AzTrials
AzTrials

Coronary Heart Disease (CHD)Phase 3VESALIUS-CVNCT03872401

Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

A Phase 3 study testing Evolocumab in people with Coronary Heart Disease (CHD), run by Amgen at 852 sites in 33 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

Search all trials

Trial summary

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event. Read more about this study

Who is it for?
Ages 50 to 79 years
Conditions the study is for
Coronary Heart Disease (CHD)
What is being tested?
Evolocumab
Type of treatment
Injection or infusion
Could I receive a placebo?
Yes, some participants may receive a placebo
How many people
12,301 participants
Where
852 sitesin 33 countries
Study dates
11 Jun 2019to 25 Jul 2025
Phase
Phase 3

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 50 to 79 years
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Age: Adult participants ≥ 50 (men) or ≥ 55 (women) to ˂ 80 years of age (either sex) and meeting lipid criteria.
  • Lipid Criteria: Low-density lipoprotein cholesterol (LDL-C) ≥ 90 mg/dL (≥ 2.3 mmol/L) or non high-density lipoprotein cholesterol (non-HDL)-C ≥ 120 mg/dL (≥ 3.1 mmol/L), or apolipoprotein B ≥ 80 mg/dL (≥ 1.56 µmol/L).
  • 3.Diagnostic evidence of at least one of the following (A-D) at screening:
  • A.Significant coronary artery disease (CAD) meeting at least 1 of the following criteria:
  • History of coronary revascularization with multi-vessel coronary disease as evidenced by any of the following:
  • percutaneous coronary intervention (PCI) of 2 or more vessels, including branch arteries,
Show all 36Show fewer
  • PCI or coronary artery bypass grafting (CABG) with residual 50% stenosis in a separate, unrevascularized vessel, or
  • multi-vessel CABG 5 years or more prior to screening.
  • Significant coronary disease without prior revascularization as evidenced by either a ≥70% stenosis of at least 1 coronary artery, ≥50% stenosis of 2 or more coronary arteries, or ≥50% stenosis of the left main coronary artery.
  • known coronary artery calcium score ≥100 in participants without a coronary artery revascularization prior to randomization.
  • Significant atherosclerotic cerebrovascular disease meeting at least 1 of the following criteria:
  • prior transient ischemic attack with ≥50% carotid stenosis.
  • internal or external carotid artery stenosis of ≥70% or 2 or more ≥50% stenoses.
  • prior internal or external carotid artery revascularization.
  • Significant peripheral arterial disease meeting at least 1 of the following criteria:
  • ≥50% stenosis in a limb artery.
  • history of abdominal aorta treatment (percutaneous and surgical) due to atherosclerotic disease.
  • ankle brachial index (ABI) <0.85.
  • Diabetes mellitus with at least 1 of the following:
  • known microvascular disease, defined by diabetic nephropathy or treated retinopathy. Diabetic nephropathy defined as persistent microalbuminuria (urinary albumin to creatinine ratio ≥30mg/g) and/or persistent estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m^2 that is not reversible due to an acute illness.
  • chronic daily treatment with an intermediate or long-acting insulin.
  • diabetes diagnosis ≥10 years ago.
  • •At least 1 of the following 1 high-risk criteria (most recent lab values within 6 months prior to screening, as applicable):
  • Polyvascular disease, defined as coronary, carotid, or peripheral artery stenosis ≥50% in a second distinct vascular location in a participant with coronary, cerebral or peripheral arterial disease (A, B, or C above).
  • Presence of either diabetes mellitus or metabolic syndrome in a participant with coronary, cerebral, or peripheral artery disease (A, B, or C above).
  • At least 1 coronary, carotid, or peripheral artery residual stenosis of ≥50% in a participant with diabetes meeting inclusion criterion (D above).
  • LDL-C ≥130 mg/dL (≥3.36 mmol/L), OR non-HDL-C ≥160 mg/dL (≥4.14 mmol/L), OR apolipoprotein B ≥120 mg/dL (2.3 µmol/L) if available.
  • Lipoprotein (a) >125 nmol/L (50 mg/dL).
  • Known familial hypercholesterolemia.
  • Family history of premature coronary artery disease defined as an MI or CABG in the participant's father or brother at age <55 years or an MI or CABG in the participant's mother or sister at age <60 years.
  • High sensitive c-reactive protein (hsCRP) ≥3.0 mg/L in the absence of an acute illness.
  • Current tobacco use.
  • -≥65 years of age.
  • Menopause before 40 years of age.
  • eGFR 15 to <45 mL/min/1.73 m^2.
  • Coronary artery calcification score ≥300 in a participant without a coronary revascularization prior to randomization.

Who cannot join

  • MI or stroke prior to randomization.
  • CABG ˂ 3 months prior to screening.
  • eGFR ˂ 15 mL/min/1.73 m^2.
  • Uncontrolled or recurrent ventricular tachycardia in the absence of an implantable-cardioverter defibrillator.
  • Atrial fibrillation or atrial flutter not on anticoagulation therapy (vitamin K antagonist, heparin, low molecular weight heparin, fondaparinux,or non-Vitamin K antagonist oral anticoagulant).
  • Triglycerides ≥ 500 mg/dL (5.7 mmol/L) measured up to 3 months prior to screening. The most recent results must be used.
  • Last measured left-ventricular ejection fraction ˂ 30% or New York Heart Association (NYHA) Functional Class III/IV.
  • Planned arterial revascularization.

Trial locations and contacts

852 sites in 33 countries.

852 sites in 33 countries

United States145 sites

  • Alexandria Cardiology Clinic

    Alexandria, Louisiana, 71301

  • Northwest Heart Clinical Research LLC

    Arlington Heights, Illinois, 60005

  • Asheville Cardiology Associates

    Asheville, North Carolina, 28803

  • North Alabama Research Center LLC

    Athens, Alabama, 35611

  • Maryland Cardiovascular Specialists

    Baltimore, Maryland, 21229

  • Northern Light Eastern Maine Medical Center

    Bangor, Maine, 04401

  • Metropolitan Cardiovascular Consultants LLC

    Beltsville, Maryland, 20705

  • Cardiovascular Research Foundation of Southern California

    Beverly Hills, California, 90210

  • Westside Medical Associates of Los Angeles

    Beverly Hills, California, 90211

  • Southern Maine Health Care

    Biddeford, Maine, 04005

  • Cardiovascular Associates

    Birmingham, Alabama, 35243

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434

  • Grace Research LLC

    Bossier City, Louisiana, 71111

  • Brigham and Womens Hospital

    Boston, Massachusetts, 02215

  • Bay Area Cardiology

    Brandon, Florida, 33511

  • Healthwise Medical Associates

    Brooklyn, New York, 11206

  • Capital Area Research LLC

    Camp Hill, Pennsylvania, 17011

  • Geisinger Holy Spirit

    Camp Hill, Pennsylvania, 17011

  • University of North Carolina at Chapel Hill

    Chapel Hill, North Carolina, 27599

  • Pharmacorp Clinical Trials Inc

    Charleston, South Carolina, 29412

  • Novant Health Heart and Vascular Institute

    Charlotte, North Carolina, 28204

  • Trinity Medical Western New York, PC

    Cheektowaga, New York, 14227

  • The Christ Hospital

    Cincinnati, Ohio, 45219

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106

  • Kootenai Heart Clinics, LLC

    Coeur d'Alene, Idaho, 83814

  • Optumcare Colorado Springs LLC

    Colorado Springs, Colorado, 80906

  • University of Colorado Memorial Health System

    Colorado Springs, Colorado, 80909

  • Saint Elizabeth Covington

    Covington, Kentucky, 41011

  • Nature Coast Clinical Research LLC

    Crystal River, Florida, 34429

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • Southwest Family Medicine Associates

    Dallas, Texas, 75235

  • Midwest Cardiovascular Research Foundation

    Davenport, Iowa, 52801

  • Daytona Heart Group

    Daytona Beach, Florida, 32114

  • Cardiology Research Associates

    Daytona Beach, Florida, 32117

  • Complete Health Research

    DeLand, Florida, 32720

  • Cohen Medical Associates PA

    Delray Beach, Florida, 33446

  • Doylestown Health Cardiology

    Doylestown, Pennsylvania, 18901

  • West Coast Research LLC

    Dublin, California, 94568

  • Saint Marys Medical Center

    Duluth, Minnesota, 55805

  • North Ohio Heart Center

    Elyria, Ohio, 44035

  • Horizon Research Group of Opelousas LLC

    Eunice, Louisiana, 70535

  • Deaconess Clinic

    Evansville, Indiana, 47713

  • Lillestol Research LLC

    Fargo, North Dakota, 58104

  • Alpine Research Organization

    Farmington, Utah, 84025

  • Ahmed Arif Medical Research Center LLC

    Flint, Michigan, 48504

  • Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care

    Fort Lauderdale, Florida, 33312

  • Piedmont Research Partners

    Fort Mill, South Carolina, 29707

  • Charles River Medical Associates

    Framingham, Massachusetts, 01701

  • New West Physicians

    Golden, Colorado, 80401

  • Healthy Heart Cardiology

    Grand Rapids, Michigan, 49546

  • East Mountain Medical Associates, PC

    Great Barrington, Massachusetts, 01230

  • Great Falls Clinic LLP

    Great Falls, Montana, 59405

  • George E Platt MD

    Green Cove Springs, Florida, 32043

  • Moses H Cone Memorial Hospital

    Greensboro, North Carolina, 27401

  • Tribe Clinical Research LLC DBA Mountain View Clinical Research

    Greenville, South Carolina, 29607

  • Louisiana Heart Center

    Hammond, Louisiana, 70403

  • Research Physicians Network Alliance

    Hollywood, Florida, 33021

  • Heart Center Research LLC

    Huntsville, Alabama, 35801

  • The University of Iowa College of Public Health

    Iowa City, Iowa, 52242

  • Rajendra H Mehta, MD, PC

    Jackson, Michigan, 49201

  • University of Florida and Shands Hospital

    Jacksonville, Florida, 32209

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216

  • First Coast Cardiovascular Institute PA

    Jacksonville, Florida, 32256

  • Baptist Health Research Institute

    Jacksonville Beach, Florida, 32250

  • Lycoming Internal Medicine Inc

    Jersey Shore, Pennsylvania, 17740

  • NSC Research

    Johns Creek, Georgia, 30024

  • The University of Kansas Medical Center

    Kansas City, Kansas, 66160-7601

  • Kansas City Veterans Affairs Medical Center

    Kansas City, Missouri, 64128

  • WMCHealth Heart and Vascular Institute Kingston Division of Cardiology

    Kingston, New York, 12401

  • Humble Cardiology Associates

    Kingwood, Texas, 77339

  • Texas Cardiology Associates of Houston

    Kingwood, Texas, 77339

  • Palm Research Center Inc

    Las Vegas, Nevada, 89128

  • The Research Group of Lexington LLC

    Lexington, Kentucky, 40503

  • Bryan Heart

    Lincoln, Nebraska, 68506

  • Main Street Physicians Care Waterway

    Little River, South Carolina, 29566

  • Arkansas Cardiology

    Little Rock, Arkansas, 72205

  • Central Arkansas Veterans Healthcare System

    Little Rock, Arkansas, 72205

  • South Denver Cardiology Associates

    Littleton, Colorado, 80120

  • Texas Institute for Kidney and Endocrine Disorders

    Lufkin, Texas, 75904

  • Northwell Health Physician Partners Cardiology

    Manhasset, New York, 11030

  • Sanjay Vora Research LLC

    Marion, Ohio, 43302

  • Texas Institute of Cardiology

    McKinney, Texas, 75071

  • Southern Endocrinology Associates PA

    Mesquite, Texas, 75149

  • Gad Research Center

    Miami, Florida, 33155

  • Cardiovascular Research Center of South Florida

    Miami, Florida, 33173

  • LaPorte County Institute for Clinical Research

    Michigan City, Indiana, 46360

  • Minneapolis Heart Institute Foundation

    Minneapolis, Minnesota, 55407

  • Mobile Heart Specialists PC

    Mobile, Alabama, 36608

  • Crossroads Clinical Research Inc

    Mooresville, North Carolina, 28117

  • The Diabetes Center

    Murrells Inlet, South Carolina, 29576

  • Barnum Medical Research

    Natchitoches, Louisiana, 71457

  • North Shore Diabetes and Endocrine Associates

    New Hyde Park, New York, 11042

  • Northwell Health Lenox Hill Heart and Vascular

    New York, New York, 10022

  • Intend Research

    Norman, Oklahoma, 73069

  • Parkway Cardiology Associates

    Oak Ridge, Tennessee, 37830

  • Ocala Research Institute, Inc

    Ocala, Florida, 34471

  • Permian Research Foundation

    Odessa, Texas, 79761

  • Nebraska Western Iowa Health Care System

    Omaha, Nebraska, 68105

  • Desert Oasis Healthcare Medical Group

    Palm Springs, California, 92262

  • Cardiology Consultants

    Pensacola, Florida, 32501

  • Perelman Center for Advanced Medicine

    Philadelphia, Pennsylvania, 19104

  • Cardiology Consultants of Philadelphia CCP

    Philadelphia, Pennsylvania, 19107

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213

  • Charlotte Heart Group Research Center

    Port Charlotte, Florida, 33952

  • Oregon Health and Science University

    Portland, Oregon, 97239

  • Hudson Valley Cardiovascular Physicians PC

    Poughkeepsie, New York, 12601

  • Miriam Hospital

    Providence, Rhode Island, 02906

  • Multicare Institute for Research and Innovation

    Puyallup, Washington, 98372

  • Monument Health Clinical Research

    Rapid City, South Dakota, 57701

  • Covigilant Research, LLC

    Riverside, California, 92506

  • Piedmont Medical Group Research of Rocky Mount

    Rocky Mount, North Carolina, 27804

  • Sierra Clinical Research

    Roseville, California, 95661

  • Center for Clinical Trials of Sacramento Inc

    Sacramento, California, 95823

  • Saint Cloud Hospital

    Saint Cloud, Minnesota, 56303

  • HealthEast Medical Research Institute

    Saint Paul, Minnesota, 55102

  • TidalHealth Peninsula Regional, Inc

    Salisbury, Maryland, 21804

  • PMG Research of Salisbury

    Salisbury, North Carolina, 28144

  • South Texas Cardiovascular Consultants PLLC

    San Antonio, Texas, 78201

  • Mercury Medical Conversions LTD

    San Antonio, Texas, 78229

  • North Ohio Heart Center-Sandusky

    Sandusky, Ohio, 44870

  • Intercoastal Medical Group

    Sarasota, Florida, 34232

  • Cardiovascular Center of Sarasota

    Sarasota, Florida, 34239

  • Saratoga Clinical Research, LLC

    Saratoga Springs, New York, 12866

  • Grace Research LLC

    Shreveport, Louisiana, 71105

  • Louisiana Heart Center

    Slidell, Louisiana, 70458

  • Division of Cardiovascular Research at Peconic Bay Medical Center

    Southampton, New York, 11968

  • Baystate Health Center

    Springfield, Massachusetts, 01199

  • Heart House Research Foundation

    Springfield, Ohio, 45504

  • Mercy Research

    St Louis, Missouri, 63141

  • Cardiology Associates of Fairfield County, PC

    Stamford, Connecticut, 06905

  • Suffolk Multispecialty Research LLC

    Suffolk, Virginia, 23435

  • Palmetto Clinical Research

    Summerville, South Carolina, 29485

  • Universal Research Group LLC

    Tacoma, Washington, 98405

  • Northwest Houston Heart Center

    Tomball, Texas, 77375

  • Harbor University of California Los Angeles Medical Center

    Torrance, California, 90502

  • Munson Medical Center

    Traverse City, Michigan, 49684

  • Oklahoma Heart Institute

    Tulsa, Oklahoma, 74133

  • Virtua Health, Inc.

    Voorhees Township, New Jersey, 08043

  • Aspirus Research Institute

    Wausau, Wisconsin, 54401

  • MercyOne Iowa Heart Center

    West Des Moines, Iowa, 50266

  • Selma Medical Associates

    Winchester, Virginia, 22601

  • Novant Health Forsyth Medical Center

    Winston-Salem, North Carolina, 27103

  • Wake Forest University Health Sciences

    Winston-Salem, North Carolina, 27157

  • Florida Cardiology Group

    Winter Park, Florida, 32792

  • The Florida Lipid Institute

    Winter Park, Florida, 32792

Other trials in United States

Czechia54 sites

  • MUDr Igor Karen

    Benátky nad Jizerou, 294 71

  • Jessenia as, Nemocnice Beroun

    Beroun, 266 01

  • Medicentrum Beroun sro

    Beroun, 266 01

  • Medicus Services sro

    Brandýs nad Labem, 250 01

  • Amkardia sro

    Brno, 602 00

  • CCR Brno sro

    Brno, 602 00

  • Centrum pro zdravi sro

    Brno, 603 00

  • Kardiologicka ambulance Brno sro

    Brno, 612 00

  • Fakultni nemocnice Brno

    Brno, 625 00

  • Vojenska nemocnice Brno

    Brno, 636 00

  • prof MUDr Lubomir Elbl, CSc, Kardiologicka ambulance

    Brno, 638 00

  • Edumed sro, Kardiologicka ambulance

    Broumov, 550 01

  • Cevni centrum Ceske Budejovice sro

    České Budějovice, 370 11

  • Dika centrum sro

    Havirov - Mesto, 736 01

  • Clinical Trial Center Hodonin sro

    Hodonín, 695 01

  • Kardio Holesov sro

    Holešov, 769 01

  • MUDr Ladislava Harrerova, kardiologicka ordinace

    Hradec Králové, 500 02

  • Karlovarska krajska nemocnice

    Karlovy Vary, 360 01

  • Oblastni nemocnice Kladno as

    Kladno, 272 59

  • Kardio Michal Cepelak sro

    Klatovy IV, 339 01

  • Oblastni nemocnice Kolin as

    Kolin III, 280 02

  • Krajska nemocnice Liberec as

    Liberec, 460 63

  • KardioBusak sro

    Louny, 440 01

  • Kardio Pudich s.r.o.

    Ludgeřovice, 747 14

  • Vseobecna intermi ambulance sro

    Milevsko, 399 01

  • MUDr Zbynek Kosek, kardiologicka ambulance sro

    Mladá Boleslav, 293 01

  • Pozdisek sro, Kardiologicka ambulance

    Mohelnice, 789 85

  • CCR Ostrava sro

    Ostrava, 702 00

  • Mestska nemocnice Ostrava

    Ostrava, 728 80

  • Benedor sro - Kardiologicka, cevni a interni ambulance

    Ostrava - Poruba, 708 00

  • Kardiologicka a angiologicka ambulance

    Ostrava-Dubina, 700 30

  • Center for Clinical Research Pardubice, sro

    Pardubice, 530 02

  • Nemocnice Pardubickeho kraje as

    Pardubice, 532 03

  • Kardiologie v sadech sro

    Pilsen, 310 01

  • Ordinace pro choroby srdce a cev

    Prague, 101 00

  • Diabet2 sro

    Prague, 110 00

  • Vseobecna fakultni nemocnice v Praze

    Prague, 128 08

  • CCR Prague sro

    Prague, 130 00

  • Thomayerova nemocnice

    Prague, 140 59

  • Milan Kvapil sro

    Prague, 149 00

  • Fakultni nemocnice v Motole

    Prague, 150 06

  • Interni a kardiologicka ordinace

    Prague, 158 00

  • Endokrinologie Cerny Most sro

    Prague, 198 00

  • Kardiologie Cor sro

    Praha 10 - Zabehlice, 106 00

  • Kardiologicke centrum MUDr Janky Skrobakove sro

    Praha 5 - Smichov, 150 00

  • Kardio Vaclavik sro, Interni a kardiologicka ambulance

    Přerov, 750 02

  • Vestra Clinics sro

    Rychnov nad Kněžnou, 516 01

  • Nemocnice Pardubickeho kraje as, Svitavska nemocnice

    Svitavy, 568 25

  • AeskuLab ks, Lipidova poradna

    Teplice, 415 01

  • Nemocnice Podlesi as

    Třinec, 739 61

  • Clinical Trials Service sro

    Uherské Hradiště, 686 01

  • Interni ambulance

    Uherské Hradiště, 686 01

  • Lekarsky dum Ormiga

    Zlín, 760 01

  • KIGE sro

    Znojmo, 669 02

Other trials in Czechia

Netherlands53 sites

  • Noordwest Ziekenhuisgroep

    Alkmaar, 1815 JD

  • Ziekenhuisgroep Twente

    Almelo, 7609 PP

  • Emotional Brain

    Almere Stad, 1311 RL

  • Meander Medisch Centrum

    Amersfoort, 3813 TZ

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, 1061 AE

  • Onze Lieve Vrouwe Gasthuis

    Amsterdam, 1091 AC

  • Academisch Medisch Centrum

    Amsterdam, 1105 AZ

  • Gelre Ziekenhuis

    Apeldoorn, 7334 DZ

  • Rijnstate Ziekenhuis

    Arnhem, 6815 AD

  • Rode Kruis Ziekenhuis

    Beverwijk, 1942 LE

  • Amphia ziekenhuis

    Breda, 4818 CK

  • Reinier de Graaf Gasthuis

    Delft, 2625 AD

  • Deventer Ziekenhuis

    Deventer, 7416 SE

  • Van Weel Bethesda Ziekenhuis

    Dirksland, 3247 BW

  • Albert Schweitzer Ziekenhuis location Dordwijk

    Dordrecht, 3318 AT

  • Albert Schweitzer Ziekenhuis, Locatie Dordwijk

    Dordrecht, 3318 AT

  • Ziekenhuis Gelderse Vallei

    Ede, 6716 RP

  • Catharina Ziekenhuis

    Eindhoven, 5623 EJ

  • Treant Zorggroep, locatie Scheper ziekenhuis Emmen

    Emmen, 7824 AA

  • Medisch Spectrum Twente

    Enschede, 7512 KZ

  • Admiraal de Ruyter Ziekenhuis

    Goes, 4462 RA

  • Groene Hart Ziekenhuis

    Gouda, 2803 HH

  • Martini Ziekenhuis

    Groningen, 9728 NT

  • Sint Jansdal Ziekenhuis

    Harderwijk, 3844 DG

  • Zuyderland Medisch Centrum

    Heerlen, 6419 PC

  • Elkerliek Ziekenhuis

    Helmond, 5707 HA

  • Tergooi

    Hilversum, 1213 XZ

  • Bethesda Diabetes Research Center

    Hoogeveen, 7909 AA

  • Dijklander Ziekenhuis Hoorn

    Hoorn, 1624 NP

  • Medisch Centrum Leeuwarden

    Leeuwarden, 8934 AD

  • Leids Universitair Medisch Centrum

    Leiden, 2333 ZA

  • Isala Diaconessenhuis

    Meppel, 7943 KA

  • Sint Antonius Ziekenhuis, locatie Nieuwegein

    Nieuwegein, 3435 CM

  • Radboudumc

    Nijmegen, 6525 GA

  • Canisius-Wilhelmina Ziekenhuis

    Nijmegen, 6532 SZ

  • Franciscus Gasthuis

    Rotterdam, 3045 PM

  • Praktijk Soerland

    Rotterdam, 3067 GJ

  • Maasstad Ziekenhuis

    Rotterdam, 3079 DZ

  • Ikazia Ziekenhuis

    Rotterdam, 3083 AN

  • Franciscus Vlietland

    Schiedam, 3118 JH

  • D&A Research and Genetics

    Sneek, 8601 ZR

  • Haga Ziekenhuis

    The Hague, 2545 AA

  • Huisartsenpraktijk Rambharose

    The Hague, 2572 GM

  • Ziekenhuis Rivierenland

    Tiel, 4002 WP

  • Elisabeth-Tweesteden Ziekenhuis

    Tilburg, 5042 AD

  • Ziekenhuis Bernhoven

    Uden, 5406 PT

  • Diakonessenhuis

    Utrecht, 3582 KE

  • Universitair Medisch Centrum Utrecht

    Utrecht, 3584 CX

  • VieCuri Medisch Centrum

    Venlo, 5912 BL

  • Zaans Medisch Centrum

    Zaandam, 1502 DV

  • Albert Schweitzer Ziekenhuis

    Zwijndrecht, 3331 LZ

  • Dokters van Nederhoven

    Zwijndrecht, 3334 SB

  • Isala Klinieken

    Zwolle, 8025 AB

Other trials in Netherlands

Poland52 sites

  • Szpital Uniwersytecki nr 1 im dr Antoniego Jurasza w Bydgoszczy

    Bydgoszcz, 85-094

  • American Heart of Poland Sa Malopolskie Centrum Sercowo-Naczyniowe PAKS - Chrzanow

    Chrzanów, 32-500

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, 80-219

  • Copernicus Podmiot Leczniczy Sp zoo

    Gdansk, 80-462

  • NZOZ Srodmiescie Spzoo

    Gdynia, 81-394

  • Marek Piepiorka Gabinet Kardiologiczno-Internistyczny

    Gdynia, 81-472

  • Spolka Cywilna Medicina

    Giżycko, 11-500

  • Samodzielny Publiczny Specjalistyczny Szpital Zachodni im swietego Jana Pawla II

    Grodzisk Mazowiecki, 05-825

  • Biokinetica SA

    Józefów, 05-410

  • Centrum Medyczne Pratia Katowice

    Katowice, 40-081

  • Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego Beata Wozakowska-Kaplon

    Kielce, 25-525

  • Wojewodzki Szpital Zespolony w Kielcach

    Kielce, 25-736

  • Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska

    Krakow, 30-082

  • Zespol Przychodni Specjalistycznych Diab-End-Cor Sp z oo

    Krakow, 31-135

  • Krakowskie Centrum Medyczne Spzoo

    Krakow, 31-501

  • CARINTART Sp zoo Krakowskie Centrum Diagnostyczno-Kliniczne

    Krakow, 31-514

  • Intercard Spzoo Centrum Kardiologii Inwazyjnej Elektroterapii i Angiologii w Krosnie

    Krosno, 38-400

  • Samodzielny Publiczny Zakład Opieki Zdrowotnej w Lecznej

    Łęczna, 21-010

  • Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi

    Lodz, 91-347

  • Instytut Centrum Zdrowia Matki Polki

    Lodz, 93-338

  • Miedziowe Centrum Zdrowia Spolka Akcyjna

    Lubin, 59-300

  • CenterMed Lublin Spzoo

    Lublin, 20-044

  • Clinical Best Solutions Sp zoo Spolka komandytowa Gabinet Lekarski

    Lublin, 20-078

  • Ko-med Centra Kliniczne Lublin II

    Lublin, 20-362

  • NZOZ Twoja Przychodnia Spzoo

    Lublin, 20-857

  • Szpital Swietej Anny w Miechowie

    Miechów, 32-200

  • Podhalanski Szpital Specjalistyczny im Jana Pawla II w Nowym Targu

    Nowy Targ, 34-400

  • Centrum Medyczne Pulawska spzoo Centrum Medyczne Pulawska NZOZ

    Piaseczno, 05-500

  • NZOZ Specjalistyczna Przychodnia Lekarska Medikard

    Płock, 09-402

  • Clinical Research Center Spzoo Medic-R Spolka Komandytowa

    Poznan, 60-848

  • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Pulawy

    Puławy, 24-100

  • NZOZ Przychodnia Specjalistyczna Andrzej Wittek Henryk Rudzki spolka jawna

    Ruda Śląska, 41-709

  • Clinical Best Solutions Spolka z ograniczona odpowiedzialnoscia Spolka komandytowa

    Siedlce, 08-110

  • ETG Network Spzoo

    Skierniewice, 96-100

  • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Staszow

    Staszów, 28-200

  • Tomasz Blicharski Lubelskie Centrum Diagnostyczne

    Świdnik, 21-040

  • Indywidualna Specjalistyczna Praktyka Lekarska

    Szczecin, 70-506

  • Centrum Szybkiej Diagnostyki Kardiologicznej Kardiomed M Zabowka E Zabowka Spolka cywilna

    Tarnów, 33-100

  • Medical Trials Institute Spzoo

    Torun, 87-100

  • Prywatne Centrum Kardiologii

    Torun, 87-100

  • Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu

    Torun, 87-100

  • Centrum Medyczne Amed Warszawa Zoliborz

    Warsaw, 01-518

  • Centrum Medyczne Pratia Warszawa

    Warsaw, 01-868

  • Clinical Best Solutions Sp zoo Spolka komandytowa

    Warsaw, 02-793

  • Instytut Psychiatrii i Neurologii

    Warsaw, 02-957

  • Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo

    Warsaw, 04-073

  • Samodzielny Publiczny Zaklad Opieki Zdrowotnej w Wegrowie

    Węgrów, 07-100

  • Medicor Plus Kardiolodzy Spzoo

    Włocławek, 87-800

  • Futuremeds spolka z ograniczona odpowiedzialnoscia

    Wroclaw, 50-088

  • Centrum Kardiologiczne Pro Corde Spzoo Centrum Kardiologicne Pro Corde Wroclaw

    Wroclaw, 50-315

  • Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska

    Wroclaw, 51-162

  • KO-MED Centra Kliniczne Spzoo KO-MED Centra Kliniczne Zamosc

    Zamość, 22-400

Other trials in Poland

United Kingdom50 sites

  • Aberdeen Royal Infirmary

    Aberdeen, AB25 2ZN

  • Barnsley Hospital

    Barnsley, S75 2EP

  • Royal United Hospital

    Bath, BA1 3NG

  • Royal Victoria Hospital

    Belfast, BT12 6BA

  • Ulster Hospital

    Belfast, BT16 1RH

  • Ormeau Health Centre

    Belfast, BT7 2EB

  • Bollington Medical Centre

    Bollington, SK10 5JH

  • Royal Bournemouth Hospital

    Bournemouth, BH7 7DW

  • West Walk Surgery

    Bristol, BS37 4AX

  • University Hospitals of Derby and Burton NHS Foundation Trust

    Burton-on-Trent, DE13 0RB

  • Ashgate Medical Practice

    Chesterfield, S40 4AA

  • Cleveleys Group Practice

    Cleveleys, FY5 3LF

  • Lakeside Healthcare

    Corby, NN17 2UR

  • Medinova Northamptonshire Dedicated Research Site

    Corby, NN18 9EZ

  • MeDiNova Warwickshire Quality Research Site

    Coventry, CV3 4FJ

  • Pound Hill Medical Group

    Crawley, RH10 7DX

  • Ninewells Hospital

    Dundee, DD1 9SY

  • Glasgow Royal Infirmary

    Glasgow, G31 2ER

  • Hull Royal Infirmary

    Hull, HU3 2RW

  • Highlands Clinical Research Facility, Raigmore Hospital

    Inverness, IV2 3JH

  • Royal Liverpool University Hospital

    Liverpool, L7 8XP

  • Barts Health NHS Trust

    London, EC1M 6BQ

  • Royal Free London NHS Foundation Trust

    London, NW3 2QG

  • Guys Hospital

    London, SE1 9RT

  • Wythenshawe Hospital

    Manchester, M23 9LT

  • Medinova North London Dedicated Research Centre

    Northwood, HA6 2RN

  • Nottingham City Hospital

    Nottingham, NG5 1PB

  • George Eliot Hospital

    Nuneaton, CV10 7DJ

  • Medinova South London Dedicated Research Centre

    Orpington, BR5 3QG

  • Mounts Bay Medical Hub

    Penzance, TR19 7HX

  • The Health Centre Yaxley

    Peterborough, PE7 1AT

  • The Adam Practice

    Poole, BH16 5PW

  • Medinova East London Dedicated Research Centre

    Romford, RM1 3PJ

  • Sherbourne Medical Centre

    Royal Leamington Spa, CV32 4RA

  • Eaton Socon Health Centre

    Saint Neots, PE19 8BB

  • Ashfield Primary Care Centre

    Sandbach, CW11 1EQ

  • Scunthorpe General Hospital

    Scunthorpe, DN15 7BH

  • Medinova Limited

    Shipley, BD18 3SA

  • Lakeside Healthcare Stamford

    Stamford, PE9 2DH

  • Lister Hospital

    Stevenage, SG1 4AB

  • Singleton Hospital

    Swansea, SA2 8PP

  • The Breckland Alliance

    Thetford, IP24 1JD

  • Torbay Hospital

    Torquay, TQ2 7AA

  • Pinderfields Hospital

    Wakefield, WF1 4DG

  • Sheepcot Medical Practice

    Watford, WD25 7NL

  • Sandwell General Hospital

    West Bromwich, B71 4HJ

  • Whitby Group Practice

    Whitby, YO21 1SD

  • MeDiNova West London Quality Research Site

    Wokingham, RG40 1XS

  • Worcestershire Royal Hospital

    Worcester, WR5 1DD

  • Yeovil District Hospital

    Yeovil, BA21 4AT

Other trials in United Kingdom

Russia42 sites

  • First City Clinical Hospital na E E Volosevich

    Arkhangelsk, 163001

  • NSHI Departmental Hospital at the station Barnaul of OJSC Russian Railways

    Barnaul, 656038

  • Regional State Budget Health care Institution Altay Regional Cardiology Dispensary

    Barnaul, 656055

  • Regional Budget Healthcare Institution Cardiology Dispensary

    Ivanovo, 153012

  • BHI of Republic Udmurtiya City clinical hospital 9 of Ministry of healthcare of Republic Udmurtiya

    Izhevsk, 426063

  • FSBI Heart and Vessels Diseases complex problems Scientific Research Institution

    Kemerovo, 650002

  • Kirov Regional State Budget Healthcare Institution Kirov City Clinical Hospital 1

    Kirov, 610014

  • Regional Clinical Hospital 2 of the Ministry of Health Krasnodar region

    Krasnodar, 350012

  • SBHI Scientific Research Institute Regional Clinical Hospital 1 named after S V Ochapovsky

    Krasnodar, 350086

  • National Medical Research Center for therapy and preventive medicine

    Moscow, 101990

  • Moscow SBHI City Clinical Hospital 15 n a O M Filatov of Moscow Healthcare Department

    Moscow, 111539

  • SBHI of Moscow City clinical hospital 64 of Moscow Healthcare department

    Moscow, 117292

  • City Clinical Hospital named after Zhadkevich

    Moscow, 121374

  • FSBI Russian Cardiology Research and Production Complex

    Moscow, 121552

  • SBHI of Nizhny Novgorod region Nizhny Novgorod regional clinical hospital na N A Semashko

    Nizhny Novgorod, 603126

  • LLC RC Medical

    Novosibirsk, 630005

  • SBHI of Novosibirsk Region City clinical hospital 1

    Novosibirsk, 630047

  • FSBSI Scientific Research Institute of Therapy and preventive medicine

    Novosibirsk, 630089

  • Budget Healthcare Institution of Omsk region Medical-sanitary unit 9

    Omsk, 644018

  • Perm Regional Hospital for War Veterans

    Perm, 614097

  • State Budget Institution of Ryazan Region Regional Clinical Hospital

    Ryazan, 390039

  • City Polyclinic 27

    Saint Petersburg, 190031

  • Saint Petersburg State Budget Healthcare Institution City Polyclinic 109

    Saint Petersburg, 192283

  • Saint Petersburg State Budget Healthcare Institution City Polyclinic 109

    Saint Petersburg, 192289

  • City polyclinic 25 Nevsky district

    Saint Petersburg, 193312

  • SBHI Medical and sports dispensary of Krasnogvardeisky district of Saint Petersburg

    Saint Petersburg, 195112

  • Saint Petersburg SBHI City Hospital 38 named after N A Semashko

    Saint Petersburg, 196601

  • Almazov National Medical Research Centre

    Saint Petersburg, 197341

  • Saint Petersburg State Budget Healthcare Institution Pokrovskaya City Hospital

    Saint Petersburg, 199106

  • LLC Mart

    Saint Petersburg, 199178

  • LLC Medinef Clinic

    Sait-Petersburg, 194044

  • Samara Regional Clinical Cardiology Dispensary

    Samara, 443070

  • Clinical Hospital named after S R Mirotvortsev

    Saratov, 410054

  • Regional State Budget Helthcare Institution Smolensk Regional Clinical Hospital

    Smolensk, 214018

  • State Budgetary Health Institution City Hospital 4 of the City of Sochi

    Sochi, 354057

  • FSBSI Tomsk National Research Medical Center of the Russian Academy of Sciences

    Tomsk, 634012

  • Tyumen State Medical University

    Tyumen, 625023

  • State Autonomous Healthcare Institution of the Tyumen region Medical Scientific Practical Center

    Tyumen, 625032

  • SBHI of Vladimirskaya region City Hospital 4 of Vladimir

    Vladimir, 600020

  • Family Medicine Clinic

    Volgograd, 400001

  • Central City Clinical Hospital 1 of the Oktyabrsky District

    Yekaterinburg, 620026

  • State Budget Medical Institution Sverdlovsk Regional Clinical Hospital N1

    Yekaterinburg, 620102

Other trials in Russia

Hungary37 sites

  • Lausmed Kft

    Baja, 6500

  • Allami Szivkorhaz Balatonfured

    Balatonfüred, 8230

  • Balatonmariafurdo Kozseg Onkormanyzatanak Haziorvosi Rendeloje

    Balatonkeresztúr, 8647

  • Med-Edu Bt

    Ballószög, 6035

  • Dr Lakatos Ferenc Private Cardiology Practice

    Békéscsaba, 5600

  • Grof Tisza Istvan Korhaz

    Berettyóújfalu, 4100

  • Betegapolo Irgalmas Rend - Budai Irgalmasrendi Korhaz

    Budapest, 1023

  • Clinexpert Kft

    Budapest, 1033

  • Obudai Egeszsegugyi Centrum Kft

    Budapest, 1036

  • Semmelweis Egyetem Varosmajori Sziv- es Ergyogyaszati Klinika

    Budapest, 1085

  • Gottsegen Gyorgy Orszagos Kardiologiai Intezet

    Budapest, 1096

  • Bajcsy-Zsilinszky Korhaz es Rendelointezet

    Budapest, 1106

  • Semmelweis Egyetem

    Budapest, 1122

  • Magyar Honvedseg Egeszsegugyi Kozpont

    Budapest, 1134

  • Uzsoki Utcai Korhaz

    Budapest, 1145

  • Zugloi Egeszsegugyi Szolgalat

    Budapest, 1148

  • Jahn Ferenc Del-pesti Korhaz es Rendelointezet

    Budapest, 1204

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032

  • Markhot Ferenc Oktatokorhaz es Rendelointezet

    Eger, 3300

  • Erzsebet Gondozohaz

    Gödöllő, 2100

  • Bugat Pal Korhaz

    Gyöngyös, 3200

  • Pharma4 Trial Kft

    Gyöngyös, 3200

  • Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz

    Gyula, 5700

  • BKS Research Kft

    Hatvan, 3000

  • Bacs-Kiskun Megyei Korhaz Szegedi Tudomanyegyetem Altalanos Orvostudomanyi Kar Oktato Korhaza

    Kalocsa, 6300

  • Selye Janos Korhaz

    Komárom, 2921

  • Borsod-Abauj-Zemplen Megyei Kozponti Korhaz es Egyetemi Oktatokorhaz

    Miskolc, 3526

  • CRU Hungary Kft

    Miskolc, 3529

  • Pecsi Tudomanyegyetem Klinikai Kozpont

    Pécs, 7624

  • Soproni Erzsebet Oktato Korhaz es Rehabilitacios Intezet

    Sopron, 9400

  • Szegedi Tudomanyegyetem Szent Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    Szeged, 6725

  • Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont Altalanos Orvostudomanyi Kar

    Szeged, 6725

  • Praxispont Belvarosi Maganegeszsegugyi Kozpont

    Székesfehérvár, 8000

  • Tolna Megyei Balassa Janos Korhaz

    Szekszárd, 7100

  • Csongrad Megyei Dr Bugyi Istvan Korhaz

    Szentes, 6600

  • Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet

    Szolnok, 5004

  • Belvarosi Egeszseghaz Kft

    Zalaegerszeg, 8900

Other trials in Hungary

Canada36 sites

  • Heart Health Institute

    Ajax, Ontario, L1Z 0B1

  • LMC Clinical Research Incorporated

    Barrie, Ontario, L4N 7L3

  • LMC Clinical Research Incorporated

    Brampton, Ontario, L6S 0C6

  • Brampton Clinical Trials

    Brampton, Ontario, L6Z 4N5

  • LMC Clinical Research Incorporated

    Calgary, Alberta, T2H 2G4

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9

  • LMC Clinical Research Incorporated Thornhill

    Concord, Ontario, L4K 4M2

  • LMC Clinical Research Incorporated

    Etobicoke, Ontario, M9R 4E1

  • Queen Elizabeth II Health Sciences Centre, Halifax Infirmary

    Halifax, Nova Scotia, B3H 3A7

  • Hamilton Health Sciences Hamilton General Hospital

    Hamilton, Ontario, L8L 2X2

  • Manna Research Incorporated

    Lévis, Quebec, G6W 0M5

  • Western Centre for Public Health and Family Medicine - Western University

    London, Ontario, N6G 2M1

  • My Endo Diabetes and Endocrinology Center

    Markham, Ontario, L3P 7P2

  • G A Research Associates Limited

    Moncton, New Brunswick, E1G 1A7

  • Clinique Sante Cardio MC

    Montreal, Quebec, H1T 3Y7

  • Institut de recherches cliniques de Montreal

    Montreal, Quebec, H2W 1R7

  • McGill University Health Centre - Montreal General Hospital

    Montreal, Quebec, H3G 1A4

  • Applied Medical Informatics Research Incorporated

    Montreal, Quebec, H4A 3T2

  • Commonwealth Medical Clinic

    Mount Pearl, Newfoundland and Labrador, A1N 1W7

  • LMC Clinical Research Incorporated

    Nepean, Ontario, K2J 0V2

  • Partners in Advanced Cardiac Evaluation

    Newmarket, Ontario, L3Y 2P6

  • SKDS Research Incorporated

    Newmarket, Ontario, L3Y 5G8

  • Oakville Cardiovascular Research

    Oakville, Ontario, L6K 3W7

  • Dr James Cha

    Oshawa, Ontario, L1J 2K1

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2

  • Clinique des Maladies Lipidiques de Quebec Incorporated

    Québec, Quebec, G1V 4W2

  • Centre intégré de santé et de services sociaux (CISSS) des Laurentides - Unité de recherche clini

    Saint-Jérôme, Quebec, J7Z 5T3

  • Bluewater Clinical Research Group Incorporated

    Sarnia, Ontario, N7T 4X3

  • Heart Health Institute Research Incorporated

    Scarborough Village, Ontario, M1B 4Z8

  • Corcare Cardiovascular Research

    Scarborough Village, Ontario, M1B 5N1

  • SMH Cardiology Clinical Trials Incorporated

    Surrey, British Columbia, V3V 0C6

  • Womens College Hospital

    Toronto, Ontario, M5S 1B2

  • North York Diagnostic and Cardiac Centre

    Toronto, Ontario, M6B 3H7

  • Dr T G Elliott Incorporated - BC Diabetes

    Vancouver, British Columbia, V5Y 3W2

  • Office of Dr Louis Yao

    Weston, Ontario, M9N 1W4

  • Winnipeg Clinic

    Winnipeg, Manitoba, R3C 0N2

Other trials in Canada

Argentina33 sites

  • Instituto de Investigaciones Clinicas Bahia Blanca

    Bahía Blanca, Buenos Aires, B8000FTD

  • Stat Research

    CABA, Buenos Aires, C1023AAB

  • Cinme - Centro de Investigaciones Metabolicas

    CABA, Buenos Aires, C1027AAP

  • Ciprec - Centro de Investigacion y Prevencion Cardiovascular

    CABA, Buenos Aires, C1119ACN

  • Consultorio Medico Dr Litvak Bruno

    CABA, Buenos Aires, C1406BOA

  • Centro de Especialidades Medicas - Cemedic

    CABA, Buenos Aires, C1407GTN

  • Centro Medico Laura Maffei

    CABA, Buenos Aires, C1425AGC

  • Cardiología Palermo

    CABA, Buenos Aires, C1425BNG

  • Cedic - Centro de Investigacion Clinica

    CABA, Buenos Aires, C1425DES

  • Centro Medico Dra De Salvo

    CABA, Buenos Aires, C1426ABP

  • Fundacion Respirar

    CABA, Buenos Aires, C1426ABP

  • Instituto de Investigaciones Metabolicas - Idim

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1012AAR

  • Hospital Universitario Fundacion Favaloro

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1093AAS

  • Icba - Instituto Cardiovascular de Buenos Aires

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1428ART

  • Glenny Corp SA

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1430CKE

  • Clinica Privada del Prado

    Córdoba, Córdoba Province, 5000

  • Instituto Medico DAMIC - Fundacion Rusculleda

    Córdoba, X5003DCE

  • Instituto de Cardiologia de Corrientes Juana Francisca Cabral

    Corrientes, W3400AMZ

  • Instituto de Investigaciones Clinicas Mar del Plata

    Mar del Plata, Buenos Aires, B7600FZN

  • Ciad - Consultorio Integral de Atencion al Diabetico

    Morón, Buenos Aires, B1708EPE

  • Dim Clinica Privada

    Ramos Mejía, Buenos Aires, B1704ETD

  • Instituto de Investigaciones Clínicas Rosario-Sanatorio Delta

    Rosario, Santa Fe Province, 2000

  • Sanatorio Plaza

    Rosario, Santa Fe Province, 2000

  • Cordis Sa

    Salta, A4400ANW

  • Clinica El Castano

    San Juan, J5400ARW

  • Instituto Cardiovascular San Luis

    San Luis, D5702JRS

  • Centro Modelo de Cardiologia

    San Miguel de Tucumán, Tucumán Province, 4000

  • Clinical Mayo de Urgencias Medicas Cruz Blanca SRL

    San Miguel de Tucumán, Tucumán Province, 4000

  • Instituto de Investigaciones Clinicas de San Nicolas

    San Nicolás de los Arroyos, Buenos Aires, B2900DMH

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO

  • Sanatorio Santa Rosa Srl

    Santa Rosa, La Pampa Province, 6300

  • Clinica Fusavim Privada SRL

    Villa María, Córdoba Province, X5900JKA

  • Instituto de Investigaciones Clinicas Zarate

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

Germany31 sites

  • Universitaets-Herzzentrum Freiburg - Bad Krozingen

    Bad Krozingen, 79189

  • Kerckhoff-Klinik Forschungs GmbH

    Bad Neuheim, 61231

  • Klinische Forschung Berlin GbR

    Berlin, 10787

  • Charite Universitätsmedizin Berlin, Charité Campus Virchow-Klinikum

    Berlin, 13353

  • Kardiologisch - Angiologische Praxis - Herzzentrum Bremen

    Bremen, 28277

  • Sankt-Johannes-Hospital

    Dortmund, 44137

  • Cardiologicum Dresden und Pirna

    Dresden, 01277

  • Diabetologische Gemeinschaftspraxis Dr Schaper und Dr Faulmann

    Dresden, 01279

  • Universitaetsklinikum Carl Gustav Carus, Medizinische Klinik und Poliklinik III

    Dresden, 01307

  • Klinikum und Fachbereich Medizin Johann Wolfgang Goethe-Universität Frankfurt am Main

    Frankfurt am Main, 60590

  • Clin Phenomics GmbH Co KG

    Frankfurt am Main, 60596

  • Medizinisches Versorgungszentrum im Altstadt-Carree Fulda

    Fulda, 36037

  • Cardiologicum Hamburg

    Hamburg, 22041

  • Universitätsklinikum Heidelberg

    Heidelberg, 69120

  • Ambulantes Herzzentrum Kassel

    Kassel, 34121

  • Universitätsklinikum Leipzig

    Leipzig, 4103

  • Otto von Guericke Universität Magdeburg

    Magdeburg, 39120

  • Johannes Gutenberg Universitaet Mainz

    Mainz, 55131

  • Universitätsklinikum Mannheim

    Mannheim, 68167

  • Praxis Doktor Jens Taggeselle

    Markleeberg, 04416

  • Deutsches Herzzentrum München des Freistaates Bayern

    München, 80636

  • Herz Gefaess Zentrum Nymphenburg

    München, 80638

  • Universitaetsklinikum Muenster

    Münster, 48149

  • Kardiologische Gemeinschaftspraxis Papenburg

    Papenburg, 26871

  • Klinikum Ernst von Bergmann gGmbH

    Potsdam, 14467

  • Universitätsklinikum Regensburg

    Regensburg, 93053

  • CardioConsil GmbH

    Rostock, 18059

  • I Medizinische Klinik Gesundheitsverbund Landkreis Konstanz

    Singen, 78224

  • Universitätsklinikum Ulm

    Ulm, 89081

  • Nephrologisches Zentrum Villingen-Schwenningen

    Villingen-Schwenningen, 78052

  • Forschungszentrum Ruhr

    Witten, 58455

Other trials in Germany

France27 sites

  • Centre Hospitalier Universitaire Amiens - Hopital Sud

    Amiens, 80054

  • Hospices Civils de Lyon Groupement Hospitalier Est, Hopital Louis Pradel

    Bron, 69677

  • Centre Hospitalier Universitaire de Caen - Hôpital Côte de Nacre

    Caen, 14033

  • Centre Hospitalier Sud Francilien

    Corbeil-Essonnes, 91106

  • Centre Hospitalier Universitaire de Dijon - Hopital Francois Mitterrand

    Dijon, 21079

  • Groupement Hospitalier Mutualiste

    Grenoble, 38000

  • Centre Hospitalier Universitaire de Grenoble - Hopital Nord Michallon

    Grenoble, 38700

  • Centre Hospitalier de Versailles - Hopital Andre Mignot

    Le Chesnay, 78150

  • Hopital Louis Pasteur

    Le Coudray, 28630

  • Centre Hospitalier Régional Universitaire de Lille - Institut Coeur Poumon

    Lille, 59037

  • Centre Hospitalier Universitaire de Lyon - Hopital Edouard Herriot

    Lyon Cédex 3, 69437

  • Hopital Saint-Joseph

    Marseille, 13285

  • Centre Hospitalier Universitaire de Marseille - Hôpital de la Timone

    Marseille, 13385

  • Centre Hospitalier Regional Universitaire de Montpellier - Hopital Arnaud de Villeneuve

    Montpellier, 34295

  • Centre Hospitalier Universitaire de Nantes - Hopital Guillaume et Rene Laennec

    Nantes, 44093

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur

    Nice, 06002

  • Centre Hospitalier Universitaire de Nimes

    Nîmes, 30029

  • Hopital Saint Antoine

    Paris, 75012

  • Hopital Pitie-Salpetriere

    Paris, 75013

  • Hopital Europeen Georges Pompidou

    Paris, 75015

  • Hopital Bichat Claude Bernard

    Paris, 75018

  • Centre Hospitalier de Pau - Hopital Francois Mitterrand

    Pau, 64000

  • Centre Hospitalier Universitaire de Rennes - Hopital Pontchaillou

    Rennes, 35033

  • Clinique Saint Hilaire

    Rouen, 76000

  • Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil

    Toulouse, 31059

  • Clinique Pasteur

    Toulouse, 31076

  • Polyclinique Vauban

    Valenciennes, 59300

Other trials in France

Spain25 sites

  • Complexo Hospitalario Universitario A Coruña

    A Coruña, Galicia, 15006

  • Hospital Virgen del Mar

    Almería, Andalusia, 04120

  • Hospital Universitari Germans Trias i Pujol

    Badalona, Catalonia, 08916

  • Equip Atencio Primaria Sardenya

    Barcelona, Catalonia, 08025

  • Hospital Clinic i Provincial de Barcelona

    Barcelona, Catalonia, 08036

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004

  • Hospital Universitario Virgen de la Arrixaca

    El Palmar, Murcia, 30120

  • Hospital Universitario Virgen de las Nieves

    Granada, Andalusia, 18012

  • Hospital Universitario de Gran Canaria Doctor Negrin

    Las Palmas de Gran Canarias, Canary Islands, 35010

  • Hospital Universitario de La Princesa

    Madrid, 28006

  • Fundacion Jimenez Diaz

    Madrid, 28040

  • Hospital Clinico San Carlos

    Madrid, 28040

  • Hospital Universitario 12 de Octubre

    Madrid, 28041

  • Hospital Universitario La Paz

    Madrid, 28046

  • Hospital Universitario Infanta Sofia

    Madrid, 28702

  • Hospital Clinico Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010

  • Complejo Hospitalario de Navarra

    Pamplona, Navarre, 31008

  • Hospital Universitari Sant Joan de Reus

    Reus, Catalonia, 43204

  • Hospital Clinico Universitario de Santiago

    Santiago de Compostela, Galicia, 15706

  • Hospital Universitario Virgen Macarena

    Seville, Andalusia, 41009

  • Hospital Universitari i Politecnic La Fe

    Valencia, Valencia, 26026

  • Hospital Clinico Universitario de Valencia

    Valencia, Valencia, 46010

  • Hospital Clinico Universitario de Valladolid

    Valladolid, Castille and León, 47005

  • Hospital Alvaro Cunqueiro

    Vigo, Galicia, 36312

  • Hospital Universitario Miguel Servet

    Zaragoza, Aragon, 50009

Other trials in Spain

Australia22 sites

  • Heart and Vascular Research

    Adelaide, South Australia, 5000

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000

  • SA Heart

    Ashford, South Australia, 5035

  • Heartcare Partners

    Auchenflower, Queensland, 4066

  • Curtin University Centre of Clinical Research and Education

    Bentley, Western Australia, 6102

  • HeartCare Victoria - Berwick

    Berwick, Victoria, 3806

  • Bundaberg Cardiology

    Bundaberg, Queensland, 4670

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050

  • Monash Medical Centre

    Clayton, Victoria, 3168

  • The Cardiologists Proprietary Limited

    Epping, Victoria, 3076

  • Holdsworth House Medical Brisbane

    Fortitude Valley, Queensland, 4006

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605

  • Barwon Health Geelong Hospital

    Geelong, Victoria, 3220

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000

  • HeartCare Western Australia - Joondalup

    Joondalup, Western Australia, 5068

  • Adelaide Cardiology Practice - Leabrook Clinic

    Leabrook, South Australia, 5068

  • Liverpool Hospital

    Liverpool, New South Wales, 2170

  • Australian Clinical Research Network

    Maroubra, New South Wales, 2035

  • Core Research Group Pty Ltd

    Milton, Queensland, 4064

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150

  • GenesisCare Ringwood

    Ringwood, Victoria, 3134

  • Dr Heart Pty Ltd

    Woolloongabba, 4102

Other trials in Australia

Brazil20 sites

  • Cardresearch Cardiologia Assistencial de Pesquisa

    Belo Horizonte, Minas Gerais, 30150-240

  • Fundaçao Hospitalar Sao Francisco de Assis

    Belo Horizonte, Minas Gerais, 31110-580

  • AngioCor Blumenau

    Blumenau, Santa Catarina, 89020-430

  • Centro de Pesquisa Clinica do Brasil

    Brasília, Federal District, 71625-175

  • Sociedade Hospitalar Angelina Caron

    Campina Grande do Sul, Paraná, 83430-000

  • Centro Especializado em Cardiologia

    Campinas, São Paulo, 13010-001

  • Instituto de Pesquisa Clinica de Campinas

    Campinas, São Paulo, 13060-080

  • Quanta Diagnosticos e Terapia

    Curitiba, Paraná, 80045-170

  • Puc Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da Pucpr/Epicenter

    Curitiba, Paraná, 80230-130

  • Nucleo de Pesquisa Clinica

    Curitiba, Paraná, 80730-150

  • Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas

    Fortaleza, Ceará, 60430-350

  • Instituto do Coracao de Marilia

    Marília, São Paulo, 17515-000

  • Núcleo de Pesquisa em Cirurgia Vascular

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul

    Porto Alegre, Rio Grande do Sul, 90610-000

  • Hospital Nossa Senhora da Conceicao

    Porto Alegre, Rio Grande do Sul, 91350-200

  • IBPClin Instituto Brasil de Pesquisa Clinica

    Rio de Janeiro, 20241-180

  • Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto

    São José do Rio Preto, São Paulo, 15090-000

  • Centro de Pesquisas Clinicas Cpclin

    São Paulo, São Paulo, 01228-200

  • Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo

    São Paulo, 05403-000

  • Eurolatino Pesquisas Medicas

    Uberlândia, Minas Gerais, 38411-186

Other trials in Brazil

Bulgaria19 sites

  • Ambulatory for special outpatient medical aid in Cardiology-Private Practice Dr Elena Dotcheva EOOD

    Burgas, 8000

  • Multiprofile Hospital for Active Treatment - Haskovo AD

    Haskovo, 6300

  • Specialty Hospital for Active treatment in Cardiology Sveti Georgi - Pernik OOD

    Pernik, 2300

  • Medical Center Medconsult OOD

    Pleven, 5800

  • University Multiprofile Hospital for Active Treatment Dr Georgi Stranski EAD

    Pleven, 5800

  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

    Plovdiv, 4001

  • Multiprofile Hospital for Active Treatment- Medical Complex- Sveti Ivan Rilski EOOD

    Plovdiv, 4003

  • Fifth Multiprofile Hospital for Active Treatment - Sofia EAD

    Sofia, 1233

  • National Multiprofile Transport Hospital Tzar Boris III

    Sofia, 1233

  • Medical Center for Specialized Medical Care of Cardiovascular Diseases OOD

    Sofia, 1309

  • Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda EAD

    Sofia, 1407

  • Medical Center Excelsior OOD

    Sofia, 1407

  • University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD

    Sofia, 1527

  • University Multiprofile Hospital for Active Treatment and Emergency Medicine N I Pirogov EAD

    Sofia, 1606

  • Diagnostic-Consultative Center Convex EOOD

    Sofia, 1680

  • Medical Center Kalimat EOOD

    Sofia, 1680

  • Multiprofile Hospital for Active Treatment Sveta Anna Sofia AD

    Sofia, 1750

  • Medical Center Orpheus OOD

    Stara Zagora, 6000

  • Multiprofile Regional Hospital for Active Treatment Dr Stefan Cherkezov AD

    Veliko Tarnovo, 5002

Other trials in Bulgaria

Slovakia19 sites

  • Alian, sro

    Bardejov, 085 01

  • MediTask, sro

    Bratislava, 831 03

  • Narodny ustav srdcovych a cievnych chorob, as

    Bratislava, 833 48

  • Veria, sro

    Bratislava, 851 01

  • Nemocnica s poliklinikou Brezno, no

    Brezno, 977 01

  • Medical group Kosice sro

    Košice, 040 01

  • Cardio D and R, sro Kosice

    Košice, 040 22

  • Kardio 1 sro

    Lučenec, 984 01

  • Medi M and M sro

    Moldava nad Bodvou, 045 01

  • Oralek, sro

    Námestovo, 029 01

  • Kardiocentrum Nitra sro

    Nitra, 949 01

  • Kardiomed NZ, sro

    Nové Zámky, 940 01

  • Medikard, sro

    Prešov, 080 01

  • Medispol, sro

    Prešov, 080 01

  • Diab sro

    Rožňava, 048 01

  • Mediluk sro

    Snina, 069 01

  • Interna SK, sro

    Svidník, 089 01

  • Areteus sro

    Trebišov, 075 01

  • CardiOr, sro

    Trenčín, 911 01

Other trials in Slovakia

South Korea19 sites

  • Inje University Busan Paik Hospital

    Busan, 47392

  • Dong-A University Hospital

    Busan, 49201

  • Chungbuk National University Hospital

    Cheongju-si, Chungcheongbuk-do, 28644

  • Yeungnam University Medical Center

    Daegu, 42415

  • Keimyung University, Dongsan Hospital

    Daegu, 42601

  • Chonnam National University Hospital

    Gwangju, 501-757

  • Gachon University Gil Medical Center

    Incheon, 21565

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620

  • Kyung Hee University Hospital

    Seoul, 02447

  • Korea University Anam Hospital

    Seoul, 02841

  • Seoul National University Hospital

    Seoul, 03080

  • Kangbuk Samsung Hospital

    Seoul, 03181

  • Severance Hospital, Yonsei University Health System

    Seoul, 03722

  • Asan Medical Center

    Seoul, 05505

  • Samsung Medical Center

    Seoul, 06351

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591

  • Gangnam Severance Hospital

    Seoul, 135-700

  • Ajou University Hospital

    Suwon-si, Gyeonggi-do, 16499

  • Yonsei University Wonju Severance Christian Hospital

    Wonju-si, Gangwon-do, 26426

Other trials in South Korea

Denmark16 sites

  • Aalborg Hospital

    Aalborg, 9000

  • Center for Clinical and Basic Research Aalborg

    Aalborg, 9000

  • Aarhus Universitetshospital

    Aarhus N, 8200

  • Centre for Clinical and Basic Research Ballerup

    Ballerup Municipality, 2750

  • Sydvestjysk Sygehus

    Esbjerg, 6700

  • Sanos Clinic

    Herlev, 2730

  • Steno Diabetes Center

    Herlev, 2730

  • Regionhospitalet Herning

    Herning, 7400

  • Hillerod Hospital

    Hillerød, 3400

  • Rigshospitalet Kobenhavn

    København Ø, 2100

  • Amager Hospital

    København S, 2300

  • Kolding Sygehus

    Kolding, 6000

  • Regionshospitalet Silkeborg

    Silkeborg, 8600

  • Svendborg Sygehus

    Svendborg, 5700

  • Center for Clinical and Basic Research Vejle

    Vejle, 7100

  • Regionshospitalet Viborg

    Viborg, 8800

Other trials in Denmark

Italy16 sites

  • Ospedale Muscatello

    Augusta, 96011

  • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII

    Bergamo, 24127

  • Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi

    Bologna, 40138

  • Azienda Ospedaliero Universitaria Mater Domini

    Catanzaro, 88100

  • Universita degli Studi Gabriele D Annunzio di Chieti e Pescara

    Chieti, 66100

  • Fondazione Toscana Gabriele Monasterio Ospedale del Cuore G Pasquinucci

    Massa, 54100

  • IRCCS Ospedale San Raffaele

    Milan, 20132

  • Centro Cardiologico Monzino

    Milan, 20138

  • Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda

    Milan, 20162

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, 56100

  • Presidio Ospedaliero Santa Maria delle Grazie

    Pozzuoli, 80078

  • Policlinico Universitario Campus Biomedico

    Roma, 00128

  • Azienda Ospedaliera Sant Andrea

    Roma, 00189

  • IRCCS Policlinico San Donato

    San Donato Milanese, 20097

  • Azienda Ospedaliera Citta della Salute e della Scienza di Torino

    Torino, 10126

  • Azienda Ospedaliero Universitaria Integrata di Udine

    Udine, 33100

Other trials in Italy

Ukraine16 sites

  • Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Frankivsk Regional Council

    Ivano-Frankivsk, 76018

  • Communal Healthcare Institution Kharkiv City Clinical Hospital No27

    Kharkiv, 61002

  • Medical and Sanitary Unit of Open Joint Stock Company Kharkiv Tractor Plant

    Kharkiv, 61106

  • Communal Noncommercial enterprise "City Hospital #8" of Kharkiv City Council

    Kharkiv, 61176

  • Oleksandrivska Clinical Hospital of Kyiv

    Kyiv, 01023

  • Kyiv City Clinical Hospital 1

    Kyiv, 02091

  • Communal Noncommercial Institution Consultative and Diagnostic Center of Desnianskyi District of Kyi

    Kyiv, 02232

  • Kyiv City Clinical Emergency Medical Care Hospital

    Kyiv, 02660

  • National Scientific Center "M.D. Strazhesko Institute of Cardiology"

    Kyiv, 03151

  • State Institution National Scientific Center Acad MD Strazhesko Institute of cardiology of NAMS Ukr

    Kyiv, 03680

  • State Institution National Scientific Center Acad Strazhesko Institute of Cardiology

    Kyiv, 03680

  • Medical Centre CONSILIUM Medical

    Kyiv, 04050

  • Zakarpattia Oblast Clinical Center of Cardiology and Cardio Surgery

    Uzhhorod, 88014

  • Private Small Enterprise, Medical Center Pulse

    Vinnytsia, 21001

  • Vinnytsia M I Pyrogov Regional Clinical Hospital Vinnytsia M I Pyrogov National Medical University

    Vinnytsia, 21018

  • Communal Non-commercial enterprise "City Hospital #6 "of Zaporizhzhia City Council

    Zaporizhzhya, 69035

Other trials in Ukraine

Belgium15 sites

  • Algemeen Stedelijk Ziekenhuis Aalst

    Aalst, 9300

  • Onze Lieve Vrouw Ziekenhuis - campus Aalst

    Aalst, 9300

  • Ziekenhuis Netwerk Antwerpen Middelheim

    Antwerp, 2020

  • Ziekenhuis Netwerk Antwerpen Stuivenberg

    Antwerp, 2060

  • Universite Catholique de Louvain Cliniques Universitaires Saint Luc

    Brussels, 1200

  • AZ Sint Blasius

    Dendermonde, 9200

  • Algemeen Ziekenhuis Sint Lucas

    Ghent, 9000

  • Medif sprl

    Gozée, 6534

  • Dokter Mortelmans bvba

    Ham, 3945

  • Jessa Ziekenhuis - Campus Virga Jesse

    Hasselt, 3500

  • Universitair Ziekenhuis Leuven - Campus Gasthuisberg

    Leuven, 3000

  • Medilink sprl

    Linkebeek, 1630

  • Centre Hospitalier Universitair Ambroise Pare

    Mons, 7000

  • Maria Ziekenhuis Noord-Limburg

    Overpelt, 3900

  • Testumed vzw

    Tessenderlo, 3980

Other trials in Belgium

Greece15 sites

  • General Hospital of Athens Evaggelismos

    Athens, 10676

  • Athens Naval Hospital

    Athens, 11521

  • General Hospital of Athens Georgios Gennimatas

    Athens, 11527

  • General Hospital of Athens Ippokrateio

    Athens, 11527

  • General Hospital of Athens Laiko

    Athens, 11527

  • Alexandra Hospital

    Athens, 11528

  • Konstantopoulio - Agia Olga Hospital of Nea Ionia

    Athens, 14233

  • Hygeia Hospital

    Athens, 15123

  • University Hospital of Heraklion

    Heraklion, 71110

  • University Hospital of Ioannina

    Ioannina, 45500

  • University Hospital of Larissa

    Larissa, 41110

  • Ahepa University Hospital

    Thessaloniki, 54636

  • General Hospital of Thessaloniki Ahepa

    Thessaloniki, 54636

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, 56403

  • Interbalkan Medical Center

    Thessaloniki, 57001

Other trials in Greece

Sweden15 sites

  • Sodra Alvsborgs sjukhus

    Borås, 501 82

  • Falu Lasarett

    Falun, 791 82

  • Carlanderska

    Gothenburg, 405 45

  • Sahlgrenska Universitetssjukhus

    Gothenburg, 413 45

  • Obackakliniken i Harnosand

    Härnösand, 871 31

  • PharmaSite Helsingborg

    Helsingborg, 252 20

  • Lanssjukhuset Ryhov

    Jönköping, 551 85

  • Centralsjukhuset Karlstad

    Karlstad, 651 85

  • Skaraborgs sjukhus Lidkoping

    Lidköping, 531 85

  • Clemenstorgets Hjartmottagning

    Lund, 222 21

  • PharmaSite Malmo

    Malmö, 211 52

  • Ostersunds sjukhus

    Östersund, 831 83

  • Akardo MedSite

    Stockholm, 117 27

  • Norrlands Universitetssjukhus

    Umeå, 901 85

  • Hallands sjukhus Varberg

    Varberg, 432 81

Other trials in Sweden

Finland11 sites

  • Helsinki University Central Hospital

    Helsinki, 00029

  • GERI-MED Oy

    Helsinki, 00100

  • Pohjois-Karjalan keskussairaala

    Joensuu, 80210

  • Terveystalo Jyvaskyla

    Jyväskylä, 40100

  • Studycor Oy

    Jyväskylä, 40620

  • Satucon Oy/Kuopion tyoterveys

    Kuopio, 70100

  • University of Eastern Finland

    Kuopio, 70210

  • Oulu University Hospital

    Oulu, 90029

  • Oulu University Hospital

    Oulu, 90220

  • Tampere University Hospital

    Tampere, 33520

  • Terveystalo Pulssi

    Turku, 20100

Other trials in Finland

Romania11 sites

  • SC Centrul Medical de Diagnostic si Tratament Ambulator Neomed S.R.L

    Brasov, 500283

  • Spitalul Clinic Universitar de Urgenta Elias

    Bucharest, 011461

  • Institutul de Urgenţă pentru Boli Cardiovasculare "Prof. Dr. C. C. Iliescu",

    Bucharest, 022328

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098

  • Cardiomed SRL

    Craiova, 200512

  • Consultmed SRL

    Iași, 700547

  • SC Cardiomed SRL

    Iași, 700732

  • SC Endodigest SRL

    Oradea, 410151

  • SC Sal Med SRL

    Piteşti, 110438

  • Mediab SRL

    Târgu Mureş, 540142

  • CMI Dr Podoleanu Cristian

    Târgu Mureş, 540143

Other trials in Romania

Austria10 sites

  • Landeskrankenhaus Feldkirch

    Feldkirch, 6800

  • Medizinische Universitaet Graz

    Graz, 8036

  • Medizinische Universitaet Innsbruck

    Innsbruck, 6020

  • Klinikum Klagenfurt am Woerthersee

    Klagenfurt, 9020

  • Ordensklinikum Linz Barmherzige Schwestern

    Linz, 4010

  • Klinik Landstrasse

    Vienna, 1030

  • Zentrum fuer klinische Studien - Dr Hanusch GmbH

    Vienna, 1060

  • Universitaetsklinikum Allgemeines Krankenhaus Wien

    Vienna, 1090

  • Klinik Hietzing

    Vienna, 1130

  • Klinik Ottakring

    Vienna, 1160

Other trials in Austria

Taiwan10 sites

  • Hualien Tzu Chi Hospital

    Hualien City, Hualien, 97002

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    Kaohsiung City, 80756

  • Kaohsiung Chang Gung Memorial Hospital

    Kaohsiung City, 83301

  • Mackay Memorial Hospital Tamsui Branch

    New Taipei City, 25160

  • Chung Shan Medical University Hospital

    Taichung, 40201

  • Taichung Veterans General Hospital

    Taichung, 40705

  • National Cheng Kung University Hospital

    Tainan, 70403

  • National Taiwan University Hospital

    Taipei, 10002

  • Taipei Veterans General Hospital

    Taipei, 11217

  • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

    Taoyuan, 33305

Other trials in Taiwan

Portugal9 sites

  • Hospital Garcia de Orta, EPE

    Almada, 2801-951

  • Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro

    Aveiro, 3814-501

  • Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz

    Carnaxide, 2790-134

  • Centro Hospitalar e Universitario de Coimbra EPE

    Coimbra, 3000-075

  • Hospital de Faro, EPE

    Faro, 8000-386

  • Hospital da Senhora da Oliveira, Guimaraes, EPE

    Guimarães, 4835-044

  • Associacao Protectora dos Diabeticos de Portugal

    Lisbon, 1250-189

  • Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano

    Matosinhos Municipality, 4464-513

  • Hospital Casa de Saude Sao Mateus

    Viseu, 3500-093

Other trials in Portugal

Lithuania7 sites

  • Klinikiniai sprendimai, UAB

    Alytus, 63200

  • Klinikiniai sprendimai, UAB

    Kaunas, 49387

  • Saules Seimos Medicinos Centras

    Kaunas, 49456

  • Hospital of Lithuanian University of Health Sciences Kaunas Clinics Public Institution

    Kaunas, 50009

  • Kardiologijos ir reabilitacijos klinika, UAB

    Klaipėda, 91131

  • Siauliai Republican Hospital, Public Institution

    Šiauliai, 76231

  • Vilnius University Hospital Santaros Clinic Public Institution

    Vilnius, 08661

Other trials in Lithuania

Mexico6 sites

  • Centro de investigacion Cardiometabolica

    Aguascalientes, 20230

  • Clinstile SA de CV

    Cd de Mexico, Mexico City, 06700

  • Scientia Investigacion Clinica Sc

    Chihuahua City, 31203

  • Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC

    Culiacán, Sinaloa, 80230

  • Unidad Biomedica Avanzada Monterrey

    Monterrey, Nuevo León, 64460

  • Centro de Estudios Clinicos de Queretaro

    Querétaro City, Querétaro, 76000

Other trials in Mexico

Latvia5 sites

  • Daugavpils Regional Hospital

    Daugavpils, 5417

  • Dace Teterovska Doctor Practice in Endocrinology

    Ogre, 5001

  • Inga Jasinkevica Cardiologist Practice

    Ogre, 5001

  • Pauls Stradins Clinical University Hospital

    Riga, 1002

  • Outpatient Clinic Veselibas Centrs 4

    Riga, 1012

Other trials in Latvia

Estonia4 sites

  • Liina Viitas OU

    Pärnu, 80014

  • Center for Clinical and Basic Research Tallinn

    Tallinn, 10128

  • Dr Arvo Rosenthal LLC

    Tallinn, 13419

  • North Estonia Medical Centre Foundation

    Tallinn, 13419

Other trials in Estonia

Iceland2 sites

  • Hjartamidstodin

    Kopavogur, 201

  • Landspitali

    Reykjavik, 101

Other trials in Iceland

About this study

Official title: A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate the Impact of Evolocumab on Major Cardiovascular Events in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

Being tested
Evolocumab, Placebo
Keywords
High Cardiovascular Risk, No prior Myocardial Infarction stroke, >= 50 years of age (men), >= 55 years of age (women), lipid-lowering therapy
Medical subject headings
Coronary Disease, Multiple Endocrine Neoplasia Type 1

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • EvolocumabDrug

    Also called AMG 145, Repatha

    Administered subcutaneously using an autoinjector pen.

  • PlaceboDrug

    Administered subcutaneously using an autoinjector pen.

Study groups in NCT03872401
Study groupRoleWhat they receive
PlaceboPlacebo comparatorParticipants will receive placebo subcutaneous injection once every 2 weeks (Q2W).
Receives: Drug: Placebo
Evolocumab 140 mg Q2WExperimentalParticipants will receive 140 mg evolocumab by subcutaneous injection Q2W.
Receives: Drug: Evolocumab

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of Participants Who Experienced Coronary Heart Disease (CHD) Death, Myocardial Infarction (MI), or Ischemic Stroke, Whichever Occurred First

    All deaths and individual components were adjudicated by an independent external clinical events committee (CEC), using standardized definitions. The number of participants who experienced CHD death, MI, or ischemic stroke, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  2. Number of Participants Who Experienced CHD Death, MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization, Whichever Occurred First

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, ischemic stroke, or any ischemia-driven arterial revascularization, whichever occurred first, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Secondary outcomes (10)

  1. Number of Participants Who Experienced MI, Ischemic Stroke, or Any Ischemia-driven Arterial Revascularization

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, ischemic stroke, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  2. Number of Participants Who Experienced CHD Death, MI, or Any Ischemia-driven Arterial Revascularization

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, MI, or any ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  3. Number of Participants Who Experienced Cardiovascular Death, MI, or Ischemic Stroke

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, MI, or ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  4. Number of Participants Who Experienced CHD Death or MI

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death or MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  5. Number of Participants Who Experienced MI

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced MI, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  6. Number of Participants Who Experienced Any Ischemia-driven Arterial Revascularization

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemia-driven arterial revascularization, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  7. Number of Participants Who Experienced CHD Death

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced CHD death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  8. Number of Participants Who Experienced Cardiovascular Death

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced cardiovascular death, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  9. Number of Participants Who Died Due to Any Cause

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who died due to any cause, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

  10. Number of Participants Who Experienced Ischemic Stroke

    All deaths and individual components were adjudicated by an independent external CEC, using standardized definitions. The number of participants who experienced ischemic stroke, among participants at high cardiovascular risk without prior MI or stroke and were receiving optimized lipid lowering therapy was analyzed.

    Measured: From enrollment to last confirmed survival status date; median (min, max) time on trial was 55.2 (0.0, 72.7) months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted13 Mar 2019
  2. Study start11 Jun 2019
  3. Primary completion25 Jul 2025
  4. Study completion25 Jul 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
Quadruple blind
Who is masked
Participant, Care provider, Investigator, Outcomes assessor
Enrolment
12,301 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03872401
Sponsor's protocol ID
20170625
Other IDs
2023-503673-38-00, 2018-004565-14, 2018, 2023
Acronym
VESALIUS-CV
Status last verified
Jun 2026
First submitted
11 Mar 2019
Last updated
25 Jun 2026
Data monitoring committee
Yes
FDA-regulated drug
Yes
FDA-regulated device
No
Individual data sharing
Yes: De-identified individual patient data for variables necessary to address the specific research question in an approved data sharing request.

Publications

  • Bohula EA, Marston NA, Ruzza A, Murphy SA, De Ferrari GM, Diaz R, Leiter LA, Elliott-Davey M, Wang H, Bhatia AK, Giugliano RP, Sabatine MS. Rationale and design of the effect of evolocumab in patients at high cardiovascular risk without prior myocardial infarction or stroke (VESALIUS-CV) trial. Am Heart J. 2024 Mar;269:179-190. doi: 10.1016/j.ahj.2023.12.004. Epub 2023 Dec 29.

    PubMed 38160917

  • Giugliano RP, Bohula EA, Bellavia A, De Ferrari GM, Leiter A, Nicolau JC, Bhatia AK, Murphy SA, Liu L, Wang H, Blaha V, Erglis A, Ferreira J, Goudev A, Jensen HK, Kiss RG, Montalescot G, Parkhomenko A, Sattar N, Sinnaeve P, Slapikas R, Paiva da Silva Lima G, Sabatine MS; VESALIUS-CV Investigators. Effects of Evolocumab on Mortality Outcomes in Patients Without Previous Myocardial Infarction or Stroke: A Prespecified Analysis of the VESALIUS-CV Randomized Clinical Trial. Circulation. 2026 Aug 31. doi: 10.1161/CIRCULATIONAHA.126.082436. Online ahead of print.

    PubMed 42670293

  • Nicolau JC, Murphy SA, Giugliano RP, Leiter LA, De Ferrari GM, Park JG, Kuder J, Liu L, Wang H, Shastri-Kumar V, Averkov O, Blaha V, Dzupina A, Ferreira J, Kuusisto J, Lopez-Sendon J, Lorenzatti AJ, Nicholls S, Pella D, Slapikas R, Tokgozoglu L, Vinereanu D, Cyrille M, Sabatine MS, Bohula EA. Cumulative Benefit With Evolocumab in Patients With No Prior Myocardial Infarction or Stroke in the VESALIUS-CV Study. J Am Coll Cardiol. 2026 Aug 28:S0735-1097(26)07440-1. doi: 10.1016/j.jacc.2026.08.015. Online ahead of print.

    PubMed 42663360

  • Monguillon V, Marston NA, Bohula EA, Park JG, Kuder JF, Murphy SA, De Ferrari GM, Leiter LA, Nicolau JC, Ebenbichler C, Sinnaeve P, Goudev A, Budaj A, Averkov O, Tokgozoglu L, Blankstein R, Vinereanu D, Giugliano RP, Sabatine MS, O'Donoghue ML. Lipoprotein(a) Levels, Risk of Cardiovascular Events, and Benefit of Evolocumab: Findings From the VESALIUS-CV Trial. Circulation. 2026 Jun 23;153(25):1960-1968. doi: 10.1161/CIRCULATIONAHA.126.080999. Epub 2026 May 25.

    PubMed 42183757

  • Bergmark BA, Bohula EA, Marston NA, Park JG, Kuder JF, Murphy SA, De Ferrari G, Leiter LA, Nicolau JC, Averkov O, Charng MJ, Ebenbichler C, Erglis A, Gouni-Berthold I, Montalescot G, Nicholls SJ, Sigurdsson A, Sinnaeve PR, Slapikas R, Tsioufis K, Verma S, Viigimaa M, Bhatia A, Xin L, Walsh E, Ohman EM, Giugliano RP, Sabatine MS. Evolocumab in Patients With Prior Percutaneous Coronary Intervention and No Prior Myocardial Infarction: Results From the VESALIUS-CV Trial. Circulation. 2026 Jul 7;154(1):28-36. doi: 10.1161/CIRCULATIONAHA.126.080616. Epub 2026 May 19.

    PubMed 42153665

  • Marston NA, Bohula EA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, Park JG, Murphy SA, Walsh E, Liu L, Verma S, Sattar N, Nicholls SJ, Lopez-Sendon J, Gouni-Berthold I, Tokgozoglu L, Blankstein R, Cyrille M, da Silva Lima GP, Giugliano RP, Sabatine MS; VESALIUS-CV Investigators. Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes: Results From the VESALIUS-CV Trial. JAMA. 2026 Apr 28;335(16):1400-1407. doi: 10.1001/jama.2026.3277.

    PubMed 41903215

  • Bohula EA, Marston NA, Bhatia AK, De Ferrari GM, Leiter LA, Nicolau JC, Park JG, Kuder JF, Murphy SA, Walsh E, Wang H, Blaha V, Budaj A, Cornel JH, Goudev A, Kiss RG, Lorenzatti AJ, Parkhomenko A, Cyrille M, Paiva da Silva Lima G, Ohman EM, Giugliano RP, Sabatine MS; VESALIUS-CV Investigators. Evolocumab in Patients without a Previous Myocardial Infarction or Stroke. N Engl J Med. 2026 Jan 8;394(2):117-127. doi: 10.1056/NEJMoa2514428. Epub 2025 Nov 8.

    PubMed 41211925

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