Vitamin C DeficiencyVitamin CNCT03807791
Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit
A study testing Blood sample in people with Vitamin C Deficiency and Scurvy, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency. Read more about this study
- Who is it for?
- Ages 65 years and older
- Conditions the study is for
- Vitamin C Deficiency, Scurvy
- What is being tested?
- Blood sample
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 100 participants
- Where
- 1 siteFrance
- Study dates
- 31 Jan 2019to 14 Jun 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- Male or female over 65 years old
- living in the Unit of Long Term Care without any limit time.
- with a system of social insurance
- Who gave its consent by his own , or with help of his representant or his tutor or curator.
Who cannot join
- rejection of the blood sample
- patient feeding with articial nutritional feeding (stomach tube feeding)
- person close to death, who is not able to feed himself and / or with life-threatening in short time.
- Patient with personal history of vitamin C deficiency.
Trial locations and contacts
1 site in 1 country.
France1 site
Unité de soins Longue Durée, Hôpital Pierre Garraud (Hospices Civils de Lyon)
Lyon, 69005
About this study
The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency. Vitamin C has a key role into the struggle against oxidant stress and is involved into the connective tissue formation of the skin and the vascular endothelium. Vitamin C deficiency affects currently 15 to 25% of the elderly over 65 years old reaching 15% women and 20% men after 65 according to Johnston and Al. It concerns mainly the people in precarious situations (persons without fixed homes, ethyl-smoking persons) and elderly over 65 years. Hypovitaminosis C, defined by plasma level between 5 mg/L and 15 mg/L (28.41 to 85.23 µmol/L), is currently undiagnosed, especially with people with a risk of food deficiency and its prevalence increases with age. The treatment consists of a daily oral supplementation of 1 gram of vitamin C/d for 15 days. A minimum intake of 10 mg/D of vitamin C is required to prevent scurvy and maintain a total pool of 350 mg. A diet modification by a systematic intake of 2 glasses of fresh orange juice and/or the consumption of raw fruits and vegetables would prevent the appearance of scurvy.
- Conditions
- Vitamin C Deficiency, Scurvy
- Being tested
- Blood sample
- Keywords
- Vitamine C deficiency, skin rash, scurvy, food texture, geriatric institution, Unit Of Long Term Care
- Medical subject headings
- Ascorbic Acid Deficiency, Scurvy, Exanthema
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Blood sampleProcedure or surgery
A blood sample will be taken by the nurse of our unit within a week after their consent. It consists as a simple blood sample and it will be taken during the normal analysis planed by the chief of the service in order to avoid to collect two different samples.
The measurement method will use equipment from the Lyon Sud hospital laboratory. The samples need a pre-treatment in the 3 hours after taking the blood to avoid the oxidation of vitamin C and a result lower than expected.
| Study group | Role | What they receive |
|---|---|---|
| Patient living in the Unit of Long Term Care | Experimental | Patient living in the Unit of Long Term Care without any limit time Receives: Procedure: Blood sample |
What is being measured
The primary outcome is the main question the study is designed to answer.
Vitamin C plasma level
- ) Collection of the consent
- ) At the same time as other analysis for current cares a blood sample taken by a nurse of our unit to determine plasma levels of vitamin C.
- ) Registration of risk factors of vitamin C deficiency. .
- ) Doing a clinical exam within 7 days after the blood sample.
Measured: Between day 0 and day 7.
Secondary outcomes (2)
Supposed risk factors of hypovitaminosis C
The supposed risk factors are represent by general risk factors, Anthropometric parameters, Nutritional risk factors, Risk factors because of Unit of Long Term Care, Pathologies associated, Clinical signs associated with vitamin C deficiency
Measured: Day 0
Cutaneous symptoms
Measured: Day 0
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted17 Jan 2019
- Study start31 Jan 2019
- Primary completion14 Jun 2019
- Study completion14 Jun 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Vitamin C DeficiencyStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 100 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03807791
- Sponsor's protocol ID
- 69HCL18_0392
- Acronym
- Vitamin C
- Status last verified
- Aug 2025
- First submitted
- 15 Jan 2019
- Last updated
- 3 Sep 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Lagorsse C., Oumédian E., Bourguignon L, de La Gastine B. Les carences en vitamine C, une cause peu connue d'affections cutanées en institution gériatrique : à propos de 2 cas en Unité de Soins de Longue Durée (USLD). Rev Geriatr 2019 Février 44 2.
Study at a glance
From the registry record, last updated by the sponsor on 3 Sep 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit
- ClinicalTrials.gov ID
- NCT03807791
- Acronym / sponsor ID
- Vitamin C / 69HCL18_0392
- Conditions
- Vitamin C Deficiency, Scurvy
- Keywords
- Vitamine C deficiency, skin rash, scurvy, food texture, geriatric institution, Unit Of Long Term Care
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 100 participants (actual)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 31 Jan 2019 (actual)
- Primary completion
- 14 Jun 2019 (actual)
- Study completion
- 14 Jun 2019 (actual)
- First posted
- 17 Jan 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency. Vitamin C has a key role into the struggle against oxidant stress and is involved into the connective tissue formation of the skin and the vascular endothelium. Vitamin C deficiency affects currently 15 to 25% of the elderly over 65 years old reaching 15% women and 20% men after 65 according to Johnston and Al. It concerns mainly the people in precarious situations (persons without fixed homes, ethyl-smoking persons) and elderly over 65 years. Hypovitaminosis C, defined by plasma level between 5 mg/L and 15 mg/L (28.41 to 85.23 µmol/L), is currently undiagnosed, especially with people with a risk of food deficiency and its prevalence increases with age. The treatment consists of a daily oral supplementation of 1 gram of vitamin C/d for 15 days. A minimum intake of 10 mg/D of vitamin C is required to prevent scurvy and maintain a total pool of 350 mg. A diet modification by a systematic intake of 2 glasses of fresh orange juice and/or the consumption of raw fruits and vegetables would prevent the appearance of scurvy.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patient living in the Unit of Long Term Care | Experimental | Procedure: Blood samplePatient living in the Unit of Long Term Care without any limit time |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Older adult
Key inclusion criteria (4 listed)
- Male or female over 65 years old
- living in the Unit of Long Term Care without any limit time.
- with a system of social insurance
- Who gave its consent by his own , or with help of his representant or his tutor or curator.
Key exclusion criteria (4 listed)
- rejection of the blood sample
- patient feeding with articial nutritional feeding (stomach tube feeding)
- person close to death, who is not able to feed himself and / or with life-threatening in short time.
- Patient with personal history of vitamin C deficiency.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Blood sampleA blood sample will be taken by the nurse of our unit within a week after their consent. It consists as a simple blood sample and it will be taken during the normal analysis planed by the chief of the service in order to avoid to collect two different samples. The measurement method will use equipment from the Lyon Sud hospital laboratory. The samples need a pre-treatment in the 3 hours after taking the blood to avoid the oxidation of vitamin C and a result lower than expected. | Procedure or surgery | Patient living in the Unit of Long Term Care |
Primary outcome
Vitamin C plasma level
Time frame: Between day 0 and day 7.
1. ) Collection of the consent 2. ) At the same time as other analysis for current cares a blood sample taken by a nurse of our unit to determine plasma levels of vitamin C. 3. ) Registration of risk factors of vitamin C deficiency. . 4. ) Doing a clinical exam within 7 days after the blood sample.
2 secondary outcomes
Supposed risk factors of hypovitaminosis C
Time frame: Day 0
Cutaneous symptoms
Time frame: Day 0
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Sep 2025.
- Results publicationLagorsse C., Oumédian E., Bourguignon L, de La Gastine B. Les carences en vitamine C, une cause peu connue d'affections cutanées en institution gériatrique : à propos de 2 cas en Unité de Soins de Longue Durée (USLD). Rev Geriatr 2019 Février 44 2.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Blood sample in people with Vitamin C Deficiency and Scurvy, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Vitamin C plasma level (time frame: Between day 0 and day 7.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03807791, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.