Resistance TrainingNCT03889548
Influence of Resistance Training Experience and Mental Imagery on Corticospinal Excitability and Inhibition
A study testing Mental Imagery in people with Resistance Training, run by University of Central Florida at 1 site in United States.
Trial summary
This study will utilize transcranial magnetic stimulation (TMS) to examine the effects of mental imagery in resistance-trained versus untrained men and women. In randomized order, each participant will perform a mental imagery task or a control condition as TMS is used to study corticospinal excitability. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Resistance Training
- What is being tested?
- Mental Imagery
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteUnited States
- Study dates
- 7 Feb 2019to 1 Jan 2023
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Over the previous six months, participant has performed at least three resistance training sessions per week or
- Over the previous six months, participant has refrained from resistance training entirely.
Who cannot join
- Do not meet the resistance training experience requirements of either group
- Neuromuscular disease (e.g. Parkinson's, MS, ALS)
- Metabolic disease (e.g. diabetes, thyroid disorder, metabolic syndrome)
- Arthritis in the upper limbs (hands, arms, shoulders)
- Trouble using or controlling one's muscles
- History of cancer
Show all 26Show fewer
- History of stroke
- History of heart attack
- Use of an assistive walking device or other mobility aids
- Physician mandated contraindication to exercise within the last 6 months
- Epilepsy or history of convulsions/seizures
- History of fainting or syncope
- History of head trauma that was diagnosed as concussion or was associated with loss of consciousness
- History of hearing problems or tinnitus
- Cochlear implants
- Implanted metal in the brain, skull, or elsewhere in the body
- Implanted neurotransmitter
- Cardiac pacemaker or intracardiac lines
- Medication infusion device
- Past problems with brain stimulation
- Past problems with MRI
- Use of muscle relaxants or benzodiazepines
- Allergy to rubbing alcohol
- Any other health related illnesses that would prohibit a participant from physical performance testing
- Lack of transportation to and from the laboratory
- Any permanent / non-removable jewelry or metal fixtures
Trial locations and contacts
1 site in 1 country.
United States1 site
Central Florida Research Park; Partnership 1 Building; UCF Neuromuscular Plasticity Laboratory
Orlando, Florida, 32826
About this study
Official title: Influence of Resistance Training Experience on the Efficacy of Mental Imagery in Modulating Corticospinal Excitability and Inhibition: A Pilot Study
This study will utilize transcranial magnetic stimulation (TMS) to examine the effects of mental imagery in resistance-trained versus untrained men and women. In randomized order, each participant will perform a mental imagery task or a control condition as TMS is used to study corticospinal excitability.
Read the detailed description
Kinesthetic mental imagery is a technique that has previously been utilized to modulate neural signaling to the limbs in the absence of any mechanical movement of the limb. Kinesthetic imagery tasks require an individual to imagine they are maximally contracting a target muscle group. Previous investigations have shown mental imagery tasks to increase maximal strength of the limb and even attenuate strength loss during periods of immobilization. Similarly, corticospinal excitability, which indicates the ease in which the cortex can stimulate muscular contraction, has also been shown to increase during mental imagery tasks. These adaptations have been attributed to the role of the cortex as a critical determinant of strength and the potent cortical stimulus posed by mental imagery.
Mental imagery and resistance training have both shown to provide a positive impact on muscle strength. However, the interplay between a mental imagery task and resistance training experience has yet to be fully investigated in terms of their impact on corticospinal excitability and inhibition. To our knowledge, no study has examined the effect of resistance training experience on corticospinal excitability and inhibition during a mental imagery task. Thus, the purpose of this study is to determine if resistance trained and untrained participants experience differences in corticospinal excitability and inhibition during kinesthetic mental imagery.
- Conditions
- Resistance Training
- Being tested
- Mental Imagery
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Mental ImageryOther
Immediately after determination of the resting motor threshold and pre-test measurements, the TMS administrator will leave the room so as to be blinded to the treatment condition of the participant. At this time the participant will be given instructions regarding the mental imagery protocol from a separate investigator who will not be blinded to the condition. During the mental imagery protocol, participants will be instructed to close their eyes and imagine they are maximally contracting the muscles in their forearm and imagine that they are making their wrist flex and that they are pushing maximally against a hand grip in their hand. This will be a kinesthetic imagery task, in which they are urging their muscles to contract maximally.
| Study group | Role | What they receive |
|---|---|---|
| Mental Imagery | Experimental | Not described Receives: Other: Mental Imagery |
| Control | No intervention | Not described |
What is being measured
The primary outcome is the main question the study is designed to answer.
Corticospinal Excitability
Peak-to-peak amplitude of the motor evoked potential of the first dorsal interosseous at 130% of resting motor threshold
Measured: Greater than or equal to 24 hours to 7 days between visits.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Mar 2019
- Study start7 Feb 2019
- Primary completion1 Jan 2023
- Study completion1 Jan 2023
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Resistance TrainingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Within-subjects design with mental imagery and control conditions performed in random order
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Central Florida
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Matt Stock, University of Central Florida
- Investigators
- Matt S Stock, Ph.D., Principal investigator, School of Kinesiology and Physical Therapy
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03889548
- Sponsor's protocol ID
- 00000170
- Status last verified
- Feb 2023
- First submitted
- 22 Mar 2019
- Last updated
- 17 Feb 2023
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Parsowith EJ, Stock MS, Girts RM, Beausejour JP, Alberto A, Carr JC, Harmon KK. The Influence of Resistance Training Experience on the Efficacy of Motor Imagery for Acutely Increasing Corticospinal Excitability. Brain Sci. 2023 Nov 25;13(12):1635. doi: 10.3390/brainsci13121635.
PubMed 38137083
Study at a glance
From the registry record, last updated by the sponsor on 17 Feb 2023. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Influence of Resistance Training Experience on the Efficacy of Mental Imagery in Modulating Corticospinal Excitability and Inhibition: A Pilot Study
- ClinicalTrials.gov ID
- NCT03889548
- Acronym / sponsor ID
- 00000170
- Conditions
- Resistance Training
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University of Central FloridaUniversity, hospital or other
- Study start
- 7 Feb 2019 (actual)
- Primary completion
- 1 Jan 2023 (actual)
- Study completion
- 1 Jan 2023 (actual)
- First posted
- 26 Mar 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will utilize transcranial magnetic stimulation (TMS) to examine the effects of mental imagery in resistance-trained versus untrained men and women. In randomized order, each participant will perform a mental imagery task or a control condition as TMS is used to study corticospinal excitability.
Detailed description
Kinesthetic mental imagery is a technique that has previously been utilized to modulate neural signaling to the limbs in the absence of any mechanical movement of the limb. Kinesthetic imagery tasks require an individual to imagine they are maximally contracting a target muscle group. Previous investigations have shown mental imagery tasks to increase maximal strength of the limb and even attenuate strength loss during periods of immobilization. Similarly, corticospinal excitability, which indicates the ease in which the cortex can stimulate muscular contraction, has also been shown to increase during mental imagery tasks. These adaptations have been attributed to the role of the cortex as a critical determinant of strength and the potent cortical stimulus posed by mental imagery.
Mental imagery and resistance training have both shown to provide a positive impact on muscle strength. However, the interplay between a mental imagery task and resistance training experience has yet to be fully investigated in terms of their impact on corticospinal excitability and inhibition. To our knowledge, no study has examined the effect of resistance training experience on corticospinal excitability and inhibition during a mental imagery task. Thus, the purpose of this study is to determine if resistance trained and untrained participants experience differences in corticospinal excitability and inhibition during kinesthetic mental imagery.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
- Model description
- Within-subjects design with mental imagery and control conditions performed in random order
| Arm | Type | Receives |
|---|---|---|
| Mental Imagery | Experimental | Other: Mental Imagery |
| Control | No intervention | – |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- Over the previous six months, participant has performed at least three resistance training sessions per week or
- Over the previous six months, participant has refrained from resistance training entirely.
Key exclusion criteria (26 listed)
- Do not meet the resistance training experience requirements of either group
- Neuromuscular disease (e.g. Parkinson's, MS, ALS)
- Metabolic disease (e.g. diabetes, thyroid disorder, metabolic syndrome)
- Arthritis in the upper limbs (hands, arms, shoulders)
- Trouble using or controlling one's muscles
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Mental ImageryImmediately after determination of the resting motor threshold and pre-test measurements, the TMS administrator will leave the room so as to be blinded to the treatment condition of the participant. At this time the participant will be given instructions regarding the mental imagery protocol from a separate investigator who will not be blinded to the condition. During the mental imagery protocol, participants will be instructed to close their eyes and imagine they are maximally contracting the muscles in their forearm and imagine that they are making their wrist flex and that they are pushing maximally against a hand grip in their hand. This will be a kinesthetic imagery task, in which they are urging their muscles to contract maximally. | Other | Mental Imagery |
Primary outcome
Corticospinal Excitability
Time frame: Greater than or equal to 24 hours to 7 days between visits.
Peak-to-peak amplitude of the motor evoked potential of the first dorsal interosseous at 130% of resting motor threshold
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Feb 2023.
- Derived from this study: PubMed 38137083Parsowith EJ, Stock MS, Girts RM, Beausejour JP, Alberto A, Carr JC, Harmon KK. The Influence of Resistance Training Experience on the Efficacy of Motor Imagery for Acutely Increasing Corticospinal Excitability. Brain Sci. 2023 Nov 25;13(12):1635. doi: 10.3390/brainsci13121635.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Matt S Stock, Ph.D. principal investigator
School of Kinesiology and Physical Therapy
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Mental Imagery in people with Resistance Training, run by University of Central Florida at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 26 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 17 Feb 2023. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Corticospinal Excitability (time frame: Greater than or equal to 24 hours to 7 days between visits.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03889548, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Feb 2023.