Optical PhenomenaMILGattentionNCT04279158
Attention Modulation of Local and Global Inhibition Mechanisms
A study testing experience 1 "The negative priming task", experience 2 "Stop signal task" and experience 3 "Anti-saccades" in people with Optical Phenomena, run by Hospices Civils de Lyon at 1 site in France.
Trial summary
Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. Read more about this study
- Who is it for?
- Ages 8 to 75 yearsHealthy volunteers can take part
- Conditions the study is for
- Optical Phenomena
- What is being tested?
- experience 1 "The negative priming task", experience 2 "Stop signal task" and experience 3 "Anti-saccades"
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteFrance
- Study dates
- 26 Nov 2022to 26 Nov 2031
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 8 to 75 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- male and female, age from 18 to 75 years included
- normal vision or corrected vision
- covered by social security
- signed written informed consent
- After a stroke (> 1 month ago), presence of a neurological impairment documented by brain imaging (standard of care) and by clinical symptoms.
- The diagnosis will be dissociated from hemianopia by perimetry. The hemispatial neglect consists of a lack of perception and responsiveness concerning the controlesional visual hemifield.
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- Patient with optic ataxia:
- After a stroke (> 1 month ago), presence of neurological injury in parietal cortex only, supported by a standard of care cerebral MRI
- Present optic ataxia symptoms (The OA consists of pointing errors with the hand contralateral to the lesion (hand effect) and / or to visual targets presented in the field contralateral to the lesion (field effect)).
- Patient (adult and children) with attention-deficit hyperactivity disorder:
- present a diagnosis of ADHD subtype inattention or impulse / hyperactivity as established by a neuropsychologist.
- Children will be between 8 and 18 years old
- Adults will be between 18 and 75 years old.
- Participants will not report any comorbid learning disabilities to ADHD.
- For minors:
- Having obtained the written consent of the legal representative(s)
- Healthy subjects
- no known neurological injury
Who cannot join
- unable to comply with requirements of the study (neurological, psychiatric, sensory or motor troubles)
- adults under legal protection
- Patient with hemispatial neglect:
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Julie OUERFELLI-ETHIER contact
France1 site, 1 recruiting
- Recruiting
Centre de Recherche en Neuroscience de Lyon
Bron, 69500
laure PISELLA, PhD, 4 72 91 34 05 ext. +33, laure.pisella@inserm.fr
Julie OUERFELLI-ETHIER, julie.ouerfelli-ethier@inserm.fr
About this study
Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. These mechanisms are not independent of attentional control. Attention acts as a selection filter for the investigator's behavior. This leads us to hypothesize that attention modulates the mechanisms of inhibition. Nevertheless, the different brain structures involved, as well as mechanisms underlying the interaction between inhibition and attention remain largely unknown.
Previous research has suggested that inhibition requires selective attention and, conversely, attentional mechanisms would result in the "deselection", or inhibition, of objects in space or irrelevant actions. Reconciling the literature on attention with the one on inhibition appears fundamental for the understanding of the instance to which the mechanisms of inhibition and the cognitive processes interact. Therefore, the goal of this research project will be to investigate how inhibition mechanisms are implemented in the brain and, in more detail, what determines the type of resulting inhibitory control: spatially localized or global. The investigator will test 3 different patient groups (optic ataxia, hemispatial neglect and attention-deficit hyperactivity disorder) compared to control.
In conclusion, this research project will aim to develop a theoretical model of the interaction between attentional control and inhibition mechanisms in order to improve diagnostic and rehabilitation tools in the future.
- Conditions
- Optical Phenomena
- Being tested
- experience 1 "The negative priming task", experience 2 "Stop signal task", experience 3 "Anti-saccades"
- Keywords
- attention-deficit hyperactivity disorder (ADHD), Attention Deficit Disorder with Hyperactivity, attention, inhibition, Healthy Volunteers, Perceptual Disorders
- Medical subject headings
- Attention Deficit Disorder with Hyperactivity, Inhibition, Psychological, Perceptual Disorders
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
experience 1 "The negative priming task"Behavioural
The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters.
experience 2 "Stop signal task"Behavioural
The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target
experience 3 "Anti-saccades"Behavioural
The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target
| Study group | Role | What they receive |
|---|---|---|
| patients with optic ataxia (OA) | Experimental | Not described Receives: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades" |
| patients with hemispatial neglect | Experimental | Not described Receives: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades" |
| patients with attention-deficit hyperactivity disorder | Experimental | Not described Receives: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades" |
| Healthy volunteers | Active comparator | Not described Receives: Behavioral: experience 1 "The negative priming task"; Behavioral: experience 2 "Stop signal task"; Behavioral: experience 3 "Anti-saccades" |
What is being measured
The primary outcome is the main question the study is designed to answer.
error rate
The investigator calculate the number of right and wrong answers (a correct answer is a saccade carried out when it is necessary and by reaching the target; a false answer is a saccade made at the wrong time and / or not reaching the target) to obtain the error rate.
Measured: at the end of the simulation passage, an average of 3 years
Secondary outcomes (1)
reaction time
The investigator measure the time it takes for the subject to respond (perform the eye saccade)
Measured: at the end of the simulation passage, an average of 3 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Feb 2020
- Study start26 Nov 2022
- Primary completion26 Nov 2031 (estimated)
- Study completion26 Nov 2031 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Optical PhenomenaStudies of the same condition, open and under way.
- More trials run by Hospices Civils de LyonThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Hospices Civils de Lyon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Laure PISELLA, Principal investigator, Centre de recherche de Neurosciences de Lyon (CRNL)
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04279158
- Sponsor's protocol ID
- 69HCL19_0728
- Other IDs
- 2019-A03055-52
- Acronym
- MILGattention
- Status last verified
- Jan 2026
- First submitted
- 11 Feb 2020
- Last updated
- 20 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Attention Modulation of Local and Global Inhibition Mechanisms
- ClinicalTrials.gov ID
- NCT04279158
- Acronym / sponsor ID
- MILGattention / 69HCL19_0728
- Conditions
- Optical Phenomena
- Keywords
- attention-deficit hyperactivity disorder (ADHD), Attention Deficit Disorder with Hyperactivity, attention, inhibition, Healthy Volunteers, Perceptual Disorders
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- Hospices Civils de LyonUniversity, hospital or other
- Study start
- 26 Nov 2022 (actual)
- Primary completion
- 26 Nov 2031 (estimated)
- Study completion
- 26 Nov 2031 (estimated)
- First posted
- 21 Feb 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Human behavior is both flexible and adapted to the environmental context through inhibition capabilities; the investigator control the subject's behavior by repressing inappropriate responses and selecting, among several possibilities, those that are appropriate. These mechanisms are not independent of attentional control. Attention acts as a selection filter for the investigator's behavior. This leads us to hypothesize that attention modulates the mechanisms of inhibition. Nevertheless, the different brain structures involved, as well as mechanisms underlying the interaction between inhibition and attention remain largely unknown.
Previous research has suggested that inhibition requires selective attention and, conversely, attentional mechanisms would result in the "deselection", or inhibition, of objects in space or irrelevant actions. Reconciling the literature on attention with the one on inhibition appears fundamental for the understanding of the instance to which the mechanisms of inhibition and the cognitive processes interact. Therefore, the goal of this research project will be to investigate how inhibition mechanisms are implemented in the brain and, in more detail, what determines the type of resulting inhibitory control: spatially localized or global. The investigator will test 3 different patient groups (optic ataxia, hemispatial neglect and attention-deficit hyperactivity disorder) compared to control.
In conclusion, this research project will aim to develop a theoretical model of the interaction between attentional control and inhibition mechanisms in order to improve diagnostic and rehabilitation tools in the future.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
| Arm | Type | Receives |
|---|---|---|
| patients with optic ataxia (OA) | Experimental | Behavioral: experience 1 "The negative priming task", Behavioral: experience 2 "Stop signal task", Behavioral: experience 3 "Anti-saccades" |
| patients with hemispatial neglect | Experimental | Behavioral: experience 1 "The negative priming task", Behavioral: experience 2 "Stop signal task", Behavioral: experience 3 "Anti-saccades" |
| patients with attention-deficit hyperactivity disorder | Experimental | Behavioral: experience 1 "The negative priming task", Behavioral: experience 2 "Stop signal task", Behavioral: experience 3 "Anti-saccades" |
| Healthy volunteers | Active comparator | Behavioral: experience 1 "The negative priming task", Behavioral: experience 2 "Stop signal task", Behavioral: experience 3 "Anti-saccades" |
Who may qualify
- Ages
- 8 to 75 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (18 listed)
- male and female, age from 18 to 75 years included
- normal vision or corrected vision
- covered by social security
- signed written informed consent
- After a stroke (> 1 month ago), presence of a neurological impairment documented by brain imaging (standard of care) and by clinical symptoms.
Key exclusion criteria (3 listed)
- unable to comply with requirements of the study (neurological, psychiatric, sensory or motor troubles)
- adults under legal protection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| experience 1 "The negative priming task"The targets are presented to the subject on a computer screen. The subject must make an eye or hand movement toward the target and ignore the distracters. | Behavioural | Healthy volunteers, patients with attention-deficit hyperactivity disorder, patients with hemispatial neglect, patients with optic ataxia (OA) |
| experience 2 "Stop signal task"The targets are presented to the subject on a computer screen. The subject must make an eye movement towards this target. Sometimes a stop signal will appear and the subject will have to avoid to look at the target | Behavioural | Healthy volunteers, patients with attention-deficit hyperactivity disorder, patients with hemispatial neglect, patients with optic ataxia (OA) |
| experience 3 "Anti-saccades"The targets are presented to the subject on a computer screen. The subject must make an eye movement toward this target. Sometimes an instruction will ask the subject to look at the opposite of the target | Behavioural | Healthy volunteers, patients with attention-deficit hyperactivity disorder, patients with hemispatial neglect, patients with optic ataxia (OA) |
Primary outcome
error rate
Time frame: at the end of the simulation passage, an average of 3 years
The investigator calculate the number of right and wrong answers (a correct answer is a saccade carried out when it is necessary and by reaching the target; a false answer is a saccade made at the wrong time and / or not reaching the target) to obtain the error rate.
1 secondary outcome
reaction time
Time frame: at the end of the simulation passage, an average of 3 years
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Jan 2026.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Julie OUERFELLI-ETHIER contact
Laure PISELLA principal investigator
Centre de recherche de Neurosciences de Lyon (CRNL)
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing experience 1 "The negative priming task", experience 2 "Stop signal task" and experience 3 "Anti-saccades" in people with Optical Phenomena, run by Hospices Civils de Lyon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 18 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 20 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Laure PISELLA, PhD (4 72 91 34 05 ext. +33, laure.pisella@inserm.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
error rate (time frame: at the end of the simulation passage, an average of 3 years). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Jan 2026.