Nurse HealthNCT04572347
National Nurses Health Cohort Study (NNHS): a Web-based Ambispective Cohort Study in China
An observational study of Nurse Health, run by Peking University Third Hospital.
Trial summary
The purpose of the current study was to build an ambispective cohort study of female nurses, based on existing physical examination and nurse work schedule data and a web-based questionnaire system, focusing on the effects of occupational, environmental, and lifestyle risk factors on the health of Chinese women. Read more about this study
- Who is it for?
- Any age, women onlyHealthy volunteers can take part
- Conditions the study is for
- Nurse Health
- What is being tested?
- Observational
- How many people
- 2,000 participants
- Where
- No sites listed yet
- Study dates
- 15 Jan 2021to 30 Dec 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: Participants will be recruited from Peking University Third Hospital through cluster sampling.
Who may be able to join
- Female registered nurses, licensed practical nurses and/or midwives with informed consent are included in this study
Who cannot join
- student nurses
- training nurses
Trial locations and contacts
No sites are listed yet.
About this study
The purpose of the current study was to build an ambispective cohort study of female nurses, based on existing physical examination and nurse work schedule data and a web-based questionnaire system, focusing on the effects of occupational, environmental, and lifestyle risk factors on the health of Chinese women.
- Conditions
- Nurse Health
- Being tested
- Observational
- Keywords
- psychophysical health, career development, stress, metabolic indexes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
ObservationalOther
It is an observational study, and no intervention will be provided.
| Study group | Role | What they receive |
|---|---|---|
| Nurses working in PUTH | Participants will be recruited from Peking University Third Hospital through cluster sampling. Female registered nurses, licensed practical nurses and/or midwives with informed consent are included in this study. The exclusion criteria are student nurses and training nurses. Receives: Other: Observational |
What is being measured
The primary outcome is the main question the study is designed to answer.
psychophysical health related events
psychophysical health related events will be collected by web-based questionnaire and hospital information system.
Measured: From 2010 to 2022
mental health
National Aeronautics and Space Administration Task Load Index was used to evaluate the mental workload every year.
Measured: From 2020 to 2022
Secondary outcomes (2)
sleep quality
Pittsburgh sleep quality index was used to evaluate the sleep quality every year.
Measured: From 2020 to 2022
social support
Self developed perceived social support scale was used to evaluate the level of social support every year.
Measured: From 2020 to 2022
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted1 Oct 2020
- Study start15 Jan 2021 (estimated)
- Primary completion30 Dec 2021 (estimated)
- Study completion30 Dec 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Nurse HealthStudies of the same condition, open and under way.
- More trials run by Peking University Third HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Other
- Enrolment
- 2,000 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Peking University Third Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Baohua Li, Principal investigator, Peking University Third Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04572347
- Sponsor's protocol ID
- NNHC_1
- Status last verified
- Sep 2020
- First submitted
- 30 Sep 2020
- Last updated
- 28 Dec 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Yu M, Chen H, Pei M, Zhan S, Li B. Bidirectional Association of Tinnitus and Psychological Distress Among Nurses at One-year Follow-up: A Propensity Score-matched Cohort Study From China. Asian Nurs Res (Korean Soc Nurs Sci). 2025 Dec;19(5):418-425. doi: 10.1016/j.anr.2025.06.003. Epub 2025 Sep 2.
PubMed 40907657Che Y, Tang R, Zhang H, Yang M, Geng R, Zhuo L, Wang P, Hu X, Zhou Y, Wang P, Zhan S, Li B. Development of a prediction model for predicting the prevalence of nonalcoholic fatty liver disease in Chinese nurses: the first-year follow data of a web-based ambispective cohort study. BMC Gastroenterol. 2024 Feb 14;24(1):72. doi: 10.1186/s12876-024-03121-1.
PubMed 38355421Zhang H, Wang J, Zhang S, Tong S, Hu J, Che Y, Zhuo L, Wang P, Geng R, Zhou Y, Wang P, Zhan S, Li B. Relationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS). Int Arch Occup Environ Health. 2023 Dec;96(10):1361-1371. doi: 10.1007/s00420-023-02014-2. Epub 2023 Oct 24.
PubMed 37874403Zhuo L, Zhang H, Geng R, Wang P, Zeng L, Che Y, Wang P, Li P, Huang T, Li B, Zhan S. Protocol for the National Nurse Health Study (NNHS): a web-based ambispective cohort study. BMJ Open. 2021 Aug 19;11(8):e049958. doi: 10.1136/bmjopen-2021-049958.
PubMed 34413106
Study at a glance
From the registry record, last updated by the sponsor on 28 Dec 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- National Nurses Health Cohort Study (NNHS): a Web-based Ambispective Cohort Study in China
- ClinicalTrials.gov ID
- NCT04572347
- Acronym / sponsor ID
- NNHC_1
- Conditions
- Nurse Health
- Keywords
- psychophysical health, career development, stress, metabolic indexes
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 2,000 participants (estimated)
- Lead sponsor
- Peking University Third HospitalUniversity, hospital or other
- Study start
- 15 Jan 2021 (estimated)
- Primary completion
- 30 Dec 2021 (estimated)
- Study completion
- 30 Dec 2022 (estimated)
- First posted
- 1 Oct 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of the current study was to build an ambispective cohort study of female nurses, based on existing physical examination and nurse work schedule data and a web-based questionnaire system, focusing on the effects of occupational, environmental, and lifestyle risk factors on the health of Chinese women.
Study design
- Observational model
- Cohort
- Time perspective
- Other
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Nurses working in PUTH | – | Other: ObservationalParticipants will be recruited from Peking University Third Hospital through cluster sampling. Female registered nurses, licensed practical nurses and/or midwives with informed consent are included in this study. The exclusion criteria are student nurses and training nurses. |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- Participants will be recruited from Peking University Third Hospital through cluster sampling.
Key inclusion criteria (1 listed)
- Female registered nurses, licensed practical nurses and/or midwives with informed consent are included in this study
Key exclusion criteria (2 listed)
- student nurses
- training nurses
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| ObservationalIt is an observational study, and no intervention will be provided. | Other | Nurses working in PUTH |
Primary outcome
psychophysical health related events
Time frame: From 2010 to 2022
psychophysical health related events will be collected by web-based questionnaire and hospital information system.
mental health
Time frame: From 2020 to 2022
National Aeronautics and Space Administration Task Load Index was used to evaluate the mental workload every year.
2 secondary outcomes
sleep quality
Time frame: From 2020 to 2022
social support
Time frame: From 2020 to 2022
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Dec 2020.
- Derived from this study: PubMed 40907657Yu M, Chen H, Pei M, Zhan S, Li B. Bidirectional Association of Tinnitus and Psychological Distress Among Nurses at One-year Follow-up: A Propensity Score-matched Cohort Study From China. Asian Nurs Res (Korean Soc Nurs Sci). 2025 Dec;19(5):418-425. doi: 10.1016/j.anr.2025.06.003. Epub 2025 Sep 2.
- Derived from this study: PubMed 38355421Che Y, Tang R, Zhang H, Yang M, Geng R, Zhuo L, Wang P, Hu X, Zhou Y, Wang P, Zhan S, Li B. Development of a prediction model for predicting the prevalence of nonalcoholic fatty liver disease in Chinese nurses: the first-year follow data of a web-based ambispective cohort study. BMC Gastroenterol. 2024 Feb 14;24(1):72. doi: 10.1186/s12876-024-03121-1.
- Derived from this study: PubMed 37874403Zhang H, Wang J, Zhang S, Tong S, Hu J, Che Y, Zhuo L, Wang P, Geng R, Zhou Y, Wang P, Zhan S, Li B. Relationship between night shift and sleep problems, risk of metabolic abnormalities of nurses: a 2 years follow-up retrospective analysis in the National Nurse Health Study (NNHS). Int Arch Occup Environ Health. 2023 Dec;96(10):1361-1371. doi: 10.1007/s00420-023-02014-2. Epub 2023 Oct 24.
- Derived from this study: PubMed 34413106Zhuo L, Zhang H, Geng R, Wang P, Zeng L, Che Y, Wang P, Li P, Huang T, Li B, Zhan S. Protocol for the National Nurse Health Study (NNHS): a web-based ambispective cohort study. BMJ Open. 2021 Aug 19;11(8):e049958. doi: 10.1136/bmjopen-2021-049958.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Baohua Li principal investigator
Peking University Third Hospital
Questions about this trial
What is this clinical trial studying?
An observational study of Nurse Health, run by Peking University Third Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 28 Dec 2020. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Zhuo Lin, PhD (861082265732, zhuolin9017@126.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
psychophysical health related events (time frame: From 2010 to 2022). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04572347, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Dec 2020.