AgingSoMiLYNCT04210934
Study of Microbiota in Longevity County, Yongfu
An observational study of Aging and Healthy Aging, run by Beijing Hospital.
Trial summary
This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was explored, and the intestinal microecological balance increased with age and natural health. Read more about this study
- Who is it for?
- Ages 22 to 111 yearsHealthy volunteers can take part
- Conditions the study is for
- Aging, Healthy Aging
- How many people
- 160 participants
- Where
- No sites listed yet
- Study dates
- 22 May 2016to 31 May 2016
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 22 to 111 years
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: The current study was based on the Longevity and Health of Aging Population in Guangxi China (LHAPGC) study conducted in Yongfu County (qualified as the longevity town by Geriatric Society of China) in 2016.The enrolled subjects do not rely on medical care and do not take antibiotics recently. They are representative of a natural healthy-aging population model .
Who may be able to join
- Obtained informed consent signed by volunteer or guardian
- Local lived for more than 50 years
Who cannot join
- Subjects being treated with antibiotic in 3 months
- People who cannot cooperate with completing the survey
- Severe gastrointestinal disorders
About this study
Official title: Study of the Feature of Intestinal Microbiota and Its Role in Healthy Aging in Southern Chinese From a Longevity County, Yongfu
This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was explored, and the intestinal microecological balance increased with age and natural health. Longevity relationship. This study was completed using a household survey. Through routine clinical examinations and analysis of biochemical laboratory indicators, at the same time, a questionnaire for ADL(activities of daily living), cognitive function, and related elderly information was carried out on the elderly to comprehensively provide health information for each elderly. Based on the remaining stool samples and serum samples, the second-generation sequencing technology and other omics-based technologies were explored. No additional collection of human specimens and information is involved.
In addition, this study also hopes to explore the transmission rules of age-related bacteria in long-lived families, and the relationship with health phenotypes such as blood sugar, blood lipids, and cognitive function. Potential impact. In summary, this study will provide data support for exploring the relationship between healthy longevity and intestinal microecological balance based on the characteristic population of the longevity hometown.
- Conditions
- Aging, Healthy Aging
- Keywords
- Microbiota, multi-omics
What is being measured
The primary outcome is the main question the study is designed to answer.
Aging-related fecal microbiota annotation
Taxonomy of bacteria(family,genus,species),Gene of bacteria
Measured: 0 week
Secondary outcomes (1)
interface of microbiota and other biomarkers in aging and related conditions
to study the correlation between microbiota and circulating biomarkers, including metabolite, and the shifts in various aging and related conditions
Measured: 0 week
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Dec 2019
- Study start22 May 2016
- Primary completion31 May 2016
- Study completion31 May 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 160 participants (actual)
Sponsor and investigators
- Lead sponsor
- Beijing Hospital
- Sponsor type
- Other government
- Collaborators
- BGI-Shenzhen
- Responsible party
- Principal investigator, Liang Sun, PhD, Beijing Hospital
- Investigators
- Liang Sun, Ph.D., Principal investigator, Beijing HospitalZe Yang, M.D., Study director, Beijing Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04210934
- Sponsor's protocol ID
- 20170307
- Acronym
- SoMiLY
- Status last verified
- Dec 2019
- First submitted
- 22 Dec 2019
- Last updated
- 27 Dec 2019
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 27 Dec 2019. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of the Feature of Intestinal Microbiota and Its Role in Healthy Aging in Southern Chinese From a Longevity County, Yongfu
- ClinicalTrials.gov ID
- NCT04210934
- Acronym / sponsor ID
- SoMiLY / 20170307
- Conditions
- Aging, Healthy Aging
- Keywords
- Microbiota, multi-omics
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 160 participants (actual)
- Lead sponsor
- Beijing HospitalOther government
- Collaborators
- BGI-Shenzhen
- Study start
- 22 May 2016 (actual)
- Primary completion
- 31 May 2016 (actual)
- Study completion
- 31 May 2016 (actual)
- First posted
- 26 Dec 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is an observational study designed to adopt a cross-sectional study design. In the context of China's longevity town (East Asian population), Yongfu, Guangxi, the background of non-medical care and antibiotic use was explored, and the intestinal microecological balance increased with age and natural health. Longevity relationship. This study was completed using a household survey. Through routine clinical examinations and analysis of biochemical laboratory indicators, at the same time, a questionnaire for ADL(activities of daily living), cognitive function, and related elderly information was carried out on the elderly to comprehensively provide health information for each elderly. Based on the remaining stool samples and serum samples, the second-generation sequencing technology and other omics-based technologies were explored. No additional collection of human specimens and information is involved.
In addition, this study also hopes to explore the transmission rules of age-related bacteria in long-lived families, and the relationship with health phenotypes such as blood sugar, blood lipids, and cognitive function. Potential impact. In summary, this study will provide data support for exploring the relationship between healthy longevity and intestinal microecological balance based on the characteristic population of the longevity hometown.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
Who may qualify
- Ages
- 22 to 111 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- The current study was based on the Longevity and Health of Aging Population in Guangxi China (LHAPGC) study conducted in Yongfu County (qualified as the longevity town by Geriatric Society of China) in 2016.The enrolled subjects do not rely on medical care and do not take antibiotics recently. They are representative of a natural healthy-aging population model .
Key inclusion criteria (2 listed)
- Obtained informed consent signed by volunteer or guardian
- Local lived for more than 50 years
Key exclusion criteria (3 listed)
- Subjects being treated with antibiotic in 3 months
- People who cannot cooperate with completing the survey
- Severe gastrointestinal disorders
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Aging-related fecal microbiota annotation
Time frame: 0 week
Taxonomy of bacteria(family,genus,species),Gene of bacteria
1 secondary outcome
interface of microbiota and other biomarkers in aging and related conditions
Time frame: 0 week
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Dec 2019.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Liang Sun, Ph.D. principal investigator
Beijing Hospital
Ze Yang, M.D. study director
Beijing Hospital
Questions about this trial
What is this clinical trial studying?
An observational study of Aging and Healthy Aging, run by Beijing Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Dec 2019. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Aging-related fecal microbiota annotation (time frame: 0 week). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Dec 2019.