Clinical trials: Post Operative Pain
Pain, Postoperative, Surgical Procedures, Operative
Postoperative Pain in Adult Patients.
Each surgical intervention associated with even a minor tissue injury is a source of pain which needs to be effectively controlled.
- Trial name
- NCT03731039
- Testing
- Observational study
- Where
- Poland
- Volunteers
- 620 people
- Sponsor
- Andrzej Frycz Modrzewski Krakow University
Surgery-Complications, Anesthesia Complication
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major…
- Conditions
- Surgery-Complications, Anesthesia Complication, Anesthesia Awareness, Anesthesia
- Trial name
- THRIVE (NCT05991453)
- Testing
- Anesthetic technique Propofol TIVA, Anesthetic technique inhaled agent
- Where
- 24 sites in United States
- Volunteers
- 13,000 people
- Sponsor
- Washington University School of Medicine
Pain
Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy
This study is evaluating the effect of a Belladonna and Opium suppository administered intraoperatively on post operative pain after laparoscopic radical prostatectomy for prostate cancer. This is a blinded randomized study.
- Trial name
- NCT00863928
- Testing
- belladonna 16.2 mg and opium 60 mg suppository
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Benaroya Research Institute
Postoperative Pain, Complications
A Trial of Closed Hemorrhoidectomy Under Local Perianal Block Versus Spinal Anesthesia
Hemorrhoidectomy can be carried out under several modes of anesthesia. In western country hemorrhoidectomy usually be performed under general anesthesia, however there may be the complications resulted from general anesthesia…
- Conditions
- Postoperative Pain, Complications, Satisfaction
- Trial name
- NCT00925912
- Testing
- spinal block, Perianal block
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Phramongkutklao College of Medicine and Hospital
Pain, Total Knee Arthroplasty
Duration of Leg Nerve Blocks With Dexamethasone Added to Local Anesthetic
This is a Randomized Double blinded controlled trial on the effect of adding dexamethasone to Ropivacaine on the duration of pain relief for ultrasound guided femoral, obturator and popliteal block after total knee replacement…
- Trial name
- NCT01511211
- Testing
- Dexamethasone, Ropivacaine
- Where
- United States
- Sponsor
- University of New Mexico
Gynecologic Disease
Efficacy of Acetaminophen-ibuprofen Combination on the Postoperative Pain After Laparoscopic Gynecology Surgery
Acetaminophen and ibuprofen has been safely used for a long time and reduces postoperative pain and opioid dosages. Investigators are planning to compare the efficacy of 1) acetaminophen only and 2) acetaminophen and ibuprofen…
- Trial name
- NCT05509244
- Testing
- Acetaminophen, Ibuprofen
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- The Catholic University of Korea
Cervical Spondylosis, Lumbar Spondylosis
Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery
A prospective, randomized, placebo controlled, double-blinded study at a single institution.
- Trial name
- NCT02276911
- Testing
- Ibuprofen, normal saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Kidney Calculi
Paravertebral Block Versus Epidural Anesthesia for Percutaneous Nephrolithotomy
This prospective, randomized study is aimed to assess the efficacy and safety of paravertebral block compared to epidural anesthesia for percutaneous nephrolithotomy.
- Trial name
- PVB (NCT03018899)
- Testing
- paravertebral block, epidural anesthesia
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huazhong University of Science and Technology
Cardiovascular Diseases
ESPB vs TPVB for Cardiac Surgery
Pain is a common and serious problem after cardiovascular surgery. It is associated with increased morbidity and mortality, and additional risk factors of cardiac surgery such as sternotomy and cardiopulmonary bypass contribute…
- Trial name
- NCT05476393
- Testing
- Postoperative management
- Where
- Turkey (Türkiye)
- Sponsor
- Medipol University
Pain, Postoperative
Effective Postoperative Pain Relief After Laparoscopic Cholecystectomy With TENS
The study evaluates the effect of TENS (transcutaneous electrical nerve stimulation) treatment for first line of treatment compared with conventional treatment with opioids on pain relief and time spent time in the…
- Trial name
- NCT04114149
- Testing
- TENS (transcutaneous electrical nerve stimulation), iv opioid
- Where
- Sweden
- Volunteers
- 166 people
- Sponsor
- Göteborg University
Pain Management, Colorectal Surgery
Opioid-Free Anesthesia in Colorectal Surgery, 2025 (OFA-CRC-2025)
This study wants to find out if using a pain control method without opioids (Opioid-Free Anesthesia or OFA) works as well as or better than standard anesthesia (which uses opioids) for adults having minimally invasive…
- Conditions
- Pain Management, Colorectal Surgery, Opioid Free Anesthesia, Postoperative Complications
- Trial name
- OFA-CRC-2025 (NCT07771049)
- Testing
- Opioid-Free Anesthesia (OFA), Opioid-Based Anesthesia (OBA)
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario La Fe
İnguinal Hernia, Complication,Postoperative
Post-Surgical Outcomes of Conventional vs 3-Point Mesh Fixation in Lichtenstein Repair: An RCT
This is a single-center, parallel-group randomized controlled trial conducted in 2025-2025 at the General Surgery Ward of the Sindh Institute of Urology and Transplantation (SIUT), Karachi.
- Conditions
- İnguinal Hernia, Complication,Postoperative, Pain, Postoperative
- Trial name
- COMET (NCT07334548)
- Testing
- 3-point mesh fixation, Conventional Mesh Fixation
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Sahar Mughis
Knee Arthroplasty, Transcranial Direct Current Stimulation
Knee Arthroplasty Recovery With Transcranial Direct Current Stimulation
Total knee arthroplasty (TKA) is widely performed to reduce pain from advanced osteoarthritis, yet many patients experience severe postoperative pain and up to 25-44% develop chronic postsurgical pain (CPSP).
- Conditions
- Knee Arthroplasty, Transcranial Direct Current Stimulation, Pain, Postoperative
- Trial name
- KART (NCT07351578)
- Testing
- Active tDCS Stimulation
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Women's College Hospital
Inflammation Eye Pain, Postoperative Cataract
A Phase 3 Study Evaluating the Efficacy and Safety of OCS-01 Eyedrops Compared to Vehicle for the Treatment of Ocular Inflammation and Pain Following Cataract Surgery
This was a randomized, double-masked, vehicle-controlled, Phase 3 study evaluating the efficacy and safety of OCS-01 QD compared to vehicle in the treatment of inflammation and pain following cataract surgery.
- Trial name
- OPTIMIZE-1 (NCT05147233)
- Testing
- OCS-01, Vehicle
- Where
- 25 sites in United States
- Volunteers
- 241 people
- Sponsor
- Oculis
Postoperative Pain
Comparison of ESP Block Versus Serratus Block
Total 60 patients, American society of anaesthesiology physical status I-II aged between 18-65 who underwent totally mastectomy will recruit to the study. The patients randomly divided into two groups.
- Trial name
- NCT03619447
- Testing
- ESP block group, serratus block group
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Pain, Postoperative
Efficacy of Fascia Iliaca Block Versus Intraoperative Nerve Infiltration During Anterior Hip Replacement Surgery
Surgical trauma causes nerve sensitization leading to amplification and prolongation of postoperative pain. In experimental studies, pre-injury neural blockade using local anesthetics has been shown to reduce post-injury…
- Trial name
- NCT01693900
- Testing
- Pre-operative Ultrasound FICB Group, Intra-operative FICB Group
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Randy Fayne, DO
Pain, Fear
Walkway Used in Postoperative Mobilization
Introduction Surgical operations are increasing globally, with abdominal surgeries accounting for approximately 70% of these procedures.
- Conditions
- Pain, Fear, Children, Surgery
- Trial name
- NCT07404163
- Testing
- Walkway
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Tarsus University
Postoperative Pain, Pulmonary Function Tests
The Effect of Superficial Parasternal Intercostal Plane Block on Pulmonary Function Tests After Cardiac Surgery
In adult patients undergoing cardiac surgery, does adding an sPIP block to standard care compared to standard care alone result in a smaller decrease in PFTs?
- Trial name
- PIPACS (NCT05999721)
- Testing
- superficial parasternal intercostal plane block, Standard care
- Where
- 2 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Shai Fein
Pain, Hispanics
Efficacy of NSAID and Acetaminophen in the Control of Post-Operative Pain in Patients Undergoing Total Knee Replacement
An alternate perioperative pain control protocol composed of intravenous ketorolac and oral acetaminophen for patients who underwent total knee replacement was designed with the aim to determine its efficacy when compared to pain…
- Conditions
- Pain, Hispanics, Opioid Use, Multimodal Analgesia
- Trial name
- NCT05393414
- Testing
- Opioid based protocol, Opioid sparing protocol
- Where
- Puerto Rico
- Volunteers
- 81 people
- Sponsor
- University of Puerto Rico
Pain, Head and Neck Disorder
Effect of Remifentanil on the Recovery Profile After Prolonged Head and Neck Surgery
Opioid tolerance in the perioperative period is inevitable especially with ultra-short acting agents such as remifentanil. Existing evidence had shown that opioid induced hyperalgesia due to neuroplastic changes in the central as…
- Trial name
- NCT02416752
- Testing
- Remifentanil, choice of intra-operative opioids were left to the discretion of anesthesiologist
- Where
- Singapore
- Volunteers
- 222 people
- Sponsor
- Singapore General Hospital
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