Post Operative PainPhase 2NCT05094323
Analgesia After Video-Assisted Thoracic Surgery
A Phase 2 study testing Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine and Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine in people with Post Operative Pain, run by Assiut University at 1 site in Egypt.
Trial summary
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS). Read more about this study
- Who is it for?
- Ages 18 to 70 years
- Conditions the study is for
- Post Operative Pain
- What is being tested?
- Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine and Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 102 participants
- Where
- 1 siteEgypt
- Study dates
- 18 Feb 2022to 15 Oct 2025
- Phase
- Phase 2
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 70 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex.
Who cannot join
- Contraindications to regional block
- Pregnancy
- Body mass index (BMI) > 30 Kg/m2
- Psychiatric diseases
- Severe renal, liver, or cardiac dysfunction
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Analgesic Efficacy of Ultrasound-Guided Deep Serratus Anterior Plane Block, Local Wound Infiltration, and Thoracic Paravertebral Block After Uniportal Video-Assisted Thoracic Surgery: A Randomized Trial
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
Read the detailed description
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.
- Conditions
- Post Operative Pain
- Being tested
- Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine, Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine
- Medical subject headings
- Pain, Postoperative
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaineDrug
Patients will receive ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine.
Local wound infiltration with isobaric bupivacaineDrug
Patients will receive local wound infiltration with isobaric bupivacaine.
Ultrasound-guided thoracic paravertebral block with isobaric bupivacaineDrug
Patients will receive ultrasound-guided thoracic paravertebral block with isobaric bupivacaine.
| Study group | Role | What they receive |
|---|---|---|
| Group I | Active comparator | Patients will receive ultrasound-guided deep serratus anterior plane block. Receives: Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine |
| Group II | Active comparator | Patients will receive local wound infiltration (LWI). Receives: Drug: Local wound infiltration with isobaric bupivacaine |
| Group III | Placebo comparator | Patients will receive ultrasound-guided thoracic paravertebral block. Receives: Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Time to first analgesic requirement
Assessed in minutes
Measured: 24 hours after surgery
Secondary outcomes (1)
Postoperative pain intensity
Assessed by the numerical rating pain scale, an 11-point scale graded from 0 to 10 (0 = no pain, 10 = the worst imaginable pain)
Measured: 24 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2021
- Study start18 Feb 2022
- Primary completion15 Oct 2025
- Study completion15 Oct 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Post Operative PainStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 2
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 102 participants (actual)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Seham Mohamed Moeen Ibrahim, Assiut University
- Investigators
- Seham M Moeen, MD, Principal investigator, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT05094323
- Sponsor's protocol ID
- 10 2021
- Status last verified
- Jan 2026
- First submitted
- 14 Oct 2021
- Last updated
- 27 Jan 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 27 Jan 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Analgesic Efficacy of Ultrasound-Guided Deep Serratus Anterior Plane Block, Local Wound Infiltration, and Thoracic Paravertebral Block After Uniportal Video-Assisted Thoracic Surgery: A Randomized Trial
- ClinicalTrials.gov ID
- NCT05094323
- Acronym / sponsor ID
- 10 2021
- Conditions
- Post Operative Pain
- Phase
- Phase 2
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 102 participants (actual)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 18 Feb 2022 (actual)
- Primary completion
- 15 Oct 2025 (actual)
- Study completion
- 15 Oct 2025 (actual)
- First posted
- 26 Oct 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
Detailed description
Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).
Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Group I | Active comparator | Drug: Ultrasound-guided deep serratus anterior plane block with isobaric bupivacainePatients will receive ultrasound-guided deep serratus anterior plane block. |
| Group II | Active comparator | Drug: Local wound infiltration with isobaric bupivacainePatients will receive local wound infiltration (LWI). |
| Group III | Placebo comparator | Drug: Ultrasound-guided thoracic paravertebral block with isobaric bupivacainePatients will receive ultrasound-guided thoracic paravertebral block. |
Who may qualify
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex.
Key exclusion criteria (5 listed)
- Contraindications to regional block
- Pregnancy
- Body mass index (BMI) > 30 Kg/m2
- Psychiatric diseases
- Severe renal, liver, or cardiac dysfunction
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-guided deep serratus anterior plane block with isobaric bupivacainePatients will receive ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine. | Drug | Group I |
| Local wound infiltration with isobaric bupivacainePatients will receive local wound infiltration with isobaric bupivacaine. | Drug | Group II |
| Ultrasound-guided thoracic paravertebral block with isobaric bupivacainePatients will receive ultrasound-guided thoracic paravertebral block with isobaric bupivacaine. | Drug | Group III |
Primary outcome
Time to first analgesic requirement
Time frame: 24 hours after surgery
Assessed in minutes
1 secondary outcome
Postoperative pain intensity
Time frame: 24 hours after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Jan 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Seham M Moeen, MD principal investigator
Assiut University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 2 study testing Ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine, Local wound infiltration with isobaric bupivacaine and Ultrasound-guided thoracic paravertebral block with isobaric bupivacaine in people with Post Operative Pain, run by Assiut University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Jan 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Time to first analgesic requirement (time frame: 24 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Jan 2026.