022 Aug 12.
PubMed 35964865
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Coupling Between Saccadic Adaptation and Visuospatial Perception Process: MRI Study in Humans
- ClinicalTrials.gov ID
- NCT03488082
- Acronym / sponsor ID
- 69HCL18_0200
- Conditions
- Healthy Volunteers
- Keywords
- saccadic adaptation, visual-spatial perception, fMRI
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 36 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 17 Oct 2018 (actual)
- Primary completion
- 17 Jul 2020 (actual)
- Study completion
- 17 Jul 2020 (actual)
- First posted
- 4 Apr 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Accurate execution of our directed behaviors in the immediate environment allows the vast majority of our daily activities. Through the movements of our eyes and different parts of our body, we perceive, explore and act on our environment and can exchange and communicate with others. The mechanisms of sensorimotor adaptation of saccades (saccadic adaptation) contribute on the one hand to maintain the accuracy of saccades in the short, medium and long term, by opposing the deleterious effects of various physiological changes (development, aging), pathological or environmental (optical corrections).
The aim of this study is to identify neuronal structures and networks involved in saccadic adaptation through the study of brain metabolic activation (BOLD) during the development of the adaptation of reactive saccades. The study will be organized in a single session with 3 runs. Each run include 4 blocks: 3 include the double-step target paradigm RND, U+, U-) and one without target jump (STA). The 'U+'/ 'U-'blocks include saccadic trials with forward/backward displacement of the target during a targeting saccade, the 'RND' block include saccadic trials with random target jump (forward or backward) and the 'STA' block are trials without displacement of the target. Each subject will make 12 repetitions of the 4 blocks.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Measurement of the bold signal | Experimental | Behavioral: fMRI |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Age: 18 to 40 years included,
Key exclusion criteria (5 listed)
- Known ophthalmological or neurological pathology,
- Non-stabilized medical condition,
- Taking psychotropic treatment,
- No fluency in reading in French,
- Pregnant and / or breastfeeding woman
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| fMRIsaccadic adaptation (target presentations, with or without target jump) during fMRI exam | Behavioural | Measurement of the bold signal |
Primary outcome
BOLD signal
Time frame: throughout the behavioral experiment at Day 1
cerebral activations with fMRI measures when the subject fixates or shifts gaze toward visual targets (behavioral tasks).
1 secondary outcome
Eye movements
Time frame: during the development of saccadic adaptation (throughout the behavioral experiments at Day 1)
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Results publication: PubMed 35964865Metais C, Nicolas J, Diarra M, Cheviet A, Koun E, Pelisson D. Neural substrates of saccadic adaptation: Plastic changes versus error processing and forward versus backward learning. Neuroimage. 2022 Nov 15;262:119556. doi: 10.1016/j.neuroimage.2022.119556. Epub 2022 Aug 12.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Denis PELISSON principal investigator
INSERM U1208
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing fMRI in people with Healthy Volunteers, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
BOLD signal (time frame: throughout the behavioral experiment at Day 1). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03488082, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.