Clinical trials: Coronary Heart Disease (CHD)
Heart Failure, Coronary Heart Disease (CHD)
Reliability of Multiple-Repetition-Maximum Tests in Patients With Cardiovascular Disease or Risk Factors
Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important.
- Conditions
- Heart Failure, Coronary Heart Disease (CHD), Atrial Fibrillation (AF), Diabetes Mellitus
- Trial name
- NCT06796582
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Technical University of Munich
Cardiovascular Disease, Asthma
Effectiveness of Pollution Monitoring in Clinical Exercise Rehabilitation
The primary objective of EPIC-AIR is to evaluate the feasibility and potential effectiveness of integrating real-time air pollution monitoring into cardiac rehabilitation (CR) and pulmonary rehabilitation (PR) programmes via an…
- Conditions
- Cardiovascular Disease, Asthma, COPD, Interstitial Lung Disease Due to Systemic Disease
- Trial name
- EPIC-AIR (NCT07500948)
- Testing
- Progressive Walking Exercise Programme, Real-time air quality information and guidance
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Coronary Heart Disease (CHD), Diabetes Mellitus, Type 2
Educational Intervention for Self-Care in Patients With Coronary Heart Disease and Type 2 Diabetes
The goal of this clinical trial was to learn whether a structured educational intervention could improve self-care and selected clinical outcomes in adults with both coronary heart disease and type 2 diabetes.
- Trial name
- NCT07852715
- Testing
- Experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Suleyman Demirel University
Ethics, Cardiac Rehabilitation
The Role of 4 Different Consent Approaches on a Pilot Study to Increase Cardiac Rehabilitation Attendance
Cardiac Rehabilitation is a lifestyle and exercise program for patients with heart disease. Cardiac Rehabilitation is strongly recommended in guidelines, but only 30% of eligible patients attend.
- Conditions
- Ethics, Cardiac Rehabilitation, Coronary Heart Disease (CHD), Heart Failure
- Trial name
- MOST-CR (NCT07123480)
- Testing
- Usual Care Group, More Support and Tools
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Baystate Medical Center
Chronic Heart Failure, Coronary Heart Disease (CHD)
Real-World Effectiveness and Costs of Yiqi Fumai Lyophilized Injection in Coronary Heart Disease-Related Chronic Heart Failure
This two-center retrospective cohort study will use de-identified electronic health records from June 1, 2021 through June 1, 2026 to compare patients with coronary heart disease-related chronic left ventricular dysfunction or…
- Trial name
- NCT07841275
- Testing
- Yiqi Fumai Lyophilized Injection
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- China Academy of Chinese Medical Sciences
Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF)
Yiqi Fumai Lyophilized Injection for Chronic Heart Failure Caused by Coronary Heart Disease
This study will evaluate whether adding Yiqi Fumai lyophilized injection to stable guideline-directed treatment improves symptoms, physical limitations, and NT-proBNP in adults with stable chronic heart failure caused by coronary…
- Conditions
- Chronic Heart Failure, Heart Failure With Reduced Ejection Fraction (HFrEF), Coronary Heart Disease (CHD)
- Trial name
- NCT07803471
- Testing
- Yiqi Fumai Lyophilized Injection(YQFM), Stable Guideline-Directed Medical Therapy
- Where
- 4 sites in China
- Volunteers
- 100 people
- Sponsor
- China Academy of Chinese Medical Sciences
Coronary Heart Disease (CHD)
Single vs. Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Intervention With DCB-only Strategy (KONG-FREEDOM-I)
This investigator-initiated, multicenter, open-label, randomized clinical trial evaluates the safety and efficacy of single antiplatelet therapy (SAPT) utilizing a P2Y12 inhibitor compared to dual antiplatelet therapy (DAPT) in…
- Trial name
- KONG-FREEDOM-I (NCT07587099)
- Testing
- Drug-coated balloon, Single antiplatelet therapy (SAPT), Dual antiplatelet therapy (DAPT)
- Where
- 14 sites in China
- Volunteers
- 2,170 people
- Sponsor
- Gan Lijun
Coronary Heart Disease (CHD), Artifical Intelligence
Construction and Validation of a Coronary Artery Disease-Specific Large Language Model and Its Evaluation Framework (CorAI)
Coronary artery disease (CAD) affects an estimated 11.39 million people in China, and mortality has continued to rise since 2012.
- Trial name
- CorAI (NCT07766551)
- Testing
- No Intervention: Observational Cohort
- Where
- 3 sites in China
- Volunteers
- 640 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease (CHD)
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke
This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a…
- Trial name
- VESALIUS-CV (NCT03872401)
- Testing
- Evolocumab
- Where
- 852 sites in United States, Argentina and 31 more
- Volunteers
- 12,301 people
- Sponsor
- Amgen
Congenital Heart Disease, Pulmonary Hypertension
Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective
Wearable health technology, particularly smartwatches, has revolutionized personal health monitoring by enabling continuous, non-invasive tracking of various physiological parameters.
- Conditions
- Congenital Heart Disease, Pulmonary Hypertension, Heart Failure, Coronary Heart Disease (CHD)
- Trial name
- WATCH-XP (NCT07663799)
- Testing
- Apple Watch Series 9
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Coronary Heart Disease (CHD), PCI
Effects of Dioscorea Yam Gruel on Blood Lipid Profiles in PCI Patients With Coronary Heart Disease
This randomized controlled trial investigated the effects of Dioscorea yam gruel on blood lipid levels in patients with coronary heart disease after percutaneous coronary intervention (PCI).
- Trial name
- NCT07589036
- Testing
- Standard Post-PCI Care, Dioscorea Yam Gruel
- Where
- China
- Volunteers
- 72 people
- Sponsor
- 900th Hospital of PLA Joint Logistic Support Force
Coronary Heart Disease (CHD)
The Effectiveness of a Theory-driven Behavioral Change Intervention on Sedentary Behavior in Individuals With Coronary Heart Disease: A Randomised Controlled Trial
The objective of this randomised controlled trial is to examine the effectiveness of a theory-driven behavioural change intervention on total sedentary time (primary outcomes), moderate-to-vigorous physical activity time…
- Trial name
- NCT07357961
- Testing
- A theory-driven behavioural change intervention, Attentive control group
- Volunteers
- 232 people
- Sponsor
- Chinese University of Hong Kong
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Right Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether real-time fNIRS-BCI neurofeedback targeting the right dorsolateral prefrontal cortex (right DLPFC), using active volitional control during a slow-wave auditory acoustic paradigm…
- Trial name
- HEART-SET-1 (NCT07238920)
- Testing
- Real-time fNIRS-ECG neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Coronary Heart Disease (CHD), Anxiety Disorders
Closed-Loop Neurofeedback Targeting the Left Dorsolateral Prefrontal Cortex for Cardiac Autonomic Modulation in Coronary Artery Disease With Anxiety
The goal of this clinical trial is to test whether closed-loop fNIRS-BCI neurofeedback(NF) targeting the left dorsolateral prefrontal cortex(DLPFC) can reduce cardiac autonomic arousal, indexed by baseline-corrected heart…
- Trial name
- HEART-SET-2 (NCT07244484)
- Testing
- Real-time fNIRS-based neurofeedback
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Shenyang Medical College
Coronary Heart Disease (CHD)
The Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Coronary Heart Disease: A Retrospective Cohort Study(CPETPCAD)
Parameters related to cardiopulmonary exercise testing (CPET) are important objective indicators for evaluating cardiopulmonary function in patients with coronary heart disease.
- Trial name
- CPET-PCHD (NCT07534410)
- Volunteers
- 15,000 people
- Sponsor
- Xinjiang Medical University
Coronary Heart Disease (CHD)
CORE-COMPARE Pilot Study
The utility of Ultra High-Resolution Computed Tomography (UHR-CT) compared to conventional CT in all-comers (i.e., a generally lower-risk population) remains uncertain but is an important area of study in order to justify wider…
- Trial name
- NCT06170541
- Testing
- Aquilion Precision, Conventional Computed Tomography
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Johns Hopkins University
Coronary Heart Disease (CHD), Coronary Arterial Disease (CAD)
Effectiveness of a Tele-cardiac Rehabilitation (Tele-CR) Program
This study represents the second phase of a three-year research project aimed at evaluating both the short- and long-term effects of a six-month tele-cardiac rehabilitation (tele-CR) program in patients with coronary heart…
- Trial name
- NCT07110389
- Testing
- A tele-CR program, Attention-controlled
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Chang Gung University of Science and Technology
Coronary Heart Disease (CHD)
Proteomic and Inflammatory Omics Changes With Colchicine Therapy in Coronary Heart Disease
The goal of this exploratory clinical trial is to investigate the proteomic changes induced by low-dose colchicine anti-inflammatory therapy in coronary heart disease (CHD) patients, with the aim of identifying novel biomarkers…
- Trial name
- PIC-CHD (NCT07462325)
- Testing
- colchicine
- Volunteers
- 176 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Coronary Heart Disease (CHD)
Scalable Clinical Oversight of Large Language Models Via Uncertainty Triangulation
This prospective, multi-reader, randomized crossover trial evaluates SCOUT (Scalable Clinical Oversight via Uncertainty Triangulation), a model-agnostic meta-verification framework that selectively defers unreliable large…
- Trial name
- SCOUT (NCT07414966)
- Testing
- SCOUT-Assisted Review Workflow, Standard Manual Review Workflow
- Volunteers
- 7 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease (CHD), Diabetes (DM)
A Prospective Multicenter Clinical Study： IntracOronary neaR-Infrared Spectroscopy and OptIcal Coherence Tomography for Evaluating Coronary vulNerable Plaque in Patients With diabeTes
To evaluate the correlation between maxLCBI4mm/FCTmin(a new index of lipid plaque based on NIRS-OCT technology) and fiber cap thickness , and the prognosis of patients, providing a new quantitative index for early, accurate and…
- Trial name
- NCT06649305
- Where
- China
- Volunteers
- 1,516 people
- Sponsor
- Shanghai Zhongshan Hospital