ObesityNCT04738929
Comparing EVCO and EVOO
A study testing Extra virgin coconut oil or extra virgin olive oil in people with Obesity and Appetitive Behavior, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
Trial summary
The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects. Read more about this study
- Who is it for?
- Ages 19 to 40 years, men only
- Conditions the study is for
- Obesity, Appetitive Behavior
- What is being tested?
- Extra virgin coconut oil or extra virgin olive oil
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 20 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 3 Jan 2019to 3 Jun 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 19 to 40 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Metabolically healthy
- Aged 19-40 years
- Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)
Who cannot join
- smoking,
- alcohol consumption,
- weight gain/loss recently (> %5, in three months),
- any genetic and metabolic diseases,
- any food allergy/intolerance,
- any medication,
- restrained eating habits.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Presidency of Republic of Turkey Health Center
Ankara
About this study
Official title: Comparing Acute Effects of Extra Virgin Coconut Oil and Extra Virgin Olive Oil Consumption on Appetite and Food Intake in Normal Weight and Obese Male Subjects
The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.
Read the detailed description
Twenty male subjects (10 normal weight; 10 obese) consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g). Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.
- Conditions
- Obesity, Appetitive Behavior
- Being tested
- Extra virgin coconut oil or extra virgin olive oil
- Keywords
- Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.
- Medical subject headings
- Obesity, Appetitive Behavior
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Extra virgin coconut oil or extra virgin olive oilOther
Subjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil"
| Study group | Role | What they receive |
|---|---|---|
| Normal weight | Experimental | Normal weight subjects (BMI=18.5-25) Receives: Other: Extra virgin coconut oil or extra virgin olive oil |
| Obese | Experimental | Obese subjects (BMI=30-34.99) Receives: Other: Extra virgin coconut oil or extra virgin olive oil |
What is being measured
The primary outcome is the main question the study is designed to answer.
Energy expenditure change
kcal
Measured: 0, 60, 120, 180 minutes
Subjective appetite feelings change
visual analogue scales rating (0-10 cm)
Measured: 0, 30, 60, 120, 180 minutes
glucose change
mg/dl
Measured: 0, 30, 60, 120, 180 minutes
insulin change
mU/L
Measured: 0, 30, 60, 120, 180 minutes
peptide YY change
pg/dl
Measured: 0, 30, 60, 120, 180 minutes
triglycerides change
mg/dl
Measured: 0, 30, 60, 120, 180 minutes
Ad libitum energy intake
kcal
Measured: 180 minute
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Feb 2021
- Study start3 Jan 2019
- Primary completion3 Jun 2019
- Study completion3 Jun 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for ObesityStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara City Hospital Bilkent
- Sponsor type
- University, hospital or other
- Collaborators
- Hacettepe University
- Responsible party
- Principal investigator, Ziyaerokaymetin, Ankara City Hospital Bilkent
- Investigators
- Ziya Erokay Metin, Dr., Principal investigator, Ankara City Hospital BilkentPelin Bilgiç, Assoc. Prof., Study chair, Hacettepe UniversityMercan Merve Tengilimoğlu Metin, Assis. Prof., Study chair, Hacettepe UniversityMuzaffer Akkoca, Assoc. Prof., Study chair, Saglik Bilimleri Universitesi
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04738929
- Sponsor's protocol ID
- EVCO
- Status last verified
- Feb 2021
- First submitted
- 20 Jan 2021
- Last updated
- 4 Feb 2021
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Metin ZE, Bilgic P, Tengilimoglu Metin MM, Akkoca M. Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects. PLoS One. 2022 Sep 16;17(9):e0274663. doi: 10.1371/journal.pone.0274663. eCollection 2022.
PubMed 36112590
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2021. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing Acute Effects of Extra Virgin Coconut Oil and Extra Virgin Olive Oil Consumption on Appetite and Food Intake in Normal Weight and Obese Male Subjects
- ClinicalTrials.gov ID
- NCT04738929
- Acronym / sponsor ID
- EVCO
- Conditions
- Obesity, Appetitive Behavior
- Keywords
- Extra virgin coconut oil; medium chain fatty acids; extra virgin olive oil; obesity; peptide YY; resting metabolic rate.
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Ankara City Hospital BilkentUniversity, hospital or other
- Collaborators
- Hacettepe University
- Study start
- 3 Jan 2019 (actual)
- Primary completion
- 3 Jun 2019 (actual)
- Study completion
- 3 Jun 2019 (actual)
- First posted
- 4 Feb 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The aim of this study is to compare acute effects of consuming extra virgin coconut oil (EVCO) as a source of medium chain fatty acids and extra virgin olive oil (EVOO) as a source of long chain fatty acids in normal weight and obese subjects.
Detailed description
Twenty male subjects (10 normal weight; 10 obese) consumed breakfast meals containing skimmed milk, fat-free white cheese, bread and EVCO (25 g) or EVOO (25 g). Visual analog scale evaluations, resting metabolic rate measurements and selected blood parameters analysis (glucose, triglyceride, insulin and plasma peptide YY) were performed before and after the test breakfast meals. In addition, energy intakes were evaluated by ad libitum lunch meal at 180 min.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Normal weight | Experimental | Other: Extra virgin coconut oil or extra virgin olive oilNormal weight subjects (BMI=18.5-25) |
| Obese | Experimental | Other: Extra virgin coconut oil or extra virgin olive oilObese subjects (BMI=30-34.99) |
Who may qualify
- Ages
- 19 to 40 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Metabolically healthy
- Aged 19-40 years
- Normal weight (BMI=18.5-24.9 kg/m²) and obese men (BMI=30-34.99 kg/m²)
Key exclusion criteria (7 listed)
- smoking,
- alcohol consumption,
- weight gain/loss recently (> %5, in three months),
- any genetic and metabolic diseases,
- any food allergy/intolerance,
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Extra virgin coconut oil or extra virgin olive oilSubjects consumed standard breakfast meals containing "extra virgin coconut oil" or "extra virgin olive oil" | Other | Normal weight, Obese |
Primary outcome
Energy expenditure change
Time frame: 0, 60, 120, 180 minutes
kcal
Subjective appetite feelings change
Time frame: 0, 30, 60, 120, 180 minutes
visual analogue scales rating (0-10 cm)
glucose change
Time frame: 0, 30, 60, 120, 180 minutes
mg/dl
insulin change
Time frame: 0, 30, 60, 120, 180 minutes
mU/L
peptide YY change
Time frame: 0, 30, 60, 120, 180 minutes
pg/dl
triglycerides change
Time frame: 0, 30, 60, 120, 180 minutes
mg/dl
Ad libitum energy intake
Time frame: 180 minute
kcal
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2021.
- Derived from this study: PubMed 36112590Metin ZE, Bilgic P, Tengilimoglu Metin MM, Akkoca M. Comparing acute effects of extra virgin coconut oil and extra virgin olive oil consumption on appetite and food intake in normal-weight and obese male subjects. PLoS One. 2022 Sep 16;17(9):e0274663. doi: 10.1371/journal.pone.0274663. eCollection 2022.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Ziya Erokay Metin, Dr. principal investigator
Ankara City Hospital Bilkent
Pelin Bilgiç, Assoc. Prof. study chair
Hacettepe University
Mercan Merve Tengilimoğlu Metin, Assis. Prof. study chair
Hacettepe University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Extra virgin coconut oil or extra virgin olive oil in people with Obesity and Appetitive Behavior, run by Ankara City Hospital Bilkent at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Feb 2021. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Energy expenditure change (time frame: 0, 60, 120, 180 minutes). The study lists 7 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04738929, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2021.