OsteoporosisChina biobankNCT03699228
China Health Big Data
An observational study of Osteoporosis and Obesity, run by Beijing Jishuitan Hospital at 6 sites in China.
Trial summary
In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. Read more about this study
- Who is it for?
- Ages 30 to 90 years
- Conditions the study is for
- Osteoporosis, Obesity, Liver Steatoses
- How many people
- 30,000 participants
- Where
- 6 sitesChina
- Study dates
- 1 Dec 2017to 31 Dec 2026
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 90 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: General health check population
Who may be able to join
- health check subjects 30-90 years old low dose chest CT scan
Who cannot join
- pregnant women metal implant in the CT scan area
Trial locations and contacts
6 sites in 1 country. Contact the study team or a site near you to ask about taking part.
xiaoxia fu, md contact
6 sites in 1 country
China6 sites, 6 recruiting
- Recruiting
Beijing Jishuitan hospital
Beijing, Beijing Municipality, 100035
Kai Li, PhD, 008615801633664
Ling Wang, MD
- Recruiting
The first affiliated hospital of Guiyang Medical University
Guiyang, Guizhou
Xia Du, MD, 008613765071289
- Recruiting
Hua Shan hospital
Shanghai, Shanghai Municipality
Shuang chen, 008613601717952
- Recruiting
Shanghai Ruijin hospital
Shanghai, Shanghai Municipality
Yong Lu, MD, 008613701995934
- Recruiting
Wu Hu Yijishan Hospital
Wuhu, Anhui, 100035
xiaojun zha, 008613705533568
- Recruiting
The first affiliated hospital of Zhengzhou University
Zhengzhou, Henan
Yan Wu, MD, 008613803843588
About this study
Official title: China Nationwide Multi Center Big Data Study on the Quantitative Computed Tomography (QCT) and Health Status of Check -up Population
In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.
Read the detailed description
Low dose Chest CT scan is the standard for lung cancer in the health check center in China. Quantitative computed tomography (QCT) is utilizing the CT raw data to measure the bone mineral density (BMD), the visceral fat (VAT) and liver fat content in human, which can be widely used in the diagnosis of osteoporosis, the assessment of obesity and liver steatosis. In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. This study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.
- Conditions
- Osteoporosis, Obesity, Liver Steatoses
- Keywords
- Bone mineral density, quantitative computed tomography, Osteoporosis, obesity, liver steatosis
- Medical subject headings
- Osteoporosis, Obesity, Fatty Liver
What is being measured
The primary outcome is the main question the study is designed to answer.
The spinal volumetric bone mineral density (vBMD)
The volumetric bone mineral density of L1-2 measured by QCT
Measured: 2 year
Secondary outcomes (2)
The visceral adipose tissue (VAT)
The visceral adipose tissue (VAT) measured by quantitative computed tomography (QCT)
Measured: 2 year
Liver fat
Liver fat measurement by quantitative computed tomography (QCT)
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Oct 2018
- Study start1 Dec 2017
- Primary completion30 Jun 2026 (estimated)
- Study completion31 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for OsteoporosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 30,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Beijing Jishuitan Hospital
- Sponsor type
- University, hospital or other
- Collaborators
- Chinese PLA General Hospital, Ruijin Hospital, Huashan Hospital, Henan Provincial People's Hospital, The Affiliated Hospital Of Guizhou Medical University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, The First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital Xi'an Jiaotong University, The renmin hospital of wuhan university, Nanjing BenQ Hospital, China-Japan Friendship Hospital, xinan hospital, Wu Hu Yijishan hospital, The fifth affiliated hospital of zhong shan university
- Responsible party
- Principal investigator, xiaoguang Cheng, Beijing Jishuitan Hospital
- Investigators
- xiaoguang cheng, MD, Principal investigator, Beijing Jishuitan Hospitalqiang zeng, Principal investigator, General PLA hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03699228
- Sponsor's protocol ID
- jst2018
- Acronym
- China biobank
- Status last verified
- Feb 2025
- First submitted
- 5 Oct 2018
- Last updated
- 17 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Sun Y, Qi X, Wang X, Lin X, Zhou Y, Du Y, Liu A, Lv X, Zhou J, Li Z, Wu X, Zou Z, Zhang M, Zhu J, Shang F, Li Y, Li H. Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study. Lipids Health Dis. 2024 Jan 24;23(1):27. doi: 10.1186/s12944-024-02023-1.
PubMed 38267987Sun Y, Qi X, Lin X, Zhou Y, Lv X, Zhou J, Li Z, Wu X, Zou Z, Li Y, Li H. Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023. Lipids Health Dis. 2023 Oct 21;22(1):180. doi: 10.1186/s12944-023-01946-5.
PubMed 37865752Cheng X, Zhao K, Zha X, Du X, Li Y, Chen S, Wu Y, Li S, Lu Y, Zhang Y, Xiao X, Li Y, Ma X, Gong X, Chen W, Yang Y, Jiao J, Chen B, Lv Y, Gao J, Hong G, Pan Y, Yan Y, Qi H, Ran L, Zhai J, Wang L, Li K, Fu H, Wu J, Liu S, Blake GM, Pickhardt PJ, Ma Y, Fu X, Dong S, Zeng Q, Guo Z, Hind K, Engelke K, Tian W; China Health Big Data (China Biobank) project investigators. Opportunistic Screening Using Low-Dose CT and the Prevalence of Osteoporosis in China: A Nationwide, Multicenter Study. J Bone Miner Res. 2021 Mar;36(3):427-435. doi: 10.1002/jbmr.4187. Epub 2020 Nov 4.
PubMed 33145809
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- China Nationwide Multi Center Big Data Study on the Quantitative Computed Tomography (QCT) and Health Status of Check -up Population
- ClinicalTrials.gov ID
- NCT03699228
- Acronym / sponsor ID
- China biobank / jst2018
- Conditions
- Osteoporosis, Obesity, Liver Steatoses
- Keywords
- Bone mineral density, quantitative computed tomography, Osteoporosis, obesity, liver steatosis
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 30,000 participants (estimated)
- Lead sponsor
- Beijing Jishuitan HospitalUniversity, hospital or other
- Collaborators
- Chinese PLA General Hospital, Ruijin Hospital, Huashan Hospital, Henan Provincial People's Hospital, The Affiliated Hospital Of Guizhou Medical University, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, The First Affiliated Hospital of Zhengzhou University, First Affiliated Hospital Xi'an Jiaotong University, The renmin hospital of wuhan university, Nanjing BenQ Hospital, China-Japan Friendship Hospital, xinan hospital, Wu Hu Yijishan hospital, The fifth affiliated hospital of zhong shan university
- Study start
- 1 Dec 2017 (actual)
- Primary completion
- 30 Jun 2026 (estimated)
- Study completion
- 31 Dec 2026 (estimated)
- First posted
- 9 Oct 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.
Detailed description
Low dose Chest CT scan is the standard for lung cancer in the health check center in China. Quantitative computed tomography (QCT) is utilizing the CT raw data to measure the bone mineral density (BMD), the visceral fat (VAT) and liver fat content in human, which can be widely used in the diagnosis of osteoporosis, the assessment of obesity and liver steatosis. In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. This study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Ages
- 30 to 90 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- General health check population
Key inclusion criteria (1 listed)
- health check subjects 30-90 years old low dose chest CT scan
Key exclusion criteria (1 listed)
- pregnant women metal implant in the CT scan area
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
The spinal volumetric bone mineral density (vBMD)
Time frame: 2 year
The volumetric bone mineral density of L1-2 measured by QCT
2 secondary outcomes
The visceral adipose tissue (VAT)
Time frame: 2 year
Liver fat
Time frame: 2 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2025.
- Derived from this study: PubMed 38267987Sun Y, Qi X, Wang X, Lin X, Zhou Y, Du Y, Liu A, Lv X, Zhou J, Li Z, Wu X, Zou Z, Zhang M, Zhu J, Shang F, Li Y, Li H. Association between high-density lipoprotein cholesterol and lumbar bone mineral density in Chinese: a large cross-sectional study. Lipids Health Dis. 2024 Jan 24;23(1):27. doi: 10.1186/s12944-024-02023-1.
- Derived from this study: PubMed 37865752Sun Y, Qi X, Lin X, Zhou Y, Lv X, Zhou J, Li Z, Wu X, Zou Z, Li Y, Li H. Association between total cholesterol and lumbar bone density in Chinese: a study of physical examination data from 2018 to 2023. Lipids Health Dis. 2023 Oct 21;22(1):180. doi: 10.1186/s12944-023-01946-5.
- Derived from this study: PubMed 33145809Cheng X, Zhao K, Zha X, Du X, Li Y, Chen S, Wu Y, Li S, Lu Y, Zhang Y, Xiao X, Li Y, Ma X, Gong X, Chen W, Yang Y, Jiao J, Chen B, Lv Y, Gao J, Hong G, Pan Y, Yan Y, Qi H, Ran L, Zhai J, Wang L, Li K, Fu H, Wu J, Liu S, Blake GM, Pickhardt PJ, Ma Y, Fu X, Dong S, Zeng Q, Guo Z, Hind K, Engelke K, Tian W; China Health Big Data (China Biobank) project investigators. Opportunistic Screening Using Low-Dose CT and the Prevalence of Osteoporosis in China: A Nationwide, Multicenter Study. J Bone Miner Res. 2021 Mar;36(3):427-435. doi: 10.1002/jbmr.4187. Epub 2020 Nov 4.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
xiaoxia fu, md contact
xiaoguang cheng, MD principal investigator
Beijing Jishuitan Hospital
qiang zeng principal investigator
General PLA hospital
6 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Osteoporosis and Obesity, run by Beijing Jishuitan Hospital at 6 sites in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 6 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact xiaoguang cheng, md (0086-010-58516947, xiao65@263.net), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The spinal volumetric bone mineral density (vBMD) (time frame: 2 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03699228, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2025.