AnxietyNCT04771195
Social Factors in the Mental Health of Young Adults: Bridging Psychological and Network Analysis
A study testing Examination of students' naturally occurring social ties in people with Anxiety and Depression, run by Stanford University at 1 site in United States.
Trial summary
The central goal of this project is to produce a novel, precise, and comprehensive account of social factors in young adult mental health - using a novel combination of network nominations, ecological momentary assessment, and neuroimaging methods. Read more about this study
- Who is it for?
- Ages 18 years and olderHealthy volunteers can take part
- Conditions the study is for
- Anxiety, Depression, Loneliness
- What is being tested?
- Examination of students' naturally occurring social ties
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 9,941 participants
- Where
- 1 siteUnited States
- Study dates
- 30 Aug 2021to 8 May 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
None listed.
Who cannot join
- -
Trial locations and contacts
1 site in 1 country.
About this study
The central goal of this project is to produce a novel, precise, and comprehensive account of social factors in young adult mental health - using a novel combination of network nominations, ecological momentary assessment, and neuroimaging methods. To that end, the investigators will collect data from two successive classes of college undergraduates (i.e., classes of 2023 and 2024) over the course of their collegiate tenure.
Read the detailed description
The proposed work will consist of four key components. The investigators will collect data from the class of 2023 in each of their remaining years at college, producing (i) longitudinal data that will allow them to probe the long-term mental health effects of connections made during the transition to college, as well as mental health issues and resilience in the wake of the COVID-19 pandemic as a function of social connectedness. The investigators will leverage this rich dataset to build (ii) prospective quantitative models to predict mental health outcomes later in college based on a range of social factors measured early in college. They will further collect (iii) a longitudinal replication cohort, the class of 2024, allowing to establish the robustness of their initial findings across samples. Finally, the investigators will add (iv) a neuroimaging component to this dataset in a subset of the class of 2024. This will allow them to examine brain "markers" of connectedness, and add them to a prospective model, providing a novel integration across brain, behavior, and community levels of analysis, and a synthetic assessment of social factors in long-term mental health.
- Conditions
- Anxiety, Depression, Loneliness, Stress
- Being tested
- Examination of students' naturally occurring social ties
- Medical subject headings
- Anxiety Disorders, Depression
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Examination of students' naturally occurring social tiesBehavioural
In this observational study, features of students' social lives, such as the number of quality of relationships they form, and their subjective loneliness, will be used to predict their mental health and well being at later time points.
| Study group | Role | What they receive |
|---|---|---|
| Class of 2023 and 2024 | Experimental | Stanford undergraduate students who are expected to graduate in Spring of 2023 or 2024 Receives: Behavioral: Examination of students' naturally occurring social ties |
What is being measured
The primary outcome is the main question the study is designed to answer.
Depression
Score on self-reported depression measure: Center for Epidemiological Studies Scale - 10 item version. Range = 0 to 30. Higher scores indicate more depressive symptoms
Measured: September 2021 - May 2024
Anxiety
Score on self-reported anxiety measure: State-Trait Anxiety Inventory - 20 item version. Range = 20 to 80. Higher scores indicate more symptoms of anxiety.
Measured: September 2021 - May 2024
Secondary outcomes (2)
Loneliness
Score on self-reported loneliness measure: University of California Loneliness Scale - 8 item version. Range = 1 to 5. Higher score indicate greater feeling of loneliness.
Measured: September 2021 - May 2024
Stress
Score on self-reported stress measure: Perceived Stress Scale. Range = 1 to 3. Higher scores indicate greater feeling of stress.
Measured: September 2021 - May 2024
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted25 Feb 2021
- Study start30 Aug 2021
- Primary completion8 May 2026
- Study completion8 May 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AnxietyStudies of the same condition, open and under way.
- More trials run by Stanford UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 9,941 participants (actual)
Sponsor and investigators
- Lead sponsor
- Stanford University
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute of Mental Health (NIMH)
- Responsible party
- Principal investigator, Jamil Zaki, Stanford University
- Investigators
- Jamil Zaki, PhD, Principal investigator, Stanford University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04771195
- Sponsor's protocol ID
- 24593
- Other IDs
- R01MH125974
- Status last verified
- May 2026
- First submitted
- 22 Feb 2021
- Last updated
- 1 Jun 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Unidentifiable data will be shared with other researchers. To that end, alphanumeric identifiers will be assigned to each individual in the sample's population. Direct nomination lists will not be shared because the potential traceability for participants who may gain access to the data after it is published.
Study at a glance
From the registry record, last updated by the sponsor on 1 Jun 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Social Factors in the Mental Health of Young Adults: Bridging Psychological and Network Analysis
- ClinicalTrials.gov ID
- NCT04771195
- Acronym / sponsor ID
- 24593
- Conditions
- Anxiety, Depression, Loneliness, Stress
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 9,941 participants (actual)
- Lead sponsor
- Stanford UniversityUniversity, hospital or other
- Collaborators
- National Institute of Mental Health (NIMH)
- Study start
- 30 Aug 2021 (actual)
- Primary completion
- 8 May 2026 (actual)
- Study completion
- 8 May 2026 (actual)
- First posted
- 25 Feb 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The central goal of this project is to produce a novel, precise, and comprehensive account of social factors in young adult mental health - using a novel combination of network nominations, ecological momentary assessment, and neuroimaging methods. To that end, the investigators will collect data from two successive classes of college undergraduates (i.e., classes of 2023 and 2024) over the course of their collegiate tenure.
Detailed description
The proposed work will consist of four key components. The investigators will collect data from the class of 2023 in each of their remaining years at college, producing (i) longitudinal data that will allow them to probe the long-term mental health effects of connections made during the transition to college, as well as mental health issues and resilience in the wake of the COVID-19 pandemic as a function of social connectedness. The investigators will leverage this rich dataset to build (ii) prospective quantitative models to predict mental health outcomes later in college based on a range of social factors measured early in college. They will further collect (iii) a longitudinal replication cohort, the class of 2024, allowing to establish the robustness of their initial findings across samples. Finally, the investigators will add (iv) a neuroimaging component to this dataset in a subset of the class of 2024. This will allow them to examine brain "markers" of connectedness, and add them to a prospective model, providing a novel integration across brain, behavior, and community levels of analysis, and a synthetic assessment of social factors in long-term mental health.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Class of 2023 and 2024 | Experimental | Behavioral: Examination of students' naturally occurring social tiesStanford undergraduate students who are expected to graduate in Spring of 2023 or 2024 |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (0 listed)
Key exclusion criteria (1 listed)
- -
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Examination of students' naturally occurring social tiesIn this observational study, features of students' social lives, such as the number of quality of relationships they form, and their subjective loneliness, will be used to predict their mental health and well being at later time points. | Behavioural | Class of 2023 and 2024 |
Primary outcome
Depression
Time frame: September 2021 - May 2024
Score on self-reported depression measure: Center for Epidemiological Studies Scale - 10 item version. Range = 0 to 30. Higher scores indicate more depressive symptoms
Anxiety
Time frame: September 2021 - May 2024
Score on self-reported anxiety measure: State-Trait Anxiety Inventory - 20 item version. Range = 20 to 80. Higher scores indicate more symptoms of anxiety.
2 secondary outcomes
Loneliness
Time frame: September 2021 - May 2024
Stress
Time frame: September 2021 - May 2024
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 1 Jun 2026.
- Individual participant dataSharing planned: Yes. Unidentifiable data will be shared with other researchers. To that end, alphanumeric identifiers will be assigned to each individual in the sample's population. Direct nomination lists will not be shared because the potential traceability for participants who may gain access to the data after it is published.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Jamil Zaki, PhD principal investigator
Stanford University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Examination of students' naturally occurring social ties in people with Anxiety and Depression, run by Stanford University at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 0 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 1 Jun 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Depression (time frame: September 2021 - May 2024). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 1 Jun 2026.