Bowel Preparation Before ColonoscopyPhase 4NCT05054036
MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy
A Phase 4 study testing MoviPrep and Golytely in people with Bowel Preparation Before Colonoscopy, run by Yale University at 2 sites in United States.
Trial summary
Adequate bowel cleansing is a critical component in the care of hospitalized patients undergoing colonoscopy. However, inpatient status is a well-established risk factor for inadequate bowel preparation. However, few strategies have been rigorously shown to reduce the risk of inadequate bowel preparation. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Bowel Preparation Before Colonoscopy
- What is being tested?
- MoviPrep and Golytely
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 520 participants
- Where
- 2 sitesUnited States
- Study dates
- 12 Jan 2022to 1 Jul 2024
- Phase
- Phase 4
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male or female, aged 18 or greater
- Hospitalized patient scheduled to undergo colonoscopy with bowel preparation (not including preparation with enemas alone)
- Ability to take bowel preparation and be willing to adhere to the regimen
Who cannot join
- Patients presenting to the hospital with ileus, toxic megacolon, evidence of gastrointestinal obstruction
- Receipt of bowel preparation for other reasons during their hospitalization prior to their colonoscopy
- Patients with prior significant gastrointestinal surgeries including colonic resection, subtotal colectomy, abdomino-perineal resection, Hartmann's procedure or other similar surgeries involving structure/function of small intestine or colon
- Unable to give informed consent to the procedure
- Known glucose-6-phosphate dehydrogenase deficiency
- Known phenylketonuria
Show all 9Show fewer
- Known hypersensitivity to polyethylene glycols or ascorbic acid
- Patients undergoing colonoscopy for foreign body removal and/or decompression
- Pregnancy or lactating women
Trial locations and contacts
2 sites in 1 country.
United States2 sites
Bridgeport Hospital
Bridgeport, Connecticut, 06610
Yale New-Haven Hospital
New Haven, Connecticut, 06510
About this study
Official title: Efficacy, Safety, and Tolerability of MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy: a Randomized Control Trial
Adequate bowel cleansing is a critical component in the care of hospitalized patients undergoing colonoscopy. However, inpatient status is a well-established risk factor for inadequate bowel preparation. However, few strategies have been rigorously shown to reduce the risk of inadequate bowel preparation. Moreover, inadequate bowel preparation is frequently related to the poor tolerability of high volumes of bowel preparation in the medically complex and comorbid hospitalized population. Low volume bowel preparations have been developed that have been shown to be noninferior compared to high volume bowel preparation with regards to adequacy of bowel preparation but with improved tolerability. However, the use of low volume bowel preparations for colonoscopies have largely been evaluated in the outpatient setting. In this study, we plan to compare rates of adequate bowel preparation and tolerability of a low volume bowel preparation, MoviPrep, compared to standard high volume bowel preparation, GoLYTELY, in hospitalized patients undergoing colonoscopy. This study promises to highlight low volume bowel preparation as a viable and better tolerated alternative to high volume bowel preparation in hospitalized patients which may ultimately decrease delays in inpatient endoscopy as well as hospital length of stay.
- Conditions
- Bowel Preparation Before Colonoscopy
- Being tested
- MoviPrep, Golytely
- Keywords
- colonoscopy, bowel preparation, inpatient, tolerability
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MoviPrepDrug
Split-dose MoviPrep bowel preparation
GolytelyDrug
Split-dose GoLYTELY bowel preparation
| Study group | Role | What they receive |
|---|---|---|
| MoviPrep | Experimental | For MoviPrep, the dose, schedule, and route of administration are as follows:
* On the evening prior to the colonoscopy, mix the powder with lukewarm water to a total volume of 32 oz. Drink 8 oz. every 15 minutes until the solution is finished. Drink 16 oz. of clear liquids before bed.
* On the morning of the procedure, repeat the above steps and make sure all fluids are consumed at least 2 hours prior to colonoscopy.
* Limit food intake to a regular breakfast, light lunch and clear soup or plain yogurt for dinner on the day prior to the colonoscopy (completed at least 1 hour prior to the first MoviPrep dose.
* Consume only clear liquids from the start of MoviPrep until after the colonoscopy. Receives: Drug: MoviPrep |
| GoLYTELY | Active comparator | For GoLYTELY, the dose, schedule, and route of administrate are as follows:
* On the evening prior to the colonoscopy, mix powder with lukewarm water to a total volume of 4 liters. Drink 2 liters of the solution and store the rest in the refrigerator.
* Drink the remaining 2 liters on the morning of the procedure.
* Limit food intake to a light breakfast on the day prior to the colonoscopy, followed by only clear liquids until the procedure is complete.
* Avoid red and purple liquids. Receives: Drug: Golytely |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants With Adequate Bowel Preparation
The Boston-Bowel-Preparation-Scale (BBPS) is a validated scoring tool that assesses the three segments of the colon (left, transverse, right) and rates them from 1-3 based on the ability to visualize the mucosa. An adequate bowel preparation is defined as a BBPS of 6 or higher with no individual segment scoring less than a 2.
Measured: At time of procedure, approximately 45 minutes
Secondary outcomes (18)
Mean Boston-Bowel-Preparation-Scale (BBPS) Score During Colonoscopy Withdrawal For Each Segment
BBPS assesses three segments of the colon (left, transverse, right) and scores each segment either a 1, 2, or 3 based on the ability to visualize the mucosa. Higher scores correspond to improved mucosal visibility.
Measured: At time of procedure, approximately 45 minutes
Number of Participants With "Excellent" Bowel Preparation
The BBPS is a validated scoring tool that assesses the three segments of the colon (left, transverse, right) and rates them from 1-3 based on the ability to visualize the mucosa. An excellent bowel preparation is defined as a BBPS score of an 8 or 9.
Measured: At time of procedure, approximately 45 minutes
Cecal Intubation
Number of participants with colonoscopies during which the cecum is successfully reached
Measured: At time of procedure, approximately 45 minutes
Cecal Intubation Time
Time from insertion of colonoscopy to reaching the cecum
Measured: At time of procedure, approximately 45 minutes
Colonoscopy Withdrawal Time
Time from reaching the cecum to complete withdrawal of the colonoscope
Measured: At time of procedure, approximately 45 minutes
Time to Colonoscopy
The time from when the patient started the bowel preparation to the colonoscopy procedure itself.
Measured: From start of prep to time of procedure, up to 21 hours
Hospital Length of Stay
Time from admission to discharge
Measured: After study completion, an average of 10 days
Number of Participants With Treatment-Related Adverse Events as Assessed by CTCAE v5.0
The National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) is a descriptive terminology which can be utilized for Adverse Event (AE) reporting. A grading (severity) scale is provided for each AE term from a scale of 1-5, with increasing score corresponding to increasing AE severity.
Measured: Through study completion, an average of 3 days
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 1
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "How much of the bowel preparation was left in the bottle after drinking it to your best effort?"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 2
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "How tolerable did you find the bowel prep?"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 3
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Based on your current experience, would you be willing to drink the same prep again if you need another colonoscopy in the future?"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 1
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Bad taste in mouth"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 2
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Gastric fullness"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 3
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Lack of sleep from excessive bathroom trips"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 4
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Nausea/vomiting"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 5
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Bloating/abdominal distension/gas"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 6
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Abdominal pain/cramps"
Measured: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 7
The Mayo Clinic Bowel Preparation Questionnaire is a survey consisting of questions that relate to symptoms and tolerability of bowel preparation before colonoscopy.
Data presented here is for "Headache"
Measured: Immediately prior to procedure
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Sep 2021
- Study start12 Jan 2022
- Primary completion1 Jul 2024
- Study completion1 Jul 2024
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (6)Papers the sponsor has linked to this study.
- Other trials for Bowel Preparation Before ColonoscopyStudies of the same condition, open and under way.
- More trials run by Yale UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 520 participants (actual)
Sponsor and investigators
- Lead sponsor
- Yale University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Darrick K Li, MD, PhD, Principal investigator, Yale University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05054036
- Sponsor's protocol ID
- 2000031169
- Other IDs
- 000
- Status last verified
- Feb 2026
- First submitted
- 9 Sep 2021
- Last updated
- 11 Mar 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- Yes
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Yadlapati R, Johnston ER, Gregory DL, Ciolino JD, Cooper A, Keswani RN. Predictors of Inadequate Inpatient Colonoscopy Preparation and Its Association with Hospital Length of Stay and Costs. Dig Dis Sci. 2015 Nov;60(11):3482-90. doi: 10.1007/s10620-015-3761-2. Epub 2015 Jun 21.
PubMed 26093612Fuccio L, Frazzoni L, Spada C, Mussetto A, Fabbri C, Manno M, Aragona G, Zagari RM, Rondonotti E, Manes G, Occhipinti P, Cadoni S, Bazzoli F, Hassan C, Radaelli F; QIPS study group. Factors That Affect Adequacy of Colon Cleansing for Colonoscopy in Hospitalized Patients. Clin Gastroenterol Hepatol. 2021 Feb;19(2):339-348.e7. doi: 10.1016/j.cgh.2020.02.055. Epub 2020 Mar 18.
PubMed 32200083Spadaccini M, Frazzoni L, Vanella G, East J, Radaelli F, Spada C, Fuccio L, Benamouzig R, Bisschops R, Bretthauer M, Dekker E, Dinis-Ribeiro M, Ferlitsch M, Gralnek I, Jover R, Kaminski MF, Pellise M, Triantafyllou K, Van Hooft JE, Dumonceau JM, Marmo C, Alfieri S, Chandrasekar VT, Sharma P, Rex DK, Repici A, Hassan C. Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2020 Jun;18(7):1454-1465.e14. doi: 10.1016/j.cgh.2019.10.044. Epub 2019 Nov 1.
PubMed 31683057Garber A, Sarvepalli S, Burke CA, Bhatt A, Ibrahim M, McMichael J, Morris-Stiff G, Rizk MK, Vargo JJ, Rothberg MB. Modifiable Factors Associated with Quality of Bowel Preparation Among Hospitalized Patients Undergoing Colonoscopy. J Hosp Med. 2019 May;14(5):278-283. doi: 10.12788/jhm.3173.
PubMed 30986186Patel M, Staggs E, Thomas CS, Lukens F, Wallace M, Almansa C. Development and validation of the Mayo Clinic Bowel Prep Tolerability Questionnaire. Dig Liver Dis. 2014 Sep;46(9):808-12. doi: 10.1016/j.dld.2014.05.020. Epub 2014 Jun 19.
PubMed 24953203Xiao K, Khan F, Link R, Dominguez-Diaz A, Ameyaw P, Alexis J, Tai CH, Assalone V, Nasufi M, Hughes ML, Loeser C, Hung K, Li DK. Efficacy and Safety of Low Volume Bowel Preparation for Colonoscopy in Hospitalized Patients: A Randomized Noninferiority Trial. J Clin Gastroenterol. 2025 Oct 24. doi: 10.1097/MCG.0000000000002269. Online ahead of print.
PubMed 41128725
Study at a glance
From the registry record, last updated by the sponsor on 11 Mar 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Efficacy, Safety, and Tolerability of MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy: a Randomized Control Trial
- ClinicalTrials.gov ID
- NCT05054036
- Acronym / sponsor ID
- 2000031169
- Conditions
- Bowel Preparation Before Colonoscopy
- Keywords
- colonoscopy, bowel preparation, inpatient, tolerability
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 520 participants (actual)
- Lead sponsor
- Yale UniversityUniversity, hospital or other
- Study start
- 12 Jan 2022 (actual)
- Primary completion
- 1 Jul 2024 (actual)
- Study completion
- 1 Jul 2024 (actual)
- First posted
- 23 Sep 2021 (actual)
- Results
- Posted 11 Mar 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Adequate bowel cleansing is a critical component in the care of hospitalized patients undergoing colonoscopy. However, inpatient status is a well-established risk factor for inadequate bowel preparation. However, few strategies have been rigorously shown to reduce the risk of inadequate bowel preparation. Moreover, inadequate bowel preparation is frequently related to the poor tolerability of high volumes of bowel preparation in the medically complex and comorbid hospitalized population. Low volume bowel preparations have been developed that have been shown to be noninferior compared to high volume bowel preparation with regards to adequacy of bowel preparation but with improved tolerability. However, the use of low volume bowel preparations for colonoscopies have largely been evaluated in the outpatient setting. In this study, we plan to compare rates of adequate bowel preparation and tolerability of a low volume bowel preparation, MoviPrep, compared to standard high volume bowel preparation, GoLYTELY, in hospitalized patients undergoing colonoscopy. This study promises to highlight low volume bowel preparation as a viable and better tolerated alternative to high volume bowel preparation in hospitalized patients which may ultimately decrease delays in inpatient endoscopy as well as hospital length of stay.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| MoviPrep | Experimental | Drug: MoviPrepFor MoviPrep, the dose, schedule, and route of administration are as follows: * On the evening prior to the colonoscopy, mix the powder with lukewarm water to a total volume of 32 oz. Drink 8 oz. every 15 minutes until the solution is finished. Drink 16 oz. of clear liquids before bed. * On the morning of the procedure, repeat the above steps and make sure all fluids are consumed at least 2 hours prior to colonoscopy. * Limit food intake to a regular breakfast, light lunch and clear soup or plain yogurt for dinner on the day prior to the colonoscopy (completed at least 1 hour prior to the first MoviPrep dose. * Consume only clear liquids from the start of MoviPrep until after the colonoscopy. |
| GoLYTELY | Active comparator | Drug: GolytelyFor GoLYTELY, the dose, schedule, and route of administrate are as follows: * On the evening prior to the colonoscopy, mix powder with lukewarm water to a total volume of 4 liters. Drink 2 liters of the solution and store the rest in the refrigerator. * Drink the remaining 2 liters on the morning of the procedure. * Limit food intake to a light breakfast on the day prior to the colonoscopy, followed by only clear liquids until the procedure is complete. * Avoid red and purple liquids. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- Provision of signed and dated informed consent form
- Stated willingness to comply with all study procedures and availability for the duration of the study
- Male or female, aged 18 or greater
- Hospitalized patient scheduled to undergo colonoscopy with bowel preparation (not including preparation with enemas alone)
- Ability to take bowel preparation and be willing to adhere to the regimen
Key exclusion criteria (9 listed)
- Patients presenting to the hospital with ileus, toxic megacolon, evidence of gastrointestinal obstruction
- Receipt of bowel preparation for other reasons during their hospitalization prior to their colonoscopy
- Patients with prior significant gastrointestinal surgeries including colonic resection, subtotal colectomy, abdomino-perineal resection, Hartmann's procedure or other similar surgeries involving structure/function of small intestine or colon
- Unable to give informed consent to the procedure
- Known glucose-6-phosphate dehydrogenase deficiency
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MoviPrepSplit-dose MoviPrep bowel preparation | Drug | MoviPrep |
| GolytelySplit-dose GoLYTELY bowel preparation | Drug | GoLYTELY |
Primary outcome
Number of Participants With Adequate Bowel Preparation
Time frame: At time of procedure, approximately 45 minutes
The Boston-Bowel-Preparation-Scale (BBPS) is a validated scoring tool that assesses the three segments of the colon (left, transverse, right) and rates them from 1-3 based on the ability to visualize the mucosa. An adequate bowel preparation is defined as a BBPS of 6 or higher with no individual segment scoring less than a 2.
18 secondary outcomes
Mean Boston-Bowel-Preparation-Scale (BBPS) Score During Colonoscopy Withdrawal For Each Segment
Time frame: At time of procedure, approximately 45 minutes
Number of Participants With "Excellent" Bowel Preparation
Time frame: At time of procedure, approximately 45 minutes
Cecal Intubation
Time frame: At time of procedure, approximately 45 minutes
Cecal Intubation Time
Time frame: At time of procedure, approximately 45 minutes
Colonoscopy Withdrawal Time
Time frame: At time of procedure, approximately 45 minutes
Time to Colonoscopy
Time frame: From start of prep to time of procedure, up to 21 hours
Hospital Length of Stay
Time frame: After study completion, an average of 10 days
Number of Participants With Treatment-Related Adverse Events as Assessed by CTCAE v5.0
Time frame: Through study completion, an average of 3 days
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 1
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 2
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Tolerability Question 3
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 1
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 2
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 3
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 4
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 5
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 6
Time frame: Immediately prior to procedure
Mayo Clinic Bowel Preparation Questionnaire- Symptom Question 7
Time frame: Immediately prior to procedure
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 11 Mar 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Background: PubMed 26093612Yadlapati R, Johnston ER, Gregory DL, Ciolino JD, Cooper A, Keswani RN. Predictors of Inadequate Inpatient Colonoscopy Preparation and Its Association with Hospital Length of Stay and Costs. Dig Dis Sci. 2015 Nov;60(11):3482-90. doi: 10.1007/s10620-015-3761-2. Epub 2015 Jun 21.
- Background: PubMed 32200083Fuccio L, Frazzoni L, Spada C, Mussetto A, Fabbri C, Manno M, Aragona G, Zagari RM, Rondonotti E, Manes G, Occhipinti P, Cadoni S, Bazzoli F, Hassan C, Radaelli F; QIPS study group. Factors That Affect Adequacy of Colon Cleansing for Colonoscopy in Hospitalized Patients. Clin Gastroenterol Hepatol. 2021 Feb;19(2):339-348.e7. doi: 10.1016/j.cgh.2020.02.055. Epub 2020 Mar 18.
- Background: PubMed 31683057Spadaccini M, Frazzoni L, Vanella G, East J, Radaelli F, Spada C, Fuccio L, Benamouzig R, Bisschops R, Bretthauer M, Dekker E, Dinis-Ribeiro M, Ferlitsch M, Gralnek I, Jover R, Kaminski MF, Pellise M, Triantafyllou K, Van Hooft JE, Dumonceau JM, Marmo C, Alfieri S, Chandrasekar VT, Sharma P, Rex DK, Repici A, Hassan C. Efficacy and Tolerability of High- vs Low-Volume Split-Dose Bowel Cleansing Regimens for Colonoscopy: A Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. 2020 Jun;18(7):1454-1465.e14. doi: 10.1016/j.cgh.2019.10.044. Epub 2019 Nov 1.
- Background: PubMed 30986186Garber A, Sarvepalli S, Burke CA, Bhatt A, Ibrahim M, McMichael J, Morris-Stiff G, Rizk MK, Vargo JJ, Rothberg MB. Modifiable Factors Associated with Quality of Bowel Preparation Among Hospitalized Patients Undergoing Colonoscopy. J Hosp Med. 2019 May;14(5):278-283. doi: 10.12788/jhm.3173.
- Background: PubMed 24953203Patel M, Staggs E, Thomas CS, Lukens F, Wallace M, Almansa C. Development and validation of the Mayo Clinic Bowel Prep Tolerability Questionnaire. Dig Liver Dis. 2014 Sep;46(9):808-12. doi: 10.1016/j.dld.2014.05.020. Epub 2014 Jun 19.
- Derived from this study: PubMed 41128725Xiao K, Khan F, Link R, Dominguez-Diaz A, Ameyaw P, Alexis J, Tai CH, Assalone V, Nasufi M, Hughes ML, Loeser C, Hung K, Li DK. Efficacy and Safety of Low Volume Bowel Preparation for Colonoscopy in Hospitalized Patients: A Randomized Noninferiority Trial. J Clin Gastroenterol. 2025 Oct 24. doi: 10.1097/MCG.0000000000002269. Online ahead of print.
- Individual participant dataSharing planned: No
Related trials for Bowel Preparation Before Colonoscopy
Not yet recruiting
Social Software-Based Intelligent Management System for Bowel Preparation
Colorectal Polyp, Colorectal Adenoma
RecruitingPhase 3
A Study to Investigate Bowel Cleansing With PLENVU® Compared to Sodium Picosulfate in Participants Aged 1 to < 18 Years of Age in Preparation for Colonoscopy
Bowel Cleansing Prior to Clinical Procedures
Recruiting
Comparison of Electrolyte Beverages and Water as Solvents for Bowel Preparation
Bowel Preparation Before Colonoscopy
Active, not recruiting
The Efficacy of AI-Driven Feces Identification for Bowel Preparation Prior to Colonoscopy
AI App Improves Bowel Preparation Quality for Colonoscopy
Not yet recruitingObservational study
The Effect of pH Value of Water Consumed During Bowel Preparation Before Colonoscopy on Colon Cleansing
Colonoscopy, Bowel Cleansing
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Darrick K Li, MD, PhD principal investigator
Yale University
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing MoviPrep and Golytely in people with Bowel Preparation Before Colonoscopy, run by Yale University at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 11 Mar 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 11 Mar 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Participants With Adequate Bowel Preparation (time frame: At time of procedure, approximately 45 minutes). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT05054036, which also lists 6 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 11 Mar 2026.