AgingNCT04048096
Krill Oil and Muscle in Older Adults
A study testing Krill Oil in people with Aging and Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
Trial summary
The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo. Read more about this study
- Who is it for?
- Ages 65 years and olderHealthy volunteers can take part
- Conditions the study is for
- Aging, Sarcopenia
- What is being tested?
- Krill Oil
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 102 participants
- Where
- 1 siteUnited Kingdom
- Study dates
- 7 Mar 2018to 10 Mar 2020
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 65 years and older
- All sexes
- Healthy volunteers accepted
- Older adult
Who may be able to join
- BMI less than 35kg/m2
Who cannot join
- Diabetes
- severe cardiovascular disease
- seizure disorders
- uncontrolled hypertension (>150/90mmHg at baseline measurement)
- cancer or cancer that has been in remission <5 years
- ambulatory impairments which would limit ability to perform assessments of muscle function
Show all 12Show fewer
- dementia
- taking medication known to affect muscle (e.g. steroids)
- have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
- on anticoagulant therapy
- allergies to seafood
- regular consumption of more than 2 portions of oily fish per week.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Effects of Krill Oil Supplementation on Muscle Function in Older Adults
The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.
- Conditions
- Aging, Sarcopenia
- Being tested
- Krill Oil, Placebo
- Medical subject headings
- Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Krill OilDietary supplement
Aker Biomarine Superba Krill Oil
PlaceboDietary supplement
Mixed vegetable oil
| Study group | Role | What they receive |
|---|---|---|
| Placebo | Placebo comparator | 4g/day of mixed vegetable oil supplements Receives: Dietary Supplement: Placebo |
| Krill | Experimental | 4g/day krill oil Receives: Dietary Supplement: Krill Oil |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Muscle strength
knee extensor muscle strength
Measured: Change from baseline to 6 months
Secondary outcomes (9)
Change in Grip strength
Grip strength
Measured: Change from baseline to 6 months
Change in Muscle thickness
Vastus lateralis muscle thickness
Measured: Change from baseline to 6 months
Change in Short performance physical battery test
SPPB
Measured: Change from baseline to 6 months
Change in Body Fat
Measured by BIA
Measured: Change from baseline to 6 months
Change in Lean Mass
Measured by BIA
Measured: Change from baseline to 6 months
Change in Fasting glucose
Fasting glucose
Measured: Change from baseline to 6 months
Change in Blood lipids
Blood lipids
Measured: Change from baseline to 6 months
Change in CRP
CRP
Measured: Change from baseline to 6 months
Change in Erythrocyte fatty acid profile
Erythrocyte fatty acid profile
Measured: Change from baseline to 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Aug 2019
- Study start7 Mar 2018
- Primary completion10 Mar 2020
- Study completion10 Mar 2020
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 102 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Glasgow
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Stuart Gray, University of Glasgow
- Investigators
- Stuart Gray, PhD, Principal investigator, University of Glasgow
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04048096
- Sponsor's protocol ID
- 200170067
- Status last verified
- Nov 2020
- First submitted
- 26 Jul 2019
- Last updated
- 3 Nov 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hayman O, Alkhedhairi SA, Combet E, Quinn TJ, Hunter AM, Goodall S, Gray SR. Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial. J Nutr Health Aging. 2026 Jan;30(1):100747. doi: 10.1016/j.jnha.2025.100747. Epub 2025 Dec 3.
PubMed 41344001Alkhedhairi SA, Aba Alkhayl FF, Ismail AD, Rozendaal A, German M, MacLean B, Johnston L, Miller AA, Hunter AM, Macgregor LJ, Combet E, Quinn TJ, Gray SR. The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial. Clin Nutr. 2022 Jun;41(6):1228-1235. doi: 10.1016/j.clnu.2022.04.007. Epub 2022 Apr 20.
PubMed 35504165
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Krill Oil Supplementation on Muscle Function in Older Adults
- ClinicalTrials.gov ID
- NCT04048096
- Acronym / sponsor ID
- 200170067
- Conditions
- Aging, Sarcopenia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 102 participants (actual)
- Lead sponsor
- University of GlasgowUniversity, hospital or other
- Study start
- 7 Mar 2018 (actual)
- Primary completion
- 10 Mar 2020 (actual)
- Study completion
- 10 Mar 2020 (actual)
- First posted
- 7 Aug 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to determine the effects of krill oil supplementation on muscle mass in function in older adults. Half of the participants will receive krill oil supplements and the other half a placebo.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Placebo | Placebo comparator | Dietary Supplement: Placebo4g/day of mixed vegetable oil supplements |
| Krill | Experimental | Dietary Supplement: Krill Oil4g/day krill oil |
Who may qualify
- Ages
- 65 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Older adult
Key inclusion criteria (1 listed)
- BMI less than 35kg/m2
Key exclusion criteria (12 listed)
- Diabetes
- severe cardiovascular disease
- seizure disorders
- uncontrolled hypertension (>150/90mmHg at baseline measurement)
- cancer or cancer that has been in remission <5 years
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Krill OilAker Biomarine Superba Krill Oil | Dietary supplement | Krill |
| PlaceboMixed vegetable oil | Dietary supplement | Placebo |
Primary outcome
Change in Muscle strength
Time frame: Change from baseline to 6 months
knee extensor muscle strength
9 secondary outcomes
Change in Grip strength
Time frame: Change from baseline to 6 months
Change in Muscle thickness
Time frame: Change from baseline to 6 months
Change in Short performance physical battery test
Time frame: Change from baseline to 6 months
Change in Body Fat
Time frame: Change from baseline to 6 months
Change in Lean Mass
Time frame: Change from baseline to 6 months
Change in Fasting glucose
Time frame: Change from baseline to 6 months
Change in Blood lipids
Time frame: Change from baseline to 6 months
Change in CRP
Time frame: Change from baseline to 6 months
Change in Erythrocyte fatty acid profile
Time frame: Change from baseline to 6 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2020.
- Derived from this study: PubMed 41344001Hayman O, Alkhedhairi SA, Combet E, Quinn TJ, Hunter AM, Goodall S, Gray SR. Do the effects of krill oil supplementation on skeletal muscle function and size in older adults differ by sex, age or BMI: A secondary analysis of a randomised controlled trial. J Nutr Health Aging. 2026 Jan;30(1):100747. doi: 10.1016/j.jnha.2025.100747. Epub 2025 Dec 3.
- Derived from this study: PubMed 35504165Alkhedhairi SA, Aba Alkhayl FF, Ismail AD, Rozendaal A, German M, MacLean B, Johnston L, Miller AA, Hunter AM, Macgregor LJ, Combet E, Quinn TJ, Gray SR. The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial. Clin Nutr. 2022 Jun;41(6):1228-1235. doi: 10.1016/j.clnu.2022.04.007. Epub 2022 Apr 20.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Stuart Gray, PhD principal investigator
University of Glasgow
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Krill Oil in people with Aging and Sarcopenia, run by University of Glasgow at 1 site in United Kingdom.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Nov 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United Kingdom. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Muscle strength (time frame: Change from baseline to 6 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04048096, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2020.