SpeechNCT04818268
Sensory Memory in Speech Motor Learning
A study testing Adaptation and cTBS in people with Speech and Consolidation, run by Yale University at 1 site in Canada.
Trial summary
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its… Read more about this study
- Who is it for?
- Ages 21 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Speech, Consolidation
- What is being tested?
- Adaptation and cTBS
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 120 participants
- Where
- 1 siteCanada
- Study dates
- 1 Aug 2019to 31 Jul 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 to 40 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- right handed adults
- no known physical or neurological abnormalities
Who cannot join
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragments in any part of the body
- pregnancy
Show all 12Show fewer
- claustrophobia
- a personal or family history of epilepsy
- currently taking antipsychotic drugs
- currently taking antidepressant drugs
- currently taking antianxiety drugs
- history of concussion.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Role of Sensory Working Memory in Speech Motor Learning Aim 2
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.
Read the detailed description
This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.
- Conditions
- Speech, Consolidation
- Being tested
- Adaptation, cTBS
- Medical subject headings
- Speech
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
AdaptationBehavioural
Sensorimotor adaptation in speech
cTBSOther
continuous theta-burst stimulation
| Study group | Role | What they receive |
|---|---|---|
| Adaptation to Altered Auditory Feedback | Experimental | Adaptation to Altered Auditory Feedback Receives: Behavioral: Adaptation |
| Auditory Sensory Memory | Experimental | Auditory Sensory Memory Receives: Behavioral: Adaptation |
| Somatosensory Sensory Memory | Experimental | Somatosensory Sensory Memory Receives: Behavioral: Adaptation |
| Adaptation to Altered Auditory Feedback + cTBS to 46v | Experimental | Adaptation to Altered Auditory Feedback + cTBS to 46v Receives: Behavioral: Adaptation; Other: cTBS |
| Sensory Memory + cTBS to 46v | Experimental | Sensory Memory + cTBS to 46v Receives: Behavioral: Adaptation; Other: cTBS |
What is being measured
The primary outcome is the main question the study is designed to answer.
Speech Motor Learning
Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.
Measured: Performance as measured at the end of learning (single day experiment)
Sensory Memory
Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.
Measured: Single day experiment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Mar 2021
- Study start1 Aug 2019
- Primary completion31 Jul 2025
- Study completion31 Jul 2025
Why it stopped: End of funding
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for SpeechStudies of the same condition, open and under way.
- More trials run by Yale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 120 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yale University
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Responsible party
- Sponsor
- Investigators
- David Ostry, Principal investigator, Haskins Laboratories
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04818268
- Sponsor's protocol ID
- 2000025475_a
- Other IDs
- R01DC017439
- Status last verified
- May 2026
- First submitted
- 19 Mar 2021
- Last updated
- 28 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 28 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Role of Sensory Working Memory in Speech Motor Learning Aim 2
- ClinicalTrials.gov ID
- NCT04818268
- Acronym / sponsor ID
- 2000025475_a
- Conditions
- Speech, Consolidation
- Study type
- Interventional
- Recruitment status
- TerminatedReason stopped: End of funding
- Enrolment
- 120 participants (actual)
- Lead sponsor
- Yale UniversityUniversity, hospital or other
- Collaborators
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Study start
- 1 Aug 2019 (actual)
- Primary completion
- 31 Jul 2025 (actual)
- Study completion
- 31 Jul 2025 (actual)
- First posted
- 26 Mar 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.
Detailed description
This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 5
| Arm | Type | Receives |
|---|---|---|
| Adaptation to Altered Auditory Feedback | Experimental | Behavioral: AdaptationAdaptation to Altered Auditory Feedback |
| Auditory Sensory Memory | Experimental | Behavioral: AdaptationAuditory Sensory Memory |
| Somatosensory Sensory Memory | Experimental | Behavioral: AdaptationSomatosensory Sensory Memory |
| Adaptation to Altered Auditory Feedback + cTBS to 46v | Experimental | Behavioral: Adaptation, Other: cTBSAdaptation to Altered Auditory Feedback + cTBS to 46v |
| Sensory Memory + cTBS to 46v | Experimental | Behavioral: Adaptation, Other: cTBSSensory Memory + cTBS to 46v |
Who may qualify
- Ages
- 21 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (2 listed)
- right handed adults
- no known physical or neurological abnormalities
Key exclusion criteria (12 listed)
- patients with:
- cardiac pacemaker
- surgical clips or values on the heart
- implants
- metal or metallic fragments in any part of the body
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| AdaptationSensorimotor adaptation in speech | Behavioural | Adaptation to Altered Auditory Feedback, Adaptation to Altered Auditory Feedback + cTBS to 46v, Auditory Sensory Memory, Sensory Memory + cTBS to 46v, Somatosensory Sensory Memory |
| cTBScontinuous theta-burst stimulation | Other | Adaptation to Altered Auditory Feedback + cTBS to 46v, Sensory Memory + cTBS to 46v |
Primary outcome
Speech Motor Learning
Time frame: Performance as measured at the end of learning (single day experiment)
Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation.
Sensory Memory
Time frame: Single day experiment
Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory.
Results and safety
The study was stopped early (reason given: End of funding). Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 May 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
David Ostry principal investigator
Haskins Laboratories
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Adaptation and cTBS in people with Speech and Consolidation, run by Yale University at 1 site in Canada.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 12 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: stopped early, as of the sponsor's last update on 28 May 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was stopped early (reason given: End of funding). Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Speech Motor Learning (time frame: Performance as measured at the end of learning (single day experiment)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 May 2026.