StrokeCHESTNCT04573114
Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke
An observational study of Stroke and Healthy, run by University of Zurich at 1 site in Switzerland.
Trial summary
This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- What is being tested?
- Verticalization
- Type of treatment
- Surgery or procedure
- How many people
- 80 participants
- Where
- 1 siteSwitzerland
- Study dates
- 2 Sep 2020to 31 Dec 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: •First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
Who may be able to join
- First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
- ≤12 hours after mechanical thrombectomy
- Conscious
- Hemodynamically stable
- 18 years or older
- Informed consent of the patient and/ or legal representative
Who cannot join
- Verticalization not allowed according to treating physician
- Known pre-stroke disease affecting cerebral blood flow
- Temporal bone windows insufficient to enable ultrasound penetration
- Intubation anticipated or occurred
- Venous thromboembolism
- Symptomatic intracranial hemorrhage
Trial locations and contacts
1 site in 1 country.
Switzerland1 site, 1 recruiting
- Recruiting
University Hospital Zurich
Zurich, Canton of Zurich, 8091
Jeremia Held, PhD, 0442555645 ext. 41, jeremia.held@uzh.ch
About this study
This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.
- Being tested
- Verticalization
- Medical subject headings
- Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
VerticalizationProcedure or surgery
Progressive levels of verticalization
| Study group | Role | What they receive |
|---|---|---|
| Stroke subjects | Not described Receives: Procedure: Verticalization | |
| Healthy | Not described Receives: Procedure: Verticalization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Blood flow velocity
Cerebral blood flow velocity measured with transcranial doppler ultrasound
Measured: within 12 hours post thrombectomy
Secondary outcomes (6)
Blood pressure
Systolic and Diastolic pressure
Measured: within 12 hours post thrombectomy
Heart rate
Number of contractions (beats) of the heart per minute
Measured: within 12 hours post thrombectomy
Oxygen saturation
Relative measure of the concentration of oxygen in the blood
Measured: within 12 hours post thrombectomy
Impairment caused by a stroke
National Institutes of Health Stroke Scale - NIHSS (Maximum score 42 - higher scores mean a worse outcome)
Measured: within 12 hours post thrombectomy
Neurological status
Glasgow Coma Scale - GCS (Maximum score 15 - higher scores mean a better outcome)
Measured: within 12 hours post thrombectomy
Adverse events
headache, focal edema, seizures, hemorrhagic transformation
Measured: within 12 hours post thrombectomy
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Oct 2020
- Study start2 Sep 2020
- Primary completion31 Dec 2022 (estimated)
- Study completion31 Dec 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for StrokeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Andreas Luft, MD, Study chair, University of Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04573114
- Sponsor's protocol ID
- 2020-01732
- Acronym
- CHEST
- Status last verified
- Nov 2021
- First submitted
- 3 Sep 2020
- Last updated
- 29 Nov 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Deseoe J, Rottenberger Y, Pipping T, Schwarz A, Lehmann A, Veerbeek JM, Wegener S, Luft AR, Held JPO, Globas C. Very early tilt-table verticalization unmasks impaired cerebral autoregulation within 24 h after endovascular thrombectomy: a transcranial Doppler study. Front Neurol. 2026 Jan 6;16:1709991. doi: 10.3389/fneur.2025.1709991. eCollection 2025.
PubMed 41567543Deseoe J, Schwarz A, Pipping T, Lehmann A, Veerbeek JM, Luft AR, Wegener S, Globas C, Held JPO. Cerebral blood flow velocity progressively decreases with increasing levels of verticalization in healthy adults. A cross-sectional study with an observational design. Front Neurol. 2023 Apr 17;14:1149673. doi: 10.3389/fneur.2023.1149673. eCollection 2023.
PubMed 37139076
Study at a glance
From the registry record, last updated by the sponsor on 29 Nov 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke
- ClinicalTrials.gov ID
- NCT04573114
- Acronym / sponsor ID
- CHEST / 2020-01732
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- 2 Sep 2020 (actual)
- Primary completion
- 31 Dec 2022 (estimated)
- Study completion
- 31 Dec 2022 (estimated)
- First posted
- 5 Oct 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Stroke subjects | – | Procedure: Verticalization |
| Healthy | – | Procedure: Verticalization |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- •First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
Key inclusion criteria (6 listed)
- First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
- ≤12 hours after mechanical thrombectomy
- Conscious
- Hemodynamically stable
- 18 years or older
Key exclusion criteria (6 listed)
- Verticalization not allowed according to treating physician
- Known pre-stroke disease affecting cerebral blood flow
- Temporal bone windows insufficient to enable ultrasound penetration
- Intubation anticipated or occurred
- Venous thromboembolism
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| VerticalizationProgressive levels of verticalization | Procedure or surgery | Healthy, Stroke subjects |
Primary outcome
Blood flow velocity
Time frame: within 12 hours post thrombectomy
Cerebral blood flow velocity measured with transcranial doppler ultrasound
6 secondary outcomes
Blood pressure
Time frame: within 12 hours post thrombectomy
Heart rate
Time frame: within 12 hours post thrombectomy
Oxygen saturation
Time frame: within 12 hours post thrombectomy
Impairment caused by a stroke
Time frame: within 12 hours post thrombectomy
Neurological status
Time frame: within 12 hours post thrombectomy
Adverse events
Time frame: within 12 hours post thrombectomy
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 29 Nov 2021.
- Derived from this study: PubMed 41567543Deseoe J, Rottenberger Y, Pipping T, Schwarz A, Lehmann A, Veerbeek JM, Wegener S, Luft AR, Held JPO, Globas C. Very early tilt-table verticalization unmasks impaired cerebral autoregulation within 24 h after endovascular thrombectomy: a transcranial Doppler study. Front Neurol. 2026 Jan 6;16:1709991. doi: 10.3389/fneur.2025.1709991. eCollection 2025.
- Derived from this study: PubMed 37139076Deseoe J, Schwarz A, Pipping T, Lehmann A, Veerbeek JM, Luft AR, Wegener S, Globas C, Held JPO. Cerebral blood flow velocity progressively decreases with increasing levels of verticalization in healthy adults. A cross-sectional study with an observational design. Front Neurol. 2023 Apr 17;14:1149673. doi: 10.3389/fneur.2023.1149673. eCollection 2023.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Andreas Luft, MD study chair
University of Zurich
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke and Healthy, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 29 Nov 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Jeremia Held, PhD (0442555645 ext. 41, jeremia.held@uzh.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Blood flow velocity (time frame: within 12 hours post thrombectomy). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04573114, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 29 Nov 2021.