Wrist ArthritisPARTENCT04580225
Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE)
A study testing Four-Corner Arthrodesis and Three-Corner or Capitolunate Arthrodesis with Triquetral Excision in people with Wrist Arthritis and Wrist Arthropathy, run by University of Alberta at 5 sites in Canada.
Trial summary
This randomized clinical trial (RCT) aims to compare clinical and radiographic outcomes of different partial wrist fusion techniques in participants with post-traumatic wrist arthritis. Read more about this study
- Who is it for?
- Ages 18 to 75 years
- Conditions the study is for
- Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse
- What is being tested?
- Four-Corner Arthrodesis and Three-Corner or Capitolunate Arthrodesis with Triquetral Excision
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 170 participants
- Where
- 5 sitesCanada
- Study dates
- 7 Jan 2021to Apr 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participant has a stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) wrist and is a surgical candidate for the included surgical interventions
Who cannot join
- Participant has been diagnosed with other forms of wrist arthritis other than SLAC or SNAC
- Participant has significant arthritis of the ipsilateral hand/finger joint(s), major joint trauma, previous major wrist surgery, infection or neuromuscular pathology affecting the function of the ipsilateral upper extremity or ability to make a fist
- Participant has a physical or mental health condition preventing completion of consent or questionnaires
- Participant does not speak/read/understand English
- Participant has no fixed address or means of contact
- Participant is unwilling to complete necessary follow-ups
- Surgeon concludes that eligible salvage techniques are not appropriate at the time of surgery (based on injury characteristics or concomitant wrist pathology)
Trial locations and contacts
5 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Collaborative Orthopaedic Research (CORe) contact
5 sites in 1 country
Canada5 sites, 5 recruiting
- Recruiting
South Health Campus
Calgary, Alberta
Sara Kayvani, 403-956-3687, sara.kayvani@ucalgary.ca
Neil White, MD, FRCSC
- Recruiting
Lawson Health Research Institute
London, Ontario
Katrina Munro, katrina.munro@sjhc.london.on.ca
Ruby Grewal, MD, FRCSC
- Recruiting
The Ottawa Hospital - Civic Campus
Ottawa, Ontario
Hoda Ghaziasgar, MSc, 613-737-8899 ext. 19217, hghaziasgar@ohri.ca
Manisha Mistry, MD, MSc, FRCSC
- Recruiting
University of Saskatchewan
Saskatoon, Saskatchewan
Laura A. Sims, MD, FRCSC, laurasims710@gmail.com
Laura A. Sims, MD, FRCSC
- Recruiting
Western Hand & Upper Limb Facility, Sturgeon Community Hospital
St. Albert, Alberta
Research Coordinator, Sturgeon Community Hospital, (780) 418-7410
Armin Badre, MD, MSc, FRCSC
About this study
This randomized clinical trial (RCT) aims to compare clinical and radiographic outcomes of different partial wrist fusion techniques in participants with post-traumatic wrist arthritis. Participants with stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) who meet the eligibility criteria will be randomly assigned to one of two parallel groups: Group A (partial wrist arthrodesis without triquetral excision i.e. four-corner arthrodesis), or Group B (partial wrist arthrodesis with triquetral excision i.e. three-corner or capitolunate arthrodesis with triquetral excision). The results of this study will provide evidence to guide surgeons in determining the ideal wrist fusion technique in the management of patients with post-traumatic wrist arthritis requiring surgery.
Read the detailed description
This study has been designed as a multi-center double-blind prospective randomized clinical trial. Eligible participants will be adults presenting with SNAC or SLAC wrist arthritis who have been deemed an operative candidate and qualify for one of the following salvage techniques: four-corner arthrodesis (without triquetral excision) or three-corner/capitolunate arthrodeses with triquetral excision.
Once eligibility is confirmed, participants will be randomly assigned to one of two treatment arms. Participants in Group A will undergo four-corner arthrodesis; the scaphoid will be excised and the lunate, capitate, triquetrum, and hamate will be prepared and fused. Participants in Group B will undergo partial wrist arthrodesis with triquetral excision; the scaphoid and triquetrum will be excised. In the three-corner arthrodesis procedure, the articular surfaces between the lunate, capitate, and hamate will be prepared and fused. In the capitolunate arthrodesis procedure, only the articular surface between the lunate and capitate will be prepared and fused.
Eligible and consented participants will undergo a pre-operative study assessment and follow-up assessments at 6-weeks, 3-, 6-, and 12-months post-operative. Assessments will be conducted by an assessor blinded to participant treatment allocation. At each assessment, grip strength, wrist range of motion (ROM), Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaire, Patient-Rated Wrist Evaluation (PRWE) questionnaire, and Visual Analog Scale (VAS) for pain will be completed. The work and sports/performing arts modules of the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), and the WOrk-Related Questionnaire for UPper extremity disorders (WORQ-UP), will be completed at baseline (pre-surgery) and at 12-months. Standard posteroanterior and lateral radiographs will be completed at all visits. Complications will be documented at each visit.
The primary outcome, grip strength, will be measured with a handheld dynamometer. Absolute values and percentage of their contralateral side will be compared between the two groups.
Statistical analysis will use the intention-to-treat approach with all outcomes attributed to the assigned group. Descriptive statistics will be used for group comparisons with independent t-tests for continuous and Pearson Chi-square or Fisher's Exact tests for categorical variables at baseline and for possible complications/adverse events. Linear Mixed Modeling (LMM), adjusted for age and sex, will compare outcomes between groups over the 12-month evaluation period. The level of significance will be set at α=0.05.
This study hypothesizes that partial wrist fusion with triquetral excision will lead to improved grip strength and ROM compared to four-corner arthrodesis. Considering the importance of ROM and grip strength in many activities of daily living and manual work, it is hypothesized that the group with triquetral excision (Group B) will have better patient-reported outcomes. We hypothesize no significant difference between the groups with regards to radiographic outcomes and complications.
- Conditions
- Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis
- Being tested
- Four-Corner Arthrodesis, Three-Corner or Capitolunate Arthrodesis with Triquetral Excision
- Keywords
- Post-traumatic wrist arthritis, Partial wrist fusions, Scapholunate advanced collapse, SLAC wrist, Scaphoid nonunion advanced collapse, SNAC wrist, Four-corner fusion, Bicolumnar wrist fusion, Three-corner fusion, Capitolunate fusion
- Medical subject headings
- Osteoarthritis, Arthritis, Musculoskeletal Diseases, Joint Diseases
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Four-Corner ArthrodesisProcedure or surgery
Participants in Group A will receive a four-corner arthrodesis (fusion of the capitate, hamate, lunate, and triquetrum) with excision of the scaphoid.
Three-Corner or Capitolunate Arthrodesis with Triquetral ExcisionProcedure or surgery
Participants in Group B will receive a three-corner arthrodesis (fusion of the capitate, hamate, and lunate) or capitolunate arthrodesis (fusion of the capitate and lunate) with excision of the scaphoid and triquetrum.
| Study group | Role | What they receive |
|---|---|---|
| Group A: Partial Wrist Arthrodesis without Triquetral Excision | Active comparator | Four-Corner Arthrodesis Receives: Procedure: Four-Corner Arthrodesis |
| Group B: Partial Wrist Arthrodesis with Triquetral Excision | Active comparator | Three-Corner or Capitolunate Arthrodesis with Triquetral Excision Receives: Procedure: Three-Corner or Capitolunate Arthrodesis with Triquetral Excision |
What is being measured
The primary outcome is the main question the study is designed to answer.
Grip Strength
Peak grip strength will be assessed using a hand-held dynamometer. Grip strength will be compared between groups over the 12-month evaluation period.
Measured: Completed at baseline (pre-surgery), 3-, 6-, 12-months post-surgery
Secondary outcomes (7)
Wrist Range of Motion (ROM)
Active and passive wrist ROM will be assessed using a goniometer. ROM will be compared between groups over the 12-month evaluation period.
Measured: Baseline, 3-, 6-, 12-months post-surgery
Patient-Reported Outcomes Measurement Information System® (PROMIS)
PROMIS questionnaire will be used to assess self-reported physical function, upper extremity, pain interference, emotional distress. PROMIS scores will be compared between groups over the 12-month evaluation period.
Measured: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Patient-Rated Wrist Evaluation (PRWE) Questionnaire
Pain and function from 0-10 will be self-reported using the PRWE. PRWE scores will be compared between groups over the 12-month evaluation period.
Measured: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Visual Analog Scale (VAS) Pain Score
Pain will be self-reported using VAS where zero equals no pain and 10 represents the worst possible pain. VAS pain scores will be compared between groups over the 12-month evaluation period.
Measured: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Complications
Complications including infection and nonunion will be compared between groups over the 12-month evaluation period.
Measured: 6-weeks, 3-, 6-, 12-months post-surgery
Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire - work and sports/performing arts modules
The work and sports/performing arts modules of the QuickDASH will be collected to measure the extent that participants experience limitations in their work and recreational activities, as applicable. Scores will be compared between groups.
Measured: Baseline, 12-months post-surgery
WOrk-Related Questionnaire for UPper extremity disorders (WORQ-UP) questionnaire
The WORQ-UP will be collected to measure the extent that participants experience limitations in their work, as applicable. Scores will be compared between groups.
Measured: Baseline, 12-months post-surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Oct 2020
- Study start7 Jan 2021
- Primary completionApr 2027 (estimated)
- Study completionApr 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Wrist ArthritisStudies of the same condition, open and under way.
- More trials run by University of AlbertaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 170 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Alberta
- Sponsor type
- University, hospital or other
- Collaborators
- Arthritis Society Canada, Wrist Evaluation Canada (WECAN)
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04580225
- Sponsor's protocol ID
- Pro00099049
- Acronym
- PARTE
- Status last verified
- Jun 2026
- First submitted
- 2 Oct 2020
- Last updated
- 24 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 24 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Randomized Comparison of PARtial Wrist Fusion With or Without Triquetral Excision (PARTE)
- ClinicalTrials.gov ID
- NCT04580225
- Acronym / sponsor ID
- PARTE / Pro00099049
- Conditions
- Wrist Arthritis, Wrist Arthropathy, Scapholunate Advanced Collapse, Scaphoid Nonunion, Post-traumatic; Arthrosis, Arthritis
- Keywords
- Post-traumatic wrist arthritis, Partial wrist fusions, Scapholunate advanced collapse, SLAC wrist, Scaphoid nonunion advanced collapse, SNAC wrist, Four-corner fusion, Bicolumnar wrist fusion
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 170 participants (estimated)
- Lead sponsor
- University of AlbertaUniversity, hospital or other
- Collaborators
- Arthritis Society Canada, Wrist Evaluation Canada (WECAN)
- Study start
- 7 Jan 2021 (actual)
- Primary completion
- Apr 2027 (estimated)
- Study completion
- Apr 2027 (estimated)
- First posted
- 8 Oct 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial (RCT) aims to compare clinical and radiographic outcomes of different partial wrist fusion techniques in participants with post-traumatic wrist arthritis. Participants with stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) who meet the eligibility criteria will be randomly assigned to one of two parallel groups: Group A (partial wrist arthrodesis without triquetral excision i.e. four-corner arthrodesis), or Group B (partial wrist arthrodesis with triquetral excision i.e. three-corner or capitolunate arthrodesis with triquetral excision). The results of this study will provide evidence to guide surgeons in determining the ideal wrist fusion technique in the management of patients with post-traumatic wrist arthritis requiring surgery.
Detailed description
This study has been designed as a multi-center double-blind prospective randomized clinical trial. Eligible participants will be adults presenting with SNAC or SLAC wrist arthritis who have been deemed an operative candidate and qualify for one of the following salvage techniques: four-corner arthrodesis (without triquetral excision) or three-corner/capitolunate arthrodeses with triquetral excision.
Once eligibility is confirmed, participants will be randomly assigned to one of two treatment arms. Participants in Group A will undergo four-corner arthrodesis; the scaphoid will be excised and the lunate, capitate, triquetrum, and hamate will be prepared and fused. Participants in Group B will undergo partial wrist arthrodesis with triquetral excision; the scaphoid and triquetrum will be excised. In the three-corner arthrodesis procedure, the articular surfaces between the lunate, capitate, and hamate will be prepared and fused. In the capitolunate arthrodesis procedure, only the articular surface between the lunate and capitate will be prepared and fused.
Eligible and consented participants will undergo a pre-operative study assessment and follow-up assessments at 6-weeks, 3-, 6-, and 12-months post-operative. Assessments will be conducted by an assessor blinded to participant treatment allocation. At each assessment, grip strength, wrist range of motion (ROM), Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaire, Patient-Rated Wrist Evaluation (PRWE) questionnaire, and Visual Analog Scale (VAS) for pain will be completed. The work and sports/performing arts modules of the Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH), and the WOrk-Related Questionnaire for UPper extremity disorders (WORQ-UP), will be completed at baseline (pre-surgery) and at 12-months. Standard posteroanterior and lateral radiographs will be completed at all visits. Complications will be documented at each visit.
The primary outcome, grip strength, will be measured with a handheld dynamometer. Absolute values and percentage of their contralateral side will be compared between the two groups.
Statistical analysis will use the intention-to-treat approach with all outcomes attributed to the assigned group. Descriptive statistics will be used for group comparisons with independent t-tests for continuous and Pearson Chi-square or Fisher's Exact tests for categorical variables at baseline and for possible complications/adverse events. Linear Mixed Modeling (LMM), adjusted for age and sex, will compare outcomes between groups over the 12-month evaluation period. The level of significance will be set at α=0.05.
This study hypothesizes that partial wrist fusion with triquetral excision will lead to improved grip strength and ROM compared to four-corner arthrodesis. Considering the importance of ROM and grip strength in many activities of daily living and manual work, it is hypothesized that the group with triquetral excision (Group B) will have better patient-reported outcomes. We hypothesize no significant difference between the groups with regards to radiographic outcomes and complications.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A: Partial Wrist Arthrodesis without Triquetral Excision | Active comparator | Procedure: Four-Corner ArthrodesisFour-Corner Arthrodesis |
| Group B: Partial Wrist Arthrodesis with Triquetral Excision | Active comparator | Procedure: Three-Corner or Capitolunate Arthrodesis with Triquetral ExcisionThree-Corner or Capitolunate Arthrodesis with Triquetral Excision |
Who may qualify
- Ages
- 18 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Participant has a stage II or III scapholunate advanced collapse (SLAC) or scaphoid nonunion advanced collapse (SNAC) wrist and is a surgical candidate for the included surgical interventions
Key exclusion criteria (7 listed)
- Participant has been diagnosed with other forms of wrist arthritis other than SLAC or SNAC
- Participant has significant arthritis of the ipsilateral hand/finger joint(s), major joint trauma, previous major wrist surgery, infection or neuromuscular pathology affecting the function of the ipsilateral upper extremity or ability to make a fist
- Participant has a physical or mental health condition preventing completion of consent or questionnaires
- Participant does not speak/read/understand English
- Participant has no fixed address or means of contact
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Four-Corner ArthrodesisParticipants in Group A will receive a four-corner arthrodesis (fusion of the capitate, hamate, lunate, and triquetrum) with excision of the scaphoid. | Procedure or surgery | Group A: Partial Wrist Arthrodesis without Triquetral Excision |
| Three-Corner or Capitolunate Arthrodesis with Triquetral ExcisionParticipants in Group B will receive a three-corner arthrodesis (fusion of the capitate, hamate, and lunate) or capitolunate arthrodesis (fusion of the capitate and lunate) with excision of the scaphoid and triquetrum. | Procedure or surgery | Group B: Partial Wrist Arthrodesis with Triquetral Excision |
Primary outcome
Grip Strength
Time frame: Completed at baseline (pre-surgery), 3-, 6-, 12-months post-surgery
Peak grip strength will be assessed using a hand-held dynamometer. Grip strength will be compared between groups over the 12-month evaluation period.
7 secondary outcomes
Wrist Range of Motion (ROM)
Time frame: Baseline, 3-, 6-, 12-months post-surgery
Patient-Reported Outcomes Measurement Information System® (PROMIS)
Time frame: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Patient-Rated Wrist Evaluation (PRWE) Questionnaire
Time frame: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Visual Analog Scale (VAS) Pain Score
Time frame: Baseline, 6-weeks, 3-, 6-, 12-months post-surgery
Complications
Time frame: 6-weeks, 3-, 6-, 12-months post-surgery
Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) questionnaire - work and sports/performing arts modules
Time frame: Baseline, 12-months post-surgery
WOrk-Related Questionnaire for UPper extremity disorders (WORQ-UP) questionnaire
Time frame: Baseline, 12-months post-surgery
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Jun 2026.
Related trials for Wrist Arthritis
Recruiting
Vibratory Anesthesia on Pain Following Corticosteroid Injections
Bilateral Arthritis of Wrist, Tendinopathy
Not yet recruiting
Effects of Paraffin Wax Therapy and Dry Cupping on Pain and Wrist Function in Patients With Rheumatoid Arthritis
Rheumatic Arthritis
Recruiting
Web-based Rehabilitation After Surgical Salvage Procedures for Wrist Osteoarthritis
Wrist Osteoarthritis
Not yet recruiting
Understanding Patient Preferences When Deciding on a Voluntary Musculoskeletal Test
Non-traumatic Musculoskeletal Conditions, Carpal Tunnel Syndrome (CTS)
Recruiting
Effect of Lavender Aromatherapy Massage on Pain and Wrist Mobility in Rheumatoid Arthritis
Rheumatoid Arthritis (RA)
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Collaborative Orthopaedic Research (CORe) contact
5 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Four-Corner Arthrodesis and Three-Corner or Capitolunate Arthrodesis with Triquetral Excision in people with Wrist Arthritis and Wrist Arthropathy, run by University of Alberta at 5 sites in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 24 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 5 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Dr. Armin Badre, MD, MSc, FRCSC ((780) 569-5494, badre@ualberta.ca), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Grip Strength (time frame: Completed at baseline (pre-surgery), 3-, 6-, 12-months post-surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Jun 2026.